Fe-porphyrin:A redox-related biosensor of hydrogen molecule
作者机构：Center of Hydrogen ScienceSchool of Materials Science and EngineeringShanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China School of Biomedical EngineeringHealth Science CenterShenzhen University1066 Xueyuan RoadShenzhen 518060China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2023年第16卷第2期
页 面：2020-2025页
核心收录：
学科分类：080202[工学-机械电子工程] 08[工学] 0703[理学-化学] 0802[工学-机械工程] 0702[理学-物理学]
基 金：support from the National Natural Science Foundation of China(Nos.51872188 and 82172078) Shenzhen Science and Technology Program(No.RCJC20210706092010008) Special Funds for the Development of Strategic Emerging Industries in Shenzhen(No.20180309154519685) Center of Hydrogen Science,Shanghai Jiao Tong University,China
主 题：hydrogen molecule molecular mechanism molecular target hydrogen medicine porphyrin catalysis carbon monoxide
摘 要：Hydrogen molecule(H_(2))exhibits broad-spectrum but microenvironment-dependent biomedical effects in varied oxidation stress-related diseases,but its molecular mechanism is unclear and its targeting molecule is unknown so ***,we originally reveal that Fe-porphyrin is a H_(2)-targeted *** have demonstrated that the oxidized Fe-porphyrin in both free and protein-confining states can self-catalyze the hydrogenation/reduction by reacting with H_(2)to catalytically scavenge∙OH,and can also catalytically hydrogenate to reduce CO_(2)into CO in the hypoxic microenvironment of in vitro simulation and in vivo tumor,confirming that Fe-porphyrin is a redox-related biosensor of H_(2)and H_(2)is an upstream signaling molecule of *** discoveries are favorable for deep understanding and exploration of profound biomedical effects of H2,and helpful for development of innovative drugs and hydrogen energy/agricultural materials.
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