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Radical Operation and Everolimus Therapy for Rectal Neuroendocrine Tumor with Liver Metastases: A Case Report with Review of the Literature

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Case Reports in Clinical Medicine 2020年第9期9卷 275-281页

作者： Jiaqi Xu Yujie Cui xinfeng huang Yongbo Meng Jian Xin Yong Cheng Burn and Plastic Surgery The Fifth Affiliated Hospital Sun Yat-sen University Zhuhai China Rheumatology The Fifth Affiliated Hospital Sun Yat-sen University Zhuhai China

Neuroendocrine tumors (NETs) are often misdiagnosed because they can involve any part of the body and have non-specific symptoms. Here, we report a case of a 39-year-old man with rectal neuroendocrine tumor (RNET) and hepatic metastases treated with a combination of radical surgery and Everolimus therapy. The patient complained of abdominal distension, pain, and constipation of one month duration. Enhanced CT scan of the abdomen, colonoscopy and Biopsy findings confirmed the diagnosis of rectal neuroendocrine tumor. As the anatomical structures were clear and the masses seemed to be resectable, we decided to initiate treatment with radical operation and Everolimus therapy. The patient has responded well to the treatment with no evidence of recurrence after 4 years of follow-up. This case is interesting because of the rarity of this neoplasm and its initial misdiagnosis as a giant hepatic carcinoma (hepatoma). It also demonstrates that a combination of curative surgical resection and Everolimus is a good option in a patient with large colorectal neuroendocrine tumors and massive hepatic metastases.

关键词： Rectal Neuroendocrine Tumor Liver Metastases Everolimus Radical Operation

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中国教育智慧的跨文化传播

上海师范大学学报（哲学社会科学版） 2022年第6期51卷 114-122页

作者：黄兴丰张民选上海师范大学国际与比较教育研究院上海200234

中国教育智慧是中国教育智慧圈集体智慧的结晶,是中国社会历史文化发展的产物,多元立体,具有鲜明的时代特征,表现在文化传统、教育理念、政策规划、课程设计、方法原则、课堂实践六个层面。中国教育智慧的跨文化传播在本质上说,是跨文... 详细信息

中国教育智慧是中国教育智慧圈集体智慧的结晶,是中国社会历史文化发展的产物,多元立体,具有鲜明的时代特征,表现在文化传统、教育理念、政策规划、课程设计、方法原则、课堂实践六个层面。中国教育智慧的跨文化传播在本质上说,是跨文化实践共同体中不同群体通过对话实现认知、说服、采纳和实施四个阶段的传播过程。其中,边界对象是实现跨文化实践共同体中不同群体跨界的重要载体。课堂作为具体的边界对象,可以有效地促进跨文化实践共同体成员的身份认同、协调、反思和改变四种学习机制的发生、发展,进而在不同群体之间生成抽象的边界对象,即共享的中国教育智慧,实现跨文化传播的目的。事实上,跨文化传播是双向的,跨界过程中的矛盾也成为中国教师专业发展的动力。在当下特殊国际环境中,要坚持教育自信,充分利用网络建立跨文化实践共同体,开发国际化的教育公共产品,对外传播中国教育智慧。

关键词：中国教育智慧跨文化实践共同体跨文化传播跨界学习

Identification of Potential Serum Biomarkers for Occupational Medicamentosa-like Dermatitis Induced by Trichloroethylene using ClinProt Technique-based High-Performance Liquid Chromatography Tandem Mass Spectrometry

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Identification of Potential Serum Biomarkers for Occupationa...

2012深圳市预防医学会学术研讨会

作者： Jianjun Liu Wei Liu Wen-Xu Hong Yanfang Zhang Xifei Yang Xiaohu Ren Jinbo Ye Haiyan huang Haiyan Tang Peiwu huang xinfeng huang Zhixiong Zhuang Key Laboratory of Modern Toxicology of Shenzhen Medical Key Laboratory of Guangdong ProvinceMedical Key Laboratory of Health Toxicology of ShenzhenShenzhen Center for Disease Control and Prevention Clinical Testing Department of Shenzhen Hospital for Occupational Disease Treatment and Prevention

Background-Occupational medicamentosa-like dermatitis induced by trichloroethylene(OMLDT) is an autoimmune disease and it has become a serious occupational health *** aim of this study was to develop potential serum biomarkers for OMLDT using a fast and efficient method of high-performance liquid chromatography(HPLC) coupled to MALDI-TOF/TOF-MS. Methods-We collected fasting blood samples from patients with OMLDT(n = 18) and healthy volunteers(n = 33) to explore serum peptidome *** proteins were purified with magnetic bead-based weak cation exchange chromatography and analyzed with *** and supervised neural network(SNN) algorithms were used on the training and testing data sets to establish classification *** protein/peptide peaks were identified by high mass accuracy measurements combined with top-down tandem mass spectrometry. Results-Thirty protein/peptide peaks were significantly different between the two groups and were selected as potential biomarkers of OMLDT *** SNN algorithm utilized three peaks(m/z 2106.3,2134.5,and 3263.67 Da) to separate the OMLDT patients from the healthy controls,with a cross validation of 94.44%and a recognition capability of 100%.The test sensitivity was 95.5%,and the test specificity was 73.8%.HPLC-TOF/TOF-MS identified two proteins that may play a role in the pathology of OMLDT:ATP-binding cassette transporter,and a fragment of albumin. Conclusion-Specific proteomic fingerprints in the sera of OMLDT patients could be used to identify OMLDT cases with high specificity and *** HPLC-TOF/TOF-MS approach will be of great value for exploring potential biomarkers and clinical studies of OMLDT.

关键词： occupational medicamentosa-like dermatitis induced by trichloroethylene(OMLDT) ClinProTools(CPT) high-performance liquid chromatography(HPLC) MALDI-TOF-MS biomarkers

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人文素质教育在高中英语教学中的渗透与应用

科教导刊 2016年第12X期 131-132页

作者：黄欣凤江苏省响水中学江苏盐城224600

随着新课程改革的不断深入,高中教育教学越来越重视素质教育,在高中英语教学中渗透人文素质教育,是新课程改革和实行全面素质教育的要求,也是英语教育发展的必然趋势。针对高中英语教学现状,如何在其中更好地培养学生的人文素质,已逐渐... 详细信息

随着新课程改革的不断深入,高中教育教学越来越重视素质教育,在高中英语教学中渗透人文素质教育,是新课程改革和实行全面素质教育的要求,也是英语教育发展的必然趋势。针对高中英语教学现状,如何在其中更好地培养学生的人文素质,已逐渐成为当代英语教育工作者的重点关注内容之一。结合高中英语实际教学,提出了渗透人文素质教育的相关建议,以期有一定的参考和借鉴价值。

关键词：人文素质教育高中英语教学

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存量生活垃圾填埋场治理工程应用研究

工程质量 2023年第5期41卷 95-98页

作者：黄鑫峰北京建材地质工程有限公司北京100020

存量垃圾场多为城市历史遗留难题,其治理已日益引起重视。论文以文昌市青山岭垃圾堆场治理工程为例,介绍了该存量生活垃圾填埋场概况,分析了垃圾场的污染现状,最后总结了治理工程应对各类污染源的具体方法和措施。

关键词：存量垃圾场污染治理

利用乳酸乳球菌AcmA表面展示β-1,3-1,4-葡聚糖酶

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生物工程学报 2009年第1期25卷 89-94页

作者：李小华黄新凤邵小虎李林华中农业大学农业微生物学国家重点实验室武汉430070

采用PCR扩增乳酸乳球菌(Lactococcus lactis)MB191菌株的全长肽聚糖水解酶基因acmA,通过C-末端融合构建了与绿色荧光基因gfp的融合基因acmA-gfp,再连接于表达载体pMG36k上后得到可组成型表达AcmA-GFP融合蛋白的重组质粒pMB137,然后将该... 详细信息

采用PCR扩增乳酸乳球菌(Lactococcus lactis)MB191菌株的全长肽聚糖水解酶基因acmA,通过C-末端融合构建了与绿色荧光基因gfp的融合基因acmA-gfp,再连接于表达载体pMG36k上后得到可组成型表达AcmA-GFP融合蛋白的重组质粒pMB137,然后将该质粒电转化导入到乳酸乳球菌AS1.2829中获得重组菌MB137。经SDS-PAGE检测,重组菌MB137可表达预期的分子量约74kD的蛋白质。Western blotting、细胞分级分离组分的荧光活性测定和特异GFP二抗标记的流式细胞仪检测证实GFP被成功锚定在重组菌细胞表面,被锚定蛋白约占总表达融合蛋白的35%。进一步通过从枯草芽胞杆菌BF7658基因组中扩增去信号肽序列的β-1,3-1,4葡聚糖酶基因gls,来取代pMB137中的gfp,得到携带融合基因acmA-gls的重组质粒pMB138,经导入到乳酸乳球菌AS1.2829后得到重组菌MB138,其全细胞β-1,3-1,4-葡聚糖水解酶的活性约为12U/mL菌液,明显高于对照菌株。

关键词：细胞表面展示 N-乙酰胞壁质酶葡聚糖酶全细胞催化剂

Nrf2 protects against oxidative stress induced by SiO2 nanoparticles

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Nrf2 protects against oxidative stress induced by SiO2 nanop...

Lentivirus-mediated silencing of I2PP2A through RNA interference attenuates trichloroethylene-induced cytotoxicity in human hepatic L-02 cells

2017环境与公共健康学术会议暨中国环境科学学会环境医学与健康分会、中国毒理学会生化与分子毒理专业委员会2017年年会

作者： Wei Liu Tao Hu Li Zhou Maggie Pui Man Hoi Desheng Wu xinfeng huang Xiaohu Ren Jianjun Liu Key Laboratory of Modern Toxicology of Shenzhen Shenzhen Center for Disease Control and Prevention State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of Macau

Objective:The aim of this study was to investigate the role of nuclear factor erythroid2-related factor 2(Nrf2) in response to oxidative stress exposure to silica nanoparticles(SiO NPs).Methods:The toxicity of SiO NPs-induced oxidative stress,and the activation of Nrf2/ARE signaling pathway were investigated in A549 cells in vitro and mouse model in ***:Exposure to SiO NPs induced significant cytotoxicity in A549 and A549-shNrf2 cells(A549 cells expressing Nrf2 shRNA),and induced activation of the Nrf2/ARE signaling *** Nrf2(-/-)mice,exposure to SiONPs increased the levels of ROS and 8-hydroxy-2’-deoxyguanosine(8-OHdG),and decreased total antioxidant capacity(T-AOC).The disruption of Nrf2/ARE signaling pathway in Nrf2(-/-) mice led to reduced expression of heme oxygenase-1(HO-1) and up-regulation of ***:The Nrf2/ARE pathway might be involved in defending mild to moderate SiO NPs-induced oxidative stress,and Nrf2 could protect against oxidative stress induced by SiONPs.

关键词： Nrf2/ARE signaling pathway silica nanoparticles Nrf2(-/-) mice oxidative stress HO-1

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Lentivirus-mediated silencing of I2PP2A through RNA interfer...

基于大数据的房地产项目全景画像构建思路与实践

2012深圳市预防医学会学术研讨会

作者： Xifei Yang Yingzhi Jiang Jie Li Wen-xu Hong Desheng Wu xinfeng huang Haiyan huang Li Zhou Lingqing Yang Jianhui Yuan Zhixiong Zhuang Jianjun Liu Key Laboratory of Modern Toxicology of Shenzhen Medical Key Laboratory of Health ToxicologyShenzhen Center for Disease Control and Prevention

Trichloroethylene(TCE) is a common chemical pollutant that exists in air,soil,and drinking *** exposure is known to cause severe hepatotoxicity,however,the mechanisms underlying TCE hepatotoxicity remain poorly *** a previous proteomics study,we found that TCE exposure up-regulated the expression of the inhibitor 2 of protein phosphatase 2A(12PP2A),a potent and specific endogenous inhibitor of protein phosphatase(PP) 2A,in human hepatic L-02 ***,we employed lentivirusmediated RNA interference(RNAi) to knock down 12PP2A expression in L-02 ceils and explored the potential role of 12PP2A in TCE-induced *** found that TCE treatment of L-02 cells causes decreased cell viability,increased apoptosis and elevated 12PP2A mRNA and protein ***-treated L-02 ceils were also found to have significantly reduced PP2A ***-mediated 12PP2A knockdown partially prevented the decrease in viability and increased apoptosis induced by TCE treatment. Knockdown of 12PP2A in TCE-treated L-02 cells also suppressed the inhibition of PP2A activity and prevented caspase-3 *** data for the first time demonstrate that the up-regulation of 12PP2A could mediate,at least in part,TCE-induced liver cell toxicity through the inhibition of PP2A activity and caspase-3-mediated pathway,and suggest that I2PP2A may play a crucial role in mediating TCE hepatotoxicity.

关键词： 12PP2A Protein phosphatase(PP) 2A Trichloroethylene(TCE) siRNA

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信息与电脑 2022年第9期34卷 25-27页

作者：黄新锋广州中软信息技术有限公司广东广州510665

随着城市建设及房地产业的快速发展,房地产业和建筑业的税收收入大幅增长,已成为地方税收收入的重要来源。房地产税收管理贯穿房地产开发全过程,涉及环节众多且环节之间的联系密切,涉及的税种广且税种信息之间互为依据,各类税费需要规... 详细信息

随着城市建设及房地产业的快速发展,房地产业和建筑业的税收收入大幅增长,已成为地方税收收入的重要来源。房地产税收管理贯穿房地产开发全过程,涉及环节众多且环节之间的联系密切,涉及的税种广且税种信息之间互为依据,各类税费需要规范管理。通过汇聚各方数据,以房地产开发企业为管理核心,以增值税预缴申报、发票信息为抓手,打通土地取得、房地产开发、房地产交易、保有和清算环节的全流程管理链条,可有效化解因建筑服务、房地产管理信息不对称产生的税收管理风险,促进多税种协同共治,实现从土地取得、材料供应、建筑施工到不动产销售的多环节联动管理。笔者结合房地产项目的特点,运用大数据及相关技术重点分析房地产项目所涉及的各方数据关系并建立房地产项目的关联关系,构建房地产项目全景画像,打造房地产项目全流程一体化台账。

关键词：大数据房地产项目全流程管理链条全景画像