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A nanoconcrete welding strategy for constructing high-performance wound dressing

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Bioactive Materials 2022年第8期7卷 31-41页

作者： Yingshuai Wang Yanxia Zhu Penghe Zhao Bin Wei Mingjian Fan Danyang Chen zhaokui jin Qianjun He School of Life Science and Technology Weifang Medical UniversityWeifangShandongChina Central Laboratory Longgang District People’s Hospital of Shenzhen&the Third Affiliated Hospital(Provisional)of the Chinese University of Hong KongShenzhenGuangdongChina School of Biomedical Engineering Health Science CenterShenzhen UniversityNo.1066 Xueyuan RoadShenzhen518060GuangdongChina Department of Quantum and Energy Materials International Iberian Nanotechnology Laboratory(INL)Braga4715-330Portugal Center of Hydrogen Science Shanghai Jiao Tong UniversityShanghai200240China

Engineering biomaterials to meet specific biomedical applications raises high requirements of mechanical performances,and simultaneous strengthening and toughening of polymer are frequently necessary but very challenging in many *** this work,we propose a new concept of nanoconcrete welding polymer chains,where mesoporous CaCO3(mCaCO_(3))nanoconcretes which are composed of amorphous and nanocrystalline phases are developed to powerfully weld polymer chains through siphoning-induced occlusion,hydration-driven crystallization and dehydration-driven compression of *** mCaCO_(3) nanoconcrete welding technology is verified to be able to remarkably augment strength,toughness and anti-fatigue performances of a model polymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate)-based porous ***,we have revealed polymer-occluded nanocrystal structure and welding-derived microstress which is much stronger than interfacial Van der Waals force,thus efficiently preventing the generation of microcracks and repairing initial microcracks by microcracks-induced hydration,crystallization and polymer welding of mCaCO_(3) *** porous membrane is used as wound dressing,exhibiting a special nanoplates-constructed surface topography as well as a porous structure with plentiful oriented,aligned and opened pore channels,improved hydrophilicity,water vapor permeability,anti-bacterial and cell adherence,in support of wound healing and skin structural/functional *** proposed nanoconcrete-welding-polymer strategy breaks a new pathway for improving the mechanical performances of polymers.

关键词： Tissue engineering Mechanical performances Calcium carbonate Mesoporous materials Organic/inorganic nanocomposite Wound dressing

Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing

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National Science Review 2023年第5期10卷 262-271页

作者： Qingqing Xu Shengqiang Chen Lingdong Jiang Chao Xia Lingting Zeng Xiaoqing Cai zhaokui jin Shucun Qin Wenjiang Ding Qianjun He Taishan Institute for Hydrogen Biomedical Research School of Basic Medical SciencesThe Second Affiliated Hospital of Shandong First Medical University&Shandong Academy of Medical Sciences Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging School of Biomedical EngineeringMedical SchoolShenzhen University Shanghai Key Laboratory of Hydrogen Science&Center of Hydrogen Science School of Materials Science and EngineeringShanghai Jiao Tong University

It is a great challenge to effectively eradicate biofilm and cure biofilm-infected diseases because dense extracellular polymeric substance matrix prevents routine antibacterial agents from penetrating into biofilm.H2is an emerging energy-regulating molecule possessing both high biosafety and high tissue *** this work,we propose a concept of sonocatalytic hydrogen/hole-combined ’inside/outside-cooperation’anti-biofilm for promoting bacteria-infected diabetic wound healing based on two-dimensional piezoelectric ***-of-concept experiments using C3N4nanosheets as a representative piezoelectric catalyst with wide band gap and high biosafety have verified that sonocatalytically generated H2and holes rapidly penetrate into biofilm to inhibit bacterial energy metabolism and oxidatively deprive polysaccharides/NADH in biofilm to destroy the bacterial membrane/electron transport chain,respectively,inside/outside-cooperatively eradicating biofilm.A bacteria-infected diabetic wound model is used to confirm the excellent in vivo antibacterial performance of sonocatalytic hydrogen/hole-combined therapy,remarkably improving bacteria-infe cted diabetic wound *** proposed strategy of sonocatalytic hole/hydrogen-combined ’inside/outside-cooperation’ will make a highway for treatment of deep-seated biofilm infection.

关键词： nanocatalytic medicine hydrogen therapy biofilm diabetic foot piezoelectric catalysis

Novel photo-theranostic GdB_(6) nanoparticles for fluorescence imaging and NIR-photothermal therapy

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Chinese Chemical Letters 2021年第11期32卷 3487-3490页

作者： Yuqi Chen Mengna Jiang Liwei Xiong Xianxian Yao Mingjian Fan Danyang Chen Qi Jiang zhaokui jin Qianjun He Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging National-Regional Key Technology Engineering Laboratory for Medical UltrasoundMarshall Laboratory of Biomedical EngineeringSchool of Biomedical EngineeringHealth Science CenterShenzhen UniversityShenzhen 518060China Hubei Key Laboratory of Plasma Chemistry and Advanced Materials Wuhan Institute of TechnologyWuhan 430205China

The development of multifunctional theranostic nano-agents is an important resolution for personalized treatment of *** this work,we synthesized a new kind of gadolinium boride nanoparticles(GBN)by a microwave-assisted chemical etching method,and discovered their optical characteristics including fluorescence imaging and near-infrared(NIR)photothermal conversion *** greenishyellow fluorescence enabled for intracellular localization,while effective NIR-photothermal conversion supported photothermal therapy(PTT).In vitro and in vivo results indicated that GBN exhibited a superior antitumor performance and high *** study demonstrated a promising multifunctional theranostic nanoplatform for cancer treatment.

关键词： Gadolinium boride Nanomedicine Photothermal therapy Fluorescence imaging Theranostics

Engineering biocompatible TeSex nano-alloys as a versatile theranostic nanoplatform

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National Science Review 2021年第6期8卷 148-159页

作者： Xiang Ling zhaokui jin Qi Jiang Xiaotao Wang Bin Wei Zhongchang Wang Yangsen Xu Tianye Cao Jonathan W.Engle Weibo Cai Chenliang Su Qianjun He International Collaborative Laboratory of 2D Materials for Optoelectronic Science & Technology Engineering Technology Research Center for 2D Materials Information Functional Devices and Systems of Guangdong ProvinceInstitute of Microscale OptoelectronicsShenzhen University Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging National-Regional Key Technology Engineering Laboratory for Medical UltrasoundSchool of Biomedical EngineeringHealth Science CenterShenzhen University Department of Quantum and Energy Materials International Iberian Nanotechnology Laboratory (INL) Departments of Radiology and Medical Physics University of Wisconsin-Madison

Photothermal nanotheranostics, especially in the near infrared II（NIR-II） region, exhibits a great potential in precision and personalized medicine, owing to high tissue penetration of NIR-II ***-II-photothermal nanoplatforms with high biocompatibility as well as high photothermal effect are urgently needed but rarely reported so far. Te nanomaterials possess high absorbance to NIR-II light but also exhibit high cytotoxicity, impeding their biomedical applications. In this work, the controllable incorporation of biocompatible Se into the lattice of Te nanostructures is proposed to intrinsically tune their inherent cytotoxicity and enhance their biocompatibility, developing TeSexnano-alloys as a new kind of theranostic nanoplatform. We have uncovered that the cytotoxicity of Te nanomaterials primarily derives from irreversible oxidation stress and intracellular imbalance of organization and energy, and can be eliminated by incorporating a moderate proportion of Se（x = 0.43）. We have also discovered that the as-prepared TeSexnano-alloys have extraordinarily high NIR-II-photothermal conversion efficiency（77.2%）,64Cu coordination and computed tomography contrast capabilities, enabling high-efficacy multimodal photothermal/photoacoustic/positron emission tomography/computed tomography imaging-guided NIR-II-photothermal therapy of cancer. The proposed nano-alloying strategy provides a new route to improve the biocompatibility of biomedical nanoplatforms and endow them with versatile theranostic functions.

关键词： nanomedicine nano-alloys photothermal therapy cancer nanotheranostics biomedical imaging

Light-triggered nitric oxide release and structure transformation of peptide for enhanced intratumoral retention and sensitized photodynamic therapy

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Bioactive Materials 2022年第6期7卷 303-313页

作者： Lingdong Jiang Danyang Chen zhaokui jin Chao Xia Qingqing Xu Mingjian Fan Yunlu Dai Jia Liu Yuanpei Li Qianjun He Marshall Laboratory of Biomedical Engineering School of Biomedical EngineeringHealth Science CenterShenzhen UniversityNo.1066 Xueyuan AvenueShenzhen518060GuangdongChina Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhen518060GuangdongChina Central Laboratory Longgang District People’s Hospital of Shenzhen&The Third Affiliated Hospital(Provisional)of The Chinese University of Hong KongShenzhen518172GuangdongChina Department of Biochemistry and Molecular Medicine UC Davis Comprehensive Cancer CenterUniversity of California DavisSacramentoCA95817USA Cancer Centre and Institute of Translational Medicine Faculty of Health SciencesUniversity of MacaoMacao SAR999078China

Tumor-targeted delivery of nanomedicine is of great importance to improve therapeutic efficacy of cancer and minimize systemic side ***,nowadays the targeting efficiency of nanomedicine toward tumor is still quite limited and far from clinical *** this work,we develop an innovative peptide-based nanoparticle to realize light-triggered nitric oxide(NO)release and structural transformation for enhanced intratumoral retention and simultaneously sensitizing photodynamic therapy(PDT).The designed nanoparticle is self-assembled from a chimeric peptide monomer,TPP-RRRKLVFFK-Ce6,which contains a photosensitive moiety(chlorin e6,Ce6),aβ-sheet-forming peptide domain(Lys-Leu-Val-Phe-Phe,KLVFF),an oligoarginine domain(RRR)as NO donor and a triphenylphosphonium(TPP)moiety for targeting *** irradiated by light,the constructed nanoparticles undergo rapid structural transformation from nanosphere to nanorod,enabling to achieve a significantly higher intratumoral accumulation by 3.26 times compared to that without light *** importantly,the conversion of generated NO and reactive oxygen species(ROS)in a light-responsive way to peroxynitrite anions(ONOO􀀀)with higher cytotoxicity enables NO to sensitize PDT in cancer *** in vitro and in vivo studies demonstrate that NO sensitized PDT based on the well-designed transformable nanoparticles enables to eradicate tumors *** light-triggered transformable nanoplatform developed in this work provides a new strategy for enhanced intratumoral retention and improved therapeutic outcome.

关键词： Nitric oxide Photodynamic therapy Structural transformation Peptide Enhanced intratumoral retention Nanomedicine

国有企业科技创新管理与提升路径探讨——以四川省国资委监管企业为例

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四川有色金属 2021年第2期 62-65,70页

作者：周益明万宁羊坤晋兆奎伍建军四川省有色科技集团有限责任公司四川成都610059

科技创新是催生新发展动能的重要驱动力,对推动国有企业高质量发展具有重要意义。加强国有企业科技创新管理,构建科学、合理、全面的科技创新能力评价体系,是推动国有企业提升科技创新水平的有效手段。本文以四川省国资委监管企业为例,... 详细信息

科技创新是催生新发展动能的重要驱动力,对推动国有企业高质量发展具有重要意义。加强国有企业科技创新管理,构建科学、合理、全面的科技创新能力评价体系,是推动国有企业提升科技创新水平的有效手段。本文以四川省国资委监管企业为例,分析了企业科技创新及创新管理现状和存在问题,提出了提升国有企业创新能力及科技创新管理的路径。

关键词：国有企业科技管理创新评价创新能力

Effect of Rhei Radix et Rhizoma and Eupolyphaga Steleophaga on liver protection mechanism based on pharmacokinetics and metabonomics

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Chinese Herbal Medicines 2024年第1期16卷 121-131页

作者： Gang Feng Jianli Bi Wenfang jin Qi Wang zhaokui Dan Baolei Fan Hubei University of Science and Technology Xianning 437100China The First People’s Hospital of Xianning Xianning 437000China The First People’s Hospital of Tongshan Tongshan 437600China Hubei Provincial Key Laboratory of Radiation Chemistry and Functional Materials Xianning 437100China

Objective:Based on metabonomics technology of high-performance liquid chromatography-mass spectrometry(HPLC-MS/MS)and hydrogen nuclear magnetic resonance spectroscopy(^(1)H NMR),the pharmacokinetic characteristics and therapeutic mechanism of Rhei Radix et Rhizoma(RhRR,Dahuang in Chinese),Eupolyphaga Steleophaga(EuS,Tubiechong in Chinese)combined with RhRR acting on acute liver injury were ***:Models of acute liver injury were established,and the pharmacokinetic methods of five components of RhRR-EuS in rats were found by HPLC-MS/*** liver tissues of different groups of mice were analyzed by ^(1)H NMR spectroscopy combined with multivariate statistical analysis to investigate the metabolomics of RhRR-EuS and ***:Pharmacokinetic results showed there were different levels of bimodal phenomenon in different groups,and the absorption of free anthraquinone in RhRR increased after compatibility with *** addition,the pathological state of acute liver injury in rats can selectively promote the absorption of emodin,chrysophanol,physcion and aloe *** 15 differential metabolites in the liver tissue of acute liver injury mice,it was revealed that RhRR-EuS and RhRR could protect the liver injury by regulating the metabolism of glutamine and glutamic acid,alanine,aspartic acid and glutamic acid,and ***,the regulation of RhRR was weaker than that of ***:For the first time,we studied the pharmacokinetics and metabolomics differences of RhRREuS and RhRR in rats and mice with acute liver injury,in order to provide theoretical reference for clinical treatment of liver disease by DHZCP.

关键词： Dahuang Zhechong Pills Eupolyphaga Steleophaga 1H NMR HPLC-MS/MS metabonomics pharmacokinetics Rhei Radix et Rhizoma

The issues on the commercialization of perovskite solar cells

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Materials Futures

Materials Futures 2024年第2期3卷 1-35页

作者： Lixiu Zhang Yousheng Wang Xiangchuan Meng Jia Zhang Pengfei Wu Min Wang Fengren Cao Chunhao Chen zhaokui Wang Fu Yang Xiaodong Li Yu Zou Xi jin Yan Jiang Hengyue Li Yucheng Liu Tongle Bu Buyi Yan Yaowen Li Junfeng Fang Lixin Xiao Junliang Yang Fuzhi Huang Shengzhong Liu Jizhong Yao Liangsheng Liao Liang Li Fei Zhang Yiqiang Zhan Yiwang Chen Yaohua Mai Liming Ding Center for Excellence in Nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing 100190People’s Republic of China Institute of New Energy Technology College of Information Science and TechnologyJinan UniversityGuangzhou 510632People’s Republic of China Institute of Polymers and Energy Chemistry(IPEC) Nanchang UniversityNanchang 330031People’s Republic of China School of Information Science and Technology Fudan UniversityShanghai 200433People’s Republic of China School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072People’s Republic of China School of Physical Science and Technology Soochow UniversitySuzhou 215006People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Institute of optoelectronics Fudan UniversityShanghai 200433People’s Republic of China College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123People’s Republic of China School of Physics and Electronic Science East China Normal UniversityShanghai 200241People’s Republic of China State Key Laboratory for Artificial Microstructure and Mesoscopic Physics Department of PhysicsPeking UniversityBeijing 100871People’s Republic of China College of Biophotonics South China Normal UniversityGuangzhou 510631People’s Republic of China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China School of Physics and Electronics Central South UniversityChangsha 410083People’s Republic of China School of Materials Science and Engineering Shaanxi Normal UniversityXi’an 710119People’s Republic of China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Microquanta semiconductor Hangzhou 311121People’s Republic of China

Perovskite solar cells have aroused a worldwide research upsurge in recent years due to their soaring photovoltaic performance,ease of solution processing,and low *** power conversion efficiency record is constantly being broken and has recently reached 26.1%in the lab,which is comparable to the established photovoltaic technologies such as crystalline silicon,copper indium gallium selenide and cadmium telluride(CdTe)solar ***,perovskite solar cells are standing at the entrance of industrialization,where huge opportunities and risks ***,towards commercialization,challenges of up-scaling,stability and lead toxicity still remain,the proper handling of which could potentially lead to the widespread adoption of perovskite solar cells as a low-cost and efficient source of renewable *** review gives a holistic analysis of the path towards commercialization for perovskite solar cells.A comprehensive overview of the current state-of-the-art level for perovskite solar cells and modules will be introduced first,with respect to the module efficiency,stability and current status of *** will then discuss the challenges that get in the way of commercialization and the corresponding strategies to address them,involving the upscaling,the stability and the lead toxicity *** into the future direction of commercialization of perovskite photovoltaics was also provided,including the flexible perovskite cells and modules and perovskite indoor ***,the future perspectives towards commercialization are put forward.

关键词： commercializations perovskite solar cells state-of-the-art level challenges and perspectives indoor photovoltaics

Recent progress in perovskite solar cells:from device to commercialization

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Science China Chemistry 2022年第12期65卷 2369-2416页

作者： Xinhui Luo Xuesong Lin Feng Gao Yang Zhao Xiaodong Li Liqing Zhan Zexiong Qiu jin Wang Cong Chen Lei Meng Xiaofeng Gao Yu Zhang Zijian Huang Rundong Fan Huifen Liu Yanrun Chen Xiaoxue Ren Jiahong Tang Chun-Hao Chen Dong Yang Yongguang Tu Xiao Liu Dongxue Liu Qing Zhao jingbi You Junfeng Fang Yongzhen Wu Hongwei Han Xiaodan Zhang Dewei Zhao Fuzhi Huang Huanping Zhou Yongbo Yuan Qi Chen zhaokui Wang Shengzhong(Frank)Liu Rui Zhu Jotaro Nakazaki Yongfang Li Liyuan Han State Key Laboratory of Metal Matrix Composites School of Material Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China State Key Lab for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Semiconductor Materials Science Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China School of Physics and Electronic Science Engineering Research Center of Nanophotonics&Advanced InstrumentMinistry of EducationEast China Normal UniversityShanghai 200241China Key Laboratory for Advanced Materials and Institute of Fine Chemicals School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage CenterSolar Energy Research CenterNankai UniversityTianjin 300350China College of Materials Science and Engineering&Engineering Research Center of Alternative Energy Materials&Devices Ministry of EducationSichuan UniversityChengdu 610065China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Beijing Key Laboratory for Theory and Technology of Advanced Battery Materials Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationSchool of Materials Science and EngineeringPeking UniversityBeijing 100871China School of Physics and Electronics Hunan Key Laboratory of Nanophotonics and DevicesCentral South UniversityChangsha 410083China Experimental Center for Advanced Materials School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Jia

Perovskite solar cells(PSCs) are undergoing rapid development and the power conversion efficiency reaches 25.7% which attracts increasing attention on their commercialization *** this review,we summarized the recent progress of PSCs based on device structures,perovskite-based tandem cells,large-area modules,stability,applications and ***,the challenges and perspectives are discussed,aiming at providing a thrust for the commercialization of PSCs in the near future.

关键词： perovskite solar cells device engineering stability application

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