One Stone Four Birds:A Novel Liposomal Delivery System Multi-functionalized with Ginsenoside Rh2 for Tumor Targeting Therapy

作     者：Chao Hong Jianming Liang Jiaxuan Xia Ying Zhu Yizhen Guo Anni Wang Chunyi Lu Hongwei Ren Chen Chen Shiyi Li Dan Wang Huaxing Zhan Jianxin Wang Chao Hong;Jianming Liang;Jiaxuan Xia;Ying Zhu;Yizhen Guo;Anni Wang;Chunyi Lu;Hongwei Ren;Chen Chen;Shiyi Li;Dan Wang;Huaxing Zhan;Jianxin Wang

作者机构：Department of PharmaceuticsSchool of PharmacyFudan University&Key Laboratory of Smart Drug DeliveryMinistry of EducationShanghai 201203People’s Republic of China Institute of Tropical MedicineGuangzhou University of Chinese MedicineGuangzhou 510006People’s Republic of China Institute of Clinical PharmacologyGuangzhou University of Chinese MedicineGuangzhou 510006People’s Republic of China School of PharmacyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Shanghai Ginposome Pharmatech Co.LtdShanghai 201600People’s Republic of China Institute of Integrated Chinese and Western MedicineFudan UniversityShanghai 200040People’s Republic of China 

出 版 物：《Nano-Micro Letters》 (纳微快报（英文版）)

年 卷 期：2020年第12卷第10期

页      面：69-86页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 0808[工学-电气工程] 0809[工学-电子科学与技术（可授工学、理学学位）] 0817[工学-化学工程与技术] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 10[医学] 

基　　金：supported by National Natural Science Foundation of China(Nos.81773911,81690263 and 81573616) the Development Project of Shanghai Peak Disciplines-Integrated Medicine(No.20150407) 

主　　题：Ginsenoside Rh2 Liposomes Cholesterol Multifunction Tumor targeting 

摘      要：Liposomes hold great potential in anti-cancer drug delivery and the targeting treatment of ***,the clinical therapeutic efficacy of liposomes is still limited by the complexity of tumor microenvironment(TME)and the insufficient accumulation in tumor ***,the application of cholesterol and polyethylene glycol(PEG),which are usually used to prolong the blood circulation and stabilize the structure of liposomes respectively,has been questioned due to various ***,we developed a ginsenoside Rh2-based multifunctional liposome system(Rh2-lipo)to effectively address these challenges once for *** with the conventional’wooden’liposomes,Rh2-lipo is a much more brilliant carrier with multiple *** Rh2-lipo,both cholesterol and PEG were substituted by Rh2,which works as membrane stabilizer,long-circulating stealther,active targeting ligand,and chemotherapy adjuvant at the same ***,Rh2 could keep the stability of liposomes and avoid the shortcomings caused by ***,Rh2-lipo showed a specifically prolonged circulation behavior in the ***,the accumulation of the liposomes in the tumor was significantly enhanced by the interaction of glucose transporter of tumor cells with ***,Rh2-lipo could remodel the structure and reverse the immunosuppressive environment in *** tested in a 4T1 breast carcinoma xenograft model,the paclitaxel-loaded Rh2-lipo realized high efficient tumor growth ***,Rh2-lipo not only innovatively challenges the position of cholesterol as a liposome component,but also provides another innovative potential system with multiple functions for anti-cancer drug delivery.