Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

作     者：Minghuang Gao Xinyue Wang Shijie Su Weicheng Feng Yaona Lai Kongli Huang Dandan Cao Qi Wang 

作者机构：Science and Technology Innovation CenterGuangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical PharmacologyGuangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2025年第20卷第3期

页      面：763-778页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China, No.82274616 the Key Laboratory Project for General Universities in Guangdong Province, No.2019KSYS005 Guangdong Province Science and Technology Plan International Cooperation Project, No.2020A0505100052 (all to QW) 

主　　题：central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease 

摘      要：Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.