Antibiotic Metabolites from the Coral-Associated Actinomycete Streptomyces sp. OUCMDZ-1703

作     者：Peng Fu Fandong Kong Yuanfei Wang Yi Wang Peipei Liu Guoying Zuo Weiming Zhu 

作者机构：Key Laboratory of Marine Drugs Ministry of Education of China School of Medicine and Pharmacy Ocean University of China Qingdao Shandong 266003 China Research Center for Natural Medicines Kunming General Hospital PLA Kunming Yunnan 650032 China Yunnan Traditional Chinese Medical College Kunming Yunnan 650500 China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2013年第31卷第1期

页      面：100-104页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 090403[农学-农药学(可授农学、理学学位）] 100705[医学-微生物与生化药学] 07[理学] 09[农学] 0904[农学-植物保护] 071005[理学-微生物学] 10[医学] 

基　　金：supported by grants from 973 Program of China 国家自然科学基金 国家863计划 山东省自然科学基金 Innovation and Research Foundation of Ocean University of China 

主　　题：coral-associated actinomycetes Streptomyces sp. polychlorinated natural products thiazole deriva-tives cytotoxicity antibiotic methicillin-resistant S. aureus 

摘      要：From the oligotrophic culture of a soft coral-associated actinomycetes strain, Streptomyces sp. OUCMDZ-1703, we isolated and identified two new chlorinated polyketides that we named strepchloritides A and B （1 and 2）, three thiazole derivatives known as watasemycin A （3）, pulicatin G （4） and aerugine （5）, along with pyrrole- 2-carboxamide, furan-2-carboxamide and 1-（3,5-dihydroxyphenyl）ethanone. The new structures of 1 and 2 were determined by spectroscopic studies such as 1D- and 2D-NMR and MS analyses, while the known compounds were identified by comparison of the NMR data with those in literatures. The results showed that actinomycete strain OUCMDZ-1703 could use the relative high ratio of chlorine in the oligotrophic medium to synthesize chlorinated natural products. New compounds 1 and 2 displayed cytotoxicity against the MCF-7 ceils with ICs0 values of 9.9 and 20.2 ~tmoloL-1, respectively. Thiazole derivatives 3 and 5 were first found to be active against three clinical strains of methicillin-resistant Staphylococcus aureus （MRSA082, MRSA111 and MRSA234） with the same MIC/MBC values of 7.81/7.81 μg·mL-1.