Distribution of per-and polyfluoroalkyl substances in blood,serum,and urine of patients with liver cancer and associations with liver function biomarkers

作     者：Cao Dai Lin Peng Yanjie Li Zhendong Li Da Chen Fei Wang Nan Lin Cao Dai;Lin Peng;Yanjie Li;Zhendong Li;Da Chen;Fei Wang;Nan Lin

作者机构：Department of Hepatobiliary SurgeryThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China School of EnvironmentGuangdong Key Laboratory of Environmental Pollution and HealthJinan UniversityGuangzhou 510632China State Key Laboratory of Environmental and Biological AnalysisDepartment of ChemistryHong Kong Baptist UniversityHong Kong 999077China South China Institute of Environmental SciencesMEEGuangzhou 510655China 

出 版 物：《Journal of Environmental Sciences》 (环境科学学报（英文版）)

年 卷 期：2024年第139卷第5期

页      面：418-427页

核心收录：

学科分类：083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1002[医学-临床医学] 07[理学] 08[工学] 09[农学] 0903[农学-农业资源与环境] 100214[医学-肿瘤学] 10[医学] 0713[理学-生态学] 

基　　金：supported by the National Natural Science Foundation of China(No.42177408) Guangdong(China)Innovative and Entrepreneurial Research Team Program(No.2016ZT06N258) 

主　　题：Per-and polyfluoroalkyl substances(PFASs) Liver cancer Serum Blood Urine Liver function biomarkers 

摘      要：Studies have shown that per-and polyfluoroalkyl substances(PFASs)may be hepatotoxic in animals or ***,data on clinical epidemiology are very *** this study,21PFASs were determined in patients with liver diseases,with the highest median concentrations detected in the serum sample(26.7 ng/mL),followed by blood(10.7 ng/mL)and urine(5.02 ng/mL).Higher total PFAS concentrations were found in hepatocellular carcinoma(HCC)patients compared to non-HCC patients,with significant discrepancies in serum and blood ***,significant correlations were also found among PFAS concentrations and age,gender,body mass index(BMI),and liver function biomarkers *** example,PFAS concentrations are significantly higher in males than in females;Several serum PFASs concentrations increase with age and BMI,while the serum perfluorohexane sulfonic acid(PFHxS)concentrations are negatively correlated with *** addition,multiple regression models adjusted for age,gender and BMI found that increased serum perfluorobutane sulfonic acid(PFBS),perfluoroheptane sulfonic acid(PFHpS)and perfluorohexylphosphonic acid(PFHxPA)conentrations are correlated with elevated alkaline phosphatase(ALP),aspartate aminotransferase(AST),and alpha-fetoprotein(AFP)(p0.05).Our results provide epidemiological support for the future study on the potential clinical hepatotoxicity of PFAS.