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Reducing Post-StroKe Spasticity:An Interactive and Hands-on Physiatric Approach

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Reducing Post-StroKe Spasticity:An Interactive and Hands-on ...

Si/SiGe异质结构的硅盖层中应变对Raman谱特征的影响

中华医学会第九次全国物理医学与康复学学术会议

作者： Marta Imamura Wu tu Hsing Department of Orthopaedics and Traumatology University of Sao Paulo School of Medicine Sao PauloBrazil

Objectives: *** the anatomy and physiology of post-stroke spasticity *** the concept of spinal segmental sensitization and apply desen- sitization techniques using acupuncture needles in reducing spasticity *** the localization of points to desensitize on a local and central level using acupuncture needles to reduce spasticity *** the anatomy and basic science of scalp acupuncture *** of superficial and deep muscles used for Botulinum Toxin injection This workshop is designed to provide the participants with direct hands on experience in the practice of office physiatric procedures using acupuncture, spinal segmental desensitization,use of functional electrical stimulation and practical identification of involved muscles techniques for neuromusclar block- ade to improve function and quality of life in stroke *** available imaging modalities used to physiologically evaluate acupuncture-induced changes will also be *** case studies will be reviewed. Upon completion of this program,participants will be able to: *** the use of scalp needling associated with electrical stimula- tion to reduce spasticity and recover function in chronic ischemic stroke patients. *** the sensitized spinal segment level of involvement by clinical examination and apply desensitization techniques to reduce post-stroke spasticity. *** the anatomical localization of most involved superficial and deep muscles in post-stroke spastic patients and check using needles.

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光谱学与光谱分析 2005年第5期25卷 719-722页

作者：肖清华屠海令北京有色金属研究总院国家半导体材料工程研究中心北京100088

应变Si/SiGe异质结构通过大剂量Ge离子注入并结合高温快速热退火制备而成。325nm波长的紫外激光被用于调查应变Si盖层的Raman谱特征。实验发现,硅盖层中的张应变导致硅的520cm-1的一级拉曼散射峰向低频方向偏移,峰的偏移程度反映硅盖层... 详细信息

应变Si/SiGe异质结构通过大剂量Ge离子注入并结合高温快速热退火制备而成。325nm波长的紫外激光被用于调查应变Si盖层的Raman谱特征。实验发现,硅盖层中的张应变导致硅的520cm-1的一级拉曼散射峰向低频方向偏移,峰的偏移程度反映硅盖层中横向张应力的大小约为12.5×108N·m-2。硅盖层中的张应变并未导致1555和2330cm-1的次级拉曼散射峰的变化。

关键词： Si SiCe 异质结构应变 Raman谱

机器人辅助下膝内侧单髁置换术后假体位置分析和早期临床疗效

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骨科 2024年第5期15卷 394-401页

作者：杨涛薛华明马童文涛薛龙雷雪枫冀家中张文正涂意辉同济大学附属杨浦医院关节外科上海200090

目的比较机器人辅助下膝关节单髁置换术(robotic-assisted unicompartmental knee arthroplasty,RAUKA)与传统膝单髁置换术(UKA)治疗膝内侧间室骨关节炎(OA)的术后早期临床疗效和假体位置。方法对2022年6月至2022年10月在我院行UKA治疗... 详细信息

目的比较机器人辅助下膝关节单髁置换术(robotic-assisted unicompartmental knee arthroplasty,RAUKA)与传统膝单髁置换术(UKA)治疗膝内侧间室骨关节炎(OA)的术后早期临床疗效和假体位置。方法对2022年6月至2022年10月在我院行UKA治疗的病人的临床资料进行回顾性分析。其中,RAUKA组32例(32膝),按照年龄、性别及术肢侧别等进行1∶1配对,选择同期行传统UKA术的32例病人(32膝)纳入传统UKA组。RAUKA组男7例,女25例,年龄为(69.2±6.1)岁。传统UKA组男6例,女26例,年龄为(68.9±5.8)岁。记录并比较两组病人手术时间及美国膝关节协会评分(KSS)、疼痛视觉模拟量表(VAS)、膝关节遗忘(FJS)评分等,测量并比较两组术后的股骨假体内外翻角(A角)、股骨假体屈伸角(B角)、胫骨假体内外翻角(E角)、胫骨假体后倾角(F角)、假体偏离总体评分及胫股角(FTA)、髋膝踝角(HKA)及下肢机械轴Kennedy区分布等。结果两组病人手术均顺利完成并获得随访,术后随访(13.8±1.3)个月,RAUKA组的手术时间与术中截骨时间长于传统UKA组。两组术后的A角及B角比较,差异有统计学意义(P0.05)。两组随访期间均无感染、假体松动等并发症发生。结论RAUKA相较传统UKA具有术后假体位置更精准、术后下肢力线矫正优良率更高的优势,传统UKA在手术时间方面优于RAUKA。RAUKA早期临床疗效满意,远期疗效如何有待进一步随访。

关键词：膝内侧间室骨关节炎膝单髁置换术机器人辅助手术假体位置下肢力线

Long-read genome assemblies reveal a cis-regulatory landscape associated with phenotypic divergence in two sister Siniperca fish species

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Zoological Research 2023年第2期44卷 287-302页

作者： Guang-Xian tu Xin-Shuang Zhang Rui-Run Jiang Long Zhang Cheng-Jun Lai Zhu-Yue Yan Yan-Rong Lv Shao-Ping Weng Li Zhang Jian-Guo He Muhua Wang State Key Laboratory for Biocontrol School of Marine SciencesSun Yat-sen UniversityZhuhaiGuangdong 519000China China-ASEAN Belt and Road Joint Laboratory on Mariculture Technology Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)ZhuhaiGuangdong 519000China Chinese Institute for Brain Research Beijing 102206China Guangdong Province Key Laboratory for Aquatic Economic Animals School of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China

Due to the difficulty in accurately identifying structural variants(SVs) across genomes,their impact on cisregulato ry diverge n ce of closely related species,especially fish,remains to be *** identified broad H3K4me3 domains are essential for the regulation of genes involved in several biological ***,the role of broad H3K4me3 domains in phenotypic divergence remains poorly *** chuatsi and *** are closely related but divergent in several phenotypic traits,making them an ideal model to study cis-regulatory evolution in sister ***,we generated chromosome-level genomes of *** and ***,with assembled genome sizes of 716.35 and740.54 Mb,*** evolutionary histories of *** and *** were studied by inferring dynamic changes in ancestral population *** explore the genetic basis of adaptation in *** and ***,we performed gene family expansion and contraction analysis and identified positively selected genes(PSGs).To investigate the role of SVs in cis-regulatory divergence of closely related fish species,we identified high-quality SVs as well as divergent H3K27ac and H3K4me3 domains in the genomes of *** and *** analysis revealed that cis-regulatory divergence caused by SVs played an essential role in phenotypic divergence between *** and ***,divergent broad H3K4me3 domains were mostly associated with cancer-related genes in *** and *** and contributed to their phenotypic divergence.

关键词： cis-regulatory divergence Structural variants H3K27ac Broad H3K4me3 Siniperca chuatsi Siniperca scherzeri

Graphene oxide-composited chitosan scaffold contributes to functional recovery of injured spinal cord in rats

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Neural Regeneration Research 2021年第9期16卷 1829-1835页

作者： Bing Yang Pang-Bo Wang Ning Mu Kang Ma Shi Wang Chuan-Yan Yang Zhong-Bing Huang Ying Lai Hua Feng Guang-Fu Yin tu-Nan Chen Chen-Shi Hu College of Biomedical Engineering Sichuan UniversityChengduSichuan ProvinceChina Department of Neurosurgery Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

The study illustrates that graphene oxide nanosheets can endow materials with continuous electrical conductivity for up to 4 weeks. Conductive nerve scaffolds can bridge a sciatic nerve injury and guide the growth of neurons;however, whether the scaffolds can be used for the repair of spinal cord nerve injuries remains to be explored. In this study, a conductive graphene oxide composited chitosan scaffold was fabricated by genipin crosslinking and lyophilization. The prepared chitosan-graphene oxide scaffold presented a porous structure with an inner diameter of 18–87 μm, and a conductivity that reached 2.83 mS/cm because of good distribution of the graphene oxide nanosheets, which could be degraded by peroxidase. The chitosan-graphene oxide scaffold was transplanted into a T9 total resected rat spinal cord. The results show that the chitosan-graphene oxide scaffold induces nerve cells to grow into the pores between chitosan molecular chains, inducing angiogenesis in regenerated tissue, and promote neuron migration and neural tissue regeneration in the pores of the scaffold, thereby promoting the repair of damaged nerve tissue. The behavioral and electrophysiological results suggest that the chitosan-graphene oxide scaffold could significantly restore the neurological function of rats. Moreover, the functional recovery of rats treated with chitosangraphene oxide scaffold was better than that treated with chitosan scaffold. The results show that graphene oxide could have a positive role in the recovery of neurological function after spinal cord injury by promoting the degradation of the scaffold, adhesion, and migration of nerve cells to the scaffold. This study was approved by the Ethics Committee of Animal Research at the First Affiliated Hospital of Third Military Medical University(Army Medical University)(approval No. AMUWEC20191327) on August 30, 2019.

关键词： angiogenesis chitosan electrical conduction graphene oxide regeneration repair scaffold spinal cord injury

The“Top 50 High Impact Researches of Traditional Medicine”published in 2021

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Acupuncture and Herbal Medicine 2023年第4期3卷 232-243页

作者： Xiao Li Dong Xu Jianfeng tu Bo Pang Xiaohui Yan Yuanlu Cui Yuefei Wang Cunzhi Liu Yi Wang Junhua Zhang Tianjin University of Traditional Chinese Medicine TianjinChina State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anChina International Acupuncture and Moxibustion Innovation Institute School of Acupuncture-Moxibustion and TuinaBeijing University of Chinese MedicineBeijingChina Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhouChina

In recent years,significant progress has been achieved in both basic and clinical research within the field of traditional medicine,garnering increasing attention *** further promote a high-quality and international development of traditional medicine,the editorial board of Acupuncture and Herbal Medicine provided a collection of the“Top 50 High-impact Researches of Traditional Medicine”published in 2021 through objective indicators and a strict selection *** findings of the selected articles have a significant academic influence and possess considerable academic value both nationally and *** selected articles cover a wide range of topics,including clinical research,acupuncture,pharmacology,chemistry,biosynthesis,medicinal plant resources,and new formulation and drug delivery system research on traditional ***,this article outlines the selection process of the top 50 high-impact research articles,analyzes their research characteristics,and provides a brief summary of their new findings and perspectives in the field of traditional medicine.

关键词： Academic influence Ethnopharmacology High-impact research Traditional medicine

Long-term results of prophylactic cranial irradiation for limited-stage small-cell lung cancer in complete remission

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Chinese Medical Journal 2005年第15期118卷 1258-1262页

作者： CAO Ka-jia HUANG Hui-ying tu Ming-chi PAN Guo—ying Department of Radiation Oncology Cancer Centre Sun Yat-sen University Guangzhou 510060 China

Background Brain metastasis is one of the most important causes of treatment failure in patients with small cell lung cancer （SCLC）. This study was conducted to evaluate the effects of prophylactic cranial irradiation （PCI） on survival and brain metastases for patients with limited stage small cell lung cancer in complete remission. Methods Fifty one patients with limited stage SCLC in complete remission after chemoradiotherapy were randomly divided into PCI group （n = 26） and control group （n = 25 ）. Patients in the PCI group received PCI at a dose of 25.2 to 30. 6 Gy in 1.8 to 2.0 Gy per fraction. The Kaplan-Meier method and Log rank test were used to analyse and compare survival rates, and X^2 test was used to compare the incidences of cranial metastases in two groups. Results There was no significant difference in clinical characteristics of patients such as age, sex, effect of treatment before PCI between the two groups. The incidence of brain metastases was 3.8% in the PCI group in contrast to 32. 0% in the control group （X^2 =5.15, P =0. 02）. The 1, 3, 5-year survival rates were 84. 6%, 42. 3%, 34. 6% respectively in the PCI group and 72.0%, 32. 0%, 24. 0% respectively in the control group, with no difference between the two groups （X^2 = 2. 25, P = 0. 13 ）. No serious sequelae were observed in patients receiving PCI. Conclusion For patients with limited stage SCLC responding completely to chemotherapy plus radiotherapy, PCI can decrease the incidence of brain metastases and improve survival rate.

关键词： small cell lung carcinoma cranial irradiation· chemotherapy

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一种综合标签和时间因素的个性化推荐方法

计算机应用研究 2013年第4期30卷 1044-1047,1054页

作者：涂金龙涂风华重庆大学计算机学院重庆400044

针对现存的基于标签的社会化推荐系统在构建用户兴趣模型时存在的缺陷,提出一种综合标签及其时间信息的资源推荐(TTRR)模型。此模型考虑了用户的兴趣具有时间性的特点,即用户兴趣是随着时间而变化的、用户最近新打的标签更能反映用户近... 详细信息

针对现存的基于标签的社会化推荐系统在构建用户兴趣模型时存在的缺陷,提出一种综合标签及其时间信息的资源推荐(TTRR)模型。此模型考虑了用户的兴趣具有时间性的特点,即用户兴趣是随着时间而变化的、用户最近新打的标签更能反映用户近期的兴趣这一特性。为此,在借鉴协同过滤思想的基础上,通过利用标签使用频率信息和项目的标注时间来构建用户评分伪矩阵;在此基础上计算目标用户的最近邻集合;最后根据邻居用户给出推荐结果。通过在CiteULike数据集上进行实验,并与传统的基于标注的推荐方法进行比较,实验结果表明,TTRR模型能够更好地反映出用户的偏好,能够显著地提高推荐准确度。

关键词：社会化标签推荐系统协同过滤时间权值相似性

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基于粒子群结构寻优的电磁隐身微网格超表面

电子学报 2023年第11期51卷 3262-3270页

作者：涂建军马丁海军研究院上海200235 中国科学院上海技术物理研究所上海200283

针对电磁隐身超表面设计中寻求精确单元反射相位时存在的难点,提出一种将单元金属贴片区域网格化分割,并通过粒子群算法(Particle Swarm Optimization,PSO)自动寻优的设计方法,可自动生成符合预设反射相频特性的金属贴片图案.该方法将... 详细信息

针对电磁隐身超表面设计中寻求精确单元反射相位时存在的难点,提出一种将单元金属贴片区域网格化分割,并通过粒子群算法(Particle Swarm Optimization,PSO)自动寻优的设计方法,可自动生成符合预设反射相频特性的金属贴片图案.该方法将方形超表面单元的金属贴片区域划分为N×N网格(N为偶数,根据N和全对称条件可得到其中的自由网格数n),再用PSO对其自由网格的贴片编码进行训练,直至对应的贴片单元所构建的平面周期结构可实现预期反射相频特性(包括目标频率的反射相位精度及其邻域频段上相频曲线的平坦度).作为案例,在厘米波段和太赫兹波段,将寻优获得的反射相位相差约90°的4种单元,分别以90°和180°的相位梯度构建1 bit和2 bit超表面,全波仿真结果显示其在中心频率附近均可以得到-10 dB以上的RCS削减效果.验证了该方法可自动设计出具备特定反射相位的单元,并且跨频段适用,其所构建的超表面在获得特定频率雷达散射截面(Radar Cross Section,RCS)削减效果的同时,可兼顾有效削减的频段宽度.

关键词：电磁隐身超表面反射相位贴片单元粒子群算法