Opening up the black box of human cell plasticity

作     者：Yusheng Cai Juan Carlos Izpisua Belmonte Jing Qu Guang-Hui Liu Weiqi Zhang 

作者机构：State Key Laboratory of Membrane BiologyInstitute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive BiologyInstitute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Genomic and Precision MedicineBeijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and RegenerationChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative MedicineBeijing 100101China China National Center for BioinformationBeijing 100101China Gene Expression LaboratorySalk Institute for Biological StudiesLa JollaCA 92037USA Advanced Innovation Center for Human Brain ProtectionNational Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China 

出 版 物：《The Innovation》 (创新（英文）)

年 卷 期：2022年第3卷第5期

页      面：13-14页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：The authors declare no competing interests 

主　　题：al. plasticity programming 

摘      要：Cell plasticity represents the ability of cells to acquire new *** plasticity can be reset in somatic cells via cellular reprogramming,a process that occurs in ***,cell plasticity occurs rarely in ***,Guan et *** cell plasticity in mature human cells,which they found to be essential for reprogramming human somatic cells to pluripotent stem cells using only small *** the first study demonstrates that chemical compounds can completely reprogram human somatic cells to a pluripotent state,it is a paradigm shift in developing pharmacological or therapeutic reprogramming approaches to control human cells.