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Rapid metabolic fingerprinting with the aid of chemometric models to identify authenticity of natural medicines: Turmeric, Ocimum, and Withania somnifera study

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Journal of Pharmaceutical Analysis 2023年第9期13卷 1041-1057页

作者： Samreen Khan abhishek Kumar Rai Anjali singh Saudan singh Basant Kumar Dubey Raj Kishori Lal Arvind singh Negi Nicholas Birse Prabodh Kumar Trivedi Christopher T.Elliott Ratnasekhar Ch Metabolomics Lab Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Department of Crop Production&Protection Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Academy of Council of Scientific and Industrial Research(ACSIR) Ghaziabad201002India Department of Biotechnology Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Genetics and Plant Breeding Department Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Department of Phytochemistry Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India School of Biological Sciences Queen's UniversityBelfastBT95DLUK

Herbal medicines are popular natural medicines that have been used for *** use of alternative medicines continues to expand rapidly across the *** World Health Organization suggests that quality assessment of natural medicines is essential for any therapeutic or health care applications,as their therapeutic potential varies between different geographic origins,plant species,and *** of herbal medicines based on a limited number of secondary metabolites is not an ideal *** quality should be considered based on a complete metabolic profile,as their pharmacological activity is not due to a few specific secondary metabolites but rather a larger group of bioactive compounds.A holistic and integrative approach using rapid and nondestructive analytical strategies for the screening of herbal medicines is required for robust *** this study,a rapid and effective quality assessment system for geographical traceability,species,and variety-specific authenticity of the widely used natural medicines turmeric,Ocimum,and Withania somnifera was investigated using Fourier transform near-infrared(FT-NIR)spectroscopy-based metabolic *** different geographical origins of turmeric,five different Ocimum species,and three different varieties of roots and leaves of Withania somnifera were studied with the aid of machine learning *** good discrimination(R^(2)>0.98,Q^(2)>0.97,and accuracy=1.0)with sensitivity and specificity of 100%was achieved using this metabolic fingerprinting *** study demonstrated that FT-NIR-based rapid metabolic fingerprinting can be used as a robust analytical method to authenticate several important medicinal herbs.

关键词： Rapid metabolic fingerprinting Natural medicines FT-NIR Chemometric models

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Deep Learning Approach for Analysis and Characterization of COVID-19

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Computers, Materials & Continua 2022年第1期70卷 451-468页

作者： Indrajeet Kumar Sultan S.Alshamrani abhishek Kumar Jyoti Rawat Kamred Udham singh Mamoon Rashid Ahmed Saeed AlGhamdi School of Computing Graphic Era Hill UniversityDehradun(UK)India Department of Information Technology College of Computer and Information TechnologyTaif UniversityTaif21944Saudi Arabia School of Computer Science&IT JAIN(to be Deemed University)BangaloreIndia School of Computing Dehradun Institute of TechnologyUttarakhandIndia Department of Computer Engineering Faculty of Science and TechnologyVishwakarma UniversityPuneIndia Department of Computer Engineering College of Computer and Information TechnologyTaif UniversityTaif21944Saudi Arabia

Early diagnosis of a pandemic disease like COVID-19 can help deal with a dire situation and help radiologists and other experts manage human resources more *** a recent pandemic,laboratories perform diagnostics manually,which requires a lot of time and expertise of the laboratorial technicians to yield accurate ***,the cost of kits is high,and well-equipped labs are needed to perform this ***,other means of diagnosis is highly *** is one of the existing methods that finds its use in the diagnosis of *** radiography observes change in Computed Tomography(CT)chest images of patients,developing a deep learning-based method to extract graphical features which are used for automated diagnosis of the disease ahead of laboratory-based *** proposed work suggests an Artificial Intelligence(AI)based technique for rapid diagnosis of COVID-19 from given volumetric chest CT images of patients by extracting its visual features and then using these features in the deep learning *** proposed convolutional neural network aims to classify the infectious and non-infectious SARS-COV2 *** proposed network utilizes 746 chests scanned CT images of 349 images belonging to COVID-19 positive cases,while 397 belong to negative cases of *** experiment resulted in an accuracy of 98.4%,sensitivity of 98.5%,specificity of 98.3%,precision of 97.1%,and F1-score of 97.8%.The additional parameters of classification error,mean absolute error(MAE),root-mean-square error(RMSE),and Matthew’s correlation coefficient(MCC)are used to evaluate our proposed *** obtained result shows the outstanding performance for the classification of infectious and non-infectious for COVID-19 cases.

关键词： Coronavirus covid-19 respiratory infection computed tomography deep neural network

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Virtual-reality-based digital twin of office spaces with social distance measurement feature

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Virtual Reality & Intelligent Hardware 2022年第1期4卷 55-75页

作者： abhishek MUKHOPADHYAY G S Rajshekar REDDY KamalPreet singh SALUJA Subhankar GHOSH Anasol PEÑA-RIOS Gokul GOPAL Pradipta BISWAS Indian Institute of Science BangaloreIndia BT Plc UK

Background Social distancing is an effective way to reduce the spread of the SARS-CoV-2 *** students and researchers have already attempted to use computer vision technology to automatically detect human beings in the field of view of a camera and help enforce social ***,because of the present lockdown measures in several countries,the validation of computer vision systems using large-scale datasets is a *** In this paper,a new method is proposed for generating customized datasets and validating deep-learning-based computer vision models using virtual reality(VR)*** VR,we modeled a digital twin(DT)of an existing office space and used it to create a dataset of individuals in different postures,dresses,and *** test the proposed solution,we implemented a convolutional neural network(CNN)model for detecting people in a limited-sized dataset of real humans and a simulated dataset of humanoid *** We detected the number of persons in both the real and synthetic datasets with more than 90%accuracy,and the actual and measured distances were significantly correlated(r=0.99).Finally,we used intermittent-layer-and heatmap-based data visualization techniques to explain the failure modes of a *** A new application of DTs is proposed to enhance workplace safety by measuring the social distance between *** use of our proposed pipeline along with a DT of the shared space for visualizing both environmental and human behavior aspects preserves the privacy of individuals and improves the latency of such monitoring systems because only the extracted information is streamed.

关键词： Virtual environment Digital twin 3D visualization Convolutional neural network Object detection Social distancing

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Prospects of diagnostic and prognostic biomarkers of pyometra in canine

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Asian pacific Journal of Reproduction 2020年第4期9卷 166-173页

作者： Laishram Kipjen singh Manas Kumar Patra Girish Kumar Mishra abhishek Chandra Saxena Ujjwal Kumar De Sanjay Kumar singh Harendra Kumar Krishnaswamy Narayanan Animal Reproduction Division Indian Veterinary Research InstituteIzatnagarU.P.243122India Animal Reproduction Gynaecology and Obstetrics Division ICAR-National Dairy Research InstituteKarnal-132001India Department of Veterinary Gynaecology andObstetrics College of Veterinary Sciences and Animal HusbandryAnjoraDurg(C.G.)India Referral Veterinary Polyclinic ICAR-Indian Veterinary Research InstituteIzatnagarU.P.243122India ICAR-Indian Veterinary Reseach Institute HebbalBangaluru 560024India

Pyometra is one of the most common uterine pathologies of intact bitch at middle to advanced age. In the early stages, the disease shows subtle changes, making diagnosis a challenge. In contrast, at later stages, it manifests as potentially life-threatening systemic inflammatory response syndrome. Ultrasonographic examination of the uterus aids in the diagnosis, although it has limitation in ascertaining the clinical severity of pyometra. Moreover, differentiation of cystic endometrial hyperplasia from pyometra could not be discerned with greater accuracy. Therefore, false negative diagnosis of pyometra patients leads to development of systemic inflammatory response, which delays administration of therapies and results in deaths during early course of treatment. Further, indiscriminate use of broad-spectrum antimicrobials at higher dose in false positive cases considerably contributes to the rising pool of drug resistant pathogens, thereby increasing the risk of case fatality due to sepsis in a long-term. Monitoring the circulating pro-inflammatory cytokines, acute phase proteins, endotoxin, growth factors and inflammatory mediators is the current trend in pyometra research, especially for developing diagnostic and prognostic biomarkers. The present review deals with the prospects of developing diagnostic and prognostic biomarkers in the canine pyometra.

关键词： Pyometra Systemic inflammatory response Acute-phase proteins Prostaglandin F metabolite Canine

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Assessment of long-term climate variability and its impact on the decadal growth of horticultural crops in central India

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Ecological Processes 2022年第1期11卷 862-889页

作者： Gaurav Sharma Amita Sharma Nishant Kumar Sinha Om Prakash Sharma Ashutosh singh Ajai Kumar Pandey abhishek Kumar Sudhir Kumar Trivedi Bharti Sao Mukesh Kumar Sahu College of Horticulture and Forestry Rani Lakshmi Bai Central Agricultural UniversityJhansiUttar Pradesh 284003India Department of Environmental Science Rajmata Vijayaraje Scindia Krishi VishwavidyalayaGwaliorMadhya Pradesh 474002India Division of Soil Physics Indian Institute of Soil ScienceBhopalMadhya Pradesh 462038India Department of Floriculture and Landscape Architecture Indira Gandhi Krishi VishwavidyalayaRaipurChhattisgarh 492012India

Background:The impact of climate change on horticultural production is of utmost concern *** such vulnerable region of horticultural importance is the Madhya Pradesh state in the central part of *** is crucial to analyse the long-term trend in climatic variations and its effect on horticultural crop ***,this study focuses on detecting trends in mean annual precipitation and temperature of 115 years for the 15 districts covering all the regions of the state as well as projections of all the Representative Concentration Pathway(RCP)climatic scenarios for 2050 and 2080 of Madhya Pradesh *** decadal(2010–2020)insight into the area and production of horticultural crops is undertaken which will help forecasting the future growth *** a better insight,case study on four horticultural crops is undertaken to assess their decadal growth trend vis-à-vis climate parameters in these 15 ***:The Mann–Kendall test for 1901–2016 and Sen’s slope indicated a non-significant change in long-term trend for precipitation except for increasing change in Khargone and decreasing change in Rewa ***-cant increasing trend of average temperature is obtained for Hoshangabad,Jabalpur,Sagar and Rewa *** Sen’s slope indicated an increase of 0.005 to 0.009℃for maximum temperature and 0.005 to 0.012℃for minimum temperature *** projections of all the RCP climate scenarios for the years 2050 and 2080 indicated non-significant variation in precipitation but an increase in maximum(1.4 to 4.1℃)and minimum(1.45 to 4.65℃)annual *** increasing trend in area and production for horticultural crops is also observed in central India for the study *** is yield increase in all the crops selected in case study except for potato,which recorded a decreased yield between the years 2010–***:The Mann–Kendall test and projections indicate towards climate change with a temperature *** the decad

关键词： Climate change Horticulture Madhya Pradesh Precipitation Temperature Trend analysis

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Implementation of drone technology for farm monitoring&pesticide spraying:A review

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Information Processing in Agriculture 2023年第2期10卷 192-203页

作者： Abdul Hafeez Mohammed Aslam Husain S.P.singh Anurag Chauhan Mohd.Tauseef Khan Navneet Kumar abhishek Chauhan S.K.Soni Rajkiya Engineering College Ambedkar NagarUP 224122India Rajkiya Engineering College BandaUP 210201India Rajkiya Engineering College BijnorUP 246725India MMMUT GorakhpurUP 273016India

The world receives more than 200 thousand people in a day and it is expected that the total world population will reach 9.6 billion by the year *** will result in extra food demand,which can only be met from enhanced crop ***,modernization of the agricultural sector becomes the need of the *** are many constraints that are responsible for the low production of crops,which can be overcome by using drone technology in the agriculture *** paper presents an analysis of drone technologies and their modifications with time in the agriculture sector in the last *** application of drones in the area of crop monitoring,and pesticide spraying for Precision Agriculture(PA)has been *** work done related to drone structure,multiple sensor development,innovation in spot area spraying has been ***,the use of Artificial Intelligent(AI)and deep learning for the remote monitoring of crops has been discussed.

关键词： Unmanned Aerial Vehicle Agriculture drone Pesticide spraying Crop monitoring Precision agriculture

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Surface Photografting of Novel Sulfobetaine Copolymers on Silica

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Materials Sciences and Applications 2012年第7期3卷 467-477页

作者： abhishek Kumar Nazia Tarannum Meenakshi singh Department of Chemistry MMV Banaras Hindu University Varanasi-221005 INDIA

A couple of novel sulfobetaine copolymer is developed via Michael-type addition reaction. The comonomers, diamines and maleimide react via Michael reaction through UV irradiation using AIBN as photoinitiator producing polyamine chain. Further, sulfobetaine copolymers were obtained on treatment of the polyamine with sulfopropylating agent, 1,3-propane sultone. These novel sulfobetaine polymers were grafted on silica surface to produce responsive biocompatible surface. This easy straightforward, catalyst free facile protocol for synthesis of polymer grafted surface is useful for developing biomedical devices. Additionally, both the copolymers show fluorescence characteristics.

关键词： Copolymer Sulfobetaine Zwitterionic Grafted Copolymer Photopolymerization Maleimide Michael-Type Reaction Surface Initiated Polymerization (SIP) Density Functional Theory (DFT) Fluorescence

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Fabrication of Graphitic Carbon Nitride-Based Film:An Emerged Highly Efficient Catalyst for Direct C-H Arylation under Solar Light

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Chinese Journal of Chemistry 2021年第3期39卷 633-639页

作者： Surabhi Chaubey Rajesh K.Yadav Tae Wu Kim Tara Chand Yadav abhishek Kumar D.K.Dwivedi B.K.Pandey Atul P.singh Department of Chemistry and Environmental Science Madan Mohan Malaviya University of TechnologyGorakhpur-273010U.PIndia Center for Nanomaterials and Chemical Reactions Institute for Basic Science(IBS)Daejeon 34141Republic of Korea Department of Chemistry Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Department of Biotechnology Indian Institute of Technology Roorkee-247667India Department of Chemistry Institute of ScienceBanaras Hindu UniversityIndia Department of Physics and Material Science Madan Mohan Malaviya University of TechnologyGorakhpur 273010U.PIndia Department of Chemistry Chandigarh UniversityMohaliIndia

Main observation and conclusion Photoredox C-H bond formation can proceed in aerobic environment under solar light and has therefore become ***-days,different types of expensive novel metal complexes and nanomaterials have been urbanized as photocatalysts for direct C-H bond formation in between derivatives of heteroarenes(HAs)and aryl diazonium *** photocatalysts,however,still suffer from poor stability,high cost,and ***,a graphitic carbon nitride-based fluorescein isothiocyanate(g-C_(3)N_(4)-FITC)film pho-tocatalyst has been reported,which shows ecellent light harvesting ability,and band gap suitability to catalyze the metal free direct C-H arylation of HAs under solar light at ambient ***,the g-C_(3)N_(4)-FITC film photocatalyst can be reused four times without significant loss of activity,confirming the excellent photocatalytic *** current strategy to constructa g-C_(3)N_(4)-FITC film photocatalyst for direct C-H arylation opens a new path towards replacing metal-based catalysts in fine chemical Sy nthesis.

关键词： Photocatalysis g-C_(3)N_(4)-FITC film photocatalyst C-H activation Heteroarenes Cyclic voltammetry

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Periprosthetic subtrochanteric femoral fracture in a megaprosthesis of the knee

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Chinese Journal of Traumatology 2013年第5期16卷 314-315页

作者： Raju Vaishya Ajay Pal singh abhishek Vaish Department of Orthopaedics & Joint ReplacementSurgery Indraprastha Apollo Hospitals New Delhi India Department of Orthopaedics Sancheti Institute of Or-thopaedics & Rehabilitation Pune India

We report a rare case of periprosthetic posttraumatic fracture of subtrochanteric region of femur alter a megaprosthesis of the knee, done for resistant non- union of distal femur with secondary osteoarthrosis in a 51... 详细信息

关键词： Periprosthetic fractures, Femur Femoral fractures Knee

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Robust Watermarking Scheme for NIfTI Medical Images

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Computers, Materials & Continua 2022年第5期71卷 3107-3125页

作者： abhishek Kumar Kamred Udham singh Visvam Devadoss Ambeth Kumar Tapan Kant Abdul Khader Jilani Saudagar Abdullah Al Tameem Mohammed Al Khathami Muhammad Badruddin Khan Mozaherul Hoque Abul Hasanat Khalid Mahmood Malik School of Computer Science and IT JAIN(Deemed to be University)Bangalore560069India Department of Computer Science and Information Engineering National Cheng Kung UniversityTainan701Taiwan Department of Computer Science&Engineering Panimalar Engineering CollegeAnna UniversityChennai600123India Patna Women’s College Patna800001India Information Systems Department College of Computer and Information SciencesImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia Department of Computer Science and Engineering Oakland UniversityRochester48309USA

Computed Tomography(CT)scan and Magnetic Resonance Imaging(MRI)technologies are widely used in medical *** the last few months,due to the increased use of CT scans,millions of patients have had their CT scans ***,as a result,images showing the Corona Virus for diagnostic purposes were digitally transmitted over the *** major problem for the world health care system is a multitude of attacks that affect copyright protection and other ethical issues as images are transmitted over the *** a result,it is important to apply a robust and secure watermarking technique to these ***,watermarking schemes have been developed for various image formats,***,.bmp,***,but their impact on NIfTI(Neuroimaging Informatics Technology Initiative)images is not noteworthy.A watermarking scheme based on the Lifting Wavelet Transform(LWT)and QR factorization is presented in this *** LWT and QR are combined,the NIfTI image maintains its inherent sensitivity and mitigates the watermarking scheme’s *** watermarks are added to the host image in this *** the performance of the graphics card is done by using PSNR,SSIM,Q(a formula which measures image quality),SNR,and Normalized *** watermarking scheme withstands a variety of noise attacks and conversions,including image compression and decompression.

关键词： Watermarking NIfTI LWT QR image security

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