Drosophila Studies on Autism Spectrum Disorders

作     者：Yao Tian Zi Chao Zhang Junhai Han 

作者机构：Institute of Life SciencesThe Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjing 210096China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2017年第33卷第6期

页      面：737-746页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(31471031,31400927,and 31671045) the Natural Science Foundation of Jiangsu Province,China(BK20140623) 

主　　题：Autism spectrum disorders Drosophila Chromatin remodeling Synaptic scaffolding Synaptic transmission 

摘      要：In the past decade, numerous genes associated with autism spectrum disorders（ASDs） have been identified. These genes encode key regulators of synaptogenesis,synaptic function, and synaptic plasticity. Drosophila is a prominent model system for ASD studies to define novel genes linked to ASDs and decipher their molecular roles in synaptogenesis, synaptic function, synaptic plasticity, and neural circuit assembly and consolidation. Here, we review Drosophila studies on ASD genes that regulate synaptogenesis, synaptic function, and synaptic plasticity through modulating chromatin remodeling, transcription, protein synthesis and degradation, cytoskeleton dynamics, and synaptic scaffolding.