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Chinese Chemical Letters 1997年第12期8卷 0-0页

作者： Jiong YANG Zbao Ming XIONG Yong Gang CREN and yu lin li(National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry,ho University, Lanzhou 730000) Lanzhou Univ Natl Lab Appl Organ Chem Lanzhou 730000 Peoples R China Lanzhou Univ Inst Organ Chem Lanzhou 730000 Peoples R China

The synthesis of 99-acetoxy-3(4), 11(13)-dien-5αH 7αH-12-eudesmanoic acid methyl ester (2) was achieved from oxycarvone. The key step is the p-toluenesulfonhydrazide assisted reductiv rearrangement reaction

关键词： The Synthesis of 9 H,7 H-12-Eudesmanoic Acid Methyl Ester Dien-5 Study on the Total Synthesis of 3-Oxo-9 Acetoxyilicic Acid Acetoxy-3

Cardiac Fibroblast-Specific Activating Transcription Factor 3 Promotes Myocardial Repair after Myocardial Infarction

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Chinese Medical Journal 2018年第19期131卷 2302-2309页

作者： yu-lin li Wen-Jing Hao Bo-Ya Chen Jing Chen Guo-Qi li Key Laboratory of Remodeling-Related Cardiovascular Disease (Ministry of Education) Beijing Anzhen Hospital Affiliated to Captital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing 100029 China

Background：Myocardial ischemia injury is one of the leading causes of death and disability *** fibroblasts （CFs） have central roles in modulating cardiac function under pathophysiological *** transcription factor 3 （ATF3） plays a self-protective role in counteracting CF ***,the precise function of CF-specific ATF3 during myocardial infarction （MI） injury/repair remains incompletely *** aim of this study was to determine whether CF-specific ATF3 affected cardiac repair after ***：Fifteen male C57BL/6 wild-type mice were performed with MI operation to observe the expression of ATF3 at 0,0.5,1.0,3.0,and 7.0 days *** for MI was constructed in ATF3TGfl/flColla2-Cre＋（CF-specific ATF3 overexpression group,n =5） and ATF3TGfl/flColla2-Cre-male mice （without CF-specific ATF3 overexpression group,n =5）.In addition,five mice of ATF3TGfl/flCol1a2-Cre＋ and ATF3TGfl/flCol 1 a2-Cre-were subjected to sham MI *** function was detected by ultrasound and left ventricular remodeling was observed by Masson staining （myocardial fibrosis area was detected by blue collagen deposition area） at the 28th day after MI surgery in ATF3TGfl/flColla2-Cre＋ and ATF3TGfl/flColla2-Cre-mice received sham or MI *** real-time polymerase chain reaction （qRT-PCR） was used to detect cell proliferation/cell cycle-related gene expression in cardiac *** staining was used to detect fibroblast ***：After establishment of an MI model,we found that ATF3 proteins were increased in the heart of mice after MI surgery and dominantly expressed in *** overexpression of ATF3 in CFs （ATF3TGfl/flCol1a2-Cre＋ group） resulted in an improvement in the heart function as indicated by increased cardiac ejection fraction （41.0% vs.30.5%,t =8.610,P =0.001） and increased fractional shortening （26.8% vs.18.1%,t =7.173,P =0.002）,which was accompanied by a decrease in cardiac scar area （23.1%

关键词： Activating Transcription Factor 3 Cardiac Fibroblast Myocardial Infarction Proliferation

A Facile Synthesis of 6β-Hydroxy-7α(H)-eudesma-4-en-3-one

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Chinese Chemical Letters 1998年第9期9卷 817-818页

作者： Gang ZHOU Zhao Ming XIONG Yong Gang CHEN yu lin li (National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry,Lanzhou University, Lanzhou 730000) Lanzhou Univ Inst Organ Chem Lanzhou 730000 Peoples R China Lanzhou Univ Natl Lab Appl Organ Chem Lanzhou 730000 Peoples R China

A stereoselective total synthesis of 6β-hydroxy-7α(H)-eudesma-4-en-3- 1startingfrom (+)-dihydrocarvone 7 has been described.

关键词： synthesis sesquiterpene 6β-Hydroxy-7α(H)-eudesm-4-en-3-one sihydrocarvone

Total Synthesis of (-)-Baimuxifuranic Acid

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Chinese Chemical Letters 1997年第8期8卷 697-700页

作者： Yong Gang CHEN Zhao Ming XIONG Jiong YANG yu lin li(National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry Lanzhou University,Lanzhou 730000) LANZHOU UNIV NATL LAB APPL ORGAN CHEMLANZHOU 730000PEOPLES R CHINA LANZHOU UNIV INST ORGAN CHEMLANZHOU 730000PEOPLES R CHINA

The first total synthesis of (-)-baimuxifuranic acid (1) starting from (-)-carvone has been described. In our studies a surprising allylic oxidation was found in the oxidation of alpha beta-unsaturated aldehyde 5 with... 详细信息

关键词： ppm MHz EIMS Baimuxifuranic Acid Total Synthesis of

Distribution of per-and polyfluoroalkyl substances in blood,serum,and urine of patients with liver cancer and associations with liver function biomarkers

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Journal of Environmental Sciences 2024年第5期139卷 418-427页

作者： Cao Dai lin Peng Yanjie li Zhendong li Da Chen Fei Wang Nan lin Department of Hepatobiliary Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China School of Environment Guangdong Key Laboratory of Environmental Pollution and HealthJinan UniversityGuangzhou 510632China State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong Kong 999077China South China Institute of Environmental Sciences MEEGuangzhou 510655China

Studies have shown that per-and polyfluoroalkyl substances(PFASs)may be hepatotoxic in animals or ***,data on clinical epidemiology are very *** this study,21PFASs were determined in patients with liver diseases,with the highest median concentrations detected in the serum sample(26.7 ng/mL),followed by blood(10.7 ng/mL)and urine(5.02 ng/mL).Higher total PFAS concentrations were found in hepatocellular carcinoma(HCC)patients compared to non-HCC patients,with significant discrepancies in serum and blood ***,significant correlations were also found among PFAS concentrations and age,gender,body mass index(BMI),and liver function biomarkers *** example,PFAS concentrations are significantly higher in males than in females;Several serum PFASs concentrations increase with age and BMI,while the serum perfluorohexane sulfonic acid(PFHxS)concentrations are negatively correlated with *** addition,multiple regression models adjusted for age,gender and BMI found that increased serum perfluorobutane sulfonic acid(PFBS),perfluoroheptane sulfonic acid(PFHpS)and perfluorohexylphosphonic acid(PFHxPA)conentrations are correlated with elevated alkaline phosphatase(ALP),aspartate aminotransferase(AST),and alpha-fetoprotein(AFP)(plinical hepatotoxicity of PFAS.

关键词： Per-and polyfluoroalkyl substances(PFASs) liver cancer Serum Blood Urine liver function biomarkers

Promoted catalytic property of Cu/SSZ-13 by introducing a minority of Mn for NO removal from diesel engine exhaust

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Chinese Journal of Chemical Engineering 2024年第7期71卷 172-182页

作者： Runnong Yang Wuyuan liu Zhaoying Wang Ming Sun Guangying Fu Zihan Gao Wenjian Jiao Rui li lin yu Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Jieyang 515200China Guangdong Engineering Technology Research Center of Modern Fine Chemical Engineering School of Chemical Engineering and Light IndustryGuangdong University of TechnologyGuangzhou 510006China Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yat-sen UniversityGuangzhou 510275China Testing and Certification Business Department China Automotive Technology and Research Center Company LimitedWuhan 430056China Guangdong Foran Technology Company limited Foshan 528000China

The Cu-exchanged SSZ-13 with the small-pore chabazite framework is considered as a highly efficient catalyst for selective catalytic reduction of NO with NH_(3)(NH_(3)-SCR).In order to further improve the catalytic property,a series of Mn ion-assisted Cu/SSZ-13 powder catalysts were prepared by co-exchange method and stepwise exchange *** is found that the NH_(3)-SCR activity,N_(2) selectivity,hydrothermal stability and sulfur resistance of Cu/SSZ-13 are promoted by introducing a minority of Mn(0.15%to 0.23%(mass))through co-exchange *** results reveal that the Cu,Mn co-exchange enables the higher amounts of Cu^(2+)active sites,the abundant medium strong and strong acid,the optimized ratio of Lewis acid to Brønsted acid etc.,which are required for a good NH_(3)-SCR catalytic property over broad temperature range and under harsh working ***,a monolithic catalyst was prepared by impregnating a cordierite ceramic support into the coating slurry containing the optimized CuMn/SSZ-13 *** diesel engine bench tests show that Cu,Mn co-exchange gives the monolith catalyst a better catalytic property than commercial *** work provides an important guidance for the rational design of secondary-ion-assisted zeolites applied in NH_(3)-SCR.

关键词： MnCu/SSZ-13 Co-exchange Zeolite Catalysis Selective catalytic reduction

Diphylleia Grayi-Inspired Intelligent Temperature-Responsive Transparent Nanofiber Membranes

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Nano-Micro Letters 2024年第4期16卷 67-78页

作者： Cengceng Zhao Gaohui liu Yanyan lin Xueqin li Na Meng Xianfeng Wang Shaoju Fu Jianyong yu Bin Ding Shanghai Frontier Science Research Center of Advanced Textiles College of TextilesDonghua UniversityShanghai 201620People’s Republic of China

Nanofiber membranes(NFMs) have become attractive candidates for next-generation flexible transparent materials due to their exceptional flexibility and breathability. However, improving the transmittance of NFMs is a great challenge due to the enormous reflection and incredibly poor transmission generated by the nanofiber-air interface. In this research, we report a general strategy for the preparation of flexible temperature-responsive transparent(TRT) membranes,which achieves a rapid transformation of NFMs from opaque to highly transparent under a narrow temperature window. In this process, the phase change material eicosane is coated on the surface of the polyurethane nanofibers by electrospray technology. When the temperature rises to 37 ℃, eicosane rapidly completes the phase transition and establishes the light transmission path between the nanofibers, preventing light loss from reflection at the nanofiber-air interface. The resulting TRT membrane exhibits high transmittance(> 90%), and fast response(5 s). This study achieves the first TRT transition of NFMs, offering a general strategy for building highly transparent nanofiber materials, shaping the future of next-generation intelligent temperature monitoring, anti-counterfeiting measures, and other high-performance devices.

关键词： Biomimetic Transparent Nanofibrous membrane Temperature response Phase change materials

Universal and efficient hybrid modeling and direct slicing method for additive manufacturing processes

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Advances in Manufacturing 2024年第2期12卷 300-316页

作者： Sen-lin Wang li-Chao Zhang Chao Cai Ming-Kai Tang Si Chen Jiang Huang yu-Sheng Shi State Key Laboratory of Materials Processing and Die and Mould Technology Huazhong University of Science and TechnologyWuhan430074People’s Republic of China School of Machinery and Automation Wuhan University of Science and TechnologyWuhan430081People’s Republic of China

Model design and slicing contour generation in additive manufacturing(AM)data processing face challenges in terms of efficiency and scalability when stereolithography files generated by complex functionally graded structures have millions of *** paper proposes a hybrid modeling and direct slicing method for AM to efficiently construct and handle complex three-dimensional(3D)*** 3D solids,including conformal multigradient structures,were uniformly described using a small amount of data via signed distance *** hybrid representations were quickly discretized into numerous disordered directed lines using an improved marching squares *** establishing a directional HashMap to construct the topological relationship between lines,a connecting algorithm with linear time complexity is proposed to generate slicing contours for *** method replaces the mesh reconstruction and Boolean operation stages and can efficiently construct complex conformal gradient models of arbitrary topologies through hybrid ***,the time and memory consumption of direct slicing are much lower than those of previous methods when handling hybrid models with hundreds of millions of faces after mesh reconstruction.

关键词： Additive manufacturing(AM) Hybrid modeling Direct slicing Signed distance field

A homopolymolybdate-supported plate-like 2D cobalt network constructed from a new pyrazole-amide-pyridyl ligand: highly electrochemical activity in both capacitive performance and the detection of Cr(Ⅵ)

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Tungsten 2024年第2期6卷 422-427页

作者： Xiu-li Wang Yong-Zhen Chen Zhi-Han Chang yu-Chun lin Jing-Yi Ma College of Chemistry and Materials Engineering Bohai UniversityJinzhou 121013China Professional Technology Innovation Center of liaoning Province for Conversion Materials of Solar Cell Jinzhou 121013China

By employing a new semi-rigid pyrazole-amide-derived bis(pyridyl)ligand[N,N'-bis(4-picolylamine)-1-hydropyrazole(4-dpap)],a new homopolymolybdate-based two-dimensional(2D)plate-like complex[Co(4-dpap)(H_(2)O)(β-Mo_(8)O_(2)6)1/2](1)has been prepared under solvothermal condition and structurally ***β-Mo_(8)anions are fi xed between the 2D metal–organic networks[Co(4-dpap)(H_(2)O)]n 2n+via hydrogen-bonding *** 1 possesses satisfactory specifi c capacitance of 1512.4 F·g^(−1)(current density:1 A·g^(−1))and good cycling stability(90.8%after 1000 cycles).Moreover,1 represents a promising amperometric sensor for measurement of Cr(Ⅵ)with low detection limit(0.042μmol·L^(−1))and high *** insertion ofβ-Mo_(8)anions between the unique 2D metal−organic networks improves the active area of polyoxometalates,which further promotes electrochemical performance.

关键词： Homopolymolybdate Metal–organic network Pyrazole-amide-derived bis(pyridyl)ligand Supercapacitor Electrochemical sensor

U-Pb zircon geochronology of basaltic pyroclastic rocks from the basement beneath the Xisha Islands in the northwestern South China Sea and its geological significance

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Acta Oceanologica Sinica 2024年第2期43卷 83-93页

作者： yu Zhang Kefu yu Shiying li Guangxi Laboratory on the Study of Coral Reefs in the South China Sea Guangxi UniversityNanning 530004China Coral Reef Research Center of China Guangxi UniversityNanning 530004China School of Marine Sciences Guangxi UniversityNanning 530004China Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of ScienceGuangzhou 510301China

As one of the micro-blocks dispersed in the South China Sea(SCS), the basement of the Xisha Islands has rarely been drilled because of the thick overlying Cenozoic sediments, which has led to a confused understanding of the pre-Cenozoic basement of the Xisha Islands. Well CK-1, a kilometer-scale major scientific drill in the Xisha Islands in the northwestern SCS, penetrated thick reefal limestone(0–888.4 m) and the underlying basement rocks(888.4–901.4 m). In this study, we present the zircon U-Pb ages of basement basaltic pyroclastic rocks from Well CK-1 in the Xisha Islands of the northwestern SCS to investigate the basement nature of the Xisha microblock. The basement of Well CK-1 consists of basaltic pyroclastic rocks on the seamount. The zircon grains yielded apparent ages ranging from ca. 2 138.9 Ma to ca. 36 Ma. The old group of zircon grains from Well CK-1 was considered to be inherited zircons. Two Cenozoic zircons gave a weighted mean 206Pb/238U age of(36.3 ± 1.1) Ma,Mean Squared Weighted Deviations(MSWD) = 1.2, which may represent the maximum age of the volcano eruption. The Yanshanian inherited zircons(116.9–105.7 Ma and 146.1–130.2 Ma) from Well CK-1 are consistent with the zircons from Well XK-1, indicating that the basement of Chenhang Island may be similar to that of Well XK-1. We propose that the Xisha micro-block may have developed on a uniform Late Jurassic metamorphic crystalline basement, intruded by Cretaceous granitic magma.

关键词： South China Sea Xisha Islands basaltic pyroclastic rocks zircon