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Evaluation of the Potential Inhibitory Activity of A Combination of ***,*** and *** on Helicobacter Pylori：A Randomized Double-Blind Placebo-Controlled Clinical Trial

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Chinese Journal of Integrative Medicine 2017年第3期23卷 176-182页

作者： Chien-Ying Lee Hung-Che Shih Min-Chien Yu Ming-yung Lee ya-Lan Chang ya-yun lai Yi-Ching Lee Yu-Hsiang Kuan Chun-Che Lin Institute of Medicine Chung Shan Medical UniversityTaichungTaiwan 40201China Department of Pharmacy Chung Shan Medical University HospitalTaichungTaiwan 40201China Department of Medicine Chung Shan Medical UniversityTaichungTaiwanChina Department of Integrated Chinese and Western Medicine Chung Shan Medical University HospitalTaichungTaiwan 40201China Department of Statistics and Informatics Science Providence UniversityChina 43301 Department of Applied Cosmetology National Tainan Junior College of NursingTaiwan 700 China Division of Hepatogastroent erology Department of Internal MedicineChung Shan Medical University HospitalTaichungTaiwan 40201China

Objective： To investigate whether three strains of probiotics, L. acidophilus, L. rhamnosus, and L. sporogenes, had significant inhibitive effects on Helicobacter pylori（H. pylori）. Methods： This is a 4-week, randomly assigned, parallel-group, doubled-blind, and placebo-controlled study. Fifty patients with a positive H. pylori infection urea breath test（△UBT） result 〉 10% and without ulcer symptoms were randomized into a treatment group and a placebo group by a computer generated allocation sheet with 1：1. These subjects took one capsule of probiotics or placebo twice daily. The primary measurement was the change in △UBT values. Results： The △UBT values during the 4-week treatment period and the 2-week follow-up period were not significantly different between the treatment group and the placebo group, indicating that the inhibitive effects on H. pylori were comparable between both groups. The monocyte count（%） was 5.77±1.11 in the treatment group versus 5.09±1.12 in the placebo group（P=0.044）, and the basophile count was 0.55±0.32 in the treatment group versus 0.36±0.23 in the placebo group（P=0.024） at week 2 of the treatment period, both of which reached statistical significance. The monocyte count was 5.75±1.26 in the treatment group and 4.72±0.99 in the placebo group at the end of the follow-up period（P=0.003）. Conclusions： There was no significant inhibitive effects of the three probiotic strains（L. acidophilus, L. rhamnosus, and L. sporogenes） on H. pylori. Probiotics can not play the same role as antibiotics in the eradication of H. pylori, the role of probiotics is likely to be important as adjuvant to the triple or quadruple therapy for H. pylori, especially in resistance cases.

关键词： probiotics Helicobacter pylori urea breath test randomized double-blind placebo-controlled trial

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No Additional Cholesterol-Lowering Effect Observed in the Combined Treatment of Red Yeast Rice and Lactobacillus Casei in Hyperlipidemic Patients：A Double-Blind Randomized Controlled Clinical Trial

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Chinese Journal of Integrative Medicine 2017年第8期23卷 581-588页

作者： Chien-Ying Lee Min-Chien Yu Wu-Tsun Perng Chun-Che Lin Ming-yung Lee ya-Lan Chang ya-yun lai Yi-Ching Lee Yu-Hsiang Kuan James Cheng-Chung Wei Hung-Che Shih Institute of Medicine Chung Shan Medical University Taichung Taiwan 40201 China Department of Pharmacy Chung Shah Medical University Hospital Taichung Taiwan 40201 China Department of Pharmacology Chung Shan Medical University Taichung Taiwan 40201 China Department of Integrated Chinese and Western Medicine Chung Shan Medical University Hospital Taichung Taiwan 40201 China Department of Recreation Sport & Health Promotion National Pingtung University of Science and Technology Taiwan 91201 China Division of Hepatogastroenterology Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 40201 China Department of Statistics and Informatics Science Providence University Taiwan 43301 China Department of Applied Cosmetology National Tainan Junior College of Nursing China Taiwan 700 Department of Internal Medicine Chung Shan Medical University HospitalGraduate Institute of Integrated Medicine China Medical University Taichung Taiwan 40201 China

Objective：To observe the effect of combining red yeast rice and Lactobacillus casei（***）in lowering cholesterol in patients with primary hyperlipidemia,the later has also been shown to remove cholesterol in in vitro ***：A double-blind clinical trial was conducted to evaluate the cholesterol-lowering effect of the combination of red yeast rice and *** patients with primary hyperlipidemia were recruited and randomized equal y to either the treatment group（red yeast rice＋***）or the control group（red yeast rice＋placebo）.One red yeast rice capsule and two *** capsules were taken twice a *** treatment lasted for 8 weeks,with an extended follow-up period of 4 *** primary endpoint was a difference of serum low-density lipoprotein cholesterol（LDL-C）level at week ***：At week 8,the LDL-C serum level in both groups was lower than that at baseline,with a decrease of 33.85±26.66 mg/dL in the treatment group and 38.11±30.90 mg/dL in the control group;however,there was no statistical difference between the two groups（P〉0.05）.The total cholesterol was also lower than the baseline in both groups,yet without a statistical difference between the two *** only statistical y significant difference between the two groups was the average diastolic pressure at week 12,which dropped by 2.67 mm Hg in the treatment group and increased by 4.43 mm Hg in the placebo group（P〈0.05）.The antihypertensive activity may be associated with *** yeast rice can significantly reduce LDL-C,total cholesterol and ***：The combination of red yeast rice and *** did not have an additional effect on lipid profiles.

关键词： red yeast rice Lactobacillus casei,low-density lipoprotein cholesterol randomizedcontrolled trial

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薄壁钢箱梁的极限强度及有效宽比分析

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铁道学报 1999年第3期21卷 77-80页

作者：吴亚平赖远明王步云兰州铁道学院土木工程系

对由线应力性强化材料制造的薄壁钢箱梁在弯曲极限状态下的强度及有效宽比进行了分析。基于弹塑性应力－应变理论及箱梁剪滞效应的分析结果，本文推导出在有限塑性变形条件下，箱梁的极限强度增大系数及翼缘有效宽比与跨宽比及允许塑性... 详细信息

对由线应力性强化材料制造的薄壁钢箱梁在弯曲极限状态下的强度及有效宽比进行了分析。基于弹塑性应力－应变理论及箱梁剪滞效应的分析结果，本文推导出在有限塑性变形条件下，箱梁的极限强度增大系数及翼缘有效宽比与跨宽比及允许塑性变形值之间的关系及剪滞系数的计算方法。通过算例分析，为实际工程设计应用提供了有关计算方法、准则及可供参考的分析结论。

关键词：箱形梁极限强度有效宽比薄壁钢箱梁桥梁

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基于ab initio计算的CF^-离子低激发态光谱性质研究

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物理学报 2017年第2期66卷 103-110页

作者：周锐李传亮和小虎邱选兵孟慧艳李亚超赖云忠魏计林邓伦华太原科技大学应用科学学院太原030024 华东师范大学精密光谱科学与技术国家重点实验室上海200062

基于相关一致基组aug-cc-pV5Z,采用高精度的内收缩多参考组态相互作用方法计算了CF^-离子两个最低解离极限C(~3p_2)+F^-(~1S_0)和C(~1D_2)+F^-(~1S_0)对应的5个A-S态(X^3Σ^-,a^1Δ,b^1Σ^+,A^3Π和c^1Π)的势能曲线.计算中考虑了Davidson修正和标量相对论修正以提高数据的可靠性.根据A-S态的势能曲线,求解径向薛定谔方程得到振转能级,通过拟合获得了这些电子态的光谱常数.此外,研究了5个A-S态的电偶极矩随核间距变化的曲线,分析了电子态的组态变化对电偶极矩的影响.计算了A^3Π-X^3Σ^-的跃迁偶极矩和Franck-Condon因子,获得了A^3Π的5个最低振动能级的辐射寿命,分析了两个电子态之间的跃迁特性,并给出了振子强度.最后,研究了A^3Π态的预解离机理,并计算得到了高振动能级的解离寿命.

关键词： CF^-离子光谱常数组态相互作用预解离

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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao lai Xu Zhen Gu Hua yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang Shijie Su Weicheng Feng yaona lai Kongli Huang Dandan Cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

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Structural Modal Parameter Recognition and Related Damage Identification Methods under Environmental Excitations: A Review

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Structural Durability & Health Monitoring 2025年第1期19卷 25-54页

作者： Chao Zhang Shang-Xi lai Hua-Ping Wang School of Civil Engineering and Mechanics Lanzhou UniversityLanzhou730000China Key Laboratory of Special Functional Materials and Structural Design Ministry of EducationLanzhou UniversityLanzhou730000China

Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the ***,it is particularly signiﬁcant to identify the structural modal parameters according to the monitoring data information in the structural health monitoring(SHM)system,so as to provide a scientiﬁc basis for structural damage identiﬁcation and dynamic model modiﬁ*** view of this,this paper reviews methods for identifying structural modal parameters under environmental excitation and brieﬂy describes how to identify structural damages based on the derived modal *** paper primarily introduces data-driven modal parameter recognition methods(e.g.,time-domain,frequency-domain,and time-frequency-domain methods,etc.),brieﬂy describes damage identiﬁcation methods based on the variations of modal parameters(e.g.,natural frequency,modal shapes,and curvature modal shapes,etc.)and modal validation methods(e.g.,Stability Diagram and Modal Assurance Criterion,etc.).The current status of the application of artiﬁcial intelligence(AI)methods in the direction of modal parameter recognition and damage identiﬁcation is further *** on the pre-vious analysis,the main development trends of structural modal parameter recognition and damage identiﬁcation methods are given to provide scientiﬁc references for the optimized design and functional upgrading of SHM systems.

关键词： Structural health monitoring data information modal parameters damage identiﬁcation AI method

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Epsilon-near-zero or mu-near-zero materials composed of dielectric photonic crystals

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Science China(Information Sciences) 2013年第12期56卷 148-157页

作者： LUO Jie lai yun Wave-Functional Materials Lab Department of Physics Soochow University

We theoretically demonstrate that at certain frequencies two-dimensional dielectric photonic crystals(PCs)may be regarded as either epsilon-near-zero or mu-near-zero *** show that the transmission through a slab of such materials upon normal incidence is normally non-unity and decays with slab ***,when the incident angle increases slightly,the transmittance experiences a dramatic increase due to the Brewster *** combination of the tunneling and resonance efects makes such materials good candidates for almost perfect bending waveguides and cloaking in *** zero index also enables applications of focusing and directive *** last,the distinction between the single-zero and double-zero media is *** all of the above results,the numerical simulations perfectly match with theoretical predictions from the efective medium analysis.

关键词： photonic crystal epsilon-near-zero material mu-near-zero material efective medium transmission properties Brewster efect

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Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

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Neural Regeneration Research 2025年第1期20卷 242-252页

作者： Daiyu Hu Yuanqing Cao Chenglin Cai Guangming Wang Min Zhou Luying Peng yantao Fan Qiong lai Zhengliang Gao Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina Shanghai Engineering Research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and *** enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid *** cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental *** organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic *** convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells

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Detection of electron-phonon coupling in two-dimensional materials by light scattering

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Nano Research 2021年第6期14卷 1711-1733页

作者： Jia-Min lai ya-Ru Xie Jun Zhang State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China CAS Center of Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing101408China Beijing Academy of Quantum Information Science Beijing100193China

Electron-phonon coupling affects the properties of two-dimensional(2D)materials significantly,leading to a series of novel *** light scattering provides a powerful experimental tool to explore electron-phonon interaction in 2D *** review gives an overview of the basic theory and experimental advances of electron-phonon coupling in 2D materials detected by Raman and Brillouin scattering,*** the Raman scattering part,we review Raman spectroscopy studies of electron-phonon coupling in graphene,transition metal disulfide compounds,van der Waals heterostructures,strongly correlated systems,and 2D magnetic *** the Brillouin scattering part,we extensively introduce Brillouin spectroscopy in non-van der Waals 2D structures,including temperature sensors for phonons and magnons,interfacial Dzyaloshinsky-Moriya interaction and spin torque in multilayer magnetic structures,as well as exciton-polariton in semiconductor quantum well.

关键词： electron-phonon coupling Raman scattering Brillouin scattering two-dimensional(2D)materials

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