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Aberrant DNA methylation in cloned ovine embryos

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Chinese Science Bulletin 2008年第3期53卷 477-480页

作者： LIU Lei HOU Jian LEI TingHua BAI JiaHua GUAN hong AN xiaorong State Key Laboratories for Agrobiotechnology China Agricultural University Beijing 100094 China

By using the approach of immunofluorescence staining with an antibody against 5-methylcytosine(5MeC),the present study detected the DNA methylation patterns of cloned ovine *** em-bryos derived from in vitro fertilization were also examined for reference *** results showed that:(1)during the pre-implantation development,cloned embryos displayed a similar demethylation profile to the fertilized embryos;that is,the methylation level decreased to the lowest at 8-cell stage,and then increased again at morulae ***,methylation level was obviously higher in cloned embryos than in stage-matched fertilized embryos,especially at 8-cell stage and afterwards;(2)at blastocyst stage,the methylation pattern in cloned embryos was different from that in fertilized *** cloned blastocyst,inner cell mass(ICM)exhibited a comparable level to trophectoderm cells(TE),while in in-vitro fertilized blastocyst the methylation level of ICM was lower than that of TE,which is not consistent with that reported by other *** results indicate that DNA methylation is abnormally reprogrammed in cloned embryos,implying that aberrant DNA methylation reprogramming may be one of the factors causing cloned embryos developmental failure.

关键词：绵羊晶胚 DNA甲基化基因克隆 5-甲基胞核嘧啶

Interface engineering of 2D NiFe LDH/NiFeS heterostructure for highly efficient 5-hydroxymethylfurfural electrooxidation

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Chinese Chemical Letters 2024年第9期35卷 514-520页

作者： Lili Wang Ya Yan Rulin Li Xujie Han Jiahui Li Ting Ran Jialu Li Baichuan Xiong xiaorong Song Zhaohui Yin hong Wang Qingjun Zhu Bowen Cheng Zhen Yin State Key Laboratory of Separation Membranes and Membrane Processes School of ChemistryTiangong UniversityTianjin 300387China School of Chemical Engineering and Technology Tiangong UniversityTianjin 300387China College of Chemical Engineering and Materials Science Tianjin University of Science and TechnologyTianjin 300457China State Key Laboratory of Biobased Fiber Manufacturing Technology Tianjin University of Science and TechnologyTianjin 300457China School of Materials Science and Engineering Tiangong UniversityTianjin 300387China Deutsches Elektronen-Synchrotron DESY Platanenallee 6Zeuthen 15738Germany Department of Chemistry and The Center for the Science of Materials Berlin Humboldt-Universitäzu BerlinBerlin 12489Germany

The electrochemical oxidation of 5-hydroxymethylfurfural(HMF)to valuable chemicals is an efficient way to upgrade biomass molecules and replace traditional catalytic *** is crucial to develop efficient and low-cost earth-abundant electrocatalysts to enhance catalytic performance of HMF ***,a new type of two-dimensional(2D)hybrid arrays consisting of Ni Fe layered double hydroxides(LDH)nanosheets and bimetallic sulfide(Ni Fe S)is constructed via interface engineering for efficient electrocatalytic oxidation of HMF to 2,5-furandicarboxylic acid(FDCA).The preparation process of 2D Ni Fe LDH/NiFeS with ultrathin heterostructure involves in anchoring a Co-based metal-organic framework(Co MOF)as template onto the carbon cloth(CC)via in-situ growth,formation of NiFe LDH on the surface of Co MOF and subsequent partial *** electrocatalyst of Ni Fe LDH/Ni Fe S exhibits outstanding performance towards HMF oxidation,about 98.5%yield for FDCA and 97.2%Faraday efficiency(FE)in the alkaline electrolyte with 10 mmol/L HMF,as well as excellent stability retaining 90.1%FE for FDCA after six cycles ***,even at an HMF concentration of 100 mmol/L,the yield and FE for FDCA remain high at 83.6%and 93.6%,*** findings highlight that 2D heterostructure containing abundant interfaces between Ni Fe LDH nanosheets and Ni Fe S can enhance the intrinsic activity of LDH and thus promote the oxidation reaction ***,the synergistic effect of the bimetallic Ni Fe compounds also improved the selectivity of HMF conversion to *** present work demonstrates that constructing 2D ultrathin heterostructure of Ni Fe LDH/Ni Fe S is a facile strategy via interface engineering to enhance the intrinsic activity of LDH electrocatalysts,which would open new avenues toward low-cost and advanced 2D nanocatalysts for sustainable energy conversion and electrochemical valorization of biomass derivatives.

关键词： Electrocatalytic oxidation Interface engineering 2D ultrathin heterostructure Layered double hydroxides 5-Hydroxymethylfurfural

Rechargeable Metasurfaces for Dynamic Color Display Based on a Compositional and Mechanical Dual-Altered Mechanism

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Research 2023年第1期2022卷 367-377页

作者： Le Yang xiaorong hong Jiafang Li Chang-Yin Ji Yu Han Shanshan Chen Hanqing Jiang Wei-Li Song Hao-Sen Chen Daining Fang Beijing Key Laboratory of Lightweight Multi-Functional Composite Materials and Structures Institute of Advanced Structure TechnologyBeijing Institute of TechnologyBeijing 100081China Key Lab of Advanced Optoelectronic Quantum Architecture and Measurement(Ministry of Education) Beijing Key Lab of Nanophotonics e Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of TechnologyBeijing 100081China School of Engineering Westlake UniversityHangzhou 310024China

Dynamic color display can be realized by tunable optical metasurfaces based on the compositional or structural ***,it is still a challenge to realize the efficient modulation by a single-field ***,we report a novel compositional and mechanical dual-altered rechargeable metasurface for reversible and broadband optical reconfiguration in both visible and near-infrared wavelength *** employing a simple fabrication and integration strategy,the continuous optical reconfiguration is manipulated through an electro-chemo-mechanical coupled process in a lithium ion battery,where lithiation and delithiation processes occur dynamically under a low electric voltage(<1.5 V).By controlling the phase transformation from Si to Li,Si,both structural morphology and optical scattering could be rapidly and dramatically tailored within 30s,exhibiting high-contrast colorization and decolorization in a large-area nanofilm and showing long cyclic *** wide-angle reconfiguration of high-resolution structural colors in bowtie metasurfaces is demonstrated from anomalous *** results provide a multifield mechanism for reconfigurable photonic devices,and the new platform can be introduced to the multidimensional information encryption and storage.

关键词： scattering figuration Dynamic

Microstructures, Fabrics, and Seismic Properties of Mylonitic Amphibolites: Implications for Strain Localization in a Thickening Anisotropic Middle Crust of the North China Craton

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Journal of Earth Science 2024年第3期35卷 769-785页

作者： Siqi Liu Bo Zhang Jinjiang Zhang Jian Zhang Lei Guo Tao Wang Baoyou Hang xiaorong Li Key Laboratory of Orogenic Belts and Crustal Evolution School of Earth and Space SciencesPeking UniversityBeijing 100871China Department of Earth Sciences The University of Hong KongHong KongChina Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China

Strain localization processes in the continental crust generate faults and ductile shear zones over a broad range of scales affecting the long-term lithosphere deformation and the mechanical response of faults during the seismic *** anisotropy originated within the continental crust can be applied to deduce the kinematics and structures within orogens and is widely attributed to regionally aligned minerals,e.g.,***,naturally deformed rocks commonly show various structural layers(e.g.,strain localization layers).It is necessary to reveal how both varying amphibole contents and fabrics in the structural layers of strain localization impact seismic property and its interpretations in terms of *** present microstructures,petrofabrics,and calculate seismic properties of deformed amphibolite with the microstructures ranging from mylonite to *** transition from mylonite to ultramylonite is accompanied by a slight decrease of amphibole grain size,a disintegration of amphibole and plagioclase aggregates,and amphibole aspect ratio increase(from 1.68 to 2.23),concomitant with the precipitation of feldspar and/or quartz between amphibole *** intensities of amphibole crystallographic preferred orientations(CPOs)show a progressively increasing trend from mylonitic layers to homogeneous ultramylonitic layers,as indicated by the JAm index increasing from 1.9–4.0 for the mylonitic layers and 4.0–4.8 for the transition layer,to 5.1–6.9 for the ultramylonitic *** CPO patterns are nearly random for plagioclase and *** amphibole aggregates in the amphibolitic mylonite deform by diffusion,mechanical rotation,and weak dislocation creep,and develop CPOs *** polymineralic matrix(such as quartz and plagioclase)of the mylonite and the ultramylonite deform dominantly by dissolution-precipitation,combined with weak dislocation *** mean P and S wave velocities are estimated to be 6.3 and 3.5 km/

关键词： amphibolitic mylonite microstructures petrofabrics seismic property middle crust rheology tectonics.

Extracting Brain Dynamics by Statistical Spatial Filtering

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Extracting Brain Dynamics by Statistical Spatial Filtering

The 7th China-India-Japan-Korea Joint Workshop on Neurobiology and Neuroinformatics 2005

作者： Bo hong, xiaorong Gao, Zhiguang Zhang, Shangkai Gao Department of Biomedical Engineering, Tsinghua University, Beijing 100084, China

Scalp EEG has a superior time resolution among non-invasive brain recording methods, which make it possible to be used not only for real-time applications as brain computer interface (BCI), but also for investigating the transient cognitive brain function. However, the signal recorded by an EEG electrode is difficult to be directly attributed to the underlying cortical activities due to the inhomogeneous conducting structure of the human head. Ton of efforts have been made to develop methods of extracting single-trial brain dynamics from scalp recordings.

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微纳光机械传感器研究进展

中国科学：物理学、力学、天文学 2023年第11期53卷 55-75页

作者：孙浩哲洪孝荣纪昌银李家方北京理工大学物理学院教育部先进光电量子结构设计与测量重点实验室北京100081 北京理工大学物理学院北京市纳米光子学与超精密光电系统重点实验室北京100081

利用机械运动与光学响应间的相互耦合和共振增强实现的微纳光机械传感器具有小型化、灵敏度高、检测阈值低等优势,其检测范围可从毫米尺度的物理机械运动到纳米尺度下的分子振动,为精确传感的实际应用提供了新颖的策略.微纳光机械传感... 详细信息

利用机械运动与光学响应间的相互耦合和共振增强实现的微纳光机械传感器具有小型化、灵敏度高、检测阈值低等优势,其检测范围可从毫米尺度的物理机械运动到纳米尺度下的分子振动,为精确传感的实际应用提供了新颖的策略.微纳光机械传感器可实现多个物理参量的精确传感,如力、位移、质量、声、化学以及热传感参量等.本文介绍了近年来光机械传感器领域的部分重要研究进展,总结了微纳光机械传感器的三个主要发展方向,即无源光机械传感器、电子-光子机械传感平台和中红外分子振动传感,介绍了微纳光机械传感器的配置、应用和集成.最后,对微纳光机械传感器的研究进行了总结和展望.

关键词：光机械传感器精密传感微纳机械系统光学耦合共振

Pyrotinib and chrysin synergistically potentiate autophagy in HER2-positive breast cancer

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Signal Transduction and Targeted Therapy 2024年第1期9卷 295-307页

作者： Xiaoxiao Liu Xing Zhang Zhiying Shao xiaorong Zhong Xin Ding Liang Wu Jie Chen Ping He Yan Cheng Kunrui Zhu Dan Zheng Jing Jing Ting Luo Institute for Breast Health Medicine Cancer CenterBreast CenterWest China HospitalSichuan University610041 ChengduSichuanChina Department of Radiation Oncology Cancer CenterAffiliated Hospital of Xuzhou Medical UniversityJiangsu Center for the Collaboration and Innovation of Cancer BiotherapyCancer InstituteXuzhou Medical University221000 XuzhouChina Department of Orthopedics Trauma and Reconstructive SurgeryUniversity Hospital RWTH AachenAachen 52074Germany Cancer Institute Xuzhou Medical University221000 XuzhouJiangsuChina Division of Nephrology and Transplantation Department of Internal MedicineUniversity Medical Center Rotterdam Erasmus MCRotterdam 3015 GDThe Netherlands Institute for Breast Health Medicine Department of General SurgeryBreast CenterWest China HospitalSichuan University610041 ChengduSichuanChina Institute for Breast Health Medicine West China HospitalSichuan University610041 ChengduSichuanChina

Human epidermal growth factor receptor 2(HER2)-positive breast cancer(BC)has been the most challenging subtype of BC,consisting of 20%of BC with an apparent correlation with poor *** that pyrotinib,a new HER2 inhibitor,has led to dramatic improvements in prognosis,the efficacy of pyrotinib monotherapy remains largely restricted due to its acquired ***,identifying a new potential antitumor drug in combination with pyrotinib to amplify therapeutic efficacy is a pressing ***,we reported a novel combination of pyrotinib with chrysin and explored its antitumor efficacy and the underlying mechanism in HER2-positive *** determined that pyrotinib combined with chrysin yielded a potent synergistic effect to induce more evident cell cycle arrest,inhibit the proliferation of BT-474 and SK-BR-3 BC cells,and repress in vivo tumor growth in xenograft mice *** may be attributed to enhanced autophagy induced by endoplasmic reticulum ***,the combined treatment of pyrotinib and chrysin induced ubiquitination and glucose-6-phosphate dehydrogenase(G6PD)degradation by upregulating zinc finger and BTB/POZ domain-containing family protein 16(ZBTB16)in tumorigenesis of ***,we identified that miR-16-5p was a potential upstream regulator of ZBTB16,and it showed a significant inverse correlation with *** of miR-16-5p overexpression by restoring ZBTB16 significantly potentiated the overall antitumor efficacy of pyrotinib combined with chrysin against HER2-positive ***,these findings demonstrate that the combined treatment of pyrotinib and chrysin enhances autophagy in HER2-positive BC through an unrecognized miR-16-5p/ZBTB16/G6PD axis.

关键词： HER2 synergistic Together

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旋桨手性微纳结构及其圆二色性研究进展

科学通报 2022年第33期67卷 3902-3914页

作者：纪昌银李夏陈珊珊刘幸韩遇洪孝荣梁清华刘娟李家方北京理工大学物理学院教育部先进光电量子结构设计与测量重点实验室北京100081 北京理工大学物理学院北京市纳米光子学与超精密光电系统重点实验室北京100081 燕山大学理学院河北省微结构材料物理重点实验室秦皇岛066004 北京理工大学光电学院、北京市混合现实与新型显示工程技术研究中心北京100081

手性是自然界的基本属性之一,其概念已经深入到我们生活的各个方面,比如艺术品、建筑设计、医药、农药、生命、信息、手性光电功能材料和器件等领域.自从科学家在19世纪发现手性物质的光学活性以来,手性光与物质相互作用研究已经成为光... 详细信息

手性是自然界的基本属性之一,其概念已经深入到我们生活的各个方面,比如艺术品、建筑设计、医药、农药、生命、信息、手性光电功能材料和器件等领域.自从科学家在19世纪发现手性物质的光学活性以来,手性光与物质相互作用研究已经成为光学领域最前沿的研究之一.由于天然手性物质的手性光学响应很弱且难以调谐,研究者创造性地设计出了各种各样的人工手性结构来增强手性光学相互作用,并实现了许多新颖的物理现象.与传统的螺旋型手性结构不同,本文重点介绍了基于纳米剪纸技术的人工旋桨手性微纳结构及其在手性光学中的应用.这种人工旋桨手性与传统的手性结构在几何形貌和物理响应机制等方面有着很大区别,例如具有新颖的面外立体扭曲和手性竞争机制.这些独特之处使其在光学圆二色性调控方面具备突出优势,仅通过微小扰动就能实现圆二色性强度、符号、波长的灵活剪裁,为新型人工手性微纳结构提供了新颖的设计思路,并为深入研究手性物理提供了一个理想平台.

关键词：旋桨手性纳米剪纸手性表面晶格共振手性竞争圆二色性符号反转

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雌雄香榧嫩枝扦插生根及响应干旱的生理差异

浙江农林大学学报 2024年第3期41卷 478-485页

作者：汪小荣邱红张启香吴家胜娄和强浙江农林大学省部共建亚热带森林培育国家重点实验室浙江杭州311300 浙江农林大学林业与生物技术学院浙江杭州311300

【目的】探究香榧Torreya grandis‘Merrillii’雌雄植株的生根差异和响应干旱胁迫的生理差异,为香榧抗干旱种质资源的培育提供科学依据。【方法】以香榧新生雌雄株枝条为材料,比较两者夏季扦插生根差异,对生根状况较一致的香榧雌雄株... 详细信息

【目的】探究香榧Torreya grandis‘Merrillii’雌雄植株的生根差异和响应干旱胁迫的生理差异,为香榧抗干旱种质资源的培育提供科学依据。【方法】以香榧新生雌雄株枝条为材料,比较两者夏季扦插生根差异,对生根状况较一致的香榧雌雄株施加聚乙二醇(PEG)模拟干旱处理,比较不同时间下香榧雌雄株幼苗的抗氧化酶活性、渗透调节物质、膜脂过氧化和活性氧质量摩尔浓度的变化。【结果】夏季扦插的香榧雄株成活率普遍高于雌株,雌雄株扦插的最佳时间不同,与7和8月相比,6月扦插的香榧雌株成活率和生根率更高,侧根数更多,而8月扦插的香榧雄株较6和7月的成活率和生根率更高,侧根数更多。在扦插相同时间下,雄株的成活率和生根率均高于雌株。干旱胁迫引起香榧叶片抗氧化酶活性发生显著变化,并扰乱其渗透调节功能和活性氧代谢平衡。在干旱胁迫下,与雄株相比,雌株具有更高的超氧化物歧化酶(SOD)、过氧化物酶(POD)和过氧化氢酶(CAT)活性,以及较低的丙二醛(MDA)、脯氨酸(Pro)、超氧阴离子(O^(2−))和过氧化氢(H2O2)质量摩尔浓度。【结论】夏季扦插的香榧雄株比雌株具有更高的扦插成活率。干旱胁迫下,香榧雌株能够更好地利用抗氧化系统来减少干旱胁迫引起的活性氧积累和细胞损伤,从而使香榧雌株比雄株更耐干旱。

关键词：香榧雌雄异株植物干旱胁迫植物生理

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