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Photo-Crosslinking Induced Geometric Restriction Controls the Self-Assembly of Diphenylalanine Based Peptides

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Chinese Physics Letters 2011年第2期28卷 235-238页

作者： TIE Zuo-Xiu QIN Meng ZOU da-Wei CAO Yi WANG Wei National Laboratory of Solid State Microstructure and Department of Physics Nanjing UniversityNanjing 210093

The diphenylalanine(FF)motif has been widely used in the design of peptides that are capable of forming various ordered structures,such as nanotubes,nanospheres and *** these assemblies,FF based peptides adopt an antiparallel structure and are stabilized by n-TT stacking among the phenyl *** we show that assembly of FF-based peptides can be controlled by their geometric *** tripeptide FFY(L-Phe-L-Phe-L-Tyr)as an example,we demonstrate that photo-crosslinking of C-terminal tyrosine can impose a geometric restriction to the formation of an antiparallel structure,leading to a structural change of the assemblies from nanosphere to amorphous.

关键词： amorphous spheres crosslinking

陕北黄土高原人工混交林和纯林对干旱的适应性差异

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陕西林业科技 2024年第3期52卷 11-18页

作者：郑伟文郭敏张旭郑申达曹扬西北农林科技大学林学院陕西杨凌712100 汉中市秦巴生态保护中心陕西汉中723000 国家林业和草原局西北调查规划院西安710001 西北农林科技大学黄土高原土壤侵蚀与旱地农业国家重点实验室陕西杨凌712100

为揭示渭北黄土高原混交林和纯林径向生长对气候变化的响应及应对极端干旱能力的差异,以黄土高原典型丘陵区延安市安塞县油松、刺槐混交林和纯林为研究对象;依据帕默尔干旱指数(PDSI)选择2005-2009年和2019年两次极端干旱事件,使用156... 详细信息

为揭示渭北黄土高原混交林和纯林径向生长对气候变化的响应及应对极端干旱能力的差异,以黄土高原典型丘陵区延安市安塞县油松、刺槐混交林和纯林为研究对象;依据帕默尔干旱指数(PDSI)选择2005-2009年和2019年两次极端干旱事件,使用156根树轮样芯,分别建立了4个林分的树轮宽度年表并量化了树木的抵抗力和恢复力。结果表明,在极端干旱事件发生年和气候适宜年,油松混交林年轮宽度均显著高于纯林,但刺槐纯林的年轮宽度显著高于刺槐混交林;气候响应方面,PDSI对油松纯林和混交林径向生长的促进作用强于刺槐;刺槐混交林对干旱的抵抗力显著高于刺槐纯林和油松林,四种林分的恢复力没有显著差异。本研究结果表明,混交营林模式显著提高了刺槐对干旱的适应能力,营造刺槐混交林将有助于提高黄土高原地区人工林对日益干旱环境的适应性。

关键词：陕北黄土高原混交林纯林树木年轮径向生长极端干旱事件

坝上及毗邻区甜菜生长中后期块根主要性状变化规律研究

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中国甜菜糖业 2024年第2期 11-19,38页

作者：林柏森李伟刘进校菅晨光付大伟赤峰绿璐种业有限公司内蒙赤峰024005 博天糖业有限公司河北张家口075000 敕勒川糖业有限公司内蒙包头014010

2022年定点调查表明,重茬、晚播甜菜R/T比值小,含糖低;距离滴灌支管在5.0米范围内KWS1197(高、绿)甜菜R/T比值小,含糖相对低,而远离滴灌支管KWS1197(矮、黄)甜菜R/T比值大,含糖相对高;丰产型品种KWS2314和高糖型品种MA097,R/T比值大,含... 详细信息

2022年定点调查表明,重茬、晚播甜菜R/T比值小,含糖低;距离滴灌支管在5.0米范围内KWS1197(高、绿)甜菜R/T比值小,含糖相对低,而远离滴灌支管KWS1197(矮、黄)甜菜R/T比值大,含糖相对高;丰产型品种KWS2314和高糖型品种MA097,R/T比值大,含糖都比较高;2023年大田调查表明,坝上及毗邻区甜菜含糖不高。随着调查时间的推迟,甜菜平均单株块根重增加、平均单株地上部重减少或稳定、R/T比值增加、含糖增加。甜菜在不同锤度范围的甜菜样本数量分布频率与锤度范围之间有如下关系:正偏态分布、负偏态分布、正态分布、幂指数关系。

关键词：甜菜锤度坝上及毗邻区分布频率

《复仇之角》中伦理话语的解读与伦理困境的解构

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外国文学研究 2015年第5期37卷 156-162页

作者：肖洒深圳大学外国语学院华中师范大学外国语学院

《复仇之角》是美国作家乔·希尔创作的一部黑色魔幻小说,讲述的是一个关于爱情、信仰以及复仇的故事。作品主人公伊格,因女友惨遭杀害而蒙受不白之冤,在一夜宿醉后发现头上竟长出两只犄角,甚至还拥有了让人吐露内心黑暗秘密的魔鬼力量... 详细信息

《复仇之角》是美国作家乔·希尔创作的一部黑色魔幻小说,讲述的是一个关于爱情、信仰以及复仇的故事。作品主人公伊格,因女友惨遭杀害而蒙受不白之冤,在一夜宿醉后发现头上竟长出两只犄角,甚至还拥有了让人吐露内心黑暗秘密的魔鬼力量。最终,化身为魔鬼的伊格利用犄角的力量将凶手正法为女友复仇。该文运用文学伦理学批评方法,阐释贯穿作品的多个伦理隐喻和伦理反讽话语的建构,同时解析伊格如何陷入伦理困境并最终通过伦理选择走出困境,从而解构伊格由人至魔的心理认知过程,并揭示作品深层的伦理呼唤和道德教诲,同时表达了对现实社会道德问题的反思。

关键词：《复仇之角》乔·希尔隐喻反讽伦理困境

广东省农业多功能评价及复合功能空间划分研究

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农业现代化研究 2024年第1期45卷 20-32页

作者：赖焕明吴大放杨木壮刘毅华卢奕帆吴钊骏广州大学地理科学与遥感学院广东广州510006 北京大学地表过程分析与模拟教育部重点实验室北京100871

农业功能结构性失衡、功能服务区域覆盖不均是城乡发展二元化的典型特征,农业功能空间的开发与转型是破解城乡发展二元结构、推进农业现代化的有力抓手。本文通过构建农业多功能评价体系,运用耦合协调模型和空间自相关等技术方法,分析... 详细信息

农业功能结构性失衡、功能服务区域覆盖不均是城乡发展二元化的典型特征,农业功能空间的开发与转型是破解城乡发展二元结构、推进农业现代化的有力抓手。本文通过构建农业多功能评价体系,运用耦合协调模型和空间自相关等技术方法,分析广东省农业多功能及其各功能的发展状况,划分农业复合功能空间类型,辨析农业复合功能空间的发展与转型演化过程。结果表明,2010—2020年广东省农业多功能指数呈上升趋势,发展先慢后快,向非生产性主导的农业多功能转型发展,空间格局呈向沿海地区集聚的发展态势。农业各类功能指数均有所提高,生产功能呈现以粤东、粤西为中心集聚,并向粤北地区延伸,珠三角地区低值集聚的特点;社会服务功能在区域内中等水平均衡分布;农业生态服务功能形成“粤北环海”的北部生态屏障与“圈层递增”的总体格局;休闲服务功能主要分布在珠三角区域,呈现高—高集聚和低—高集聚的特点。农业复合功能空间类型主要向生态型、休闲型复合功能空间转型,形成生产—生态服务型、生产—社会服务型、生产—休闲服务型、社会—休闲服务型、社会—生态服务型5种类型的农业复合功能空间新格局。广东省农业多功能持续融合、复合功能空间类型多元化发展,但区域间农业功能模式存在异质性。因此,本文提出应统筹规划农业功能空间的开发与转型,开发与保护并举,探索因地制宜的农业功能空间协调发展路径,以期为广东省农业功能空间格局优化、农业空间集约高效利用、城乡融合发展提供理论依据。

关键词：农业多功能复合功能功能空间划分空间格局农业现代化广东省

Panax quinquefolium saponin Optimizes Energy Homeostasis by Modulating AMPK-Activated Metabolic Pathways in Hypoxia-Reperfusion Induced Cardiomyocytes

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Chinese Journal of Integrative Medicine 2021年第8期27卷 613-620页

作者： YU Yong-hui ZHANG Pei WANG Cheng-long LIU Jian-gang LI Peng ZHANG da-wu Department of Traditional Chinese Medicine China-Japan Friendship HospitalBeijing100029China Graduate Shcool Beijing University of Chinese MedicineBeijing100029China Department of Cardiovascular Disease Mongolian Hospital of Traditional Chinese MedicineWuhaiInner Mongolia Autonomous Region016000China Center for Cardiovascular Diseases Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China

Objective To investigate the effects and underlying mechanisms of Panax quinquefolium saponin(PQS)on energy deficiency in hypoxia-reperfusion(H/R)induced *** The H/R injury involved hypoxia for 3 h and then reperfusion for 2 *** recruited from neonatal rat ventricular myocytes(NRVMs)were randomly divided into control,H/R,H/R+compound C(C.C),H/R+PQS,and H/R+C.C+PQS *** assay,lactase dehydrogenase(LDH)leakage and early apoptosis rate were evaluated to assess cell *** of high energy phosphate compounds were conducted to detect the energy *** expression levels of adenosine monophosphate-activated protein kinase a(AMPKα),glucose transporter 4(GLUT4),phosphate fructose kinase 2(PFK2),fatty acid translocase/cluster of differentiation 36(FAT/CD36),and acetyl CoA carboxylase 2(ACC2)in the regulatory pathways were measured by Western *** staining of GLUT4 and FAT/CD36 was used to observe the mobilization of metabolic *** PQS(50 mg/L)pretreatment significantly alleviated H/R-induced inhibition of NRVMs viability,up-regulation of LDH leakage,acceleration of early apoptosis,and reduction of energy production(Pdamages and energy metabolic disorders,by activation of AMPKα-mediated GLUT4-PFK2 and FAT/CD36-ACC2 pathways.

关键词： Panax quinquefolium saponin Chinese medicine neonatal rat ventricular myocytes hypoxia-reperfusion energy metabolism adenosine monophosphate-activated protein kinaseαpathways

Comparison of the effects of 3 kinds of oils rich in omega-3 polyunsaturated fatty acids on glycolipid metabolism and lipoprotein subfractions

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Food Science and Human Wellness 2023年第6期12卷 2221-2231页

作者： Hechun Liu Feng Wang Hui Xia da Pan Ligang Yang Shaokang Wang Feng Zhao Guiju Sun Key Laboratory of Environmental Medicine and Engineering of Ministry of Education Department of Nutrition and Food HygieneSchool of Public HealthSoutheast UniversityNanjing 210009China Department of Endocrinology and Metabolism The First Affi liated Hospital of Nanjing Medical UniversityNanjing 210029China Tianjin Institute of Environmental and Operational Medicine Tianjin 300050China Research Center of Fatty Acid and Human Health Qingdao UniversityQingdao 266000China

Dietary omega-3 polyunsaturated fatty acids(ω-3 PUFAs)can be classifi ed into animal-and plant-derivedω-3 *** with type 2 diabetes(T2DM)are frequently accompanied by dyslipidemia,which is closely related to the high-density lipoprotein(HDL-C)subfractions *** study aimed to determine the effects of different sourcesω-3 PUFAs on glucolipid metabolism and lipoprotein subfractions in T2DM with *** T2DM patients with dyslipidemia were randomly assigned to take 3 g/day fi sh oil(FO,containing eicosapentaenoic acid(EPA)and docosahexaenoic acid(DHA)),3 g/day perilla oil(PO,containingα-linolenic acid(ALA)),or 3 g/day blend oil(BO,containing EPA,DHA and ALA)for 3 months.90 patients completed the *** was a significant reduction of glycated hemoglobin(HbA1c)in all the *** triglycerides(TG)in the FO group were signifi cantly different with a group×time interaction(P=0.043),which was higher compared with the other two *** serum small HDL-C subfractions in the PO group was higher and the serum large HDL-C subfractions in the PO group was lower than those in the BO and FO ***-derivedω-3 PUFAs are more effective at controlling blood glucose than animal-derivedω-3 ***,animal-derivedω-3 PUFAs have a signifi cant lowering effect on TG compared with plant-derivedω-3 ***,large HDL-C subfractions after animal-derivedω-3 PUFAs intake were higher than plant-derivedω-3 PUFAs intake;while small HDL-C subfractions were *** the animal-and plant-derivedω-3 PUFAs have practical value in improving glucose and lipids metabolism in T2DM patients with dyslipidemia.

关键词： Diabetes Omega-3 polyunsaturated fatty acid Lipoprotein subfraction Dyslipidemia

SNHG16 promotes hepatocellular carcinoma development via activating ECM receptor interaction pathway

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Hepatobiliary & Pancreatic Diseases International 2022年第1期21卷 41-49页

作者： Qi-Jun Zhang da-Zhi Li Bing-Yi Lin Lei Geng Zhe Yang Shu-Seng Zheng Department of Thyroid Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China NHC Key Laboratory of Combined Multi-organ Transplantation The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310000China

Background:Accumulating data have suggested that long non-coding RNAs(lncRNAs)play important roles in regulating tumor cell *** study was designed to investigate the role of SNHG16 in hep-atocellular carcinoma(HCC).Methods:SNHG16 expression was detected with real-time polymerase chain reaction(PCR).The cut-offvalue of SNHG16 for tumor-free survival(TFS)was determined with receiver operating characteristic curve *** interfering RNA was used to inhibit the expression of SNHG16 in HCC cell *** biologic behavior of HCC cell was determined with cell viability assay and Transwell assay in *** potential predictive value of SNHG16 on prognosis was analyzed by Kaplan-Meier curves and Cox proportional hazards regression ***:SNHG16 expression was upregulated in tumor tissues and HCC cell *** expression of SNHG16 was associated with tumor recurrence and poor prognosis after *** analysis revealed that SNHG16 was an independent prognostic factor for poor recurrence-free ***,inhibition of SNHG16 in HepG2,Hep3B,and BEL-7402 cells significantly reduced cell invasiveness and *** analyses indicated that the ECM-receptor interaction pathway was remarkably activated by ***:SNHG16 might be a promising biomarker for predicting tumor recurrence in HCC patients after surgery and a potential therapeutic target for HCC.

关键词： Hepatocellular carcinoma SNHG16 ECM-receptor interaction pathway Long non-coding RNA

Dynamics of microbial diversity during the composting of agricultural straw

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Journal of Integrative Agriculture 2021年第5期20卷 1121-1136页

作者： CHANG Hui-qing ZHU Xiao-hui WU Jie GUO da-yong ZHANG Lian-he FENG Yao Henan University of Science and Technology Luoyang 471023P.R.China Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences/Key Laboratory of Plant Nutrition and FertilizerMinistry of Agriculture and Rural AffairsBeijing 100081P.R.China

The dynamic changes in microbial diversity during the aerobic composting of agricultural crop straw with additives were evaluated using high-throughput sequencing at four phases of composting(mesophilic,thermophilic,cooling and maturation phases).In addition,the physicochemical parameters of the composting system were determined in this *** fermentation time of the thermophilic period was prolonged with the addition of urea or urea combined with a microbial *** ratio of C/N and germination index variation indicated that the additives were favorable for composting,because the additives directly changed the physicochemical properties of the compost and had effects on the diversity and abundance of bacteria and *** abundance of operational taxonomic units(OTUs),diversity index(Shannon)and richness index(Chao1)of fungi and bacteria were found to significantly increase when urea+microbial agents were added to straw in the thermophilic *** relative abundance of the predominant bacteria and fungi at the phylum and genus levels differed during different composting *** abundance of the phyla Firmicutes and Proteobacteria declined in the order of treatments SNW>SN>S(S is straw only compost;SN is straw+5 kg t^(–1) urea compost;and SNW is straw+5 kg t^(–1) urea+1 kg t^(–1) microbial agent compost)in the thermophilic *** abundance of the genera Staphylococcus,Bacillus and Thermobifida followed the same order in the mesophilic *** accounted for more than 92%of the total fungal *** the progression of the composting process,the abundance of Ascomycota decreased *** abundance of Ascomycota followed the order of S>SN>SNW during the thermophilic *** abundance of Aspergillus accounted for 4–59%of the total abundance of fungi and increased during the first two sampling *** abundance followed the order of SNW>SN>***,principal component analysis(PCA)revealed that the community compositi

关键词： crop straws microbial diversity community composition dynamic characteristics high-throughput sequencing