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Acyl-CoA thioesterase 7 is oncogenic in breast cancer by promoting oxidative phosphorylation via PGC1a

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Genes & Diseases 2024年第5期11卷 13-16页

作者： Xiangyu Sun Qiang Zhang Mozhi Wang Litong Yao Xiang Li Hongyi Cao yingying Xu Department of Breast Surgery Liaoning Cancer Hospital&InstituteShenyangLiaoning 110000China Department of Breast Surgery The First Hospital of China Medical UniversityShenyangLiaoning 110000China Department of Ultrasound The First Hospital of China Medical UniversityShenyangLiaoning 110000China Department of Pathology The First Hospital of China Medical University and College of Basic Medical SciencesShenyangLiaoning 110000China

Metabolic reprogramming is a key feature of tumor cells and plays a key role in the adaptation of tumor cells to increased demands of biosynthesis and rapid proliferation.1 Numerous studies have shown that some key metabolic enzymes are essential for the initiation and progression of breast cancer(BC).These metabolic enzymes are involved in the regulation of many biological processes such as gene transcription,post-translational modification,and antioxidant capacity of cells,which endow tumor cells with the ability to adapt to divergent environmental stimuli.2 Therefore,it is of great significance to identify the role of important metabolic enzymes in the occurrence and development of BC to determine promising therapeutic targets.

关键词： breast cancer oxidative

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化工园区源谱库建设及污染源排查探析

皮革制作与环保科技 2023年第3期4卷 187-189页

作者：杜盈盈上海科德环保测试技术咨询服务有限公司上海200235

本文介绍了2021年5月~2021年12月期间,对某化工园区6家企业进行源谱库建设,并对5家企业进行污染源排查的相关工作,分析了源谱库建设筛选及污染源排查的相关方法,旨在为工业园区后续污染溯源、减排提供借鉴。

关键词：化工园区污染源排查源谱库

Making the Complicated Simple:A Minimizing Carrier Strategy on Innovative Nanopesticides

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Nano-Micro Letters 2024年第10期16卷 31-46页

作者： Wenjie Shangguan Qiliang Huang Huiping Chen yingying Zheng Pengyue Zhao Chong Cao Manli Yu Yongsong Cao Lidong Cao State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193People's Republic of China College of Plant Protection China Agricultural UniversityBeijing 100193People's Republic of China State Key Laboratory of Element-Organic Chemistry Department of Chemical BiologyCollege of ChemistryNankai UniversityTianjin 300071People's Republic of China

The flourishing progress in nanotechnology offers boundless opportunities for agriculture,particularly in the realm of nanopesticides research and ***,concerns have been raised regarding the human and environmental safety issues stemming from the unrestrained use of non-therapeutic nanomaterials in *** is also important to consider whether the current development strategy of nanopesticides based on nanocarriers can strike a balance between investment and return,and if the complex material composition genuinely improves the efficiency,safety,and circularity of ***,we introduced the concept of nanopesticides with minimizing carriers(NMC)prepared through prodrug design and molecular self-assembly emerging as practical tools to address the current limitations,and compared it with nanopesticides employing non-therapeutic nanomaterials as carriers(NNC).We further summarized the current development strategy of NMC and examined potential challenges in its preparation,performance,and ***,we asserted that the development of NMC systems can serve as the innovative driving force catalyzing a green and efficient revolution in nanopesticides,offering a way out of the current predicament.

关键词： Nanopesticides Green agrochemicals Self-assembly Nanomaterial safety Sustainable development strategies

浙江省耕地多功能价值时空变化与权衡-协同关系

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农业工程学报 2020年第14期36卷 263-272页

作者：朱从谋李武艳杜莹莹许红卫王珂浙江大学环境与资源学院杭州310058 浙江财经大学土地与城乡发展研究院杭州310018 浙江工商大学公共管理学院杭州310018

耕地多功能价值的时空演变与权衡-协同关系测度对于深化耕地可持续利用和管理具有重要意义。该研究以经济快速发展地区浙江省为例,采用价值量化方法对2000、2010和2015年浙江省耕地多功能进行价值评估并分析其时空变化特征。运用Spearma... 详细信息

耕地多功能价值的时空演变与权衡-协同关系测度对于深化耕地可持续利用和管理具有重要意义。该研究以经济快速发展地区浙江省为例,采用价值量化方法对2000、2010和2015年浙江省耕地多功能进行价值评估并分析其时空变化特征。运用Spearman秩相关系数法、双变量空间自相关模型以及可拓展随机性环境影响评估(StochasticImpactsby Regression on Population,Affluence and Technology,STIRPAT)模型探究耕地多功能之间的权衡-协同关系及影响因素。结果表明:1)2000—2015年浙江省耕地多功能总价值下降,地均耕地多功能价值呈现先下降后上升的趋势。其中气体调节、水源涵养和社会保障功能价值下降明显,食物生产和美学景观功能价值增加;耕地多功能总价值在空间上呈现北高南低的分布格局,2000—2015年大部分县市耕地多功能总价值均有不同程度的下降,西南山地丘陵区耕地多功能总价值有所提升。2)浙江省耕地多功能之间主要表现为协同关系,各项功能之间的协同-权衡关系存在空间异质性;2000—2015年,浙江省耕地多功能协同关系总体减弱,在空间上主要表现为高值协同区减少。3)城镇居民可支配收入和地均农业机械总动力对耕地多功能总价值有负面影响,农村居民可支配收入增加有助于耕地多功能总价值的提升。该研究成果可为科学划定耕地利用与保护区,促进耕地多功能的协同利用和提升耕地资源价值提供科学依据。

关键词：土地利用模型耕地权衡协同多功能浙江省

Perspective on powder technology for all-solid-state batteries:How to pair sulfide electrolyte with high-voltage cathode

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Particuology 2024年第3期86卷 55-66页

作者： Jiangkui Hu Shijie Yang yingying Pei Xilong Wang Yulong Liao Shuai Li Aolong Yue Jia-Qi Huang Hong Yuan School of Materials Science&Engineering Beijing Institute of TechnologyBeijing100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing100081China

Sulfide solid electrolytes(SEs)have attracted ever-increasing attention due to their superior roomtemperature ionic conductivity(~10^(-2) S cm^(-1)).Additionally,the integration of sulfide SEs and highvoltage cathodes is promising to achieve higher energy ***,the incompatible interfaces between sulfide SEs and high-voltage cathodes have been one of the key factors limiting their ***,this review presents a critical summarization of the interfacial issues in all-solid-state lithium batteries based on sulfide SEs and high-voltage cathodes and proposes strategies to stabilize the electrolyte/cathode ***,the future research direction of electrolyte/cathode interfaces and application prospects of powder technology in sulfide-based ASSLBs were also discussed.

关键词： Sulfide solid electrolytes High-voltage cathodes Electrode/electrolyte interfaces All-solid-state lithium batteries

microRNA-21对肺癌A549细胞增殖和Smad7表达的影响

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安徽医科大学学报 2015年第12期50卷 1766-1769页

作者：李斌潘跃银杜瀛瀛安徽医科大学第一附属医院干部肿瘤科合肥230022

目的探讨微小RNA-21(miR-21)对肺癌A549细胞中Smad7表达的调控和对肺癌A549细胞增殖的影响。方法常规培养肺癌细胞系A549,经脂质体转染miR-21模拟物和抑制物及阴性对照片段48 h后,采用Western blot、qRTPCR法检测Smad7基因及蛋白的表达... 详细信息

目的探讨微小RNA-21(miR-21)对肺癌A549细胞中Smad7表达的调控和对肺癌A549细胞增殖的影响。方法常规培养肺癌细胞系A549,经脂质体转染miR-21模拟物和抑制物及阴性对照片段48 h后,采用Western blot、qRTPCR法检测Smad7基因及蛋白的表达水平,MTT法检测A549细胞增殖情况。结果转染miR-21模拟物后Smad7的mRNA和蛋白表达量降低(P<0.05),而转染miR-21抑制物后Smad7的mRNA和蛋白表达量升高(P<0.05);MTT结果显示转染miR-21模拟物后细胞的增殖能力明显增强(P<0.05),而转染miR-21抑制物后细胞增殖能力明显减弱(P<0.05)。结论通过下调miR-21可提高Smad7的mRNA和蛋白表达,进而抑制A549细胞的增殖。

关键词：肺癌微小RNA-21 Smad7 增殖

健康公平视域下城乡居民基本医疗保险制度优化——以安徽省为例

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安徽开放大学学报 2022年第1期 11-17页

作者：杜莹莹铜陵学院财税与公共管理学院安徽铜陵244061

从健康公平视角入手,以安徽省城乡居民基本医疗保险为依托,从资金筹集、医疗服务利用和保障结果三个方面考察城乡居民基本医疗保险制度的健康公平,分析表明致力于促进城乡居民健康公平的基本医疗保险制度可能面临形式公平大于实质公平... 详细信息

从健康公平视角入手,以安徽省城乡居民基本医疗保险为依托,从资金筹集、医疗服务利用和保障结果三个方面考察城乡居民基本医疗保险制度的健康公平,分析表明致力于促进城乡居民健康公平的基本医疗保险制度可能面临形式公平大于实质公平的结果。提出建立缴费贡献与缴费能力关联的筹资机制,加大对低收入群体的财政补贴力度,渐进式提高城乡居民基本医保统筹层次,构建有机衔接的多层次医疗保障体系等优化路径。

关键词：健康公平基本医疗保险筹资医疗服务利用

用气相色谱-质谱法测定纺织柔软剂中的环硅氧烷

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纺织学报 2020年第8期41卷 69-73,80页

作者：于岩章若红钟毅杜英英毛志平徐红东华大学生态纺织教育部重点实验室上海201620 上海市质量监督检验技术研究院上海201114

为开发纺织柔软剂中环硅氧烷高效定量分析方法,建立了气相色谱-质谱(GC-MS)联用测定纺织柔软剂中环硅氧烷的分析方法。利用乙酸乙酯作为提取溶剂对样品进行振荡提取,并将提取的溶液经过滤后与六甲基二硅氮烷进行衍生化反应,反应后的溶... 详细信息

为开发纺织柔软剂中环硅氧烷高效定量分析方法,建立了气相色谱-质谱(GC-MS)联用测定纺织柔软剂中环硅氧烷的分析方法。利用乙酸乙酯作为提取溶剂对样品进行振荡提取,并将提取的溶液经过滤后与六甲基二硅氮烷进行衍生化反应,反应后的溶液采用GC-MS进行检测。结果表明:在混合标准溶液质量浓度为1~100 mg/L范围内,GC-MS法测定八甲基环四硅氧烷(D4)、十甲基环五硅氧烷(D5)和十二甲基环六硅氧烷(D6)的峰面积与混合标准溶液质量浓度具有良好的线性关系,相关系数R^2≥0.9953;GC-MS法的检出限为0.1170~0.2010 mg/L,定量限为0.3900~0.6700 mg/L,重复性和稳定性相对标准偏差分别小于1.0%和7.4%,样品加标回收率为89.8%~114.3%,相对标准偏差为1.3%~6.4%,满足检测的要求;GC-MS法的操作简单,可精准地检测出纺织柔软剂中D4、D5、D6的微量残留。

关键词：气相色谱-质谱联用法纺织柔软剂环硅氧烷测定八甲基环四硅氧烷十甲基环五硅氧烷十二甲基环六硅氧烷

Storage, form, and influencing factors of karst inorganic carbon in a carbonate area in China

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Science China Earth Sciences 2024年第3期67卷 725-739页

作者： Chaochao du Xiaoyong BAI Yangbing LI Qiu TAN Cuiwei ZHAO Guangjie LUO Luhua WU Fei CHEN Chaojun LI Chen RAN Sirui ZHANG Lian XIONG Fengjiao SONG Biqin XIAO Zilin LI yingying XUE Mingkang LONG Qing LUO Xiaoyun ZHANG Minghui LI Xiaoqian SHEN Shu YANG State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China School of Geography and Environmental Sciences Guizhou Normal UniversityGuiyang 550001China CAS Center for Excellence in Quaternary Science and Global Change Xi'an 710061China Guizhou Provincial Key Laboratory of Geographic State Monitoring of Watershed Guizhou Normal CollegeGuiyang 550018China College of Resources and Environmental Engineering Guizhou UniversityGuiyang 550025China

Carbonate rock chemical weathering carbon sinks reduce the rate of increase of the atmospheric CO_(2) concentration and global warming. However, uncertainty still exists in the estimation results of carbonate rock chemical weathering carbon sink fluxes(CCSF), and the contributions of climate change and ecological restoration to the CCSF are not clear. To this end, we compiled published site data on ion concentrations in different watersheds in China and used a classical thermodynamic dissolution model to reassess the potential and spatial and temporal patterns of the CCSF in China from 1991 to 2020. We quantified the contributions of temperature(MAT), precipitation(MAP), evapotranspiration(ET), soil water(SM), and the normalized difference vegetation index(NDVI) to the CCSF. The results revealed that(1) China's CCSF was 22.76 t CO_(2)km^(-2)yr^(-1), which was higher than the global average(15.77 t CO_(2)km^(-2)yr^(-1)). The total carbonate rock chemical weathering carbon sink(CCS) was 4772.67×10^(4)t CO_(2), contributing 14.91% of the global CCS through a carbonate rock area of 252.98×10^(4)km^(-2).(2) China's CCSF decreased gradually from southeast to northwest, with values of 33.14, 12.93, and7.27 t CO_(2)km^(-2)yr^(-1)in the southern karst, Qinghai-Tibetan karst, and northern karst regions, respectively.(3) The overall CCSF in China exhibited an increasing trend from 1991 to 2020, with a rate of increase of 0.16 t CO_(2)km^(-2)yr^(-1).(4) The contributions of the MAP, MAT, ET, SM, and NDVI to the CCSF were 63.3%, 3.02%, 27.5%, 3.1%, and 3.05%, respectively. Among them, the increase in precipitation was the main contributor to the increase in the CCSF in China over the last 30 years, while the enhancement of ET offset part of the positive contribution of the increase in precipitation to the CCSF. In conclusion, the results of this study provide a systematic quantification of the magnitude, the patterns, and the influencing factors of CCS over a long time series in

关键词： Carbonate rocks Carbon sinks Patterns Influencing factors Thermodynamic dissolution modeling