Novel regulation of the eEF2K/eEF2 pathway:prospects of'PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation'

作     者：Yuqian Shen Junhai Han Zi Chao Zhang Yuqian Shen;Junhai Han;Zi Chao Zhang

作者机构：School of Life Science and TechnologyKey Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjing 210096China Co-innovation Center of NeuroregenerationNantong UniversityNantong 226001China 

出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)

年 卷 期：2021年第13卷第5期

页      面：392-394页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：The described work was supported by the National Natural Science Foundation of China(81730034 to J.H.,31671045 to Z.C.Z.,and 81901287 to Shuting Xia) the Natural Science Foundation of Jiangsu Province(BK20170080 to Z.C.Z.) Guangdong Key Project(2018B030335001 to J.H.) 

主　　题：synthesis EF2 translational 

摘      要：Protein synthesis involves initiation,elongation,and termination.A number of studies show that translation elongation is highly regulated and is the most energy-intensive process,which controls the efficiency and accuracy of protein *** the elongation process,eukaryotic elongation factor 2(eEF2)binds to the ribosome to induce its conformation change and promotes the translocation of the tRNAs by hydrolyzing guanosine triphosphate,which then allows the next AA-tRNA to enter the A site for translation *** activity of eEF2 is negatively regulated by its kinase eEF2K that phosphorylates eEF2 at threonine-56(Thr56).