Radical Operation and Everolimus Therapy for Rectal Neuroendocrine Tumor with Liver Metastases: A Case Report with Review of the Literature

作     者：Jiaqi Xu Yujie Cui Xinfeng Huang Yongbo Meng Jian Xin Yong Cheng Jiaqi Xu;Yujie Cui;Xinfeng Huang;Yongbo Meng;Jian Xin;Yong Cheng

作者机构：Burn and Plastic Surgery The Fifth Affiliated Hospital Sun Yat-sen University Zhuhai China Rheumatology The Fifth Affiliated Hospital Sun Yat-sen University Zhuhai China 

出 版 物：《Case Reports in Clinical Medicine》 (临床医学病理报告（英文）)

年 卷 期：2020年第9卷第9期

页      面：275-281页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Rectal Neuroendocrine Tumor Liver Metastases Everolimus Radical Operation 

摘      要：Neuroendocrine tumors (NETs) are often misdiagnosed because they can involve any part of the body and have non-specific symptoms. Here, we report a case of a 39-year-old man with rectal neuroendocrine tumor (RNET) and hepatic metastases treated with a combination of radical surgery and Everolimus therapy. The patient complained of abdominal distension, pain, and constipation of one month duration. Enhanced CT scan of the abdomen, colonoscopy and Biopsy findings confirmed the diagnosis of rectal neuroendocrine tumor. As the anatomical structures were clear and the masses seemed to be resectable, we decided to initiate treatment with radical operation and Everolimus therapy. The patient has responded well to the treatment with no evidence of recurrence after 4 years of follow-up. This case is interesting because of the rarity of this neoplasm and its initial misdiagnosis as a giant hepatic carcinoma (hepatoma). It also demonstrates that a combination of curative surgical resection and Everolimus is a good option in a patient with large colorectal neuroendocrine tumors and massive hepatic metastases.