Engineering biocompatible TeSex nano-alloys as a versatile theranostic nanoplatform

作     者：Xiang Ling Zhaokui Jin Qi Jiang Xiaotao Wang Bin Wei Zhongchang Wang Yangsen Xu Tianye Cao Jonathan W.Engle Weibo Cai Chenliang Su Qianjun He Xiang Ling;Zhaokui Jin;Qi Jiang;Xiaotao Wang;Bin Wei;Zhongchang Wang;Yangsen Xu;Tianye Cao;Jonathan W.Engle;Weibo Cai;Chenliang Su;Qianjun He

作者机构：International Collaborative Laboratory of 2D Materials for Optoelectronic Science & TechnologyEngineering Technology Research Center for 2D Materials Information Functional Devices and Systems of Guangdong ProvinceInstitute of Microscale OptoelectronicsShenzhen University Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound ImagingNational-Regional Key Technology Engineering Laboratory for Medical UltrasoundSchool of Biomedical EngineeringHealth Science CenterShenzhen University Department of Quantum and Energy MaterialsInternational Iberian Nanotechnology Laboratory (INL) Departments of Radiology and Medical PhysicsUniversity of Wisconsin-Madison 

出 版 物：《National Science Review》 (国家科学评论(英文版))

年 卷 期：2021年第8卷第6期

页      面：148-159页

核心收录：

学科分类：1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100215[医学-康复医学与理疗学] 0702[理学-物理学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (51701127 and 51872188) the Special Funds for the Development of Strategic Emerging Industries in Shenzhen(20180309154519685) the Shenzhen Basic Research Program(JCYJ20170302151858466 and JCYJ20170818093808351) the Shenzhen Peacock Plan (KQTD2016053112051497and KQTD2016053112042971) the High-Level University Construction Project of Health Science Center Shenzhen University (860-00000210) the Educational Commission of Guangdong Province (2016KTSCX126) the Guangdong Special Support Program and Pengcheng Scholar Program supported,in part,by the University of Wisconsin—Madison and the National Institutes of Health(P30CA014520) 

主　　题：nanomedicine nano-alloys photothermal therapy cancer nanotheranostics biomedical imaging 

摘      要：Photothermal nanotheranostics, especially in the near infrared II（NIR-II） region, exhibits a great potential in precision and personalized medicine, owing to high tissue penetration of NIR-II ***-II-photothermal nanoplatforms with high biocompatibility as well as high photothermal effect are urgently needed but rarely reported so far. Te nanomaterials possess high absorbance to NIR-II light but also exhibit high cytotoxicity, impeding their biomedical applications. In this work, the controllable incorporation of biocompatible Se into the lattice of Te nanostructures is proposed to intrinsically tune their inherent cytotoxicity and enhance their biocompatibility, developing TeSexnano-alloys as a new kind of theranostic nanoplatform. We have uncovered that the cytotoxicity of Te nanomaterials primarily derives from irreversible oxidation stress and intracellular imbalance of organization and energy, and can be eliminated by incorporating a moderate proportion of Se（x = 0.43）. We have also discovered that the as-prepared TeSexnano-alloys have extraordinarily high NIR-II-photothermal conversion efficiency（77.2%）,64Cu coordination and computed tomography contrast capabilities, enabling high-efficacy multimodal photothermal/photoacoustic/positron emission tomography/computed tomography imaging-guided NIR-II-photothermal therapy of cancer. The proposed nano-alloying strategy provides a new route to improve the biocompatibility of biomedical nanoplatforms and endow them with versatile theranostic functions.