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从反文化到文化同化:日本大麻管制政策演变的历程与启示

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公安学研究 2024年第2期7卷 103-122,124页

作者：郭一禛广西警察学院治安学院广西警察学院中国-东盟禁毒研究中心南宁530022

全球大麻政策呈现出割裂的态势,欧美国家倡导的“合法化”似乎已经成为不可忽视也难以阻却的趋势,但在大多数的国家和地区,大麻的管制依旧严格。东亚的大麻管制政策与西方大相径庭,这一现象既是当下毒品管制策略的延续,也是文化和历史... 详细信息

全球大麻政策呈现出割裂的态势,欧美国家倡导的“合法化”似乎已经成为不可忽视也难以阻却的趋势,但在大多数的国家和地区,大麻的管制依旧严格。东亚的大麻管制政策与西方大相径庭,这一现象既是当下毒品管制策略的延续,也是文化和历史因素影响的结果,但东亚国家对大麻的认知与管制政策同样受到文化全球化所带来的冲击和挑战。在日本,反文化群体通过长年累月“自下而上”的自由化运动,影响了普通民众对大麻的认知,最终促成厚生劳动省修订《大麻取缔法》并重构了日本的大麻管制政策。日本反文化群体推动的大麻合法化运动的本质,是全球化过程中政治权力处于主导地位的西方对非主导地位国家的文化进行同化的过程。作为经济全球化重要参与国,我国需要警惕全球范围内大麻自由化思潮的扩散对我国文化主权的塑造与维护造成的影响。

关键词：日本文化同化反文化社会运动大麻管制禁毒政策

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1型神经纤维瘤病发病机制的研究进展

国际儿科学杂志 2024年第1期51卷 23-28页

作者：郭艺桢袁芳陈育才上海交通大学医学院附属儿童医院、上海市儿童医院神经内科 200062

1型神经纤维瘤病(neurofibromatosis type 1,NF1)是常见的常染色体显性遗传病之一。该疾病由NF1基因突变所引起,可累及多个系统,具有多种临床表现,包括牛奶咖啡斑、虹膜结节、神经胶质瘤、孤独症谱系障碍、学习困难、神经纤维瘤和骨骼... 详细信息

1型神经纤维瘤病(neurofibromatosis type 1,NF1)是常见的常染色体显性遗传病之一。该疾病由NF1基因突变所引起,可累及多个系统,具有多种临床表现,包括牛奶咖啡斑、虹膜结节、神经胶质瘤、孤独症谱系障碍、学习困难、神经纤维瘤和骨骼发育不良等。既往在NF1发病机制的研究中,多聚焦在神经纤维蛋白调控RAS信号通路。近年来,研究者开始探索除RAS信号之外的通路,挖掘神经纤维蛋白潜在功能。该文就近年来对NF1发病机制的研究进展进行综述,旨在为治疗提供新思路。

关键词： 1型神经纤维瘤病发病机制神经纤维蛋白治疗

北方浓香型白酒发酵过程中不同空间层次糟醅理化指标及风味物质的变化

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中国酿造 2024年第3期43卷 63-71页

作者：王乐魏功郭逸臻刘德王慧张敏石惠屈慧何云军任国军严伟内蒙古河套酒业集团股份有限公司内蒙古巴彦淖尔015400

该研究对北方浓香型白酒发酵过程中不同空间层次六个位置点糟醅的理化指标和主要风味物质的变化进行分析。结果表明,不同空间层次糟醅的理化指标和风味物质变化均呈现一定的规律。糟醅中水分、酸度、淀粉、丁酸、己酸、异戊醇、正丁醇... 详细信息

该研究对北方浓香型白酒发酵过程中不同空间层次六个位置点糟醅的理化指标和主要风味物质的变化进行分析。结果表明,不同空间层次糟醅的理化指标和风味物质变化均呈现一定的规律。糟醅中水分、酸度、淀粉、丁酸、己酸、异戊醇、正丁醇含量在中、上层四个位置点的变化规律基本一致且与底层两个位置点的完全不同。糟醅中残糖、乳酸乙酯、乙醛、乙酸、丙酸和甲醇含量在六个位置点变化规律基本一致,而乙缩醛、异丁醇、正丙醇和仲丁醇在各个位置点变化却各有差异。己酸乙酯和丁酸乙酯在其中三个位置点均未检出,另外三个点有较大差异。底层的己酸和正丁醇含量明显高于中、上层,中、上层的乳酸乙酯增幅远大于底层,中、底层仲丁醇含量明显升高而上层无明显变化。中、底层中心点残糖含量明显高于窖边点,同层中心点与窖边点淀粉含量无明显差异,同层窖边点甲醇、己酸、正丙醇和异戊醇含量明显高于中心点,而异丁醇相反。己酸乙酯和丁酸乙酯主要依靠底层和中层窖边点糟醅在发酵中后期生成。

关键词：北方浓香型白酒不同空间层次糟醅理化指标风味物质变化规律

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原酒贮存过程中香味和微量成分的变化规律

酿酒 2024年第1期51卷 80-83页

作者：刘晓柯郭逸臻李擎胡博文严伟淦吉林任国军王加彬内蒙古河套酒业集团股份有限公司内蒙古巴彦淖尔015000

对2013年生产的原酒逐年进行感官品评和气相色谱分析,探索了原酒在贮存过程中感官和微量成分的变化规律。

关键词：白酒香味微量成分贮存

河套浓香型白酒蒸馏过程酒中馏分及排酸前后酒醅中风味物质的变化规律研究

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酿酒 2024年第3期51卷 100-103页

作者：李擎马飞张敏刘红微郭逸臻刘晓柯任国军严伟淦吉林王加彬内蒙古河套酒业集团股份有限公司内蒙古巴彦淖尔015400 河套学院内蒙古巴彦淖尔015400

探索河套浓香型白酒蒸馏过程中酒醅材料及原酒中微量成分的变化规律。研究表明:材料中产生的高级醇类物质都蒸馏到了酒中,乙酸乙酯和丁酸乙酯大多被蒸馏到了酒中,而己酸乙酯和乳酸乙酯在入池糟醅中还有一定量的残留,酸类物质则更难被蒸... 详细信息

探索河套浓香型白酒蒸馏过程中酒醅材料及原酒中微量成分的变化规律。研究表明:材料中产生的高级醇类物质都蒸馏到了酒中,乙酸乙酯和丁酸乙酯大多被蒸馏到了酒中,而己酸乙酯和乳酸乙酯在入池糟醅中还有一定量的残留,酸类物质则更难被蒸馏出来。不同馏分段原酒中微量成分分析发现,高级醇类前后变化不大,乳酸乙酯随蒸馏过程逐渐增加,其它三大类酯及醛类物质呈减少趋势。另外,在整个蒸馏过程甑桶中温度的变化不是很剧烈。

关键词：蒸馏甑桶酒醅原酒微量成分

Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2936-2952页

作者： Liang Zhao yizhen Pang Yangfan Zhou Jianhao Chen Hao Fu Wei guo Weizhi Xu Xin Xue guoqiang Su Long Sun Hua Wu Jingjing Zhang Zhanxiang Wang Qin Lin Xiaoyuan Chen Haojun Chen Department of Nuclear Medicine and Minnan PET Center Xiamen Key Laboratory of RadiopharmaceuticalsThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingaporeSingapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Department of Radiation Oncology Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Department of Colorectal Tumor Surgery Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Department of Cardiothoracic Surgery Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingChina Nanomedicine Translational Research Program NUS Center for NanomedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Department of Neurosurgery and Department of Neuroscience Fujian Key Laboratory of Brain Tumors Diagnosis and Precision TreatmentXiamen Key Laboratory of Brain Centerthe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamenChina

Radiotherapy combined with immune checkpoint blockade holds great promise for synergistic antitumor *** radionuclide therapy delivers radiation directly to tumor ***1004 is a fibroblast activation protein(FAP)-targeting radiopharmaceutical,conjugated with the albumin binder Evans Blue,which has demonstrated enhanced tumor uptake and retention in previous preclinical and clinical ***,we demonstrate that^(68)Ga/^(177)Lu-labeled LNC1004 exhibits increased uptake and prolonged retention in MC38/NIH3T3-FAP and CT26/NIH3T3-FAP tumor *** therapy with^(177)Lu-LNC1004 induced a transient upregulation of PD-L1 expression in tumor *** combination of^(177)Lu-LNC1004 and anti-PD-L1 immunotherapy led to complete eradication of all tumors in MC38/NIH3T3-FAP tumor-bearing mice,with mice showing 100%tumor rejection upon ***,single-cell RNA sequencing(scRNA-seq),and TCR sequencing revealed that combination therapy reprogrammed the tumor microenvironment in mice to foster antitumor immunity by suppressing malignant progression and increasing cell-to-cell communication,CD8^(+)T-cell activation and expansion,M1 macrophage counts,antitumor activity of neutrophils,and T-cell receptor diversity.A preliminary clinical study demonstrated that^(177)Lu-LNC1004 was well-tolerated and effective in patients with refractory ***,scRNA-seq of peripheral blood mononuclear cells underscored the importance of addressing immune evasion through immune checkpoint blockade *** was emphasized by the observed increase in antigen processing and presentation juxtaposed with T cell *** conclusion,our data supported the efficacy of immunotherapy combined with^(177)Lu-LNC1004 for cancer patients with FAP-positive tumors.

关键词： immunity retention holds

One Stone Four Birds:A Novel Liposomal Delivery System Multi-functionalized with Ginsenoside Rh2 for Tumor Targeting Therapy

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Nano-Micro Letters 2020年第10期12卷 69-86页

作者： Chao Hong Jianming Liang Jiaxuan Xia Ying Zhu yizhen guo Anni Wang Chunyi Lu Hongwei Ren Chen Chen Shiyi Li Dan Wang Huaxing Zhan Jianxin Wang Department of Pharmaceutics School of PharmacyFudan University&Key Laboratory of Smart Drug DeliveryMinistry of EducationShanghai 201203People’s Republic of China Institute of Tropical Medicine Guangzhou University of Chinese MedicineGuangzhou 510006People’s Republic of China Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhou 510006People’s Republic of China School of Pharmacy Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Shanghai Ginposome Pharmatech Co. LtdShanghai 201600People’s Republic of China Institute of Integrated Chinese and Western Medicine Fudan UniversityShanghai 200040People’s Republic of China

Liposomes hold great potential in anti-cancer drug delivery and the targeting treatment of ***,the clinical therapeutic efficacy of liposomes is still limited by the complexity of tumor microenvironment(TME)and the insufficient accumulation in tumor ***,the application of cholesterol and polyethylene glycol(PEG),which are usually used to prolong the blood circulation and stabilize the structure of liposomes respectively,has been questioned due to various ***,we developed a ginsenoside Rh2-based multifunctional liposome system(Rh2-lipo)to effectively address these challenges once for *** with the conventional’wooden’liposomes,Rh2-lipo is a much more brilliant carrier with multiple *** Rh2-lipo,both cholesterol and PEG were substituted by Rh2,which works as membrane stabilizer,long-circulating stealther,active targeting ligand,and chemotherapy adjuvant at the same ***,Rh2 could keep the stability of liposomes and avoid the shortcomings caused by ***,Rh2-lipo showed a specifically prolonged circulation behavior in the ***,the accumulation of the liposomes in the tumor was significantly enhanced by the interaction of glucose transporter of tumor cells with ***,Rh2-lipo could remodel the structure and reverse the immunosuppressive environment in *** tested in a 4T1 breast carcinoma xenograft model,the paclitaxel-loaded Rh2-lipo realized high efficient tumor growth ***,Rh2-lipo not only innovatively challenges the position of cholesterol as a liposome component,but also provides another innovative potential system with multiple functions for anti-cancer drug delivery.

关键词： Ginsenoside Rh2 Liposomes Cholesterol Multifunction Tumor targeting

Construction of SECRAL LHe Station

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2007年第1期 173-174页

作者： Jin Tao Man Kaidi Hao Chaoying guo yizhen guo Xiaohong

早产儿的脑干听觉诱发电位的特征、规律及在听力筛查中的作用

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中华儿科杂志 1996年第3期34卷 174-176页

作者：郭异珍北京协和医院儿科

为了观察早产儿听力成熟变化规律和密切相关因素，采用听觉诱发电位法筛查了１６８例早产儿的听力。结果：早产儿的脑干听觉诱发电位波Ⅰ、波Ⅲ和波Ⅴ的平均潜伏期是随着胎龄的增加而缩短。差异有显著意义。峰间期、波Ⅰ～Ⅴ、Ⅲ～Ⅴ和... 详细信息

为了观察早产儿听力成熟变化规律和密切相关因素，采用听觉诱发电位法筛查了１６８例早产儿的听力。结果：早产儿的脑干听觉诱发电位波Ⅰ、波Ⅲ和波Ⅴ的平均潜伏期是随着胎龄的增加而缩短。差异有显著意义。峰间期、波Ⅰ～Ⅴ、Ⅲ～Ⅴ和Ⅰ～Ⅲ同样也随胎龄的递增而递减。早产儿于胎龄３４周，在３０ｄＢ强度的刺激下，９０％早产儿的脑干听觉诱发电位，其波Ⅴ的潜伏期达正常成人水平。因此，胎龄３４周是早产儿听觉成熟的关键年龄。提示：对早产儿的听力筛查应该从胎龄３４周开始。

关键词：诱发电位听觉脑干早产儿听力筛查