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Influence of functional polymorphism in MIF promoter on sudden cardiac death in Chinese populations

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Forensic Sciences Research 2017年第3期2卷 152-157页

作者： zhixia yin Qing Zhang Wei Zhou Shouyu Wang Chaoqun Wang Yan He Lijuan Li Yuzhen Gao Department of Forensic Medicine Medical College of Soochow UniversitySuzhouChina Department of Epidemiology Medical College of Soochow UniversitySuzhouChina

Sudden cardiac death(SCD)is defined as an unexpected natural death without any obvious non-cardiac causes that occurs within 1 h with witnessed symptom onset or within 24 h without witnessed symptom *** studies conducted during the past decade have markedly illuminated the genetic basis of the cardiac disorders associated with *** migration inhibitory factor(MIF)is an upstream immunoregulatory cytokine associated with the pathogenesis of many inflammatory diseases including atherosclerosis and myocardial *** studies have reported that the functional -794(CATT)_(5-8) polymorphism in MIF is unrelated to sudden infant deth syndrome ***,there are no reports concerning the association between the polymorphism and adult SCD *** the current study,we investigated the association between the-794(CATT)_(5-8) polymorphism and adult SCD susceptibility using 79 adult SCD cases and 313 healthy *** samples were analysed using a conventional polymerase chain reaction(PCR)*** found that CATT_(6) and 5-6 were the most common allele and genotype in both groups,respectively,while no significant association was found between the-794(CATT)_(5-8) polymorphism and SCD *** also summarized the allele frequencies of 794(CATT)_(5-8) in cohorts of healthy people from different countries and found that the allele frequency distributions of the polymorphism in Chinese populations were quite different from that of American and European populations(P=0.005,P=0.0001,respectively),but similar to Japanese populations(P=0.827).In conclusion,this study indicates that the-794(CATT)_(5-8) polymorphism may not be associated with adult SCD susceptibility in Chinese *** allele frequency distributions of the polymorphism in multiple populations may provide a useful reference for further genetic association studies.

关键词： Forensic science forensic pathology death,sudden,cardiac genetic predisposition to disease macrophage migration inhibitory factor ¡794(CATT)5–8 polymorphism genetic susceptibility

The Application of Adaptive Sliding Mode Observer-based Fault Detection in Helicopter SystemHua

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The Application of Adaptive Sliding Mode Observer-based Faul...

The Teaching Application of Systemview in Signal and System

第25届中国控制与决策会议

作者： Lianghao Yang Pu yin zhixia College of Automation Engineering Nanjing University of Aeronautics and Astronautics

Considering the interference and fault problem of unmanned helicopter, and aiming to improve the reliability of the unmanned helicopter aircraft, the fault diagnosis problem of unmanned helicopter is researched. A robust adaptive sliding mode observer is design based on the sliding mode observer theory. Lyapunov discriminant is adopted to ensure the stability of the observer. Finally, the simulations verify the effectiveness of the proposed method.

关键词： Unmanned Helicopter Sliding Mode Observer Fault Detection

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The Teaching Application of Systemview in Signal and System

2011高等职业教育电子信息类专业学术暨教学研讨会

作者： Xinhong SU,Jinyan HU,Liqiang yin,zhixia ZHANG Henan Institute of Science and Technology

Due to the insufficiencies in the traditional teaching of signal and system,this paper adopts SystemView software auxiliary signal and system teaching,through the application of case analysis of the signal system SystemView in *** results show that the software is easy to use,the effect is real,intuitive,helps the students the course of signals and systems to understand and grasp.

关键词： Traditional Teaching SystemView Signal and System

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无人机故障注入与故障诊断实时仿真平台研制

计算机应用与软件 2013年第8期30卷 106-108,142页

作者：花良浩殷芝霞杨蒲南京航空航天大学自动化学院江苏南京210016

对无人机故障注入与故障诊断实时仿真平台的功能模块进行划分和描述,构建仿真系统的框架。在VxWorks环境下建立无人机故障注入与故障诊断半物理实时仿真平台。利用该平台可以进行飞行控制、故障注入与故障诊断等不同的仿真任务,同时各... 详细信息

对无人机故障注入与故障诊断实时仿真平台的功能模块进行划分和描述,构建仿真系统的框架。在VxWorks环境下建立无人机故障注入与故障诊断半物理实时仿真平台。利用该平台可以进行飞行控制、故障注入与故障诊断等不同的仿真任务,同时各模块相对独立,有较好的移植性和工程应用性,系统测试结果表明了该平台设计的合理性,为无人机故障注入与故障诊断通用仿真平台设计提供了有益参考。

关键词：无人机故障注入故障诊断半物理仿真平台

蓝芩口服液对小儿手足口病的临床疗效及其对免疫功能的影响

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世界中医药 2017年第12期12卷 2912-2915页

作者：印志霞蒋新江苏省泰兴市中医院儿科泰兴225400 江苏省江阴市第五人民医院预防保健科江阴214415

目的:观察蓝芩口服液治疗小儿手足口病的临床疗效,分析其机制并探讨其对免疫功能的影响。方法:随机选取2015年3月至2016年12月确诊为手足口病的小儿患者86例,通过随机分组法分别将患儿纳入对照组和观察组,各43例,2组患者均一般对症治疗... 详细信息

目的:观察蓝芩口服液治疗小儿手足口病的临床疗效,分析其机制并探讨其对免疫功能的影响。方法:随机选取2015年3月至2016年12月确诊为手足口病的小儿患者86例,通过随机分组法分别将患儿纳入对照组和观察组,各43例,2组患者均一般对症治疗,对照组以阿昔洛韦静脉滴注治疗,观察组在对照组基础上加以蓝芩口服液治疗。同期随机选取30例体检的健康小儿作为健康对照组进行参照。在治疗前后抽取各组患儿静脉血液测定其hs-CRP、Th1及Th2细胞及CD3^+,CD19^+,同时对其退热时间、疱疹消失时间、平均住院时间及临床疗效进行评定。结果:在治疗后,观察组总有效率为95.35%,对照组总有效率为79.07%(P<0.05),观察组患儿的症状改善时间(退热时间、疱疹消失时间、平均住院时间)明显少于对照组(P<0.05),同时其hs-CRP,CD3^+,CD19^+,Th1及Th2细胞百分比在治疗后的均较前改善,且观察组明显优于对照组(P<0.05)。结论:蓝芩口服液能有效改善手足口病患儿预后,提高患儿免疫力,可明显缩短住院时间,提高临床疗效,增强患儿免疫功能。

关键词：蓝芩口服液阿昔洛韦手足口病疗效机制

Effect of titanium and rare earth microalloying on microsegregation,eutectic carbides of M2 high speed steel during ESR process

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Journal of Rare Earths 2020年第9期38卷 1030-1038,I0005页

作者： Fuxing yin Lu Wang zhixia Xiao Jianhang Feng Lin Zhao School of Materials Science and Engineering Hebei University of TechnologyTianjin 300130China Research Institute for Energy Equipment Materials Hebei University of TechnologyTianjin 300130China Tianjin Key Laboratory of Materials Laminating Fabrication and Interfacial Controlling Technology Tianjin 300130China Central Iron and Steel Research Institute Beijing 100081China

The effects of RE and Ti microalloying during electroslag remelting(ESR)process on the microsegregation and morphology of eutectic M2C carbides in M2 high speed steel were *** results show that the addition of 0.2 wt%RE can alleviate the segregation of C,W,Mo,V and Cr,while the morphology of eutectic M2C carbides hardly *** microalloying with the addition of 0.5 wt%Ti has the lowest degree of microsegregation due to the improvement of primary dendrites by the effective heterogeneous nucleating agent of(Ti,V)(C,N)*** addition of Ti makes the mo rphology of M2C carbides change from rod-like or maze-like shape into a coarse feathery shape,exhibiting anisotropic facet growth *** the microalloying of 0.2 wt%RE and 0.5 wt%Ti,the segregation of the main metal alloying elements is slightly more severe than that of the addition of only RE or *** the combined action of RE and Ti,the feathery eutectic M2C becomes thinner and shorter and tends to be isolated or distributed in a discontinuous network.

关键词： Microsegregation Morphology Eutectic carbides High speed steel Electroslag remelting Rare earths

互联网+健康教育对糖尿病患者居家医疗废物处置认知及行为的影响

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当代护士（下旬刊） 2022年第6期29卷 9-12页

作者：陆永珍胡坤徐燕尹志侠顾桂香宁夏医科大学总医院全科医学科银川750004

目的探究分析互联网+健康教育对糖尿病患者居家医疗废物处置认知及行为的影响。方法选取2019年10月—2020年10月某院收治的140例居家注射胰岛素的糖尿病患者为研究对象,采用随机数字表法将患者分为对照组和观察组,每组70例。对照组采用... 详细信息

目的探究分析互联网+健康教育对糖尿病患者居家医疗废物处置认知及行为的影响。方法选取2019年10月—2020年10月某院收治的140例居家注射胰岛素的糖尿病患者为研究对象,采用随机数字表法将患者分为对照组和观察组,每组70例。对照组采用常规健康教育,观察组采用互联网+健康教育。比较两组患者干预前后糖尿病医疗废物知识认知得分、医疗废物处置方法认知情况、居家医疗废物处置行为情况、医疗废物收集设施满意度。结果干预后观察组医疗废物知识认知得分高于对照组,正确处置行为高于对照组(P<0.05);干预后患者医疗废物处置行为情况明显好转,观察组优于对照组(P<0.05);干预后两组对感染性医疗废物收集设施满意度升高,观察组得分高于对照组(P<0.05)。结论互联网+健康教育有利于制订和实施专业干预措施,提高糖尿病患者对居家医疗废物知识和处置行为的认知水平,提高对居家医疗废物的处置行为能力,值得临床推广应用。

关键词：互联网+健康教育糖尿病居家医疗废物处置认知

Preparation of 20 (S)-protopanaxadiol PLGA Nanoparticles

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Medicinal Plant 2024年第1期15卷 13-17页

作者： Tao PAN Baifang GONG zhixia WANG Hanyu SUN Xuanle yin Key Laboratory of Molecular Pharmacology and Drug Evaluation of the Ministry of Education(Yantai University) School of PharmacyYantai UniversityYantai 264005China

[Objectives]To prepare 20(S)-protopanaxadiol PLGA nanoparticles(20(S)-PPD-PLGA-NPs).[Methods]20(S)-PPD-PLGA-NPs were prepared by emulsion solvent evaporation method,and the optimal formulation was screened by Box-Behnken experiment with particle size and drug loading as the indicators through single factor experiment,and the drug release in vitro was carried out.[Results]The average diameter of the nanoparticles was(119.60±2.29)nm and the polydispersity index was(0.12±0.02),the size was *** encapsulation efficiency and drug loading of protopanaxadiol were(87.99±1.29)%and(14.86±0.25)%,respectively.[Conclusions]The 20(S)-PPD-PLGA-NPs were successfully prepared by emulsion solvent evaporation method,and the 20(S)-PPD-PLGA-NPs had good stability,to lay a foundation for the study of 20(S)-PPD-PLGA-NPs in vitro and in vivo.

关键词： 20(S)-protopanaxadiol PLGA nanoparticles Emulsion solvent evaporation method

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海洋采油平台打桩工程中土塞效应研究

岩石力学与工程学报 2009年第4期28卷 703-709页

作者：闫澍旺董伟刘润尹汉军樊之夏天津大学建筑工程学院天津300072 海洋石油工程股份有限公司天津300451

根据太沙基深基础计算方法提出新的土塞效应判断方法,考虑边载效应,同时考虑打桩对周围土体的影响,引入动力效应系数,并将其应用于实际工程中,实测打桩记录结果与计算结果吻合较好,可用于桩的可打入性分析。

关键词：土力学土塞桩的可打入性超大直径桩太沙基理论深基础