Three New Chromone Derivatives Produced by Phomopsis sp. HNY29-2B from Acanthus ilicifolius Linn.
Three New Chromone Derivatives Produced by Phomopsis sp. HNY29-2B from Acanthus ilicifolius Linn.作者机构：School of Chemistry Sun Yat-Sen University Guangzhou Guangdong 510275 China Guangdong Inspection and Quarantine Technology Center Guangdong Entry-Exit Inspection and Quarantine Bureau Guangzhou Guangdong 510623 China Institute of Tumor Pharmacology College of Pharmacy Jinan University Guangzhou Guangdong 510632 China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2017年第35卷第12期
页 面：1889-1893页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 081202[工学-计算机软件与理论] 0812[工学-计算机科学与技术（可授工学、理学学位）]
基 金：Supporting information for this article is available on the WWW under http://dx.doi.org/10.1002/cjoc.201700375 or from the author.Acknowledgement We thank the National Natural Science Foundation of China (Nos. 21472251 41276146) the Key Project of Natural Science Foundation of Guangdong Province (No. 2016A030311026) the Science & Technology Plan Project of Guangdong Province of China (Nos. 2013B021100011 2016A040403091) the Special Financial Fund of Innovative Development of Marine Economic Demonstration Project (No. GD2012-D01- 001) the China's Marine Commonweal Research Project (No. 201305017) the Guangzhou Project of Science & Technology Planning (No. 201300000062) the Fundamental Research Funds for the Central Universities (No. 141gjc16) and the Supercomputing Center of Chinese Academy of Sciences (SCCAS) for generous support
主 题：phomochromenones Phomopsis sp. absolution configurations electronic circular dichroism cytotoxicity
摘 要：Three new chromone derivatives, phomochromenones A-C （1-3）, and one known chaetocyclinone B （4） were obtained from the cultures ofPhomopsis sp. HNY29-2B isolated from the mangrove Acanthus ilicifolius Linn., which was collected from the South China Sea. Their structures were determined by the analysis of 1D NMR and 2D NMR as well as mass spectroscopic data. The absolute configurations of I and 2 were assigned by quantum chemi- cal calculations of the electronic circular dichroism （ECD） spectra. Compound 3 is the third example of alkaloids possessing the unique chromeno [3,2-c] pyridine nucleus. In the bioactivity assay, compound 4 showed cytotoxicity against human prostate cancer cell lines （PC-3 and DU145 cells） with the IC50 values of 8.13 and 3.59 μmol/L, respectively.
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