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水泥土大直径单桩水平承载性能试验研究

东南大学学报（自然科学版） 2024年第1期54卷 142-148页

作者：高鲁超戴国亮姚中原张继生王安辉陈浩河海大学海岸灾害及防护教育部重点实验室南京210098 华能国际电力江苏能源开发有限公司清洁能源分公司南京210009 东南大学土木工程学院南京211189 中建安装集团有限公司南京210023

为研究水泥土中大直径单桩的水平承载性能,开展了水泥土中大直径单桩水平承载性能离心机试验,分析了加固前后桩基水平承载力、弯矩和水平土抗力-水平位移(p-y)曲线的变化规律.基于黏土典型p-y曲线,考虑土体径向非均质性和桩径效应,修正... 详细信息

为研究水泥土中大直径单桩的水平承载性能,开展了水泥土中大直径单桩水平承载性能离心机试验,分析了加固前后桩基水平承载力、弯矩和水平土抗力-水平位移(p-y)曲线的变化规律.基于黏土典型p-y曲线,考虑土体径向非均质性和桩径效应,修正初始地基反力模量和极限土抗力,提出了一种适用于水泥土加固桩水平承载力的计算模型.结果表明,相比未加固桩,加固桩的水平承载力明显提升,单桩初始刚度和极限承载力分别增加2.61倍和6.29倍.加固桩和未加固桩的桩身弯矩随荷载和深度变化趋势大致相同,但加固桩的最大弯矩位于泥面附近.水泥土加固可以提高桩身p-y曲线的初始刚度和极限土抗力,进而提高桩基水平承载力.计算值与实测值吻合较好,从而验证了所提计算模型的合理性.

关键词：海上风电大直径单桩水泥土水平承载性能离心机试验

Current and future therapies for abnormal early embryogenesis with assisted reproductive technology

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BIOCELL 2022年第8期46卷 1803-1806页

作者： XIAOXIA WANG zhongyuan yao DI LIU CHUNHONG YU HUI LI Department of Reproductive Medicine Xiangya HospitalCentral South UniversityChangsha410000China Center for Medical Genetics&Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangsha410078China Hunan Key Laboratory of Molecular Precision Medicine Xiangya Hospital&Hunan Key Laboratory of Medical GeneticsSchool of Life SciencesCentral South UniversityChangsha410000China

Each stage of embryonic development,including normal gamete maturation,fertilization,zygotic genome activation,and cleavage,is crucial for human *** embryo arrest is a common *** is estimated that about 40%–70%of human embryos are arrested at early developmental ***,the exact mechanism remains largely *** can be investigated in vitro by way of the development of in vitro fertilization/intracytoplasmic sperm *** addition to iatrogenic factors related to abnormal oocyte/embryo development,multiple gene mutations have been found to be involved in such *** on the knowledge of known etiological factors,several therapies are proposed to improve clinical ***,we shed light on current and potential therapies for treating these conditions through reviewing articles and combining with our clinical and research experience.

关键词： Oocyte maturation arrest Preimplantation embryonic lethality Gene mutation Infertility Embryo development

A New Next-Generation Sequencing-Based Assay for Concurrent Preimplantation Genetic Diagnosis of Charcot-Marie-Tooth Disease Type 1A and Aneuploidy Screening

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Journal of Genetics and Genomics 2016年第3期43卷 155-159页

作者： Baoheng Gui Pu Yang zhongyuan yao Yanping Li Donge Liu Nenghui Liu Sijia Lu Desheng Liang Lingqian Wu The State Key Laboratory of Medical Genetics of China Central South University Changsha 410008 China The Reproductive Medical Center of Xiangya Hospital Central South University Changsha 410008 China Yikon Genomics Co. Ltd. Taizhou 225300 China

Charcot-Marie-Tooth （CMT） disease is the most common hereditary neuropathy, with a population prevalence of 1 in 2500. CMT disease type 1A （CMT1A）, accounting for ~70% of CMT1 cases and ~ 50% of all CMT cases, is transmitted in an autosomal dominant manner. CMT1A maps to chromo- some 17pl 1.2 and is caused, in the majority of cases, by a 1.4- Mb tandem duplication that includes the peripheral myelin protein22 （PMP22） gene （Li et al., 2013）. The disease usually presents in the first 20 years of age, causing difficulty in walking or running, distal symmetrical muscle weakness and wasting, and sensory loss （van Paassen et al., 2014）.

关键词： A New Next-Generation Sequencing-Based Assay for Concurrent Preimplantation Genetic Diagnosis of Charcot-Marie-Tooth Disease Type 1A and Aneuploidy Screening CNVs

The role of soil-borne fungi in driving the coexistence of Pinus massoniana and Lithocarpus glaber in a subtropical forest via plant-soil feedback

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Journal of Plant Ecology 2021年第6期14卷 1189-1203页

作者： Yumei Pan zhongyuan yao Naili Zhang G.F(Ciska)Veen College of Forestry Beijing Forestry UniversityBeijing 100083China Process Improvement Department ChanachunGeneScience Pharmaceutical Co.Ltd.Changchun 130012China Department of Terrestrial Ecology Netherlands Institute of Ecology(NIOO-KNAW)Droevendaalsesteeg 10Wageningen 6708 PBThe Netherlands

Aims Plant–soil feedback(PSF)is a key mechanism that can facilitate tree species coexistence and *** evidence suggests that species-specific soil-borne pathogens around adult trees limit the performance of home(conspecific)seedlings relative to foreign(heterospecific)***,the underlying mechanism remains largely *** Here,we conducted a reciprocal transplant pot experiment using seedlings and from two tree species,Pinus massoniana and Lithocarpus glaber that are dominant and coexist in a subtropical,evergreen,broad-leaf forest in Gutianshan,Zhejiang Province of eastern *** examined how seedlings from the two tree species responded to soils originating from underneath their own versus the other tree species,using a full-factorial ***,we added a fungicide(benomyl)to half of the pots to evaluate the role of soil-borne fungi on seedling *** Findings We found that the seedlings from *** grew better in soils that were collected from beneath the canopy of ***,while seedling growth of *** was not affected by soil *** addition of fungicide benomyl resulted in a shift towards more positive PSF effects for ***,indicating that *** seedlings performed better in their own soils than in soils from *** in the absence of *** findings highlight the importance of soil-borne pathogenic and ectomycorrhizal fungi in driving PSF,and indicate that PSF may promote the coexistence of two subtropical tree species by reducing the performance of *** in own soils.

关键词： benomyl fungicide addition plant pathogen saprotrophic fungi ectomycorrhizal fungi

Strain distribution and electronic structures of the InAs/GaAs quantum ring molecule in an applied electric field

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Science China(Physics,Mechanics & Astronomy) 2010年第9期53卷 1594-1599页

作者： JIA BoYong,YU zhongyuan,LIU YuMin,yao WenJie,YE Han & FENG Hao Key Laboratory of Information Photonics and Optical Communications(Beijing University of Posts and Telecommunications),Ministry of Education,Beijing 100876,China Ministry of Education Key Laboratory of Information Photonics and Optical Communications (Beijing University of Posts and Telecommunications) Beijing China

The strain distribution and electronic structures of the InAs/GaAs quantum ring molecule are calculated via the finite element *** our model,three identical InAs quantum rings are aligned vertically and embedded in the cubic GaAs *** the band edge modification induced by the strain,the electronic ground state and the dependence of ground state energy on geometric parameters of the quantum ring molecule are *** change of localization of the wavefunction resulting from the applied electric field along the growth direction is *** ground state energy decreases as the electric field intensity increases in a parabolic-like *** electric field changes the monotonic dependence of the energy level on the inter-ring distance into a non-monotonic ***,the electric field has no effect on the relationships between the energy level and other geometric parameters such as the inner radius and outer radius.

关键词： strain distribution electronic structure quantum ring molecule applied electric field

Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development

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Protein & Cell 2020年第12期11卷 921-927页

作者： Lin Zhao Songguo Xue zhongyuan yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang Institute of Pediatrics Children's Hospital of Fudan University and the Shanghai Key Laboratory of Medical Epigeneticsthe International Co-laboratory of Medical Epigenetics and metabolismMinistry of Science and technology and Institutes of Biomedical SciencesState Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200032China Center of Assisted Reproduction Shanghai East hospitalTongji UniversityShanghai 200120China The Reproductive Medical Center of Xiangya Hospital Central South UniversityChangsha 41008China Reproductive Medicine Center Shaanxi Maternal and Child Care Service CenterXi'an 710069China NHC Key Lab of Reproduction Regulation(Shanghai Institute of Planned Parenthood Research) Fudan UniversityShanghai 200032China Reproductive Medicine Center Shanghai Ninth HospitalShanghai Jiao Tong UniversityShanghai 200011China Shanghai Ji Ai Genetics and IVF Institute Obstetrics and Gynecology HospitalFudan UniversityShanghai 200011China Key Laboratory of Molecular Virology Immuno logy In stitute Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China Bio-X Center Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200030China State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development School of Life SciencesFudan UniversityShanghai 200438China Zhuhai Fudan Innovation Institute Zhuhai 519000China Shanghai Center for Women and Children's Health Shanghai 200062China

Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely *** recent years,"missing"Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated.

关键词： female maturation arrest

基于联盟链的可搜索电子病历双重授权共享方案

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应用科学学报 2023年第5期41卷 881-895页

作者：马雪潘恒姚中原斯雪明中原工学院前沿信息技术研究院河南郑州450007 河南省区块链数据共享国际联合实验室河南郑州450007 复旦大学计算机学院上海201203 郑州经贸学院大数据与人工智能学院河南郑州450007

在云环境下检索电子病历存在安全问题和患者隐私数据泄露问题,为此提出了一种支持链上关键字密文检索的电子病历双重授权共享方案。将原始病历密文存储在云端,借助可搜索加密技术构造病历关键词索引信息并将其存储在区块链上。在获取医... 详细信息

在云环境下检索电子病历存在安全问题和患者隐私数据泄露问题,为此提出了一种支持链上关键字密文检索的电子病历双重授权共享方案。将原始病历密文存储在云端,借助可搜索加密技术构造病历关键词索引信息并将其存储在区块链上。在获取医院检索权限的前提下,利用分布式条件下的关键字检索算法实现病历密文数据的安全检索。基于可搜索代理重加密算法提出了电子病历链上授权方法,保证了患者对所属病历的访问控制权,实现了医院和患者对共享病历的双重授权。最后,采用随机预言机模型验证了该方案在n-QBDH假设下的语义安全性,并通过实验证明了该方案在计算开销方面的优越性。

关键词：联盟链病历安全共享可搜索加密代理重加密双重授权访问控制

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一种病人可控的电子病历安全访问方案

应用科学学报 2020年第1期38卷 127-138页

作者：潘恒潘磊姚中原斯雪明中原工学院前沿信息技术研究院郑州450007 中原工学院计算机学院郑州450007 复旦大学计算机学院上海201203

部分病人对其电子病历访问有全程管控的特殊需求,而现有云环境下的电子病历共享系统却无法满足这一需求,于是提出了一种基于超级账本和星际文件系统的电子病历安全访问方案HyperEHR.该方案设计了由病历请求者所在机构以及病人双重审核... 详细信息

部分病人对其电子病历访问有全程管控的特殊需求,而现有云环境下的电子病历共享系统却无法满足这一需求,于是提出了一种基于超级账本和星际文件系统的电子病历安全访问方案HyperEHR.该方案设计了由病历请求者所在机构以及病人双重审核且由病人决定病历最终访问权的方法.为保证跨机构之间的医疗数据安全互访,将病历生成、更新以及访问等信息存储在联盟链区块中,而将各医院、诊所产生的具体病历信息和访问控制策略加密存储在云端星际文件系统中.系统实现及分析表明:该方案有较好的可扩展性、互操作性及安全性,可满足病人对其医疗数据访问的管控,有效防止病历隐私泄露.

关键词：病人可控电子病历联盟区块链安全访问星际文件系统

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区块链物联网融合:研究现状与展望

应用科学学报 2021年第1期39卷 174-184页

作者：姚中原潘恒祝卫华斯雪明中原工学院前沿信息技术研究院河南郑州450007 复旦大学计算机学院上海201203

区块链与物联网飞速发展,并在技术层面和应用层面开始走向融合。为帮助区块链物联网融合领域的科研工作者更好地分析把握热点和趋势,广泛调研了该领域的相关研究文献,并将这些文献分类后综述。该文还详细对比了国内外同行在该领域的研... 详细信息

区块链与物联网飞速发展,并在技术层面和应用层面开始走向融合。为帮助区块链物联网融合领域的科研工作者更好地分析把握热点和趋势,广泛调研了该领域的相关研究文献,并将这些文献分类后综述。该文还详细对比了国内外同行在该领域的研究工作,客观阐述了这些研究工作的优势与不足。最后,结合文献调研成果展望了区块链物联网融合研究的发展趋势。

关键词：区块链物联网体系架构共识算法融合应用