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Peniazaphilones A—I,Produced by Co-culturing of Mangrove Endophytic Fungi,Penicillium sclerotiorum THSH-4 and Penicillium sclerotiorum ZJHJJ-18

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Chinese Journal of Chemistry 2021年第12期39卷 3404-3412页

作者： Wencong Yang Jie Yuan Qi Tan Yan Chen Yujia Zhu Hongming Jiang Ge Zou Zhenming Zang Bo Wang zhigang she School of Chemistry Sun Yat-Sen UniversityGuangzhouGuangdong 510275China Department of Biochemistry Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhouGuangdong 510080China Key Laboratory of Tropical Disease Control Sun Yat-Sen UniversityMinistry of EducationGuangzhouGuangdong 510080China National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifengHenan 475004China

Co-culturing the mangrove endophytic fungus Penicillium sclerotiorum THSH-4 with Penicillium sclerotiorum ZJHJJ-18 in PDB medium resulted in the production of nine new azaphilones derivatives,peniazaphilones A—I(1-9),and six known azaphilones derivatives(10-15).Their structures were elucidated by analysis of detailed spectroscopic data,single-crystal X-ray diffraction,ECD spectra,^(13)C NMR calculation and DP4+*** is noteworthy that compound 1 with an isoquinoline quinone moiety,was isolated from natural source for the first ***,compound 2 is the third reported phenylhydrazone derivative from *** the bioactivity assays,compounds 1,12,14 and 15(IC_(50)=4.71-17.64μmol/L)exhibited potent inhibition of LPS-induced NO release from RAW264.7 without obvious cytotoxicity within 50μmol/L compared to the positive control indomethacin(IC_(50)=35.27μmol/L).Moreover,compounds 1 and 13 displayed moderate to strong cytotoxicity to A549 and MDA-MB-435,with IC_(50) values in the range of 6.84-14.63μmol/*** compound 1 showed moderate broad-spectrum antibacterial activity.

关键词： Co-culture Natural products Azaphilones Structure elucidation Cytotoxicity

(+)/(-)-Mycosphatide A,a pair of highly oxidized polyketides with lipid-lowering activity from the mangrove endophytic fungus Mycosphaerella ***-DZG01

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Chinese Chemical Letters 2024年第9期35卷 210-213页

作者： Qi Tan Run-Zhu Fan Wencong Yang Ge Zou Tao Chen Jianying Wu Bo Wang sheng Yin zhigang she School of Chemistry Sun Yat-sen UniversityGuangzhou 510006China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China

(±)-Mycosphatide A(1a/1b),a pair of highly oxidized enantiomeric polyketides featuring a unique5/5/6/5-fused tetracyclic ring system,were isolated from the mangrove endophytic fungus Mycosphaerella *** structures were established by extensive spectroscopic analyses,single crystal Xray diffraction,and experimental electronic circular dichroism(ECD)spectra *** plausible biosynthetic pathway of 1 was proposed,which involved the generation of a key spiro[4.5]decane ***(+)-1a and(-)-1b exhibited significant lipid-lowering activity in 3T3-L1 adipocytes model,with EC50values of 7.85±1.56 and 8.87±0.80μmol/L,respectively.

关键词： Mangrove endophytic fungus Mycosphaerella sp. Polyketide Highly oxidized Lipid-lowering activity

Griseofulvin enantiomers and bromine-containing griseofulvin derivatives with antifungal activity produced by the mangrove endophytic fungus Nigrospora ***1

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Marine Life Science & Technology 2024年第1期6卷 102-114页

作者： Ge Zou Wencong Yang Tao Chen Zhaoming Liu Yan Chen Taobo Li Gulab Said Bing Sun Bo Wang zhigang she School of Chemistry Sun Yat-sen UniversityGuangzhou 510275China State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationInstitute of MicrobiologyGuangdong Academy of SciencesGuangzhou 510070China School of Pharmacy Anhui Medical UniversityHefei 230032China Department of Chemistry Women University SwabiSwabi 23430Pakistan

Marine microorganisms have long been recognized as potential sources for drug *** was one of the first antifungal natural products and has been used as an antifungal agent for *** this study,12 new griseofulvin derivatives[(±)-1-2,(+)-3,(±)-4,10-12,and 14-15]and two new griseofulvin natural products(9 and 16)together with six known analogues[(-)-3,5-8,and 13]were isolated from the mangrove-derived fungus Nigrospora ***1 treated with 0.3%NaCl or 2%NaBr in rice solid *** 2D structures and absolute configurations were established by extensive spectroscopic analysis(1D and 2D NMR,HRESIMS),ECD spectra,computational calculation,DP4+analysis,and X-ray single-crystal *** 1-4 represent the first griseofulvin enantiomers with four absolute configurations(2S,6'S;2R,6'R;2S,6'R;2R,6'S),and compounds 9-12 represent the first successful production of brominated griseofulvin derivatives from fungi via the addition of NaBr to the culture *** the antifungal assays,compounds 6 and 9 demonstrated significant inhibitory activities against the fungi Colletotrichum truncatum,Microsporum gypseum,and Trichophyton mentagrophyte with inhibition zones varying between 28 and 41 mm(10μg/disc).The structure-activity relationship(SAR)was analyzed,which showed that substituents at C-6,C-7,C-6'and the positions of the carbonyl and double bond of griseofulvin derivatives significantly affected the antifungal activity.

关键词： Mangrove endophytic fungus Nigrospora sp. Griseofulvin Antifungal activity

Association Analysis of Hyperlipidemia with the 28-Day All-Cause Mortality of COVID-19 in Hospitalized Patients

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Chinese Medical Sciences Journal 2021年第1期36卷 17-26页

作者： Bin Wu Jianghua Zhou Wenxin Wang Huilin Yang Meng Xia Binghong Zhang zhigang she Hongliang Li Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan 430071China Institute of Model Animal Wuhan UniversityWuhan 430071China Basic Medical School Wuhan UniversityWuhan 430071China Department of Neonatology Renmin Hospital of Wuhan UniversityWuhan 430072China Medical Science Research Center Zhongnan Hospital of Wuhan UniversityWuhan 430071China

Objective This study aimed to determine the association of hyperlipidemia with clinical endpoints among hospitalized patients with COVID-19,especially those with pre-existing cardiovascular diseases(CVDs)and *** This multicenter retrospective cohort study included all patients who were hospitalized due to COVID-19 from 21 hospitals in Hubei province,China between December 31,2019 and April 21,*** who were aged<18 or≥85 years old,in pregnancy,with acute lethal organ injury(e.g.,acute myocardial infarction,severe acute pancreatitis,acute stroke),hypothyroidism,malignant diseases,severe malnutrition,and those with normal lipid profile under lipid-lowering medicines(e.g,statin,niacin,fenofibrate,gemfibrozil,and ezetimibe)were *** score matching(PSM)analysis at 1:1 ratio was performed to minimize baseline differences between patient groups of hyperlipidemia and *** analyses with the same strategies were further conducted for the parameters of hyperlipidemia in patients with increased triglyceride(TG),increased low・density lipoprotein cholesterol(LDL-C),and decreased high-density lipoprotein cholesterol(HDL-C).Mixed-effect Cox model analysis was performed to investigate the associations of the 28-days all-cause deaths of COVID-19 patients with hyperlipidemia and the abnormalities of lipid *** results were verified in male,female patients,and in patients with pre-existing CVDs and type 2 *** Of 1094S inpatients confirmed as COVID-19,there were 9822 inpatients included in the study,comprising 3513(35.8%)cases without hyperlipidemia and 6309(64.2%)cases with *** on a mixed-effect Cox model after PSM at 1:1 ratio,hyperlipidemia was not associated with increased or decreased 28-day all-cause death[adjusted hazard ratio(HR),1.17(95%C/,0.95-1.44),P二0.151].Wb found that the parameters of hyperlipidemia were not associated with the risk of 28-day all-cause mortality[adjusted HR,1.23(

关键词： coronavirus disease 2019(COVID-19) lipid disorder mortality cardiovascular diseases diabetes

无瓣海桑来源内生真菌Aspergillus ***16-5B中的二聚呫吨类化合物

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中山大学学报（自然科学版）（中英文） 2022年第5期61卷 76-83页

作者：刘亚月吴颖楠佘志刚广东海洋大学食品科技学院广东湛江524088 中山大学化学学院广东广州510006

研究了海南红树植物无瓣海桑Sonneratia apetala来源内生真菌Aspergillus sp.(HNY16-5B)的次级代谢产物。利用察氏培养基对该菌株进行发酵培养,并综合运用正、反相硅胶柱层析,Sephadex LH-20凝胶和重结晶等分离手段,从中分离获得了5个... 详细信息

研究了海南红树植物无瓣海桑Sonneratia apetala来源内生真菌Aspergillus sp.(HNY16-5B)的次级代谢产物。利用察氏培养基对该菌株进行发酵培养,并综合运用正、反相硅胶柱层析,Sephadex LH-20凝胶和重结晶等分离手段,从中分离获得了5个二聚呫吨化合物(1~5)。运用MS和1D、2D NMR等现代波谱技术,并与文献数据对比,鉴定为:asperpyrone B(1)、fonsecinone A(2)、aurasperone A(3)、asperpyrone A(4)和dianhydroaurasperone C(5)。通过培养成功获得了化合物2的单晶,并利用铜靶X-Ray单晶衍射技术确定其轴手性为S。通过对比CD谱,最终确定了化合物1~5的轴手性均为S。

关键词：红树林内生真菌 Aspergillus sp. 次级代谢产物二聚呫吨

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鲍鱼多糖Hal-A的甲醇解研究

有机化学 2002年第5期22卷 367-370页

作者：佘志刚胡谷平吴耀文林永成中山大学化学化工学院广州510275

从鲍鱼中分离出一种鲍鱼多糖Hal A ,并用改进甲醇解方法研究了Hal A的组成 ,该多糖甲醇解产物经三甲硅醚衍生后 ,进行GC/MS分析 ,结果表明鲍鱼多糖Hal A主要由萄萄糖、半乳糖、甘露糖和少量木糖。

关键词： Hal-A 鲍鱼硫酸酯多糖甲醇解三甲硅醚反应药理免疫功能抗癌作用多糖药物

改进GA-BP算法的油气管道腐蚀剩余强度预测

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西南石油大学学报（自然科学版） 2013年第3期35卷 160-167页

作者：孙宝财武建文李雷佘志刚甘肃省锅炉压力容器检验研究中心甘肃兰州730020 中国石油华东设计院山东青岛266071 中国石油克拉玛依石化公司新疆克拉玛依834003

利用人工神经网络能够逼近任意复杂函数的特性,可对在役油气管道的腐蚀剩余强度进行预测,但其缺点在于人工神经网络的权值和阈值的初始化分配具有随机性且只是一种局部优化算法,收敛过程中容易出现局部极小解。引入遗传算法的全局搜索... 详细信息

利用人工神经网络能够逼近任意复杂函数的特性,可对在役油气管道的腐蚀剩余强度进行预测,但其缺点在于人工神经网络的权值和阈值的初始化分配具有随机性且只是一种局部优化算法,收敛过程中容易出现局部极小解。引入遗传算法的全局搜索特性和不依赖于梯度信息特性,对采用Levenberg-Marquardt(L-M)算法的BP神经网络的权值和阈值进行优化,并结合由敏感性分析确定的油气管道失效压力的影响因素,建立GA-BP(L-M)网络预测模型。采用Modified ASME B31G计算出的样本数据训练网络并进行预测。预测结果表明,GA-BP(L-M)网络预测模型可以相对更好地预测油气管道的失效压力,在满足工程需要的前提下,是一种更加科学、准确的预测模型。

关键词：遗传算法神经网络 GA-BP(L-M)网络油气管道剩余强度

红树林内生真菌K38和E33混合发酵代谢产物研究

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中山大学学报（自然科学版） 2010年第6期49卷 136-138,144页

作者：李春远佘志刚林永成周世宁华南农业大学理学院生物材料研究所广东广州510642 中山大学化学与化学工程学院广东广州510275 中山大学生命科学学院广东广州510275

将混合发酵技术应用于来自南海红树林内生真菌E33和K38的培养,其发酵液乙酸乙酯萃取物对多种植物病原菌有较强抑制活性,从该提取物中分离到deoxyscytalidin(1),1-甲氧基-2-羟基-3-甲基蒽醌(2),5-丁基-2-吡啶甲酸甲酯(3),5-(3-丁烯基)-2... 详细信息

将混合发酵技术应用于来自南海红树林内生真菌E33和K38的培养,其发酵液乙酸乙酯萃取物对多种植物病原菌有较强抑制活性,从该提取物中分离到deoxyscytalidin(1),1-甲氧基-2-羟基-3-甲基蒽醌(2),5-丁基-2-吡啶甲酸甲酯(3),5-(3-丁烯基)-2-吡啶甲酸甲酯(4),sescandelin(5)五个单独培养未能得到的代谢产物,其中化合物1,2,3,4为首次从海洋真菌里得到。

关键词：红树内生真菌混合发酵抗真菌活性

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鲍鱼多糖Hal-A的热分析研究

有机化学 2003年第10期23卷 1149-1151页

作者：佘志刚胡谷平郭志勇林永成林木良中山大学化学与化学工程学院广州510275 中山大学测试中心广州510275

采用热重、热重 -红外谱联用及差示扫描量热法 ,对鲍鱼多糖进行热分析研究 ,结果表明鲍鱼多糖在空气和氮气氛中 ,2 3 0～ 3 40℃之间发生剧烈的分解反应 .氮气氛中 ,是吸热的分解过程 ;而空气氛中 ,是放热氧化反应 ,并且在 45 3℃左右 ... 详细信息

采用热重、热重 -红外谱联用及差示扫描量热法 ,对鲍鱼多糖进行热分析研究 ,结果表明鲍鱼多糖在空气和氮气氛中 ,2 3 0～ 3 40℃之间发生剧烈的分解反应 .氮气氛中 ,是吸热的分解过程 ;而空气氛中 ,是放热氧化反应 ,并且在 45 3℃左右 ,有另一个急剧的氧化裂解过程 .与淀粉、肝素、甲壳素和半乳糖的热分析比较 ,含有硫酸酯的鲍鱼多糖和肝素热稳定性较低 ,含氨基的甲壳素最高 ,这反映出不同基团对多糖热稳定性的影响 .

关键词：鲍鱼多糖 Hal-A 热分析热重法热重-红外谱联用差示扫描量热法