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Comparison analysis of multiple-omics data between female germline stem cells and spermatogonial stem cells

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Genes & Diseases 2023年第3期10卷 727-730页

作者： Geng G.Tian Jing Li Ji Wu Renji Hospital Key Laboratory for the Genetics of Developmental&Neuropsychiatric Disorders(Ministry of Education)Bio-X InstitutesSchool of MedicineShanghai Jiao Tong UniversityShanghai 200240China Department of Bioinformatics and Biostatistics School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education Ningxia Medical UniversityYinchuanNingxia 750004China

female germline stem cells(FGSCs)and spermatogonial stem cells(SSCs)are germline stem cells that transmit the genetic material from generation to generation.Hence,it is essential to understand the similarities and differences between FGSCs and SSCs.In this study,we comprehensively compared the epigenetics of FGSCs and SSCs,including high-order chromatin organization,chromatin histone modification,and transcriptome by analyzing multiple-omics data(Hi-C,ChIP-seq,and RNA-seq).

关键词： SSCs female analysis

female representation in intensive care medicine:Challenges and perspectives from China

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Journal of Intensive Medicine 2022年第2期2卷 89-91页

作者： Xuelian Liao Yi Yang Rubulotta Francesca Yan Kang Jordi Rello Department of Critical Care Medicine West China HospitalSichuan University.ChengduSichuan 610044China Department of Critical Care Medicine West China Tianfu HospitalSichuan University.ChengduSichuan 610213China Department of Critical Care Medicine Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Intensive Care Medicine McGill UniversityMontreal H3A 0G4Canada Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias Instituto de Salud Carlos IIIand Infections AreaVall d’Hebron Institute of ResearchBarcelona 08035Spain

The gender gap in the practice of intensive care medicine has increasingly been recognized as a problem in recent years.Despite limited information,the available data suggest that representation of women in the physician workforce,academic positions,and leadership roles in intensive care is inadequate globally.In this article,we describe the situation of female intensive care unit(ICU)physicians from the perspective of Chinese intensivists.The proportion of female ICU physicians in China has been increasing in recent years.The biggest challenges faced by female ICU physicians include balance of work and life,difficulties in career planning,and lack of academic influence.More attention and policy support should be provided to help them play a better role in intensive care medicine.

关键词： Gender gap female Critical care

Update Knowledge Assessment and Influencing Predictor of female Fertility Preservation in Oncologists

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Current Medical Science 2022年第4期42卷 824-831页

作者： Li-xia ZHU Lei JIN Jing-hang JIANG Liu YANG Zi-shui FANG Meng WANG Ying XIAO Qing-song XI Reproductive Medicine Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Reproductive Medicine Center Jingmen Second People's HospitalJingmen 448000China Cancer Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:This study aims to offer an update assessment of the knowledge of Chinese oncologists on female fertility preservation,and identify the determinants that influence the implementation of fertility preservation.Methods:A total of 713 Chinese oncologists with different specialties completed the online self-report questionnaire to assess their understanding of fertility risks in cancer treatment,knowledge on female fertility preservation,and perceptions on the barriers in referring patients for fertility preservation.Results:Although most oncologists were familiar with fertility risk in cancer treatment,half of them lacked the knowledge for reproduction and preservation methods.In the multivariable model,oncologists in a hospital with a specialized reproductive institution,positive precaution for fertility risk,and fertility preservation discussion with patients were significantly correlated with the possibility of fertility preservation referral.Conclusions:The intervention targets based on the update evaluation and identified influencing determinants will be helpful for all the oncofertility researchers,oncologists and institutions in future efforts for well-established female fertility preservation services.

关键词： fertility preservation oncologists female infertility neoplasms

Gonadal mosaicism mediated female-biased gender control in mice

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Protein & Cell 2022年第11期13卷 863-868页

作者： Meizhu Bai Dan Liang Yan Cheng Guolong Liu Qiudao Wang Jinsong Li Yuxuan Wu State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular AndrologyCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Shanghai Frontiers Science Center of Genome Editing and Cell Therapy Shanghai Key Laboratory of Regulatory BiologyInstitute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Department of Obstetrics and Gynecology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University) Hefei 230032China Key Laboratory of Population Health Across Life Cycle(Anhui Medical University) Ministry of Education of the People’s Republic of ChinaHefei 230032China

Dear Editor, In nature or during artificial breeding,evolutionary interven-tion or desirable trait selection could be achieved by means of gender control in an organism.Previously reported approaches including sex-sorted semen and genetic manipulation of a certain gene(Holden and Butler,2018;Yosef et al.,2019).In mice,a recent study demonstrated a genetic system for biasing sex ratio through crossing two genetically engineered mouse lines(Yosef et al.,2019).The maternal line encodes functional Cas9 protein on an auto-somal chromosome,whereas the paternal encodes guide RNAs on Y chromosome targeting vital genes.After fertil-ization,males carrying both Cas9 and guide RNAs were self-destructed,resulting in a female biased sex ratio.However,the litter size is proximate half of normal size since half of the progeny are eliminated.Moreover,a reproductive reservoir of males and females must be maintained for crossing.Here,we established a mouse line carrying Hspa2 promoted Cas9 and constitutively expressed sgRNA targeting repetitive sequences on Y chromosome.In those mice,spermatogenic cells carrying Y chromosome were eliminated during sper-matogenesis,resulting in female biased sex ratio in proge-nies whereas the total number was unaffected.

关键词： female eliminated reservoir

Prevalence of hepatic steatosis and metabolic associated fatty liver disease among female breast cancer survivors

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Chinese Medical Journal 2022年第19期135卷 2372-2374页

作者： Shen Tian Hao Li Renhua Li Liang Ran Shu Li Juan Wu Zhou Xu Xinyu Liang Yuling Chen Jun Xiao Jiaying Wei Chenyu Ma Jingyu Song Ruiling She Kainan Wu Lingquan Kong Department of Endocrine and Breast Surgery The First Afiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Infectious Diseases The First Afliated Hospital of Chongqing Medical UniversityChongqing 400016China The Health Management Center of the First Afiliated Hospital of Chongqing Medical University Chongqing 400016China Department of Thyroid and Breast Surgery Afiliated Hospital of North Sichuan Medical CollegeNanchongSichuan 637000China Department of General Surgery People's Hospital of Linshui CountyGuang'anSichuan 638500China.

To the Editor:Non-alcoholic fatty liver disease(NAFLD)comes to prevail in Asia and,the prevalence in China is reported tobe24%to36%.lilThe prevalence ofNAFLD and its associated medical burden might be underestimated.The diagnosis of NAFLD led to the exclusion of other chronic liver diseases including“excess”alcohols,thus the population with alcoholic consumptions or other liver diseases might be neglected.In March 2020,the international expert consensus proposed a new concept,“metabolic associated fatty liver disease(MAFLD),”“and replaced the earlier term” of NAFLD.2As themost prevalent female malignancy,breast cancer(BC)shares similar risk factors to MAFLD.Higher levels of obesity and physical inactivity are closely correlated to BC and are significant drive for the increasing trends in the prevalence of BC.Some BC survivors may receive chemotherapy and endocrine therapy,both of which are reported to increase the risk of hepatic steatosis(HS),which is the fundamental criteria of the diagnosis of MAFLD.

关键词： diagnosis female vivo chemotherapy

Ginsenoside Rg1 and astaxanthin act on the hypothalamus to protect female mice against reproductive aging

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Chinese Medical Journal 2022年第1期135卷 107-109页

作者： Xiaoman Dai Guirong Zeng Luyan Hong Qinyong Ye Xiaochun Chen Jing Zhang Department of Neurology and Geriatrics Fujian Institute of GeriatricsFujian Medical University Union HospitalFuzhouFujian 350001China Fujian Key Laboratory of Molecular Neurology Institute of NeuroscienceFujian Medical UniversityFuzhouFujian 350005China

To the Editor:female infertility due to reproductive aging has become a prominent concern in the population.Evidence indicates that oxidative stress is one of the dominant mechanisms underlying reproductive aging.[1,2]Although female reproductive aging involves gradual changes to the hypothalamic-pituitary-ovarian(HPO)axis,previous studies support a key involvement of the hypothalamus.[3,4]In our recent dataset,it was shown that estrogen-induced oxidative stress led to the senescence of hypothalamic astrocytes that predated reproductive dysfunction.[3]Growing evidence has demonstrated that antioxidants might delay reproductive aging by reducing oxidative damage to ovaries.[1,2]However,the effect of antioxidants on the hypothalamus has not been reported.Astaxanthin(AST),3,3'-dihydroxy-β-carotene-4,4'-dione,is a xanthophyll carotenoid found predominantly in marine animals such as salmon,trout,lobster,and shrimp.Ginseng is a tonic drug in traditional Chinese medicine.Ginsenoside Rg1,a class of steroidal glycosides,is a prominent active anti-aging ingredient within ginseng responsible for these effects.Notably,the two antioxidants freely cross the blood-brain barrier.In this study,we evaluated the effects of these two natural compounds on the hypothalamus and ovaries in protecting female mice from reproductive aging.

关键词： hypothalamus female involvement

Effect of date palm pollen supplementation on female sexual function in non-menopausal women:A double blind randomized clinical trial

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Chinese Herbal Medicines 2022年第4期14卷 643-648页

作者： Roghayeh Salmani Khadijeh Nasiri Yousef Javadzadeh Roya Salmani Cain C.T.Clark Vahideh Aghamohammadi Instructor of Midwifery Department of MidwiferyKhalkhal University of Medical SciencesKhalkhal ***Iran Instructor of Nursing Department of NursingKhalkhal University of Medical SciencesKhalkhal ***Iran Biotechnology Research Center and Faculty of Pharmacy Tabriz University of Medical ScienceTabriz ***Iran Department of Midwifery Khalkhal University of Medical SciencesKhalkhal ***Iran Centre for Intelligent Healthcare Coventry UniversityCoventry CV15FB cv13rwUK Nutritional Sciences Department of NutritionKhalkhal University of Medical SciencesKhalkhal ***Iran

Objective:Despite numerous experimental studies in the literature,there are few clinical trials regarding the effect of date palm pollen(DPP)supplementation on sexual function improvement.In the present study,we sought to evaluate the impact of DPP on female sexual function in Iranian non-menopausal women.Methods:Between October 2019 and December 2019,health centers in the city of Khalkhal,volunteers meeting the inclusion criteria were recruited in randomized clinical trials.Sixty-eight women were randomly stratified and assigned to one of the two study groups:placebo group(n=35)and palm pollen group(n=35),and received a starch or palm pollen capsule(300 mg per day),respectively,for 35 d.The female Sexual Function Index(FSFI)instrument was used to assess female sexual function.Results:After DPP supplementation,the increase in desire,lubrication,and the overall score,was statistically significant compared to the placebo group(P=0.002,P=0.000,and P=0.042;respectively);Whilst there was no significant differences in the remaining domains(arousal:P=0.763;orgasm:P=0.370;satisfaction:P=0.474;pain:P=0.259).There was a statistically significant positive correlation between the coitus and preintervention levels of desire(r=0.298,P=0.038),arousal(r=0.328,P=0.021),lubrication(r=0.361,P=0.011),orgasm(r=0.320,P=0.025),satisfaction(r=0.327,P=0.022),and overall scores(r=0.338,P=0.018).Conclusion:This study suggests that DPP(300 mg supplementation for 35 d),given to non-menopausal women,could improve the lubrication and desire domains of FSFI.

关键词： date palm polle female lubrication randomized controlled trial sexual dysfunction

Stem cell treatment improves post stroke neurological outcomes:a comparative study in male and female rats

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Stroke & Vascular Neurology 2021年第4期6卷 519-527,I0005-I0010页

作者： Koteswara Rao Nalamolu Bharath Chelluboina Casimir A Fornal Siva Reddy Challa David M Pinson David Z Wang Jeffrey D Klopfenstein Krishna Kumar Veeravalli Cancer Biology and Pharmacology College of MedicineUniversity of IllinoisPeoriaIllinoisUSA Pharmaceutical and Biomedical Sciences California Health Sciences UniversityClovisCaliforniaUSA Neurological Surgery University of Wisconsin-MadisonMadisonWisconsinUSA Health Sciences Education College of MedicineUniversity of IllinoisPeoriaIllinoisUSA Neurology College of MedicineUniversity of IllinoisPeoriaIllinoisUSA Neurology Barrow Neurological InstitutePhoenixArizonaUSA Neurosurgery College of MedicineUniversity of IllinoisPeoriaIllinoisUSA OSF HealthCare Illinois Neurological Institute PeoriaIllinoisUSA Pediatrics College of MedicineUniversity of IllinoisPeoriaIllinoisUSA

Background and purpose The therapeutic potential of different stem cells for ischaemic stroke treatment is intriguing and somewhat controversial.Recent results from our laboratory have demonstrated the potential benefits of human umbilical cord blood-derived mesenchymal stem cells(MSC)in a rodent stroke model.We hypothesised that MSC treatment would effectively promote the recovery of sensory and motor function in both males and females,despite any apparent sex differences in post stroke brain injury.Methods Transient focal cerebral ischaemia was induced in adult Sprague-Dawley rats by occlusion of the middle cerebral artery.Following the procedure,male and female rats of the untreated group were euthanised 1 day after reperfusion and their brains were used to estimate the resulting infarct volume and tissue swelling.Additional groups of stroke-induced male and female rats were treated with MSC or vehicle and were subsequently subjected to a battery of standard neurological/neurobehavioral tests(Modified Neurological Severity Score assessment,adhesive tape removal,beam walk and rotarod).The tests were administered at regular intervals(at days 1,3,5,7 and 14)after reperfusion to determine the time course of neurological and functional recovery after stroke.Results The infarct volume and extent of swelling of the ischaemic brain were similar in males and females.Despite similar pathological stroke lesions,the clinical manifestations of stroke were more pronounced in males than females,as indicated by the neurological scores and other tests.MSC treatment significantly improved the recovery of sensory and motor function in both sexes,and it demonstrated efficacy in both moderate stroke(females)and severe stroke(males).Conclusions Despite sex differences in the severity of post stroke outcomes,MSC treatment promoted the recovery of sensory and motor function in male and female rats,suggesting that it may be a promising treatment for stroke.

关键词： neurological female rats

Bile acid homeostasis in female mice deficient in Cyp7a1 and Cyp27a1

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3847-3856页

作者： Daniel Rizzolo Bo Kong Rulaiha E.Taylora Anita Brinker Michael Goedken Brian Buckley Grace L.Guo Department of Pharmacology and Toxicology School of PharmacyRutgers UniversityPiscatawayNJ 08854USA Environmental and Occupational Health Institute Rutgers UniversityPiscatawayNJ 08854USA Office of Research and Economic Development Research Pathology ServicesRutgers UniversityPiscatawayNJ 08854USA Rutgers Center of Lipid Research Rutgers UniversityNew BrunswickNJ 08901USA Department of Veterans Affairs New Jersey Health Care System East OrangeNJ 07018USA

Bile acids(BAs) are amphipathic molecules important for metabolism of cholesterol,absorption of lipids and lipid soluble vitamins,bile flow,and regulation of gut microbiome.There are over 30 different BA species known to exist in humans and mice,which are endogenous modulators of at least 6 different membrane or nuclear receptors.This diversity of ligands and receptors play important roles in health and disease;however,the full functions of each individual BA in vivo remain unclear.We generated a mouse model lacking the initiating enzymes,CYP7 A1 and CYP27 A1,in the two main pathways of BA synthesis.Because females are more susceptible to BA related diseases,such as intrahepatic cholestasis of pregnancy,we expanded this model into female mice.The null mice of Cyp7 a1 and Cyp27 a1 were crossbred to create double knockout(DKO) mice.BA concentrations in female DKO mice had reductions in serum(63%),liver(83%),gallbladder(94%),and small intestine(85%),as compared to WT mice.Despite low BA levels,DKO mice had a similar expression pattern to that of WT mice for genes involved in BA regulation,synthesis,conjugation,and transport.Additionally,through treatment with a synthetic FXR agonist,GW4064,female DKO mice responded to FXR activation similarly to WT mice.

关键词： Bile acids Farnesoid X receptor female Fibroblast growth factor 15 CYP7A1 CYP27A1