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An Appreciation for the Rabbit Ladderlike Modeling of Radiation-induced Lung Injury with High-energy X-Ray

Chinese Medical Journal 2015年第12期128卷 1636-1642页

作者： Xiang-Ming Fang Chun-Hong Hu Xiao-Yun Hu xuan-jun yao Ping-Yan Qian Ju-Ying Zhou Jian Guo Alexander Lerner Imaging Center The First Affiliated Hospital of Soochow University Jiangsu 215006 China Imaging Center Wuxi People's Hospital Affiliated to Nanjing Medical University Jiangsu 214023 China Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Suzhou Jiangsu 215123 China Radiotherapy Center The First Affiliated Hospital of Soochow University Jiangsu 215006 China Department of Radiology LAC+USC Medical Center University of Southern California Los Angeles CA USA

Background：To evaluate the utility of rabbit ladderlike model of radiation-induced lung injury （RILI） for the future investigation of computed tomography ***：A total of 72 New Zealand rabbits were randomly divided into two groups：36 rabbits in the test group were administered 25 Gy of single fractionated radiation to the whole lung of unilateral lung;36 rabbits in the control group were *** rabbits were subsequently sacrificed at 1,6,12,24,48,72 h,and 1,2,4,8,1 6,24 weeks after radiation,and then six specimens were extracted from the upper,middle and lower fields of the bilateral *** pathological changes in these specimens were observed with light and electron microscopy;the expression of tumor necrosis factor-α （TNF-a） and transforming growth factor-βl （TGF-β1） in local lung tissue was detected by ***：（1） Radiation-induced lung injury occurred in all rabbits in the test group.（2） Expression of TNF-a and TGF-β1 at 1 h and 48 h after radiation,demonstrated a statistically significant difference between the test and control groups （each P 〈 0.05）.（3） Evaluation by light microscopy demonstrated statistically significant differences between the two groups in the following parameters （each P 〈 0.05）：thickness of alveolar wall,density of pulmonary interstitium area （1 h after radiation）,number offibroblasts and fibrocytes in interstitium （24 h after radiation）.The test group metrics also correlated well with the time ofpostradiation.（4） Evaluation by electron microscopy demonstrated statistically significant differences in the relative amounts of collagen fibers at various time points postradiation in the test group （P 〈 0.005）,with no significant differences in the control group （P 〉 0.05）.At greater than 48 h postradiation the relative amount of collagen fibers in the test groups significantly differ from the control groups （each P 〈 0.05）,correlating well with the time postradiation （r =0.99318）.Conclusions：A c

关键词： Radiation-induced Lung Injury Radiation-induced Fibrosis Radiation Therapy Rabbit Model

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Effects of ultrasonic-assisted extraction on bioactive compounds,volatile flavors and antioxidant activities of vine tea water extracts

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Traditional Medicine Research 2025年第1期10卷 73-81页

作者： Xiao-Long Zhou Wei-Jin Jiang Ji Yu Mao-jun yao Yun-Tong Li Hunan Provincial Key Laboratory of Research Resource Mining and High-valued Utilization on Edible&Medicinal PlantCollege of Chemistry and Chemical EngineeringJishou UniversityJishou 416000China Hunan Gaoge Dairy Co. Ltd.Changsha 410000China

Background:Ampelopsis grossedentata,vine tea,which is the tea alternative beverages in *** vine tea processing,a large amount of broken tea is produced,which has low commercial ***:This study investigates the influence of different extraction methods(room temperature water extraction,boiling water extraction,ultrasonic-assisted room temperature water extraction,and ultrasonic-assisted boiling water extraction,referred to as room temperature water extraction(RE),boiling water extraction(BE),ultrasonic assistance at room temperature water extraction(URE),and ultrasonic assistance in boiling water extraction(UBE))on the yield,dihydromyricetin(DMY)content,free amino acid composition,volatile aroma components,and antioxidant properties of vine tea ***:A notable influence of extraction temperature on the yield of vine tea extracts(P<0.05),with BE yielding the highest at 43.13±0.26%,higher than that of RE(34.29±0.81%).Ultrasound-assisted extraction significantly increased the DMY content of the extracts(P<0.05),whereas DMY content in the RE extracts was 59.94±1.70%,that of URE reached 66.14±2.78%.Analysis revealed 17 amino acids,with L-serine and aspartic acid being the most abundant in the extracts,nevertheless ultrasound-assisted extraction reduced total free amino acid *** chromatography-mass spectrometry analysis demonstrated an increase in the diversity and quantity of compounds in the vine tea water extracts obtained through ultrasonic-assisted ***,69 and 68 volatile compounds were found in URE and UBE extracts,which were higher than the number found in RE and BE *** vitro,antioxidant activity assessments revealed varying antioxidant capacities among different extraction methods,with RE exhibiting the highest DPPH scavenging rate,URE leading in ABTS•+free radical scavenging,and BE demonstrating superior ferric ion reducing antioxidant ***:The findings suggest that extraction methods signi

关键词： vine tea dihydromyricetin ultrasonic-assisted extraction volatile aroma components

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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肠道菌群体外酵解不同种类单糖研究

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陕西科技大学学报 2025年第1期43卷 35-45页

作者：郝俊宇孙玉姣高润凝姚佳轩陕西科技大学食品科学与工程学院陕西西安710021 陕西农产品加工技术研究院陕西西安710021

碳水化合物的结构特征影响着其被微生物的利用效果,为了探究其结构对肠道菌群的影响,本文从单糖组成角度入手,研究了以葡萄糖、甘露糖、阿拉伯糖、半乳糖、岩藻糖、木糖、鼠李糖、葡萄糖醛酸和半乳糖醛酸这九种单糖作为碳源,在进行体外... 详细信息

碳水化合物的结构特征影响着其被微生物的利用效果,为了探究其结构对肠道菌群的影响,本文从单糖组成角度入手,研究了以葡萄糖、甘露糖、阿拉伯糖、半乳糖、岩藻糖、木糖、鼠李糖、葡萄糖醛酸和半乳糖醛酸这九种单糖作为碳源,在进行体外培养的过程中,肠道菌群及其代谢产物发生的变化.主要检测了OD_(600)、糖消耗量、短链脂肪酸和乳酸含量等指标.经过筛选后,对七种中性单糖混合发酵的培养基进行了单糖组成分析,明确了七种中性单糖在酵解过程中的被利用顺序.以16S rRNA高通量测序分析了肠道菌群群落多样性和丰度变化,发现不同单糖在被乳酸杆菌等有益菌利用的过程中存在竞争关系,甘露糖和半乳糖有利于肠道中的乳酸杆菌属等有益菌的生长繁殖,研究结果将为多糖与肠道菌群的构效关系研究提供了理论依据.

关键词：单糖组成体外酵解短链脂肪酸肠道菌群多样性分析

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Emerging progress: photochemical transformation of nitroso compounds

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Science China Chemistry 2025年第1期 118-133页

作者： Ze-Le Chen Qiang-Qiang Li Armido Studer jun xuan Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials School of Chemistry & Chemical Engineering Anhui University Organisch-Chemisches Institut Universitat Münster

Nitroso compounds have emerged as highly valuable reaction partners or reagents in organic synthesis due to their rich *** versatile profile of these compounds allows them to function as electrophiles, nucleophiles, diradicals, and radical acceptors in diverse transformations. In recent years, notable progress has been made in harnessing photochemical reactions with nitroso compounds to prepare N,O-containing structures using mild and eco-friendly conditions. Various nitroso compounds like nitrosoarenes, acyloxy nitroso compounds, N-nitrosoamines and nitrites have received significant attention for their ability to introduce NO moieties into complex molecules that are otherwise difficult to access. In this review, we provide an overview of the recent advancements in the visible light-induced conversion of nitroso compounds, with particular emphasis on their role as bifunctional reagents and acceptors of radicals, carbenes and nitrenes.

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Effect of inclusion size on the high cycle fatigue strength and failure mode of a high V alloyed powder metallurgy tool steel

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International Journal of Minerals,Metallurgy and Materials 2012年第7期19卷 608-614页

作者： jun yao xuan-hui Qu Xin-bo He Lin Zhang State Key Laboratory for Advanced Metals and Materials School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083China

The fatigue strength of a high V alloyed powder metallurgy tool steel with two different inclusion size levels, tempered at different temperatures, was investigated by a series of high cycle fatigue tests. It was shown that brittle inclusions with large sizes above 30μm prompted the occurrence of subsurface crack initiation and the reduction in fatigue strength. The fracture toughness and the stress amplitude both exerted a significant influence on the fish-eye size. A larger fish-eye area would form in the sample with a higher fracture toughness subjected to a lower stress amplitude. The stress intensity factor of the inclusion was found to lie above a typical value of the threshold stress intensity factor of 4 MPa.m^1/2. The fracture toughness of the sample with a hardness above HRC 56 could be estimated by the mean value of the stress intensity factor of the fish-eye. According to fractographic evaluation, the critical inclusion size can be calculated by linear fracture mechanics.

关键词： powder metallurgy tool steel fatigue of materials strength of materials failure modes inclusions fractography

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Precipitation Type Estimation and Validation in China

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Journal of Mountain Science 2014年第4期11卷 917-925页

作者： CHEN Ren-sheng LIU jun-feng SONG yao-xuan Qilian Alpine Ecology & Hydrology Research Station Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Key Laboratory of Inland River Ecohydrology Chinese Academy of Sciences

The results from three methods aimed at improving precipitation type （e.g., rain, sleet, and snow） estimation are presented and compared in this paper. The methods include the threshold air temperature （AT）, threshold wet bulb temperature （WBT） and Koistinen and Saltikoff （KSS） methods. Dot graphs are plotted to acquire the threshold air temperature or the threshold wet bulb temperature using daily averaged air temperature, wet bulb temperature and precipitation data at 643 stations from 1961 to 1979 （precipitation types are not labeled in the database from 1980 to present） in China. The results indicate that the threshold AT or WBT methods are not able to differentiate rain, sleet and snow in the most regions in China; sleet is difficult to differentiate from other precipitation types based on the two threshold methods. Therefore, one threshold AT and WBT method was used in this study to differentiate rain and snow. Based on Gaussian- Kriging interpolation of threshold air temperature （To） and wet bulb temperature （Tw）, the To and Tw contour lines and contour surfaces are calculated for China. Finally, a comparison between the KSS, AT and WBT methods are provided in which the KSS method is calculated based on air temperature and relative humidity. The results suggest that the KSS method is more appropriate for water phase estimation than are the other methods; the maximum precision for rain and snow is 99% and 94%, respectively. The AT method performs better than the WBT method when the critical air temperature is 2℃.

关键词： Threshold temperature Wet bulbtemperature Precipitation type Hydrologicalprocesses

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SimWall:a practical user-friendly stereo tiled display wall system

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第4期8卷 596-604页

作者： XIE Li-jun ZHENG yao YANG Ting-jun GAO Wen-xuan PAN Ning-he School of Computer Science and Center for Engineering and Scientific Computation Zhejiang University Hangzhou 310027 China

SimWall is a user-friendly, stereo tiled display wall system composed of 18 commodity projectors operated by a Linux graphics cluster. Collaborating together, these projectors work as a single logical display capable of giving a high-resolution show, large-scale, and passive stereo scene. In order to avoid tedious system setup and maintenance, software-based automatic geometry and photometric calibration are used. The software calibration is integrated to the system seamlessly by an on-card transform method and is transparent to users. To end-users, SimWall works just as a common PC, but provides super computing, rendering and displaying ability. In addition, SimWall has stereoscopic function that gives users a semi-immersive experience in polarized passive way. This paper presents system architecture, implementation, and other technical issues such as hardware constraints, projectors alignment, geometry and photometric calibration, implementation of passive stereo, and development of overall soft- ware environment.

关键词： Tiled display wall Stereoscopic display Multi-projectors display Parallel rendering Camera-based geometry and photometric calibration

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Learning a hierarchical image manifold for Web image classification

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第10期13卷 719-735页

作者： Rong ZHU Min yao Li-hua YE jun-ying xuan School of Information Engineering Jiaxing UniversityJiaxing 314001China School of Computer Science and Technology Zhejiang UniversityHangzhou 310027China

Image classification is an essential task in content-based image ***,due to the semantic gap between low-level visual features and high-level semantic concepts,and the diversification of Web images,the performance of traditional classification approaches is far from users' *** an attempt to reduce the semantic gap and satisfy the urgent requirements for dimensionality reduction,high-quality retrieval results,and batch-based processing,we propose a hierarchical image manifold with novel distance measures for *** that the images in an image set describe the same or similar object but have various scenes,we formulate two kinds of manifolds,object manifold and scene manifold,at different levels of semantic *** manifold is developed for object-level classification using an algorithm named extended locally linear embedding(ELLE) based on intra-and inter-object difference *** manifold is built for scene-level classification using an algorithm named locally linear submanifold extraction(LLSE) by combining linear perturbation and region *** results show that our method is effective in improving the performance of classifying Web images.

关键词： Web image classification Manifold learning Image manifold Semantic granularity Distance measure

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基于多分支增强和融合注意力机制的水下图像增强算法

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陕西科技大学学报 2025年第1期43卷 193-202页

作者：姚斌韩典芝徐轩李婉陕西科技大学电子信息与人工智能学院陕西西安710021

由于水对光的折射和吸收,水下图像通常会出现严重的退化,如色偏、模糊、能见度低等.为了提高水下图像的可视性,提出了一种基于多分支增强和融合注意力机制的水下图像增强网络MBFA-GAN.首先,通过分析水下图像的色彩退化和模糊因素,设计... 详细信息

由于水对光的折射和吸收,水下图像通常会出现严重的退化,如色偏、模糊、能见度低等.为了提高水下图像的可视性,提出了一种基于多分支增强和融合注意力机制的水下图像增强网络MBFA-GAN.首先,通过分析水下图像的色彩退化和模糊因素,设计了青品色温修复模块和模糊恢复模块对水下图像进行色彩矫正和模糊恢复.然后,基于对多个分支特征的互补性考虑,采用循环合并策略将多个分支增强的特征利用自适应融合模块进行融合,逐步增强图像细节.最后,设计了融合注意力模块,用于深度挖掘图像在通道维度和像素维度的相关性矩阵,以提高增强图像的真实性.实验结果表明,与现有算法相比,提出的水下图像增强算法去模糊效果较好且颜色更真实,可以有效改善水下图像色偏和模糊的问题.

关键词：水下图像增强多分支增强融合注意力生成对抗网络

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