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Comprehensive Treatment with Chinese Medicine in Patients with Advanced Non-Small Cell Lung Cancer: A Multicenter, Prospective, Cohort Study

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Chinese Journal of Integrative Medicine 2017年第10期23卷 733-739页

作者： LIU jie LIN Hong-sheng HOU Wei HUA Bao-jin ZHANG Pei-tong LI jie WANG Shen-yu XIE Ying ZHANG yue XIE Guang-ru ZHANG Mei-ying SHI Wen-guang GUAN Nian-bo GUAN Tian-yu LI Cong-huang LU Li-yuan ZHANG Ying LI Dao-rui LIU Hao Department of Oncology Guang'anmen Hospital China Academy of Chinese Medical Sciences Department of Integrative Oncology Liaoning Cancer Hospital Department of Traditional Chinese Medicine Shanxi Cancer Hospital Traditional Chinese Medicine Department Jilin Cancer Hospital Department of Integrative Oncology Tianjin Medical University Cancer Institute and Hospital

Objective： To determine whether additional Chinese medicine（CM） could prolong survival and improve the quality of life（QOL） in patients with advanced non-small cell lung cancer（NSCLC） compared with Western medicine（WM） alone. Methods： This was a multicenter, prospective cohort study. A total of 474 hospitalized patients with stage Ⅲ–Ⅳ NSCLC were recruited and divided into 2 groups. Patients in the WM group received radiotherapy, chemotherapy, and optimal supportive therapy according to the National Comprehensive Cancer Network（NCCN） guidelines. In the integrative medicine（IM） group, individualized CM（Chinese patent medicines and injections） and WM were administered. The primary end point was overall survival, and the secondary end points were time to disease progression, adverse events, and QOL. Follow-up clinical examinations and chest radiography were performed every 2 months. Results： The median survival was 16.60 months in the IM group and 13.13 months in the WM group（P〈0.01）. The incidences of loss of appetite, nausea, and vomiting in the IM group were significantly lower than those in the WM group（P〈0.05）. The QOL based on Functional Assessment of Cancer Therapy-Lung in the IM group was markedly higher than that in the WM group at the fourth course（P〈0.05）. Conclusions： Additional CM may prolong survival and improve the QOL patients with NSCLC. The adverse effects of radio-and chemotherapy may be attenuated as CM is used in combination with conventional treatments.

关键词： advanced non-small cell lung cancer Chinese medicine integrative medicine

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Improving the biotransformation efficiency of soybean phytosterols in Mycolicibacterium neoaurum by the combined deletion of fbpC3 and embC in cell envelope synthesis

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Synthetic and Systems Biotechnology 2022年第1期7卷 453-459页

作者： Liang-Bin Xiong Hao-Hao Liu Lu Song Miao-Miao Dong jie Ke yong-Jun Liu Ke Liu Ming Zhao Feng-Qing Wang Dong-Zhi Wei Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences Shanghai201800PR China State Key Laboratory of Bioreactor Engineering Newworld Institute of BiotechnologyEast China University of Science and TechnologyShanghai200237PR China Huawei Safety Evaluation&Medical Research(Shanghai)Co. Ltd.Shanghai201206PR China

Biotransformation of soybean phytosterols into 9α-hydroxy-4-androstene-3,17-dione(9-OHAD)by mycobacteria is the core step in the synthesis of adrenocortical ***,the low permeability of the dense cell envelope largely inhibits the overall conversion efficiency of *** antigen 85(Ag85)complex encoded by fbpA,fbpB,and fbpC was proposed as the key factor in the combined catalysis of mycoloyl for producing mycolyl-arabinogalactan(m-AG)and trehalose dimycolate(TDM)in mycobacterial cell ***,we confirmed that fbpC3 was essential for the biotransformation of trehalose monomycolate(TMM)to TDM in Mycolicibacterium *** deficiency of this gene raised the cell permeability,thereby enhancing the steroid uptake and *** 9-OHAD yield in the fbpC3-deficient 9-OHAD-producing strain was increased by 21.3%.Moreover,the combined deletion of fbpC3 and embC further increased the 9-OHAD yield compared to the single deletion of ***,after 96 h of bioconversion in industrial resting cells,the 9-OHAD yield of 11.2 g/L was achieved from 20 g/L phytosterols and the productivity reached 0.116 g/L/*** summary,this study suggested the critical role of the fbpC3 gene in the synthesis of TDM in *** and verified the feasibility of improving the bioconversion efficiency of phytosterols through the cell envelope en-gineering strategy.

关键词： Mycolicibacterium 9-OHAD Cell permeability Soybean phytosterol fbpC3 embC

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艾司氯胺酮在全髋关节置换术麻醉诱导中的应用效果

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新乡医学院学报 2024年第4期41卷 322-325,332页

作者：杨孟丽张雪莹杨鑫李晓芳张红伟樊腾马闻苛杨明月高宁宁王玉淼郭自伟殷婕岳修勤新乡医学院第一附属医院麻醉科河南卫辉453100

目的探讨艾司氯胺酮用于全髋关节置换术麻醉诱导的效果。方法选择2021年10月至2022年6月新乡医学院第一附属医院收治的60例全身麻醉下行全髋关节置换术的患者为研究对象,按随机数字表法将患者分为对照组和观察组,每组30例。观察组患者... 详细信息

目的探讨艾司氯胺酮用于全髋关节置换术麻醉诱导的效果。方法选择2021年10月至2022年6月新乡医学院第一附属医院收治的60例全身麻醉下行全髋关节置换术的患者为研究对象,按随机数字表法将患者分为对照组和观察组,每组30例。观察组患者在麻醉诱导时给予艾司氯胺酮0.5 mg·kg^(-1),对照组患者给予安慰剂,其余诱导用药及术中维持用药均相同。记录并比较2组患者入室后(T_(0))、麻醉诱导给药后(T_(1))、气管插管后(T_(2))、缝合皮肤时(T_(3))的心率(HR)、平均动脉压(MAP)和脉搏血氧饱和度(SpO_(2));比较2组患者麻醉苏醒时间、麻醉后监测治疗(PACU)停留时间;分别于术后2、6、12、24 h时采用Ramasy镇静评分和疼痛数字等级评分(NRS)评估患者的镇静程度和疼痛程度;比较2组患者术后躁动、恶心呕吐、呼吸抑制等不良反应发生情况。结果T_(0)、T_(2)、T_(3)时,2组患者的HR、MAP比较差异无统计学意义(P>0.05);T_(1)时观察组患者的HR、MAP显著高于对照组(P0.05)。2组患者PACU停留时间比较差异无统计学意义(P>0.05);观察组患者麻醉苏醒时间显著短于对照组(P0.05)。对照组和观察组患者术后不良反应发生率分别为13.3%(4/30)、6.7%(2/30),2组患者术后不良反应发生率比较差异无统计学意义(χ^(2)=0.741,P>0.05)。结论艾司氯胺酮可减轻行全髋关节置换术患者术后疼痛,缩短麻醉苏醒时间,使血流动力学更加稳定,且安全性较高。

关键词：艾司氯胺酮全髋关节置换术麻醉诱导

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Spinal cord conduits for spinal cord injury regeneration

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再生工程(英文) 2023年第1期4卷 68-80页

作者： Yanyu Ma Quanchi Chen Wenhan Li Haiwen Su Song Li Yitong Zhu jie Zhou Zhenhua Feng Zhen Liu Saihu Mao yong Qiu Huan Wang Zezhang Zhu Division of Spine Surgery Department of Orthopedic SurgeryAffiliated Drum Tower HospitalMedical SchoolNanjing UniversityNanjing210008China Division of Spine Surgery Department of Orthopedic SurgeryAffiliated Drum Tower Hospital Clinical College of Nanjing University of Chinese MedicineNanjing210008China Department of Nephrology Affiliated Drum Tower Hospital Clinical College of Nanjing University of Chinese MedicineNanjing210008China Division of Spine Surgery Department of Orthopedic SurgeryNanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjing210008China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen518033China

Spinal cord injury(SCI),which causes irreversible damage in both sensory and motor function,is considered an insurmountable challenge in the field of *** previous researchers have developed many kinds of biomaterials for SCI,and spinal cord conduits(SCCs)are an important classification for bridging spinal cord tissues while performing their corresponding *** this review,we first describe the original sources of the different polymers that determine the properties of the different ***,we focus on the different types of crosslinking methods used for preparing ***,various practical applications and therapeutic effects of SCCs are summarized and ***,we conclude the existing limitations of current *** hope that this paper will serve as a further inspiration for the development of SCCs in future.

关键词： Spinal cord injury Neuron regeneration Hydrogel Spinal cord conduit Tissue engineering

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隋唐高僧与儒学

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陕西师范大学学报（哲学社会科学版） 2010年第6期39卷 102-106页

作者：介永强陕西师范大学学报编辑部陕西西安710062

隋唐高僧涉览外典,兼通儒学者甚多,他们与儒学之因缘各有不同:一是禀承家学,淹贯儒家经典;二是出家前在地方学校业习儒家经典;三是出家后在佛教寺院兼习儒家经典。积习所染,兼通儒学的隋唐高僧在翻译经典、讲习经义、著书立说的过程中,... 详细信息

隋唐高僧涉览外典,兼通儒学者甚多,他们与儒学之因缘各有不同:一是禀承家学,淹贯儒家经典;二是出家前在地方学校业习儒家经典;三是出家后在佛教寺院兼习儒家经典。积习所染,兼通儒学的隋唐高僧在翻译经典、讲习经义、著书立说的过程中,往往参以儒义,在佛教中国化的过程中扮演了独特而重要的角色。高僧儒佛双修是隋唐时期儒佛融合的典型表现,是隋唐佛教中国化的重要标志。

关键词：隋唐佛教高僧儒学佛教中国化

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离子液体在天然产物分离分析中的应用

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林产化学与工业 2013年第3期33卷 143-148页

作者：姚曦岳永德汤锋国际竹藤中心国家林业局竹藤科学与技术重点开放实验室北京100102

在查阅了大量国内外文献资料的基础上,综述了近几年离子液体在天然产物研究中的提取、分离(如液-液萃取、液-固萃取、双水相萃取、离子液体微波辅助萃取)及色谱分析中(高效液相色谱(HPLC)、气相色谱(GC)、薄层色谱(TLC)、毛细管电泳(CE)... 详细信息

在查阅了大量国内外文献资料的基础上,综述了近几年离子液体在天然产物研究中的提取、分离(如液-液萃取、液-固萃取、双水相萃取、离子液体微波辅助萃取)及色谱分析中(高效液相色谱(HPLC)、气相色谱(GC)、薄层色谱(TLC)、毛细管电泳(CE))的应用进展,并展望了其应用前景和发展方向。

关键词：离子液体天然产物分离分析色谱

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Chemical formation and source apportionment of PM_(2.5) at an urban site at the southern foot of the Taihang mountains

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Journal of Environmental Sciences 2021年第5期33卷 20-32页

作者： Xiaoyong Liu Mingshi Wang Xiaole Pan Xiyue Wang Xiaolong yue Donghui Zhang Zhigang Ma Yu Tian Hang Liu Shandong Lei Yuting Zhang Qi Liao Baozhu Ge Dawei Wang jie Li Yele Sun Pingqing Fu Zifa Wang Hong He Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Henan Polytechnic University Jiaozuo 454003China Jiaozuo Ecological Environment Monitoring Center Jiaozuo 454003China Jiaozuo Environmental Science Research Institute Jiaozuo 454003China Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China Institute of Surface-Earth System Science Tianjin UniversityTianjin 300072China University of Chinese Academy of Sciences Beijing 100049China College of Earth Sciences University of Chinese Academy of SciencesBeijing 100049China

The region along the Taihang Mountains in the North China Plain(NCP) is characterized by serious fine particle pollution. To clarify the formation mechanism and controlling factors, an observational study was conducted to investigate the physical and chemical properties of the fine particulate matter in Jiaozuo city, China. Mass concentrations of the water-soluble ions(WSIs) in PM_(2.5) and gaseous pollutant precursors were measured on an hourly basis from December 1, 2017, to February 27, 2018. The positive matrix factorization(PMF) method and the FLEXible PARTicle(FLEXPART) model were employed to identify the sources of PM_(2.5). The results showed that the average mass concentration of PM_(2.5) was 111 μg/m^(3) during the observation period. Among the major WSIs, sulfate, nitrate, and ammonium(SNA) constituted 62% of the total PM_(2.5) mass, and NO_(3)^(-) ranked the highest with an average contribution of 24.6%. NH_(4)^(+) was abundant in most cases in Jiaozuo. According to chemical balance analysis, SO_(2)-4, NO_(3)^(-), and Cl^(-) might be present in the form of(NH_4)_(2)SO_4, NH_4NO_3, NH_4Cl, and KCl. The liquid-phase oxidation of SO_(2) and NO_(2) was severe during the haze period. The relative humidity and pH were the key factors influencing SO_(4)^(2-) formation. We found that NO_(3)^(-) mainly stemmed from homogeneous gas-phase reactions in the daytime and originated from the hydrolysis of N_(2)O_5 in the nighttime, which was inconsistent with previous studies. The PMF model identified five sources of PM_(2.5) : secondary origin(37.8%), vehicular emissions(34.7%), biomass burning(11.5%), coal combustion(9.4%), and crustal dust(6.6%).

关键词： PM_(2.5) Chemical components Source identification

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Detection　of　Catecholic　Compounds　with　Field-ampilfied　CZE-Amperometry

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Chemical Research in Chinese Universities 1997年第3期13卷 221-228页

作者： HU Shen, PANG Dai-wen , HU yong-gang , CHENG jie-ke (Department of Chemistry, Wuhan University, Wuhan, 430072 )

On-column sample stacking technique has been used extensively in capillary zone electrophoresis (CZE) to enhance the sensitivity of the measurements with UV-Vis detection. However, the detection limits for CZE-separation are still limit- ed due to the poor sensitivity of a UV-Vis detector. We incorporated field-amplified sample stacking technique into CZE with amperometric detection. Compared with the conventional electromigration injection , a negative peak of water was observed and a great enhancement of signals was obtained. The results in phosphate buffer with sodium dodecyl sulfate (SDS ) and 2-N-(morpholino) ethane sulphonic acid ( MES ) buffer were compared. Subnanomolar concentration limits for cate- cholamine neurotransmitters (dopamine, norepinephrine , epinephriine) and isopro- terenol were achieved in the 25 um capillary with two or three orders of magnitude lower than those with amperometric detection reported previously.

关键词： Capillary zone electrophoresis Amperometric detection Stacking

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兖州煤田奥陶系灰岩地下水水化学特征及其形成机理

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地球学报 2017年第2期38卷 236-242页

作者：卞跃跃赵丹韩永中国地质博物馆北京100034 中国地质大学(北京) 北京100083 华北科技学院北京101601

鲁西南兖州煤田的奥陶系灰岩地下水对煤田深部煤炭开采具有潜在的水害威胁,且为研究区的主要供水水源之一,其水化学特征及形成机理分析,可为该区深部煤炭开采水害防治和地下水资源利用提供依据。经过目的层水样的采集与测试可知,地下水... 详细信息

鲁西南兖州煤田的奥陶系灰岩地下水对煤田深部煤炭开采具有潜在的水害威胁,且为研究区的主要供水水源之一,其水化学特征及形成机理分析,可为该区深部煤炭开采水害防治和地下水资源利用提供依据。经过目的层水样的采集与测试可知,地下水水化学类型以SO_4-Ca-Mg型为主,SO_4^(2-)含量为537~2 296 mg/L,Ca^(2+)和Mg^(2+)的平均含量分别为455.7 mg/L和116.6 mg/L,TDS的范围为961~3 555 mg/L,pH值为6.9~8.0。Ca^(2+)和SO_4^(2-)随TDS的增加而增加,呈良好线性关系,推断TDS的增加主要来自Ca^(2+)和SO_4^(2-)的贡献。由饱和指数(SI)可知,地下水中的白云石和方解石均处于过饱和状态,而绝大部分的水样的石膏饱和指数均小于0,处于不饱和状态。石膏的饱和指数与地下水中TDS呈正相关关系。这些结果表明,在该含水层中地下水运移过程中不断发生水岩相互作用,主要包括石膏溶解、白云石和方解石沉淀或溶解、离子交换等反应。

关键词：水化学特征饱和指数水岩相互作用灰岩含水层兖州煤田

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Clinical and Angiographic Predictors of Major Side Branch Occlusion after Main Vessel Stenting in Coronary Bifurcation Lesions

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Chinese Medical Journal 2015年第11期128卷 1471-1478页

作者： Dong Zhang Bo Xu Dong Yin Yi-Ping Li Yuan He Shi-jie You Shu-Bin Qiao yong-Jian Wu Hong-Bing Yan yue-Jin Yang Run-Lin Gao Ke-Fei Dou Department of Cardiology State Key Laboratory of Cardiovascular Disease Cardiovascular Institute Fuwai Hospital and National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background： Major side branch （SB） occlusion is one of the most serious complications during percutaneous coronary intervention （PCI） for bifurcation lesions. We aimed to characterize the incidence and predictors of major SB occlusion during coronary bifurcation intervention. Methods： We selected consecutive patients undergoing PCI （using one stent or provisional two stent strategy） for bifurcation lesions with major SB. All clinical characteristics, coronary angiography findings, PCI procedural factors and quantitative coronary angiographic analysis data were collected. Multivariate logistic regression analysis was performed to identify independent predictors of SB occlusion. SB occlusion after main vessel （MV） stenting was defined as no blood flow or any thrombolysis in myocardial infarction （TIMI） flow grade decrease in SB after MV stenting. Results： Among all 652 bifurcation lesions, 32 （4.91%） SBs occluded. No blood flow occurred in 18 lesions and TIMI flow grade decreasing occurred in 14 lesions. In multivariate analysis, diameter ratio between MV/SB （odds ratio [OR]： 7.71,95% confidence interval [C/]： 1.53-38.85, P = 0.01）, bifurcation angle （OR： 1.03, 95% CI： 1.02-1.05, P 〈 0.01）, diameter stenosis of SB before MV stenting （OR： 1.05, 95% CI： 1.03-1.07, P〈 0.01）, TIMI flow grade of SB before MV stenting （OR： 3.59, 95% CI： 1.48-8.72, P〈 0.01） and left ventricular eject fraction （LVEF）（OR： 1.06, 95% Cl： 1.02-1.11, P 〈 0.01） were independent predictors of SB occlusion. Conclusions： Among clinical and angiographic findings, diameter ratio between MV/SB, bifurcation angle, diameter stenosis of SB before MV stenting, TIMI flow grade of SB before MV stenting and LVEF were predictive of major SB occlusion after MV stenting.

关键词： Coronary Bifurcation Lesions Major Side Branch Occlusion Percutaneous Coronary Intervention

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