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Influence of vacuum annealing and irradiation on magnetic properties of Fe-3% Y_2O_3 films

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Rare Metals 2011年第5期30卷 453-457页

Yttria （Y） dispersed ferrum （Fe） films were prepared by a double-target magnetron co-sputtering method. Vacuum annealing and xenon ion irradiation were conducted to investigate the influence on the magnetic and mechanical properties of the films. The crystal grain growth mechanism and second phase precipitation mechanism were conducted simultaneously in the vacuum annealing process. These two effects led to an opposite variation of nano-hardness and coercivity in the films. Xenon ion irradiation played a role in rapid annealing, which also affected the magnetic performance of the yttria dispersed ferrum films.

关键词： magnetic films yttria magnetron sputtering annealing irradiation magnetic properties

CT diagnosis of 52 patients with lymphoma in abdominal lymph nodes

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World Journal of Gastroenterology 2006年第48期12卷 7869-7873页

作者： Ri-Sheng yu wei-Min zhang Yi-Qing Liu Department of Radiology Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009 Zhejiang Province China

AIM： To assess CT manifestations and its diagnostic value for lymphoma in the abdominal lymph nodes （LALN）.METHODS： CT findings in 52 cases of LALN proved by surgery or biopsy, including Hodgkin＇s disease （HD） in 16 cases and non-Hodgkin＇s lymphoma （NHL） in 36 cases, were retrospectively analyzed.RESULTS：（1） CT manifestations based on distribution of the lesions of LALN： Solitary mass type was found in 10 cases, including solitary, round, uniform-density, enlarged lymph nodes in 3 cases; and multiple, enlarged lymph nodes fusing into singular Iobular mass in 7 cases. Thirty-feur cases of multiple-nodular type showed multiple, round, enlarged lymph nodes with uniform density and clear margins. Vessels-embedded signs, including mesenteric vessels, renal vessels, abdominal aorta or inferior vena cava, were seen in 6 cases, and duodenum-embedded signs were seen in 2 cases. Eight cases of diffuse type showed characteristic ＂cobblestone signs＂. （2） CT manifestations correlated with pathological type： CT manifestations of 12 cases of HD were different from those of 40 cases of NHL in distribution, size, quantity and fused lesion of enlarged lymph nodes. （3） Twenty-eight cases of 52 patients were accompanied with extra-nodal lymphoma in the abdomen, especially gastrointestinal lymphoma, which had characteristic CT findings. （4） In follow-up examinations, CT images showed uniform, heterogeneous or rim enhancement in 15 cases, and occasional calcifications accompanied with reduction of the lesion size and quantity in 12 cases, whereas the lesions disappeared in 3 cases after treatment.CONCLUSION： CT images show many characteristic manifestations valuable for qualitative diagnosis of LALN, and it is also helpful for pathological classification of LALN and therapeutic evaluation in follow-up of patients.

关键词： Lymphoma Lymph nodes Computed tomography Diagnosis Classification

Study on the Relationship between Tourist Influence and Residents' Sense of Community:An Empirical Study from Changdao Countyin Shandong Province

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Chinese Journal of Population,Resources and Environment 2012年第1期10卷 101-104页

作者： yu wei zhang Yan School of Business Management Shandong University of Finance Jinan Shandong 250014 China

Residents' sense of community is an important prerequisite to promote the development of *** has significant influence on residents' sense of *** empirical study from Changdao shows that economy and life conflict caused by tourism can affect neighborhood-friendly and community participation ***,environment and social services from tourism can significantly affect community association,community care and place ***,the regional managers should pay attention to allocate revenues in the residents fairly and protect own culture to avoid the negative impact from tourism.

关键词： tourism residents sense of community

Letter to the editor: Aggressive variant prostate cancer: An exemplary case study and comprehensive literature survey

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World Journal of Clinical Cases 2023年第35期11卷 8431-8433页

作者： Han-wei Ke wei-yu zhang Ke-Xin Xu Department of Urology Peking University People's HospitalBeijing 100044China

This article enthusiastically explores the study of highly aggressive variant prostate cancer(AVPC),acknowledging its relatively rare yet highly menacing presence within the realm of prostate *** paper delves into the patho-logical characteristics of AVPC,diagnostic and therapeutic challenges,and the potential applications of precision medicine and molecular imaging in the future.

关键词： Highly aggressive variant prostate cancer Prostate cancer Precision medicine Genetic testing Molecular imaging

Characteristics of Disorder and Defect in Hydrogenated Amorphous Silicon Nitride Thin Films Containing Silicon Nanograins

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Chinese Journal of Aeronautics 2006年第B12期19卷 173-178页

作者： DING Wen-ge yu wei zhang Jiang-yong HAN Li FU Guang-sheng College of Physics Science and Technology Hebei University Baoding 071002 China

The hydrogenated amorphous silicon nitride （SiNx） thin films embedded with nano-structural silicon were prepared and the micro- structures at the interface of silicon nano-grains/SiNx were identified by the optical absorption and Raman scattering measurements. Characterized by the exponential tail of optical absorption and the band-width of the Raman scattering TO mode, the disorder in the interface region increases with the gas flow ratio increasing. Besides, as reflected by the sub-gap absorption coefficients, the density of interface defect states decreases, which can be attributed to the structural mismatch in the interface region and also the changes of hydrogen content in the deposited films. Additional annealing treatment results in a significant increase of defects and degree of disorder, for which the hydrogen out-diffusion in the annealing process would be responsible.

关键词： silicon nanostructures disorder and defect role of hydrogen

Identifying defect energy levels using DLTS under different electron irradiation conditions

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Nuclear Science and Techniques 2017年第12期28卷 262-268页

作者： Chun-Sheng Guo Ruo-Min Wang yu-wei zhang Guo-Xi Pei Shi-wei Feng Zhao-Xian Li College of Electronic Information and Control Engineering Beijing University of TechnologyBeijing 100124China Wuxi EL Pont Group Wuxi 214151China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Electron beams of 0.5, 1.5, 2.0, and 5.0 MeV were used to irradiate n-Si diodes to fluences of5.5×10^(13), 1.7×10^(14), and 3.3×1014 e cm^(-2). The forward voltage drop, minority carrier lifetime, and deep level transient spectroscopy(DLTS) characteristics of silicon p–n junction diodes before and after irradiation were compared. At the fluence of 3.3×10^(14) e cm^(-2), the forward voltage drop increased from 1.25 V at 0.5 MeV to 7.96μs at 5.0 MeV, while the minority carrier lifetime decreased significantly from 7.09 ls at 0.5 MeV to 0.06μs at 5.0 MeV. Six types of changes in the energy levels in DLTS spectra were analyzed and discussed.

关键词： Electron irradiation Deep level transient spectroscopy (DLTS) Minority carrier life time Silicon diode

Synthesis and characterization of phosphotungstic acid/ activated carbon as a novel ultrasound oxidative desulfurization catalyst

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Frontiers of Chemical Science and Engineering 2013年第4期7卷 422-427页

作者： Liyan LIU yu zhang wei TAN School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

Phosphotungstic acid/activated carbon （PTA/ AC） catalysts with various AC sizes or PTA content have been synthesized and characterized by N2 physisorption, X-ray diffraction, Fourier transform infrared spectroscopy and temperature programmed desorption of ammonia. These catalysts were then evaluated in terms of the removal of dibenzothiophene （DBT） by ultrasound- assisted oxidative desulfurization process. The results showed that the DBT conversion obviously increased with the decrease of AC support size and the increase of PTA content. After supporting PTA on AC, the DBT conversion can be improved by 38.9% after ultrasound irradiation for 10 min. In addition, the stability tests of PTA/AC showed that the catalytic oxidative activity of PTA/AC was nearly kept constant after ultrasound irradiation for 20 min, which makes it a promising catalyst to use in ultrasound-assisted oxidative desulfurization process

关键词： phosphomngstic acid activated carbon ultra-sound-assisted oxidative desulfurization

TAX1BP1 and FIP200 orchestrate non-canonical autophagy of p62 aggregates for mouse neural stem cell maintenance

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Zoological Research 2024年第4期45卷 937-950页

作者： Yi-Fu Zhu Rong-Hua yu Shuai Zhou Pei-Pei Tang Rui zhang yu-Xin Wu Ran Xu Jia-Ming wei Ying-Ying Wang Jia-Li zhang Meng-Ke Li Xiao-Jing Shi yu-wei zhang Guang-Zhi Liu Rick FThorne Xu Dong zhang Mian Wu Song Chen School of Life Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China Translational Research Institute of Henan Provincial People’s Hospital and People'’s Hospital of Zhengzhou University Tianjian Laboratory of Advanced Biomedical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan 450053China Institute of Medicinal Biotechnology Jiangsu College of NursingHuai’anJiangsu 223300China Laboratory Animal Center Academy of Medical ScienceZhengzhou UniversityZhengzhouHenan 450052China Henan Key Laboratory of Stem cell Differentiation and Modification Henan Provincial People’s HospitalHenan UniversityZhengzhouHenan 450053China School of Biomedical Sciences and Pharmacy The University of NewcastleNSW 2308Australia

Autophagy plays a pivotal role in diverse biological processes,including the maintenance and differentiation of neural stem cells(NSCs).Interestingly,while complete deletion of Fip200 severely impairs NSC maintenance and differentiation,inhibiting canonical autophagy via deletion of core genes,such as Atg5,Atg16l1,and Atg7,or blockade of canonical interactions between FIP200 and ATG13(designated as FIP200-4A mutant or FIP200 KI)does not produce comparable detrimental *** highlights the likely critical involvement of the non-canonical functions of FIP200,the mechanisms of which have remained ***,utilizing genetic mouse models,we demonstrated that FIP200 mediates non-canonical autophagic degradation of p62/sequestome1,primarily via TAX1BP1 in *** deletion of Tax1bp1 in fip200hGFAP conditional knock-in(cKI)mice led to NSC deficiency,resembling the fip200hGFAP conditional knockout(cKO)mouse ***,reintroducing wild-type TAX1BP1 not only restored the maintenance of NSCs derived from tax1bp1-knockout fip200hGFAP cKI mice but also led to a marked reduction in p62 aggregate ***,a TAX1BP1 mutant incapable of binding to FIP200 or NBR1/p62 failed to achieve this ***,conditional deletion of Tax1bp1 in fip200hGFAP cKO mice exacerbated NSC deficiency and p62 aggregate accumulation compared to fip200hGFAP cKO ***,these findings illustrate the essential role of the FIP200-TAX1BP1 axis in mediating the non-canonical autophagic degradation of p62 aggregates towards NSC maintenance and function,presenting novel therapeutic targets for neurodegenerative diseases.

关键词： Non-canonical autophagy TAX1BP1 FIP200 p62 Aggregates Neural stem cell

LB100 ameliorates nonalcoholic fatty liver disease via the AMPK/Sirt1 pathway

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World Journal of Gastroenterology 2019年第45期25卷 6607-6618页

作者： Xue-Yang Chen Chang-Zhou Cai Meng-Li yu Ze-Min Feng yu-wei zhang Pei-Hao Liu Hang Zeng Chao-Hui yu Department of Gastroenterology The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Clinical Research Center for Hepatobiliary and Pancreatic Diseases of Zhejiang Province Hangzhou 310003Zhejiang ProvinceChina

BACKGROUND It is well known that nonalcoholic fatty liver disease(NAFLD)is associated with insulin resistance(IR).LB100,a serine/threonine protein phosphatase 2A(PP2A)inhibitor,is closely related to ***,there is little data regarding its direct influence on *** To elucidate the effect and underlying mechanism of LB100 in *** After 10 wk of high fat diet(HFD)feeding,male C57BL/6 mice were injected intraperitoneally with vehicle or LB100 for an additional 6 wk(three times a week).The L02 cell line was treated with LB100 and free fatty acids(FFAs)for 24 *** and eosin and oil red O staining were performed for histological *** blot analysis was used to detect the protein expression of Sirtuin 1(Sirt1),total and phosphorylated AMP-activated protein kinaseα(AMPKα),and the proteins involved in lipogenesis and fatty acid *** mRNA levels were determined by *** inhibition of AMPK was performed to further examine the exact mechanism of LB100 in *** LB100 significantly ameliorated HFD-induced obesity,hepatic lipid accumulation and hepatic injury in *** addition,LB100 significantly downregulated the protein levels of acetyl-CoA carboxylase,sterol regulatory element-binding protein 1 and its lipogenesis target genes,including stearoyl-CoA desaturase-1 and fatty acid synthase,and upregulated the levels of proteins involved in fatty acidβ-oxidation,such as peroxisome proliferator-activated receptorα(PPARα),peroxisome proliferator-activated receptor gamma coactivator-1α(PGC-1α),carnitine palmitoyltransferase 1α,acyl-CoA oxidase 1 and uncoupling protein 2,as well as the upstream mediators Sirt1 and AMPKαin the livers of HFD-fed *** vitro,LB100 alleviated FFA-induced lipid accumulation in L02 cells through the AMPK/Sirt1 signaling *** studies showed that the curative effect of LB100 on lipid accumulation was abolished by inhibiting AMPKαin L02 *** PP2A inhibition by LB

关键词： LB100 Nonalcoholic fatty liver disease Serine/threonine-protein phosphatase 2A Lipid metabolism AMP-activated protein kinaseα Sirtuin 1