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文献计量学挖掘中药材非药用资源的研究现状

华西药学杂志 2024年第5期39卷 621-627页

作者：杨豆豆牟炜凤张庆庆赵郦炎杨坤姜晓凤陈垣梁引库陕西理工大学、陕南秦巴山区生物资源综合开发协同创新中心、秦巴生物资源与生态环境省部共建国家重点实验室陕西省资源生物重点实验室陕西汉中723000 陕西云检分析科技有限公司陕西汉中723000 甘肃省农科院甘肃兰州730070 甘肃农业大学甘肃兰州730070

基于文献计量学方法对国内近2.年中药材非药用部分的文献进行挖掘。自2.00年以来,该领域经历了初始发展、快速增长及稳定增长阶段,累积发文量目前以拟合度极高的线性速度增加,回归方程为:Y=13.488X+18.475(r^(2.=0.9930)。研究内容主要... 详细信息

基于文献计量学方法对国内近2.年中药材非药用部分的文献进行挖掘。自2.00年以来,该领域经历了初始发展、快速增长及稳定增长阶段,累积发文量目前以拟合度极高的线性速度增加,回归方程为:Y=13.488X+18.475(r^(2.=0.9930)。研究内容主要集中在化学物质基础和药理活性方面;化学物质基础为主导方向,包括结构鉴定、成分检测、分离提取等;黄酮、挥发油、多糖等为核心关注成分;抗氧化、抑菌及抗炎是药理活性的主要研究方向。当前研究的热点与前沿为化学成分的鉴定分离及多糖。

关键词：非药用资源化学物质基础资源化利用文献计量中药材

Chloroplast DNA reveals genetic population structure in Sinomenium acutum in subtropical China

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chinese Herbal medicines 2023年第2期15卷 278-283页

作者： Chun Guo ying He Xiyao zeng Xingyao Xiong Ping Qiu Xueshuang Huang Hua Yang center for Medical research and Innovation The First Hospital of Hunan University of Chinese MedicineChangsha 410007China College of Bioscience and Biotechnology Hunan Agricultural UniversityChangsha 410125China Hunan Zhengqing Pharmaceutical Group Co. Ltd.Huaihua 418000China College of Horticulture and Landscape Hunan Agricultural UniversityChangsha 410125China Hunan Provincial Key Laboratory for Synthetic Biology of Traditional chinese Medicine Hunan University of MedicineHuaihua 418000China

Objective:The population density and diversity of Sinomenium acutum(Menispermaceae)have been greatly reduced recently by overharvesting for medicinal purposes in ***,it is urgent that the remaining populations are investigated,and that strategies for the utilization and conservation of this species are *** study aimed to find the possible glacial refugia and define the genetic diversity of *** for its proper utilization and ***:A total of 77 *** samples were collected from four locations,Qinling Mountains,Daba Mountains,Dalou Mountains,and Xuefeng Mountains,in subtropical *** diversity among and between these populations were phylogenetically analyzed using four chloroplast DNA molecular markers(atpI-atpH,trnQ-50 rps16,trnH-psbA and trnL-trnF).Results:A total of 14 haplotypes(C1 to C14)were found in collected *** C1 and C3 were shared among all populations,with C3 as the ancestral *** C11 and C12.diverged the most from C3 and other *** obvious phylogeographic structure was found in four locations using the GST/NST *** is no evidence of rapid demographic expansion in *** based on the mismatch distribution,and the results of Tajima’s D test,and Fu’s FS *** analyses of molecular variance revealed a high level of genetic variation within *** contrast,the genetic differentiation among *** populations was low,indicating frequent gene ***:Xuefeng,Dalou,and Daba Mountains were possible glacial refugia for the populations of ***.C1,C3,C11 and C12.haplotypes of *** should be carefully preserved and managed for their genetic value.

关键词： chloroplast DNA genetic diversity phylogeny population variation Sinomenium acutum(Thunb.)Rehd.et Wils

牛黄及其代用品的化学成分及质量控制研究进展

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中国中药杂志 2024年第18期49卷 4874-4884页

作者：左池靖刘艳汪杰余卫东梁万徽单晓晓韩岚彭代银彭灿安徽中医药大学新安医学与中医药现代化研究所安徽合肥230012 安徽中医药大学药学院安徽合肥230012 安徽中医药大学安徽省现代中药产业共性技术研究中心安徽合肥230012 安徽中医药大学安徽省乡村振兴协同技术服务中心安徽合肥230012 省部共建安徽道地中药材品质提升协同创新中心安徽合肥230012

牛黄是清热解毒、息风止痉的传统中药,常用于心脑血管疾病的治疗。然而,由于其药用资源匮乏及代用品使用范围的局限性,牛黄及其代用品的质量控制备受关注。该文以代用品采用沿革为基础,以化学成分为切入点,从性状-显微-理化鉴别分析到... 详细信息

牛黄是清热解毒、息风止痉的传统中药,常用于心脑血管疾病的治疗。然而,由于其药用资源匮乏及代用品使用范围的局限性,牛黄及其代用品的质量控制备受关注。该文以代用品采用沿革为基础,以化学成分为切入点,从性状-显微-理化鉴别分析到以胆汁酸、胆红素为指标性成分的光谱-色谱-质谱的量化分析,发展至以药效-生物导向关联模式的中药质量标志物(Q-marker)研究,对牛黄及其代用品的质量控制方法进行综述,以期为其质量标准研究提供科学的参考依据。最后,就其全息化学成分解析和核心功效物质在确定的问题进行展望,拟为牛黄及其代用品的合理开发提供参考。

关键词：牛黄及代用品化学成分质量标志物质量控制

Therapy to Obese Type 2.Diabetes Mellitus:How Far Will We Go Down the Wrong Road?

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chinese Journal of Integrative Medicine 2020年第1期26卷 62-71页

作者： HENG Xian-pei LI Xiu-jun LI liang YANG Liu-qing WANG Zi-ta HUANG Su-ping Department of Endocrinology People's Hospital Affiliated to Fujian University of Traditional Chinese MedicineFuzhou 350004China West China Medical center of Sichuan Medical University(West China University of Medical Science) Chengdu 610041China Academy of Integrative Medicine Fujian Fujian University of Traditional Chinese MedicineFuzhou 350122China

Traditional glucose-lowering chemical agents, including various types of insulin and insulin secretagogues, insulin sensitizers, gliptins, etc., are based on diabetic pathogenesis of insulin resistance(IR) and islet insufficiency. Numerous evidence-based medical studies have shown that these traditional hypoglycemic chemical agents do not provide cardiovascular benefit to patients with type 2.diabetes mellitus(T2.DM) and may even increase the risk of all-cause mortality. Based on research evidence published to date, these studies show that overload of energy could increase the incidence and prevalence of T2.DM, and reduction in the heat load can significantly reduce the incidence of T2.DM. Therefore, the essence of T2.DM is heat overload, meaning heat overload is the etiology of obese T2.DM. At the same time, results of numerous studies show that heat overloading is the cause of IR. IR and islet dysfunction are protective factors in intervening with heat *** drugs, which are based on the mechanisms of IR and islet insufficiency, increase caloric reserve and cause or worsen obesity, which is equivalent to exacerbating the basic etiology and the cardiovascular risk factor of T2.DM. Thus, a reasonable strategy for prevention and treatment of obese T2.DM appears to promote the negative balance of calories and the elimination of caloric reserves. chinese herbal {2. can promote negative balance of heat in many aspects, which can bring new hope for prevention and treatment of T2.DM.

关键词： obese type 2.diabetes mellitus etiology prevention and treatment chinese herbal medicine

多组分光谱相关色谱及其在中药色谱指纹图谱分析中的应用

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化学学报 2003年第9期61卷 1466-1470页

作者：胡芸梁逸曾李博岩徐承建曾仲大中南大学化学化工学院中药现代化研究中心长沙410083

基于正交投影理论和相关色谱方法提出多组分光谱相关色谱 .为克服联用色谱仪器的不等性噪声影响 ,采用目标组分投影前后的光谱夹角余弦判据 ,判断不同的中药色谱指纹图谱的相关组分色谱峰簇 .该方法为中药指纹图谱的数据处理、合理评价... 详细信息

基于正交投影理论和相关色谱方法提出多组分光谱相关色谱 .为克服联用色谱仪器的不等性噪声影响 ,采用目标组分投影前后的光谱夹角余弦判据 ,判断不同的中药色谱指纹图谱的相关组分色谱峰簇 .该方法为中药指纹图谱的数据处理、合理评价以及中药谱效学的基本理论研究提供一种实用的工具 .

关键词：多组分光谱相关色谱中药化学色谱分析指纹图谱色谱峰簇正交投影

不同中成药对痰瘀互结型冠心病患者血脂及微循环状态影响的网状Meta分析

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中药新药与临床药理 2024年第7期35卷 1069-1083页

作者：崔晓珊李洪峥李亮高佳明陈原原张会雨郝伟付建华郭浩中国中医科学院西苑医院基础医学研究所北京100091 中国中医科学院西苑医院北京100091 北京中医药大学北京100029 国家中医心血管病临床医学研究中心北京100091

目的基于网状Meta分析方法对不同中成药改善痰瘀互结型冠心病患者血脂及微循环状态的有效性和安全性进行评估。方法检索中国知网(CNKI)、万方数据库(Wanfang)、维普中文期刊(VIP)、中国生物医学文献数据库(SinoMed)、PubMed、EMbase、Co... 详细信息

目的基于网状Meta分析方法对不同中成药改善痰瘀互结型冠心病患者血脂及微循环状态的有效性和安全性进行评估。方法检索中国知网(CNKI)、万方数据库(Wanfang)、维普中文期刊(VIP)、中国生物医学文献数据库(SinoMed)、PubMed、EMbase、Cochrane Library、Web of Science等数据库自建库至2.2.年4月3日有关中成药治疗痰瘀互结型冠心病患者血脂及微循环状态的随机对照试验(RCTs),采用Review Manager 5.4和Stata 15.1软件进行文献质量评价及网状Meta分析。结果最终纳入37项RCTs,总样本量4064例,包括15种中成药。网状Meta分析综合结果提示中成药联合西医常规治疗冠心病的疗效优于单纯西医常规治疗,且未见严重不良反应。临床总疗效累积概率排前3位的中成药为冠脉再通膏、瓜蒌皮注射液、祛瘀消斑胶囊;在改善甘油三酯(TG)及低密度脂蛋白(LDL-C)方面,排前3位的中成药为瓜蒌皮注射液、护心康片、冠心舒通胶囊;在改善血浆黏度及纤维蛋白原方面,排前3位的中成药为银杏达莫注射液、瓜蒌皮注射液、冠心舒通胶囊;在改善内皮功能[一氧化氮(NO)及内皮素1(ET-1)]方面,排前3位的中成药为银杏达莫注射液、丹蒌片、通脉愈心丸;在降低炎症超敏C反应蛋白(hs-CRP)方面,排前3位的中成药为银杏达莫注射液、护心康片、冠心舒通胶囊。结论当前证据表明,痰瘀同治类中成药联合西医常规治疗冠心病在提高临床疗效、改善血脂及微循环状态方面具有较明显的优势,尤其是能兼顾治疗痰与瘀的中成药优势更明显,如冠脉再通膏、瓜蒌皮注射液,可作为中西医临床指导用药方案之一。但因纳入文献的数量少、质量不高,研究结果仍需要更多高质量、多中心、双盲随机试验加以验证,以提供更可靠的循证医学参考。

关键词：中成药冠心病痰瘀互结证血脂微循环网状Meta分析

Effect of physicochemical properties on in vivo fate of nanoparticle-based cancer immunotherapies

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Acta Pharmaceutica Sinica B 2021年第4期11卷 886-902页

作者： Yongchao Wang Jinjin Wang Dandan Zhu Yufei Wang Guangchao Qing Yuxuan Zhang Xiaoxuan Liu Xing-Jie liang State Key Laboratory of Natural medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases Center of Drug DiscoveryCenter of Advanced Pharmaceutics and BiomaterialsChina Pharmaceutical UniversityNanjing 210009China Laboratory of Controllable Nanopharmaceuticals Chinese Academy of Sciences(CAS)Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and TechnologyBeijing 100190China University of chinese Academy of Sciences Beijing 100049China

Current advances of immunotherapy have greatly changed the way of cancer *** the same time,a great number of nanoparticle-based cancer immunotherapies(NBCIs)have also been explored to elicit potent immune responses against ***,few NBCIs are nearly in the clinical trial which is mainly ascribed to a lack understanding of in vivo fate of nanoparticles(NPs)for cancer *** for cancer immunotherapy mainly target the immune organs or immune cells to enable effcient antitumor immune *** physicochemical properties of NPs including size,shape,elasticity and surface properties directly affect their interaction with immune systems as well as their in vivo fate and therapeutic ***,systematic analysis of the physicochemical properties and their effect on in vivo fate is urgently *** this review,we frst recapitulate the fundamentals for the in vivo fate of NBCIs including physio-anatomical features of lymphatic system and strategies to modulate immune ***,we highlight the effect of physicochemical properties on their in vivo fate including lymph nodes(LNs)drainage,cellular uptake and intracellular *** and opportunities for rational design of NPs for cancer immunotherapy are also discussed in detail.

关键词： Physicochemical properties Nanoparticle-based cancer immunotherapies Cancer treatment In vivo fate Immune responses Lymph nodes drainage Cellular uptake Intracellular transfer

Antibiotic Metabolites from the Coral-Associated Actinomycete Streptomyces sp. OUCMDZ-1703

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chinese Journal of Chemistry 2013年第1期31卷 100-104页

作者： Peng Fu Fandong Kong Yuanfei Wang yi Wang Peipei Liu Guoying Zuo Weiming Zhu Key Laboratory of Marine Drugs Ministry of Education of China School of Medicine and Pharmacy Ocean University of China Qingdao Shandong 266003 China research center for Natural {2. Kunming General Hospital PLA Kunming Yunnan 650032 China Yunnan Traditional chinese Medical College Kunming Yunnan 650500 China

From the oligotrophic culture of a soft coral-associated actinomycetes strain, Streptomyces sp. OUCMDZ-1703, we isolated and identified two new chlorinated polyketides that we named strepchloritides A and B （1 and 2., three thiazole derivatives known as watasemycin A （3）, pulicatin G （4） and aerugine （5）, along with pyrrole- 2.carboxamide, furan-2.carboxamide and 1-（3,5-dihydroxyphenyl）ethanone. The new structures of 1 and 2.were determined by spectroscopic studies such as 1D- and 2.-NMR and MS analyses, while the known compounds were identified by comparison of the NMR data with those in literatures. The results showed that actinomycete strain OUCMDZ-1703 could use the relative high ratio of chlorine in the oligotrophic medium to synthesize chlorinated natural products. New compounds 1 and 2.displayed cytotoxicity against the MCF-7 ceils with ICs0 values of 9.9 and 2..2.~tmoloL-1, respectively. Thiazole derivatives 3 and 5 were first found to be active against three clinical strains of methicillin-resistant Staphylococcus aureus （MRSA082. MRSA111 and MRSA2.4） with the same MIC/MBC values of 7.81/7.81 μg·mL-1.

关键词： coral-associated actinomycetes Streptomyces sp. polychlorinated natural products thiazole deriva-tives cytotoxicity antibiotic methicillin-resistant S. aureus

Houttuynia cordata polysaccharides alleviate ulcerative colitis by restoring intestinal homeostasis

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chinese Journal of Natural medicines 2022年第12期20卷 914-924页

作者： CEN Lifeng yi Tong HAO Yuanzhen SHI Chenchen SHI Xunlong LU Yan CHEN Daofeng ZHU Haiyan Department of Biological medicines&Shanghai Engineering research {2. of ImmunoTherapeutics School of PharmacyFudan UniversityShanghai 200000China Division of Spine Department of OrthopedicsTongji HospitalShanghai 200000China Department of Natural Medicine School of PharmacyFudan UniversityShanghai 200000China

Houttuynia cordata is traditionally used as phytoantibiotics for treating lung disease in *** cordata polysaccharides(HCPs)have been reported to alleviate influenza virus-induced intestinal and lung immune injury by regulating the gutlung *** present study aims to investigate the effects and mechanisms of HCPs on ulcerative colitis(UC).Male C57BL/6 mice were induced by dextran sodium sulfate(DSS)to establish the UC animal *** results showed that HCPs significantly reduced the weight loss and the shortening of colon length in colitis mice,and relieved the pathological damage of colon mucosa and inhibited the expression of pro-inflammatory cytokines such as TNF-α,IL-1β,IL-6,*** was suggested that HCPs could significantly improve DSS-induced colitis in *** directly protected intestinal epithelial cells,ameliorated epithelial barrier dysfunction and cell apoptosis,which was also proved in H2.2.stimulated cell apoptosis *** inhibited inflammation in the colon,which was related to suppressing the infiltration of macrophages,inhibiting the expression of pro-inflammatory cytokines and proteins(TLR4,NF-κB),and restoring the dysfunction of Th17 and Treg *** also restored the alteration of intestinal flora induced by DSS,increased the abundance of Firmicutes and Bacteroides,and reduced the abundance of *** study confirmed the protective effect of Houttuynia cordata polysaccharide extracted from traditional chinese medicine on ulcerative colitis,of which the mechanism was closely related to the maintenance of intestinal homeostasis(intestinal barrier,immune cells,and intestinal bacteria).

关键词： Houttuynia cordata polysaccharide Ulcerative colitis Anti-inflammation Intestinal homeostasis Gut microbiota