Preparation of 20 (S)-protopanaxadiol PLGA Nanoparticles

作     者：Tao PAN Baifang GONG Zhixia WANG Hanyu SUN Xuanle YIN 

作者机构：Key Laboratory of Molecular Pharmacology and Drug Evaluation of the Ministry of Education(Yantai University)School of PharmacyYantai UniversityYantai 264005China 

出 版 物：《Medicinal Plant》 (药用植物：英文版)

年 卷 期：2024年第15卷第1期

页      面：13-17页

学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 

主　　题：20(S)-protopanaxadiol PLGA nanoparticles Emulsion solvent evaporation method 

摘      要：[Objectives]To prepare 20(S)-protopanaxadiol PLGA nanoparticles(20(S)-PPD-PLGA-NPs).[Methods]20(S)-PPD-PLGA-NPs were prepared by emulsion solvent evaporation method,and the optimal formulation was screened by Box-Behnken experiment with particle size and drug loading as the indicators through single factor experiment,and the drug release in vitro was carried out.[Results]The average diameter of the nanoparticles was(119.60±2.29)nm and the polydispersity index was(0.12±0.02),the size was *** encapsulation efficiency and drug loading of protopanaxadiol were(87.99±1.29)%and(14.86±0.25)%,respectively.[Conclusions]The 20(S)-PPD-PLGA-NPs were successfully prepared by emulsion solvent evaporation method,and the 20(S)-PPD-PLGA-NPs had good stability,to lay a foundation for the study of 20(S)-PPD-PLGA-NPs in vitro and in vivo.