No Additional Cholesterol-Lowering Effect Observed in the Combined Treatment of Red Yeast Rice and Lactobacillus Casei in Hyperlipidemic Patients：A Double-Blind Randomized Controlled Clinical Trial

作     者：Chien-Ying Lee Min-Chien Yu Wu-Tsun Perng Chun-Che Lin Ming-Yung Lee Ya-Lan Chang Ya-Yun Lai Yi-Ching Lee Yu-Hsiang Kuan James Cheng-Chung Wei Hung-Che Shih 

作者机构：Institute of Medicine Chung Shan Medical University Taichung Taiwan 40201 China Department of Pharmacy Chung Shah Medical University Hospital Taichung Taiwan 40201 China Department of Pharmacology Chung Shan Medical University Taichung Taiwan 40201 China Department of Integrated Chinese and Western Medicine Chung Shan Medical University Hospital Taichung Taiwan 40201 China Department of Recreation Sport & Health Promotion National Pingtung University of Science and Technology Taiwan 91201 China Division of Hepatogastroenterology Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 40201 China Department of Statistics and Informatics Science Providence University Taiwan 43301 China Department of Applied Cosmetology National Tainan Junior College of Nursing China Taiwan 700 Department of Internal Medicine Chung Shan Medical University HospitalGraduate Institute of Integrated Medicine China Medical University Taichung Taiwan 40201 China 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2017年第23卷第8期

页      面：581-588页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by the Committee on Chinese Medicine and Pharmacy,Department of Health,Taiwan,China(Protocol No.:CCMP97-RD-043) Chung Shan Medical University(Protocol No.:CSMU-INT-104-03) 

主　　题：red yeast rice Lactobacillus casei,low-density lipoprotein cholesterol randomizedcontrolled trial 

摘      要：Objective：To observe the effect of combining red yeast rice and Lactobacillus casei（***）in lowering cholesterol in patients with primary hyperlipidemia,the later has also been shown to remove cholesterol in in vitro ***：A double-blind clinical trial was conducted to evaluate the cholesterol-lowering effect of the combination of red yeast rice and *** patients with primary hyperlipidemia were recruited and randomized equal y to either the treatment group（red yeast rice＋***）or the control group（red yeast rice＋placebo）.One red yeast rice capsule and two *** capsules were taken twice a *** treatment lasted for 8 weeks,with an extended follow-up period of 4 *** primary endpoint was a difference of serum low-density lipoprotein cholesterol（LDL-C）level at week ***：At week 8,the LDL-C serum level in both groups was lower than that at baseline,with a decrease of 33.85±26.66 mg/dL in the treatment group and 38.11±30.90 mg/dL in the control group;however,there was no statistical difference between the two groups（P〉0.05）.The total cholesterol was also lower than the baseline in both groups,yet without a statistical difference between the two *** only statistical y significant difference between the two groups was the average diastolic pressure at week 12,which dropped by 2.67 mm Hg in the treatment group and increased by 4.43 mm Hg in the placebo group（P〈0.05）.The antihypertensive activity may be associated with *** yeast rice can significantly reduce LDL-C,total cholesterol and ***：The combination of red yeast rice and *** did not have an additional effect on lipid profiles.