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Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis

Protein & Cell 2022年第3期13卷 220-226页

作者： Jinghui Lei Xiaoyu Jiang Wei Li Jie Ren datao Wang Zhejun Ji Zeming Wu Fang Cheng Yusheng Cai Zheng-Rong Yu Juan Carlos Izpisua belmonte Chunyi Li Guang-Hui Liu Weiqi Zhang Jing Qu Si Wang Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging translational Medicine Center Xuanwu HospitalCapital Medical UniversityBeijing 100053China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Institute of Antler Science and Product technology Changchun Sci-Tech UniversityChangchun 130000China University of Chinese Academy of Sciences Beijing 100049China national Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China China national Center for Bioinformation Beijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China department of orthopaedics Peking University First HospitalBeijing 100034China Gene Expression Laboratory Salk Institute for Biological StudiesLa JollaCAUSA

dear Editor,Stem cell therapy holds enormous and revolutionary promise to treat various age-related diseases,such as diabetes,heart failure,and Parkinson’s ***,low retention and survival rate of delivered stem cells,partially due to immunological rejection,constitute major hurdles for the clinical implementation of stem cell therapy(Lei et al.,2021a).Since mounting evidence showed that several types of stem cells mainly exert their therapeutic effects through the secretion of paracrine effects,exosomes,which are released by stem cells and execute most paracrine functions,have begun to draw attention in the field(tran and damaser,2015).Exosomes are membrane-enclosed vesicles with an average diameter of∼100 nanometers secreted by the cells,containing cytokines.

关键词： Exosomes holds mount

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Single-cell transcriptomic atlas of mouse cochlear aging

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Protein & Cell 2023年第3期14卷 180-201页

作者： Guoqiang Sun Yandong Zheng Xiaolong Fu Weiqi Zhang Jie Ren Shuai ma Shuhui Sun Xiaojuan He QiaoranWang zhejun ji Fang Cheng KaowenYan Ziyi Liu Juan Carloszpisuaemonte Jing Qu Si Wang Renjie Chai Guang-Hui Liu State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Bioelectronics Jiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSchool of Life Sciences and TechnologySoutheast UniversityNanjing 211189China Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical University.Beijing100053China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China national Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Aging translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital MedicalUniversityBeijing100053China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration CASBeijing 100101China China national Center for Bioinformation Beijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China the Fifth People's Hospital of Chongqing Chongqing 400062China Gene Expression Laboratory Salk Institute for Biological StudiesLa JollaCA 92037USA Co-Innovation Center of neuroregeneration Nantong UniversityNantong 226001China Shandong Provincial Hospital and School of Laboratory Animal Science Shandong First Medical UniversityJinan 250000China

Progressive functional deterioration in the cochlea is associated with age-related hearing loss(ARHL).However,the cellular and molecular basis underlying cochlear aging remains largely ***,we established a dynamic single-cell transcriptomic landscape of mouse cochlear aging,in which we characterized aging-associated transcriptomic changes in 27 different cochlear cell types across five different time ***,our analysis pinpoints loss of proteostasis and elevated apoptosis as the hallmark features of cochlear aging,highlights unexpected age-related transcriptional fluctuations in intermediate ceils localized in the stria vascularis(SV)and demonstrates that upregulation of endoplasmic reticulum(ER)chaperon protein HSP90AA1 mitigates ER stress-induced damages associated with *** work suggests that targeting unfolded protein response pathways may help alleviate aging-related sVatrophyand hencedelay theprogressionofARHL.

关键词： single-cell transcriptomic atlas mouse cochlea aging

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Morphological Evaluation of Adhesion and Proliferation of osteoblast Like Cells Grown on Gelatin/Genipin Scaffold

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Journal of Life Sciences 2013年第9期7卷 965-970页

作者： Gabriella teti Adriana Bigi Monica ma.tioli-belmonte Roberto Giardino Milena Fini Antonio mazzotti Mirella Falconi department of Biomedical and neuromotor Sciences University of Bologna Bologna 40126 Italy department of Chemistry "G. Ciamician" University of Bologna Bologna 40126 Italy department of Clinical and Molecular Sciences Universita Politecnica delle Marche Ancona 60121 Italy Laboratory of Preclinical Surgical Studies Rizzoli Orthopaedic Institute Bologna 40136 Italy Rizzoli orthopaedic Institute IRCCS Bologna 40136 Italy

this work focusing on studying the biocompatibility and the effect of gelatin porous scaffold on the characteristics of human osteoblast like cells, including proliferation, adhesion, scaffold-cell interaction and its potential to induce bone regeneration. osteoblast like cells were seeded on gelatin/genipin scaffolds for 7, 14 and 21 days. Cell proliferation assay, light microscopy, transmission electron microscopy and high resolution scanning electron microscopy were carried to evaluate cell viability, cell adhesion and the production of extracellular matrix. Cell proliferation assay showed a high biocompatibility of the material. High resolution scanning electron microscopy and light microscopy showed a strong adhesion of MG63 ceils on the surface of gelatin scaffold and high penetration in the macroporosities of the material. tEM analysis showed an intense production of extracellular matrix protein. In vitro analysis indicated a good biocompatibility of the scaffold and presents it as a potential candidate material for tissue engineering.

关键词： 3d gelatine scaffold scaffold adhesion extracellular matrix biocompatibility electron microscopy

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人体怎样辨别左右

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科学 1999年第9期51卷 1-6页

作者： JuanCarlosIzpisańbelmonte 张牛郭凯声索尔克生物学研究所及加利福尼亚大学(圣迭戈)发育生物学副教授、博士不详

请你照一照镜子，并从你的头顶起，沿着你的鼻梁等等，往下直到胸膛和腹部，画一条虚线。你会发现，这条虚线一侧的外部解剖结构与另一侧是对称的。然而，你只有一个心脏、一副肝脏、一个胃、一只胰脏和一叶脾脏，并且你的结肠是从你身... 详细信息

请你照一照镜子，并从你的头顶起，沿着你的鼻梁等等，往下直到胸膛和腹部，画一条虚线。你会发现，这条虚线一侧的外部解剖结构与另一侧是对称的。然而，你只有一个心脏、一副肝脏、一个胃、一只胰脏和一叶脾脏，并且你的结肠是从你身体的左边盘绕到右边的。即使是那些成对出现的器官也显示出某种程度的不对称——例如，

关键词：器官结构人体镜象布局不对称性亨森氏结

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opening up the black box of human cell plasticity

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the Innovation 2022年第5期3卷 13-14页

作者： Yusheng Cai Juan Carlos Izpisua belmonte Jing Qu Guang-Hui Liu Weiqi Zhang State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China China national Center for Bioinformation Beijing 100101China Gene Expression Laboratory Salk Institute for Biological StudiesLa JollaCA 92037USA Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China

Cell plasticity represents the ability of cells to acquire new *** plasticity can be reset in somatic cells via cellular reprogramming,a process that occurs in ***,cell plasticity occurs rarely in ***,Guan et *** cell plasticity in mature human cells,which they found to be essential for reprogramming human somatic cells to pluripotent stem cells using only small *** the first study demonstrates that chemical compounds can completely reprogram human somatic cells to a pluripotent state,it is a paradigm shift in developing pharmacological or therapeutic reprogramming approaches to control human cells.

关键词： al. plasticity programming

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赢过巴菲特

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2017年

作者： (美)约瑟夫·贝尔蒙特(Joseph belmonte)

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Step 4：印刷

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中国电子商情（空调与冷冻） 2005年第4期 58-61页

作者： Joe belmonte Bob Boyes Alden Johnson Speedline technologies公司先进工艺小组项目经理 Speedline technologies公司高性能印刷机产品营销经理 Speedline technologies公司高级应用工程师

在焊膏印刷工艺中，缺陷通常是由基板与模板之间对位不准、材料（基板、焊膏种类和模板设计）选择不当、或焊膏沉积量变化造成的。要消除缺陷的发生，工程师和操作人员需要处理好这些变量，监控整个工艺过程。

关键词：印刷工艺 Step 模板设计操作人员工艺过程焊膏工程师基板缺陷

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盾牌δ型变星Hd213534的多重频率

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天文学报 1992年第3期33卷 327-336页

作者：傅建宁蒋世仰 E.MICHEL J.A.belmonte M.ALVAREZ M.CHEVREton M.AUVERGnE M.J.GoUPIL A.BAGLIn A.manGEnEY M.CHALoUPI t.RoCA CoRtES 江西大学物理系南昌330047 中国科学院北京天文台北京100080 observatoire de Paris-Meudon MeudonFrance Instituto de Astrofisica Canarias TenerifeSpain Instituto de Astronomia Universidad National AutonomaMexico

本文利用三国联合观测获得的大量高精度光电测光数据,采用Fourier周期分析的方法,得到了δScuti型变星Hd213534的多重脉动周期,认为该星存在五个以上的脉动频率.文中给出了该星的各项参量,并对其脉动模式进行了讨论,认为Hd213534星是一... 详细信息

本文利用三国联合观测获得的大量高精度光电测光数据,采用Fourier周期分析的方法,得到了δScuti型变星Hd213534的多重脉动周期,认为该星存在五个以上的脉动频率.文中给出了该星的各项参量,并对其脉动模式进行了讨论,认为Hd213534星是一颗以非径向脉动为主的多重周期脉动变星.

关键词：周期分析变星 δ型测光频率

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彩色Si_3n_4陶瓷的金刚石涂层

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超硬材料工程 2005年第6期17卷 48-52页

作者： M. belmonte 蒋德伦蒋修治

分析了S i3n4二次相变化对化学气相沉积(CVd)金刚石薄膜生长的影响。氮化硅基底是将生坯试样放入S i3n4/Bn粉末床内,通过无压烧结而成。经X射线衍射和导热试验证实,烧结气氛的局部变化会导致试样具有不同的灰度和化学物理性能,从而影响... 详细信息

分析了S i3n4二次相变化对化学气相沉积(CVd)金刚石薄膜生长的影响。氮化硅基底是将生坯试样放入S i3n4/Bn粉末床内,通过无压烧结而成。经X射线衍射和导热试验证实,烧结气氛的局部变化会导致试样具有不同的灰度和化学物理性能,从而影响金刚石薄膜生长。对薄膜,包括厚度、平均晶粒度、表面粗糙度、织构和附着强度等进行了全面的表征。与玻璃相含量不多的陶瓷基底沉积的金刚石薄膜相比,含有玻璃相的S i3n4基底的薄膜厚度大、晶粒度小、薄膜与基底的附着强度高。

关键词：金刚石薄膜氮化硅等离子体CVd 显微组织陶瓷基底

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αKLotHo and stGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model

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Protein & Cell 2020年第3期11卷 219-226页

作者： Paloma ma.tinez-Redondo Isabel Guillen-Guillen noah davidsohn Chao Wang Javier Prieto masakazu Kurita Fumiyuki Hatanaka Cuiqing Zhong Reyna Hernandez-Benitez tomoaki Hishida takashi Lezaki Akihisa Sakamoto Amy nnemeth Yuriko Hishida Concepcion Rodriguez Esteban Kensaku Shojima Ling Huang maxim Shokhirev Estrella nunez-delicado Josep MCampistol Isabel Guillen-Vicente Elena Rodriguez-Inigo Juan manuel Lopez-Alcorocho ma.ta Guillen-Vicente George Church Pradeep Reddy Pedro Guillen-Garcia Guang-Hui Liu Juan Carlos Izpisua belmonte Gene Expression Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Wyss Institute for Biologically Inspired Engineering Harvard UniversityCambridgeMA 02115USA department of Genetics Harvard Medical SchoolBostonMA 02115USA Integrative Genomics and Bioinformatics Core Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Universidad Catolica San Antonio de Murcia(UCAM) Campus de los JeronimosNo 1351230107 GuadalupeSpain Hospital Clinic of Barcelona Career Villarroel17008036 BarcelonaSpain department of traumatology and Research Unit Clinica CEMTRO28035 MadridSpain national Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem cell and Regeneration Chinese Academy of SciencesBeijing 100101China translational Medical Center for Stem Cell therapy Shanghai East HospitalTongji University School of MedicineShanghai 200120China

dear Editor,Homeostasis and repair are critical biological processes that allow for tissue and organ preservation and function in multicellular *** regulation and extension vary drastically across the animal kingdom,and mammals show limited tissue-specific regenerative capacity that declines with *** aging,articular cartilage is one of the tissues that undergo substantial changes in the matrix structure,molecular composition,metabolic activity,and mechanical properties(Loeser et al.2016).

关键词： aging treatment critical

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