(+)/(-)-Mycosphatide A,a pair of highly oxidized polyketides with lipid-lowering activity from the mangrove endophytic fungus Mycosphaerella ***-DZG01

作     者：Qi Tan Run-Zhu Fan Wencong Yang Ge Zou Tao Chen Jianying Wu Bo Wang Sheng Yin Zhigang She 

作者机构：School of ChemistrySun Yat-sen UniversityGuangzhou 510006China School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第9期

页      面：210-213页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：National Natural Science Foundation of China(Nos.U20A2001,81973195,21877133) the Guangdong Marine Economy Development Special Project(Nos.GDNRC35,GDNRC39) 

主　　题：Mangrove endophytic fungus Mycosphaerella sp. Polyketide Highly oxidized Lipid-lowering activity 

摘      要：(±)-Mycosphatide A(1a/1b),a pair of highly oxidized enantiomeric polyketides featuring a unique5/5/6/5-fused tetracyclic ring system,were isolated from the mangrove endophytic fungus Mycosphaerella *** structures were established by extensive spectroscopic analyses,single crystal Xray diffraction,and experimental electronic circular dichroism(ECD)spectra *** plausible biosynthetic pathway of 1 was proposed,which involved the generation of a key spiro[4.5]decane ***(+)-1a and(-)-1b exhibited significant lipid-lowering activity in 3T3-L1 adipocytes model,with EC50values of 7.85±1.56 and 8.87±0.80μmol/L,respectively.