Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development

作     者：Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang Lin Zhao;Songguo Xue;Zhongyuan Yao;Juanzi Shi;Biaobang Chen;Ling Wu;Lihua Sun;Yao Xu;Zheng Yan;Bin Li;Xiaoyan Mao;Jing Fu;Zhihua Zhang;Jian Mu;Wenjing Wang;Jing Du;Shuai Liu;Jie Dong;Weijie Wang;Qiaoli Li;Lin He;Li Jin;Xiaozhen Liang;Yanping Kuang;Xiaoxi Sun;Lei Wang;Qing Sang

作者机构：Institute of PediatricsChildren's Hospital of Fudan University and the Shanghai Key Laboratory of Medical Epigeneticsthe International Co-laboratory of Medical Epigenetics and metabolismMinistry of Science and technology and Institutes of Biomedical SciencesState Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200032China Center of Assisted ReproductionShanghai East hospitalTongji UniversityShanghai 200120China The Reproductive Medical Center of Xiangya HospitalCentral South UniversityChangsha 41008China Reproductive Medicine CenterShaanxi Maternal and Child Care Service CenterXi'an 710069China NHC Key Lab of Reproduction Regulation(Shanghai Institute of Planned Parenthood Research)Fudan UniversityShanghai 200032China Reproductive Medicine CenterShanghai Ninth HospitalShanghai Jiao Tong UniversityShanghai 200011China Shanghai Ji Ai Genetics and IVF InstituteObstetrics and Gynecology HospitalFudan UniversityShanghai 200011China Key Laboratory of Molecular Virology Immuno logyIn stitute Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China Bio-X CenterKey Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200030China State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and DevelopmentSchool of Life SciencesFudan UniversityShanghai 200438China Zhuhai Fudan Innovation InstituteZhuhai 519000China Shanghai Center for Women and Children's HealthShanghai 200062China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2020年第11卷第12期

页      面：921-927页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：supported by the National Key Research and Development Program of China 国家自然科学基金 the project supported by Shanghai Municipal Science and Technology Major Project Project of Shanghai Municipal Science and Technology Commission the Shanghai Rising Star Program 上海市自然科学基金 Shuguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission The Strategic Collaborative Research Program of the Ferring Institute of Reproductive Medicine, Ferring Pharmaceuticals and Chinese Academy of Sciences 

主　　题：female maturation arrest 

摘      要：Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely *** recent years,missingMen delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated.