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A Model for Detecting Fake News by Integrating Domain-Specific Emotional and Semantic Features

Computers, Materials & Continua 2024年第8期80卷 2161-2179页

作者： Wen Jiang mingshu zhang Xu’an Wang Wei Bin Xiong zhang Kelan Ren Facheng Yan College of Cryptography Engineering Engineering University of People’s Armed PoliceXi’an710086China Key Laboratory of Network and Information Security Engineering University of People’s Armed PoliceXi’an710086China Key Laboratory of CTC&Information Engineering Engineering University of People’s Armed PoliceMinistry of EducationXi’an710086China

With the rapid spread of Internet information and the spread of fake news,the detection of fake news becomes more and more *** detection methods often rely on a single emotional or semantic feature to identify fake news,but these methods have limitations when dealing with news in specific *** order to solve the problem of weak feature correlation between data from different domains,a model for detecting fake news by integrating domain-specific emotional and semantic features is *** method makes full use of the attention mechanism,grasps the correlation between different features,and effectively improves the effect of feature *** algorithm first extracts the semantic features of news text through the Bi-LSTM(Bidirectional Long Short-Term Memory)layer to capture the contextual relevance of news ***-BiLSTM is then used to extract emotional features and predict the probability of positive and negative emotions in the *** then uses domain features as an enhancement feature and attention mechanism to fully capture more fine-grained emotional features associated with that ***,the fusion features are taken as the input of the fake news detection classifier,combined with the multi-task representation of information,and the MLP and Softmax functions are used for *** experimental results show that on the Chinese dataset Weibo21,the F1 value of this model is 0.958,4.9% higher than that of the sub-optimal model;on the English dataset FakeNewsNet,the F1 value of the detection result of this model is 0.845,1.8% higher than that of the sub-optimal model,which is advanced and feasible.

关键词： Fake news detection domain-related emotional features semantic features feature fusion

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Cross-Target Stance Detection with Sentiments-Aware Hierarchical Attention Network

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Computers, Materials and Continua 2024年第1期81卷 789-807页

作者： Ren, Kelan Yan, Facheng Chen, Honghua Jiang, Wen Wei, Bin zhang, mingshu College of Cryptographic Engineering Engineering University of PAP Xi'an 710086 China

The task of cross-target stance detection faces significant challenges due to the lack of additional background information in emerging knowledge domains and the colloquial nature of language patterns. Traditional stance detection methods often struggle with understanding limited context and have insufficient generalization across diverse sentiments and semantic structures. This paper focuses on effectively mining and utilizing sentimentsemantics knowledge for stance knowledge transfer and proposes a sentiment-aware hierarchical attention network (SentiHAN) for cross-target stance detection. SentiHAN introduces an improved hierarchical attention network designed to maximize the use of high-level representations of targets and texts at various fine-grain levels. This model integrates phrase-level combinatorial sentiment knowledge to effectively bridge the knowledge gap between known and unknown targets. By doing so, it enables a comprehensive understanding of stance representations for unknown targets across different sentiments and semantic structures. The model's ability to leverage sentimentsemantics knowledge enhances its performance in detecting stances that may not be directly observable from the immediate context. Extensive experimental results indicate that SentiHAN significantly outperforms existing benchmark methods in terms of both accuracy and robustness. Moreover, the paper employs ablation studies and visualization techniques to explore the intricate relationship between sentiment and stance. These analyses further confirm the effectiveness of sentence-level combinatorial sentiment knowledge in improving stance detection capabilities. © 2024 Tech Science Press. All rights reserved.

关键词： Semantics

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单核细胞趋化蛋白1对肺癌A549细胞迁移和侵袭的影响及其机制

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吉林大学学报（医学版） 2024年第3期50卷 666-675页

作者：王远王志娟张明姝王艺慧张晴叶丽平锦州医科大学基础医学院病理学教研室辽宁锦州121001 锦州医科大学基础医学院病理生理学教研室辽宁锦州121001 锦州医科大学生物人类学研究所辽宁锦州121001

目的:探讨单核细胞趋化蛋白1(MCP-1)对肺癌A549细胞迁移和侵袭的影响,并阐明其作用机制。方法:采用免疫组织化学法检测80例非小细胞肺癌(NSCLC)及癌旁正常肺组织中MCP-1蛋白表达情况。体外培养人肺癌A549细胞,MCP-1-小干扰RNA(siRNA)实... 详细信息

目的:探讨单核细胞趋化蛋白1(MCP-1)对肺癌A549细胞迁移和侵袭的影响,并阐明其作用机制。方法:采用免疫组织化学法检测80例非小细胞肺癌(NSCLC)及癌旁正常肺组织中MCP-1蛋白表达情况。体外培养人肺癌A549细胞,MCP-1-小干扰RNA(siRNA)实验分为空白组、阴性对照组(si-NC组)、MCP-1-siRNA-1组和MCP-1-siRNA-2组;MCP-1过表达实验分为对照组、空载对照组(OE-NC组,转染MCP-1过表达空载质粒)、过表达MCP-1组(OE-MCP-1组,转染MCP-1过表达质粒)、过表达MCP-1+细胞外调节蛋白激酶(ERK)信号通路抑制剂PD98059组(OE-MCP-1+PD98059组,共转染MCP-1过表达质粒和PD98059)和PD98059组(转染PD98059)。分别将MCP-1-siRNA和质粒转染至肺癌A549细胞,Western blotting法验证各组A549细胞转染效率。细胞划痕实验和Transwell小室实验观察各组A549细胞迁移率和侵袭细胞数,Western blotting法检测各组A549细胞中磷酸化ERK(p-ERK)、总ERK(t-ERK)和上皮-间质转化(EMT)相关蛋白表达水平。结果:与癌旁组织比较,NSCLC组织中MCP-1蛋白阳性表达率明显升高(P<0.05);NSCLC组织中MCP-1蛋白表达水平与TNM分期和淋巴结转移有关联(P<0.05)。与si-NC组比较,MCP-1-siRNA-1组和MCP-1-siRNA-2组A549细胞中MCP-1蛋白表达水平均明显降低(P<0.01);与对照组和OE-NC组比较,OE-MCP-1组A549细胞中MCP-1蛋白表达水平明显升高(P<0.01)。细胞划痕实验,与si-NC组比较,MCP-1-siRNA-1组和MCP-1-siRNA-2组细胞迁移率均明显降低(P<0.01);与OE-NC组比较,OE-MCP-1组细胞迁移率明显升高(P<0.01);与OE-MCP-1组比较,OE-MCP-1+PD98059组细胞迁移率明显降低(P<0.01);与OE-MCP-1+PD98059组比较,PD98059组细胞迁移率明显降低(P<0.01)。Transwell小室实验,与si-NC组比较,MCP-1-siRNA-1组和MCP-1-siRNA-2组侵袭细胞数明显减少(P<0.01);与OE-NC组比较,OE-MCP-1组侵袭细胞数明显增加(P<0.01);与OE-MCP-1组比较,OE-MCP-1+PD98059组侵袭细胞数明显减少(P<0.01);与OE-MCP-1+PD98059组比较,PD98059组侵袭细胞数明显减少(P<0.01)。Western blotting法,与si-NC组比较,MCP-1-siRNA-1组和MCP-1-siRNA-2组A549细胞中p-ERK、波形蛋白(Vimentin)和N-钙黏蛋白(N-cadherin)表达水平均明显降低(P<0.05或P<0.01),E-钙黏蛋白(E-cadherin)表达水平均明显升高(P<0.01);与OE-NC组比较,OE-MCP-1组A549细胞中p-ERK、Vimentin和N-cadherin蛋白表达水平均明显升高(P<0.01),E-cadherin蛋白表达水平均明显降低(P<0.01);与OE-MCP-1组比较,OE-MCP-1+PD98059组A549细胞中p-ERK、Vimentin和N-cadherin蛋白表达水平均明显降低(P<0.01),E-cadherin蛋白表达水平均明显升高(P<0.05);与OE-MCP-1+PD98059组比较,PD98059组A549细胞中p-ERK、 Vimentin和N-cadherin蛋白表达水平均明显降低(P<0.05或P<0.01),E-cadherin蛋白表达水平明显升高(P<0.01)。结论:MCP-1蛋白可上调肺癌A549细胞中EMT相关蛋白表达,促进肺癌A549细胞的迁移和侵袭,其作用机制与激活ERK信号通路有关。

关键词：单核细胞趋化蛋白1 细胞外信号调节激酶癌,非小细胞肺细胞侵袭细胞迁移

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Extending the spatiotemporal resolution of super-resolution microscopies using photomodulatable °uorescent proteins

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Journal of Innovative Optical Health Sciences 2016年第3期9卷 52-62页

作者： mingshu zhang Zhifei Fu Pingyong Xu Key Laboratory of RNA Biology Institute of Biophysics Chinese Academy of Sciences Beijing100101P.R.China Beijing Key Laboratory of Noncoding RNA Institute of Biophysics Chinese Academy of Sciences Beijing100101P.R.China Graduate School of the Chinese Academy of Sciences Beijing P.R.China

In the past two decades,various super-resolution(SR)microscopy techniques have been developed to break the di®raction limit using subdi®raction excitation to spatially modulate the°uorescence ***°uorescent proteins(FPs)can be activated by light of speci¯c wavelengths to produce either stochastic or patterned subdi®raction excitation,resulting in improved optical *** this review,we focus on the recently developed photomodulatable FPs or commonly used SR microscopies and discuss the concepts and strategies for optimizing and selecting the biochemical and photophysical properties of PMFPs to improve the spatiotemporal resolution of SR techniques,especially time-lapse live-cell SR techniques.

关键词： Super-resolution PMFP mGeos mEos3 Skylan-S Skylan-NS

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基于CatBoost-NSGA-Ⅲ的盾构隧道施工参数分析及优化控制

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隧道建设（中英文） 2024年第8期44卷 1587-1598页

作者：陈礼博张明书陈海勇吴贤国曹源中铁开发投资集团云南昆明650500 华中科技大学土木与水利工程学院湖北武汉430074

由于盾构在施工过程中受环境、设备和作业等不确定因素的影响,导致隧道开挖的安全性、效率和成本难以协调。针对这种情况,以武汉轨道交通某标段施工为依托,采用基于梯度增强(CatBoost)和非支配排序遗传算法(NSGA-Ⅲ)的混合算法,在全面... 详细信息

由于盾构在施工过程中受环境、设备和作业等不确定因素的影响,导致隧道开挖的安全性、效率和成本难以协调。针对这种情况,以武汉轨道交通某标段施工为依托,采用基于梯度增强(CatBoost)和非支配排序遗传算法(NSGA-Ⅲ)的混合算法,在全面考虑掘进效率、成本、安全风险等因素的基础上,选择以推进速度、掘进比能、刀具磨损量为目标,构建施工参数智能控制决策系统。首先,通过CatBoost回归模型预测盾构隧道推进速度、掘进比能和刀具磨损量,得到控制目标的适应度函数;然后,基于CatBoost预测模型构建的适应度函数,利用CatBoost-NSGA-Ⅲ进行施工参数的多目标优化;最后,通过模糊决策法从多个Pareto最优解集中选出最佳的施工参数组合,为隧道盾构掘进参数智能预测与优化提供参考。结果表明:1)Catboost可以进行模型精准预测,拟合优度R2大于0.9,均方根误差RMSE和平均绝对误差MAE较小;2)Catboost-NSGA-Ⅲ多目标优化,模糊决策法确定最优方案。经过优化,相较于实测数据的平均值,掘进比能和刀具磨损量分别降低5.3%和13.5%、掘进速度提升6.3%,为盾构隧道的智能化掘进控制和管理决策提供依据。

关键词：盾构施工推进速度掘进比能刀具磨损量施工参数多目标优化 CatBoost-NSGA-Ⅲ算法

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Bayesian localization microscopy based on intensity distribution of fluorophores

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Protein & Cell 2015年第3期6卷 211-220页

作者： Fan Xu mingshu zhang Zhiyong Liu Pingyong Xu Fa zhang Key Lab of Intelligent Information Processing Institute of Computing Technology Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China Laboratory of Non Coding RNA Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China

Super-resolution microscopy techniques have overcome the limit of optical diffraction. Recently, the Bayesian analysis of Bleaching and Blinking data （3B） method has emerged as an important tool to obtain super-resolution fluorescence images. 3B uses the change in information caused by adding or removing fiuorophores in the cell to fit the date. When adding a new fluorophore, 3B selects a random initial position, optimizes this position and then determines its reliability. However, the fluorophores are not evenly distributed in the entire image region, and the fluorescence intensilty at a given position positively correlates with the probability of observing a fluorophore at this position. In this paper, we present a Bayesian analysis of Bleaching and Blinking microscopy method based on fluorescence intensity distribution （FID3B）. We utilize the intensity distribution to select more reliable positions as the initial positions of fluorophores. This approach can improve the reconstruction results and significantly reduce the computational time. We validate the perfor. mance of our method using both simulated date and experimental date from cellular structures. The results confirm the effectiveness of our method.

关键词： super-resolution fluorescence image 3B,intensity distribution

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Research and Design of Reconfigurable Composite Field Multiplication in Symmetric Cipher Algorithms

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Wuhan University Journal of Natural Sciences 2016年第3期21卷 235-241页

作者： SU Yang zhang mingshu YANG Kai Key Laboratory of Information Security Engineering University of Chinese People's Armed Police Force

The composite field multiplication is an important and complex module in symmetric cipher algorithms, and its realization performance directly restricts the processing speed of symmetric cipher algorithms. Based on the characteristics of composite field multiplication in symmetric cipher algorithms and the realization principle of its reconfigurable architectures, this paper describes the reconfigurable composite field multiplication over GF（（2^8）k）（k=1,2,3,4） in RISC （reduced instruction set computer） processor and VLIW （very long instruction word） processor architecture, respectively. Through configuration, the architectures can realize the composite field multiplication over GF（2^8）, GF （（2^8）2）, GF（（28）3） and GF（（28）4） flexibly and efficiently. We simulated the function of circuits and synthesized the reconfigurable design based on the 0.18 μm CMOS （complementary metal oxide semiconductor） standard cell library and the comparison with other same kind designs. The result shows that the reconfigurable design proposed in the paper can provide higher efficiency under the premise of flexibility.

关键词： reconfigurable composite field multiplication symmetric cipher algorithm RISC VLIW (very long instruction word)

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Solidification Behavior of in situ TiB_(2)/Cu Composite Powders during Reactive Gas Atomization

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Journal of Wuhan University of Technology(Materials Science) 2021年第2期36卷 203-208页

作者： JIANG Yihui zhang mingshu LI Yufa HE Jiangtan CAO Fei LIANG Shuhua Shaanxi Province Key Laboratory for Electrical Materials and Infiltration Technology Xi'an University of TechnologyXi'an 710048China

2wt%TiB_(2)/Cu composite powders were fabricated in situ by reactive gas *** fabricated composite powder exhibits high sphericity,and the powder sizes range from 5μm to 150μ*** morphology of the Cu matrix and the distribution of the TiB2 particles in the composite powders vary with the powder *** critical transitions of interface morphologies from dendritic-to-cellular and cellular-to-planar interfaces occurs when the composite powder sizes decrease to 34μm and 14μm,*** with pure Cu droplets,the composite droplets undergo critical transition of the interface morphologies at a smaller droplet size corresponding to a higher cooling rate because the existence of TiB2 particles can cause instability in the advancing solidification front and heterogeneous *** decreasing powder size,the extent of the TiB_(2) particle interdendritic segregation decreases as the result of enhanced engulfment of TiB2 particles by the advancing solidification front.

关键词： composite powder reactive gas atomization solidification microstructure evolution

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The specific and rapid labeling of cell surface proteins with recombinant FKBP-fused fluorescent proteins

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Protein & Cell 2014年第10期5卷 800-803页

作者： Xi zhang Yongqiang Deng Hao Chang Chen Ji mingshu zhang Jianxin Peng Tao Xu Pingyong Xu Institute of Entomology School of Life Sciences Central ChinaNormal University Wuhan 430079 China National Key Laboratory of Biomacromolecules Institute ofBiophysics Chinese Academy of Sciences Beijing 100101 China School of Life Sciences University of Science and Technology ofChina Hefei 230026 China Laboratory of interdisciplinary Research Institute of BiophysicsChinese Academy of Sciences Beijing 100101 China

Dear Editor, The presence and abundance of proteins in the plasma membrane （PM） is regulated by exocytosis and endocytosis. Exocytosis is required for the maintenance of cellular homeostasis following stimulation, whereas endocytosis is important for the reuse and degradation of PM and receptor proteins. Through the specific labeling of proteins on the PM, the process of endocytosis can be tracked and monitored in living cells. Several genetic tags and site-specific labeling approaches that involve the coupling of small organic mol- ecules to tag-fused proteins through either self-labeling or enzymatic ligation have been developed for this purpose （Chen et al., 2005; George et al., 2004; Hoffmann et al.,

关键词： Cell Surface Protein Label Efficiency Ascomycin Retrograde Trafficking Dynamic Label

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A Study of Rules-Based OPS5 Parallel Firing

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哈尔滨工业大学学报 1990年第3期22卷 32-38页

作者： zhang Xuehai Li mingshu Hu Mingzeng (Dpartment of Computer Science)

Based on the introduction of the PS, this paper analyzes the correlation of parallel firing rules. Then it presents an algorithm to support OPS5 parallel firing during the act phase and a new parallel reasoning model ... 详细信息

关键词：生产系统平行模型配对关联学习规则 OPS5 并行烧成规则算法

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