An Appreciation for the Rabbit Ladderlike Modeling of Radiation-induced Lung Injury with High-energy X-Ray
An Appreciation for the Rabbit Ladderlike Modeling of Radiation-induced Lung Injury with High-energy X-Ray作者机构：Imaging Center The First Affiliated Hospital of Soochow University Jiangsu 215006 China Imaging Center Wuxi People's Hospital Affiliated to Nanjing Medical University Jiangsu 214023 China Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Suzhou Jiangsu 215123 China Radiotherapy Center The First Affiliated Hospital of Soochow University Jiangsu 215006 China Department of Radiology LAC+USC Medical Center University of Southern California Los Angeles CA USA
出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)
年 卷 期：2015年第128卷第12期
页 面：1636-1642页
核心收录：
学科分类：083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 07[理学] 0905[农学-畜牧学] 08[工学] 09[农学] 0903[农学-农业资源与环境] 0713[理学-生态学]
基 金：This work was supported by the National Natural Science Foundation of China (NSFC) grants (Youth Fund No. 81101043 ) Jiangsu Province Natural Science Foundation (No. BK2011178) the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD 2011-0318) and Key Project of Nanjing Medical University Technology Development Fund (No. 2008NMUZ051)
主 题：Radiation-induced Lung Injury Radiation-induced Fibrosis Radiation Therapy Rabbit Model
摘 要：Background：To evaluate the utility of rabbit ladderlike model of radiation-induced lung injury （RILI） for the future investigation of computed tomography ***：A total of 72 New Zealand rabbits were randomly divided into two groups：36 rabbits in the test group were administered 25 Gy of single fractionated radiation to the whole lung of unilateral lung;36 rabbits in the control group were *** rabbits were subsequently sacrificed at 1,6,12,24,48,72 h,and 1,2,4,8,1 6,24 weeks after radiation,and then six specimens were extracted from the upper,middle and lower fields of the bilateral *** pathological changes in these specimens were observed with light and electron microscopy;the expression of tumor necrosis factor-α （TNF-a） and transforming growth factor-βl （TGF-β1） in local lung tissue was detected by ***：（1） Radiation-induced lung injury occurred in all rabbits in the test group.（2） Expression of TNF-a and TGF-β1 at 1 h and 48 h after radiation,demonstrated a statistically significant difference between the test and control groups （each P 〈 0.05）.（3） Evaluation by light microscopy demonstrated statistically significant differences between the two groups in the following parameters （each P 〈 0.05）：thickness of alveolar wall,density of pulmonary interstitium area （1 h after radiation）,number offibroblasts and fibrocytes in interstitium （24 h after radiation）.The test group metrics also correlated well with the time ofpostradiation.（4） Evaluation by electron microscopy demonstrated statistically significant differences in the relative amounts of collagen fibers at various time points postradiation in the test group （P 〈 0.005）,with no significant differences in the control group （P 〉 0.05）.At greater than 48 h postradiation the relative amount of collagen fibers in the test groups significantly differ from the control groups （each P 〈 0.05）,correlating well with the time postradiation （r =0.99318）.Conclusions：A c
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