Photo-Crosslinking Induced Geometric Restriction Controls the Self-Assembly of Diphenylalanine Based Peptides

作     者：TIE Zuo-Xiu QIN Meng ZOU Da-Wei CAO Yi WANG Wei 铁祚庥;秦猛;邹大维;曹毅;王炜

作者机构：National Laboratory of Solid State Microstructure and Department of PhysicsNanjing UniversityNanjing 210093 

出 版 物：《Chinese Physics Letters》 (中国物理快报（英文版）)

年 卷 期：2011年第28卷第2期

页      面：235-238页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Supported by the National Natural Science Foundation of China under Grant Nos 10834002,10904064 and 11074115 the Natural Science Foundation of Jiangsu Province under Grant No BK2009008 

主　　题：amorphous spheres crosslinking 

摘      要：The diphenylalanine(FF)motif has been widely used in the design of peptides that are capable of forming various ordered structures,such as nanotubes,nanospheres and *** these assemblies,FF based peptides adopt an antiparallel structure and are stabilized by n-TT stacking among the phenyl *** we show that assembly of FF-based peptides can be controlled by their geometric *** tripeptide FFY(L-Phe-L-Phe-L-Tyr)as an example,we demonstrate that photo-crosslinking of C-terminal tyrosine can impose a geometric restriction to the formation of an antiparallel structure,leading to a structural change of the assemblies from nanosphere to amorphous.