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Bioinspired flexible,high-strength,and versatile hydrogel with the fiberboard-and-mortar hierarchically ordered structure

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Nano Research 2021年第10期14卷 3643-3652页

作者： han-Ping Yu Ying-jie Zhu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

The synthetic hydrogels with high water contents are promising for various applications,however,they usually exhibit low mechanical *** this work,inspired by the natural biological soft tissues,whose hierarchically ordered fibrous structures result in high strength and good flexibility,a flexible,high-strength,and versatile hydrogel with the fiberboard-and-mortar hierarchically ordered structure(HFMOS)is developed based on ultralong hydroxyapatite(HAP)nanowires and polyacrylic acid(PAA).The as-prepared HFMOS hydrogel has a high water content(~70 wt.%),dense structure,and excellent mechanical properties,and these properties are similar to those of the human cartilage and are superior to many hydrogels reported in the *** excellent mechanical properties of the HFMOS hydrogel originate from the combination of the fiberboard-and-mortar hierarchically ordered structure,reinforcement of ultralong HAP nanowires,strong interfacial strength,and multiple energy dissipation ***,thanks to the controllable components and injection procedure,the HFMOS hydrogel with a Janus structure is prepared for particular *** HFMOS hydrogel possesses abundant ordered water channels,and can be used for loading,release,and directed delivery of various functional ***,the as-prepared flexible,high-strength,and versatile HFMOS hydrogel possesses a great potential for various applications such as water purification,pollution treatment,biomedicine,nanofluidic devices,and high-performance structural materials.

关键词： hydrogel nanowire hydroxyapatite ordered structure

Network Coding-Aware Routing Protocol in Wireless Mesh Networks

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Tsinghua Science and Technology 2015年第1期20卷 40-49页

作者： Yan Gu han han Xujie Li jie Guo College of Computer and Information Hohai University

Network coding mechanisms, such as COPE, can improve network throughput effectively in Wireless Mesh Networks（WMN）. While the Hybrid Wireless Mesh Protocol（HWMP） is suitable for WMN, its extension with COPE does not provide any added benefits; specifically, HWMP cannot establish paths with more coding opportunities. As a result, the advantages of network coding cannot be exploited sufficiently. This paper proposes improvements upon HWMP with a new, network Coding-Aware routing protocol（CAHWMP） for WMN. In the CAHWMP protocol, we propose a coding criterion based on data streams to devise an algorithm for actively detecting coding opportunities during path discovery. CAHWMP subsequently establishes paths using the codingaware routing metric, which can balance channel resource consumption and the gain due to sharing resources introduced by network coding. Simulation results show that CAHWMP can establish paths with more coding opportunities; as a result, it improves network performance such as network throughput.

关键词： wireless mesh network network coding-aware Hybrid Wireless Mesh Protocol(HWMP) COPE mechanism coding criterion

Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali Chen Yiyang Li Xingping Quan Jinfen Chen Yan han Li Yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

干旱半干旱地区变时滞反应扩散植被-水系统的阈值动力学

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应用数学 2025年第1期38卷 71-78页

作者：胡静朱磊任杰吴涵张启敏宁夏大学土木与水利工程学院宁夏银川750021 宁夏大学数学统计学院宁夏银川750021 宁夏医科大学医学信息与工程学院宁夏银川750021 宁夏数学基础学科研究中心宁夏银川750021 可口可乐(饮料)上海有限公司上海200123

考虑地表水的渗透和扩散作用对干旱半干旱地区生态系统的影响,本文建立了具有时变时滞的反应扩散植被-水系统模型.给出阈值R^(∗),并讨论了系统的动力学行为,当R^(∗)1,植被一致持久.此外,通过拉丁方抽样(LHS)及偏秩相关系数(PRCCs)方法... 详细信息

考虑地表水的渗透和扩散作用对干旱半干旱地区生态系统的影响,本文建立了具有时变时滞的反应扩散植被-水系统模型.给出阈值R^(∗),并讨论了系统的动力学行为,当R^(∗)1,植被一致持久.此外,通过拉丁方抽样(LHS)及偏秩相关系数(PRCCs)方法对模型阈值进行敏感性分析,给出了参数对系统动力学行为的影响并为制定防治荒漠化的措施提出建议.此外,通过分析系统有限时间稳定性,讨论了时滞对植被水模型的动力学行为的影响.

关键词：植被-水模型阈值动力学反应扩散敏感性分析有限时间稳定

Novel regulation of the eEF2K/eEF2 pathway:prospects of'PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation'

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Journal of Molecular Cell Biology 2021年第5期13卷 392-394页

作者： Yuqian Shen Junhai han zi Chao Zhang School of Life Science and Technology Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjing 210096China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226001China

Protein synthesis involves initiation,elongation,and termination.A number of studies show that translation elongation is highly regulated and is the most energy-intensive process,which controls the efficiency and accuracy of protein *** the elongation process,eukaryotic elongation factor 2(eEF2)binds to the ribosome to induce its conformation change and promotes the translocation of the tRNAs by hydrolyzing guanosine triphosphate,which then allows the next AA-tRNA to enter the A site for translation *** activity of eEF2 is negatively regulated by its kinase eEF2K that phosphorylates eEF2 at threonine-56(Thr56).

关键词： synthesis EF2 translational

Drosophila Studies on Autism Spectrum Disorders

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Neuroscience Bulletin 2017年第6期33卷 737-746页

作者： Yao Tian zi Chao Zhang Junhai han Institute of Life Sciences The Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjing 210096China

In the past decade, numerous genes associated with autism spectrum disorders（ASDs） have been identified. These genes encode key regulators of synaptogenesis,synaptic function, and synaptic plasticity. Drosophila is a prominent model system for ASD studies to define novel genes linked to ASDs and decipher their molecular roles in synaptogenesis, synaptic function, synaptic plasticity, and neural circuit assembly and consolidation. Here, we review Drosophila studies on ASD genes that regulate synaptogenesis, synaptic function, and synaptic plasticity through modulating chromatin remodeling, transcription, protein synthesis and degradation, cytoskeleton dynamics, and synaptic scaffolding.

关键词： Autism spectrum disorders Drosophila Chromatin remodeling Synaptic scaffolding Synaptic transmission

Power-law Distribution and Scale-invariant Structure from the First CHIME/FRB Fast Radio Burst Catalog

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Research in Astronomy and Astrophysics 2023年第2期23卷 42-46页

作者： zi-han Wang Yu Sang Xue Zhang Center for Gravitation and Cosmology College of Physical Science and TechnologyYangzhou UniversityYangzhou 225009.China Shanghai Frontier Science Research Center for Gravitational Wave Detection School of Aeronautics and AstronauticsShanghai Jiao Tong UniversityShanghai 200240China

We study the statistical property of fast radio bursts(FRBs) based on a selected sample of 190 one-off FRBs in the first CHIME/FRB *** power law models are used in the analysis,and we find the cumulative distribution functions of energy can be well fitted by bent power law and thresholded power law *** distribution functions of fluctuations of energy well follow the Tsallis q-Gaussian *** q values in the Tsallis q-Gaussian distribution are constant with small fluctuations for different temporal scale intervals,indicating a scale-invariant structure of the *** earthquakes and soft gamma repeaters show similar properties,which are consistent with the predictions of self-organized criticality systems.

关键词： methods statistical-radio continuum galaxies-catalogs

Anomaly monitoring and early warning of electric moped charging device with infrared image

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Optoelectronics Letters 2025年第3期21卷 136-141页

作者： LI Jiamin han Bo JIANG Mingshun School of Control Science and Engineering Shandong University

Potential high-temperature risks exist in heat-prone components of electric moped charging devices, such as sockets,interfaces, and controllers. Traditional detection methods have limitations in terms of real-time performance and monitoring scope. To address this, a temperature detection method based on infrared image processing has been proposed:utilizing the median filtering algorithm to denoise the original infrared image, then applying an image segmentation algorithm to divide the image.

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Minimum safe thickness of rock plug in karst tunnel according to upper bound theorem

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Journal of Central South University 2016年第9期23卷 2346-2353页

作者： YANG zi-han ZhanG Jia-hua School of Civil Engineering Central South University Changsha 410075 China

High pressure and water-bearing caverns ahead of a karst tunnel face tend to cause geological disasters, such as water and mud bursts. So, the determination of safe thickness of the reserved rock plug is a key technical problem to be solved for karst tunnel construction. Based on the Hoek-Brown nonlinear failure criterion, the minimum safe thickness of rock plug was investigated in the light of the limit analysis theory. On the basis of the proposed failure mode, the expression of the minimum thickness for rock plug was obtained by means of upper bound theorem in combination with variational principle. The calculation results show the influence of each parameter on safe thickness and reveal the damage range of rock plug. The proposed method is verified by comparing the results with those of the drain cavern of Maluqing Tunnel. The research shows that with the increase of compressive strength and tensile strength as well as constant A of Hoek-Brown criterion, the safe thickness decreases, whereas with the increase of cavern pressure, tunnel diameter, and constant B from Hoek-Brown criterion, the safe thickness increases. Besides, the tensile strength, or constants A and B affect the shear failure angle of rock plug structure, but other parameters do not. In conclusion, the proposed method can predict the minimum safe thickness of rock plug, and is useful for water burst study and prevention measures of tunnels constructed in high-risk karst regions.

关键词： karst tunnels rock plug minimum safe thickness upper limit theorem failure mode