SNHG16 promotes hepatocellular carcinoma development via activating ECM receptor interaction pathway

作     者：Qi-Jun Zhang Da-Zhi Li Bing-Yi Lin Lei Geng Zhe Yang Shu-Seng Zheng Qi-Jun Zhang;Da-Zhi Li;Bing-Yi Lin;Lei Geng;Zhe Yang;Shu-Seng Zheng

作者机构：Department of Thyroid SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China NHC Key Laboratory of Combined Multi-organ TransplantationThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Hepatobiliary and Pancreatic SurgeryShulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310000China 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2022年第21卷第1期

页      面：41-49页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from Science and Tech-nology Projects of Medicine and Health in Zhejiang Province(2020383364) Natural Science Foundation of Zhejiang Province(LY21H160055) 

主　　题：Hepatocellular carcinoma SNHG16 ECM-receptor interaction pathway Long non-coding RNA 

摘      要：Background:Accumulating data have suggested that long non-coding RNAs(lncRNAs)play important roles in regulating tumor cell *** study was designed to investigate the role of SNHG16 in hep-atocellular carcinoma(HCC).Methods:SNHG16 expression was detected with real-time polymerase chain reaction(PCR).The cut-offvalue of SNHG16 for tumor-free survival(TFS)was determined with receiver operating characteristic curve *** interfering RNA was used to inhibit the expression of SNHG16 in HCC cell *** biologic behavior of HCC cell was determined with cell viability assay and Transwell assay in *** potential predictive value of SNHG16 on prognosis was analyzed by Kaplan-Meier curves and Cox proportional hazards regression ***:SNHG16 expression was upregulated in tumor tissues and HCC cell *** expression of SNHG16 was associated with tumor recurrence and poor prognosis after *** analysis revealed that SNHG16 was an independent prognostic factor for poor recurrence-free ***,inhibition of SNHG16 in HepG2,Hep3B,and BEL-7402 cells significantly reduced cell invasiveness and *** analyses indicated that the ECM-receptor interaction pathway was remarkably activated by ***:SNHG16 might be a promising biomarker for predicting tumor recurrence in HCC patients after surgery and a potential therapeutic target for HCC.