Prospects of diagnostic and prognostic biomarkers of pyometra in canine
作者机构：Animal Reproduction DivisionIndian Veterinary Research InstituteIzatnagarU.P.243122India Animal Reproduction Gynaecology and Obstetrics DivisionICAR-National Dairy Research InstituteKarnal-132001India Department of Veterinary Gynaecology andObstetricsCollege of Veterinary Sciences and Animal HusbandryAnjoraDurg(C.G.)India Referral Veterinary PolyclinicICAR-Indian Veterinary Research InstituteIzatnagarU.P.243122India ICAR-Indian Veterinary Reseach InstituteHebbalBangaluru 560024India
出 版 物：《Asian pacific Journal of Reproduction》 (亚太生殖杂志（英文版）)
年 卷 期：2020年第9卷第4期
页 面：166-173页
学科分类：0710[理学-生物学] 1002[医学-临床医学] 0905[农学-畜牧学] 0906[农学-兽医学] 100214[医学-肿瘤学] 0901[农学-作物学] 0902[农学-园艺学] 10[医学]
基 金：The review article was a part of the work supported by Department of Biotechnology Government of India funded project on "Identification of diagnostic and prognostic biomarkers in cystic endometrial hyperplasia and pyometra led systemic inflammatory response syndrome in dog"(Reference BT/ADV/Canine Health/GADVASU 2017-18, Project Code: OXX04211)
主 题：Pyometra Systemic inflammatory response Acute-phase proteins Prostaglandin F metabolite Canine
摘 要：Pyometra is one of the most common uterine pathologies of intact bitch at middle to advanced age. In the early stages, the disease shows subtle changes, making diagnosis a challenge. In contrast, at later stages, it manifests as potentially life-threatening systemic inflammatory response syndrome. Ultrasonographic examination of the uterus aids in the diagnosis, although it has limitation in ascertaining the clinical severity of pyometra. Moreover, differentiation of cystic endometrial hyperplasia from pyometra could not be discerned with greater accuracy. Therefore, false negative diagnosis of pyometra patients leads to development of systemic inflammatory response, which delays administration of therapies and results in deaths during early course of treatment. Further, indiscriminate use of broad-spectrum antimicrobials at higher dose in false positive cases considerably contributes to the rising pool of drug resistant pathogens, thereby increasing the risk of case fatality due to sepsis in a long-term. Monitoring the circulating pro-inflammatory cytokines, acute phase proteins, endotoxin, growth factors and inflammatory mediators is the current trend in pyometra research, especially for developing diagnostic and prognostic biomarkers. The present review deals with the prospects of developing diagnostic and prognostic biomarkers in the canine pyometra.
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