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Piezo1 channel activation in response to mechanobiological acoustic radiation force in osteoblastic cells

Bone Research 2021年第2期9卷 223-232页

作者： Guangdao Zhang Xiaofei Li Lin Wu yi-xian Qin Department of Biomedical Engineering Stony Brook UniversityStony BrookNY 11794USA Department of Prosthodontics School of StomatologyChina Medical UniversityShenyangChina

Mechanobiological stimuli,such as low-intensity pulsed ultrasound(LIPUS),have been shown to promote bone regeneration and fresh fracture repair,but the fundamental biophysical mechanisms involved remain ***,we propose that a mechanosensitive ion channel of Piezo1 plays a pivotal role in the noninvasive ultrasound-induced mechanical transduction pathway to trigger downstream cellular signal *** study aims to investigate the expression and role of Piezo1 in MC3T3-E1 cells after LIPUS *** analysis shows that Piezo1 was present on MC3T3-E1 cells and could be ablated by shRNA ***3T3-E1 cell migration and proliferation were significantly increased by LIPUS stimulation,and knockdown of Piezo1 restricted the increase in cell migration and *** labeling with Fluo-8,MC3T3-E1 cells exhibited fluorescence intensity traces with several high peaks compared with the baseline during LIPUS *** obvious change in the fluorescence intensity tendency was observed after LIPUS stimulation in shRNA-Piezo1 cells,which was similar to the results in the GsMTx4-treated *** phosphorylation ratio of ERK1/2 in MC3T3-E1 cells was significantly increased(P<0.01)after LIPUS *** addition,Phalloidin-iFluor-labeled F-actin filaments immediately accumulated in the perinuclear region after LIPUS stimulation,continued for 5 min,and then returned to their initial levels at 30 *** results suggest that Piezo1 can transduce LIPUS-induced mechanical signals into intracellular *** influx of Ca2+serves as a second messenger to activate ERK1/2 phosphorylation and perinuclear F-actin filament polymerization,which regulate the proliferation of MC3T3-E1 cells.

关键词： stimulation Piezo1 activation

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Biosynthesis of Unsaturated Fatty Acids via Mortierella Isabellina Cultivated in a Medium Containing Butanol

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Chemical Research in Chinese Universities 2002年第3期18卷 303-306页

作者： xian Mo yan Ji chang CHENG Tie xin KANG yi jian LI Wen xing BI ying li ZHEN Kai ji College of Chemistry Jilin UniversityChangchun 130023P.R.China College of Chemistry Northeast Normal UniversityChangchun 130024P.R.China Department of Chemical Engineering Qingdao Chimical Industry InstituteQingdao 266042P.R.China

Mortierella isabellina was found to accumulate large amounts of unsaturated fatty acids when it was grown in a medium containing butanol(5 g/L) and yeast extract(10 g/L) and cultivated at 25 ℃ for 5 d during which additional feeding butanol of 2 g/L was fed after being cultivated for 48 h . The resultant mycelial lipids accounted for 40 1% of the dry mycelia, while about 34% of butanol in the medium was converted. The mycelial lipids contained four kinds of unsaturated fatty acids, i.e ., palmitoleic(4 9%), oleic(54 1%), linoleic(10 4%) and linolenic(5 4%) acids. Those accounted for 74 8% of the total fatty acids. The effects of the culture conditions, such as cultivation temperature, initial pH of the medium and additional feeding butanol in the course of cultivation, on the production of mycelial lipids by M. isabellina were studied.

关键词： Mortierella isabellina Butanol Unsaturated fatty acid Biosynthesis

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Secure personal data sharing in cloud computing using attribute-based broadcast encryption

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The Journal of China Universities of Posts and Telecommunications 2014年第6期21卷 45-51,77页

作者： FU Jing-yi HUANG Qin-long MA Zhao-feng yanG yi-xian Information Security Center Beijing University of Posts and Telecommunications National Engineering Laboratory for Disaster Backup and Recovery Beijing University of Posts and Telecommunications Beijing National Security Science and Technology Co. Ltd

The ciphertext-policy（CP） attribute-based encryption（ABE）（CP-ABE） emergings as a promising technology for allowing users to conveniently access data in cloud computing. Unfortunately, it suffers from several drawbacks such as decryption overhead, user revocation and privacy preserving. The authors proposed a new efficient and privacy-preserving attribute-based broadcast encryption（BE）（ABBE） named EP-ABBE, that can reduce the decryption computation overhead by partial decryption, and protect user privacy by obfuscating access policy of ciphertext and user＇s attributes. Based on EP-ABBE, a secure and flexible personal data sharing scheme in cloud computing was presented, in which the data owner can enjoy the flexibly of encrypting personal data using a specified access policy together with an implicit user index set. With the proposed scheme, efficient user revocation is achieved by dropping revoked user＇s index from the user index set, which is with very low computation cost. Moreover, the privacy of user can well be protected in the scheme. The security and performance analysis show that the scheme is secure, efficient and privacy-preserving.

关键词： data sharing ABBE ABE user revocation partial decryption privacy preserving

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Nanoscale zero-valent iron integrated with bioreactor for recalcitrant antimony-Congo red dyeing wastewater treatment

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Progress in Natural Science:Materials International 2023年第5期33卷 569-574页

作者： Jing Liu Airong Liu yi Wei Jiahui Fu Wei-xian Zhang College of Environmental Science and Engineering Tongji University State Key Laboratory for Pollution Control and Resource Reuse

Antimony(Sb) and recalcitrant organic dyes often coexist in dyeing wastewater, and the simultaneous removal of Sb and dyes has been a challenge for traditional biological method in the treatment of Sb-dyeing *** zero-valent iron(n ZVI) is particularly suitable for separating heavy metals and enhancing the biodegradability of recalcitrant organic compounds. Herein, n ZVI is integrated with bioreactors(n ZVI-bio system) to achieve enhanced removal of Sb and degradation of Congo red(CR) in wastewater. The n ZVI-bio system achieves a reduction in Sb levels from 2.5 g L-1to 0.064 mg L-1, with a color removal efficiency of up to 98.60 % and a reduction in COD from 167 mg L-1to 55 mg L-1. The excellent performance is mainly attributed to n ZVI pretreatment, which removes Sb and degrades CR into smaller and more biodegradable organic compounds,providing favorable environmental conditions for the subsequent biotreatment system. This suggests that integrated n ZVI-bio system has potential for the treatment of complex wastewater containing heavy metals and recalcitrant organic dyes.

关键词： Nanoscale zero-valent iron Biotreatment Antimony Congo red nZVI-bio system

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Air combat decision-making of multiple UCAVs based on constraint strategy games

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Defence Technology（防务技术） 2022年第3期18卷 368-383页

作者： Shou-yi Li Mou Chen Yu-hui Wang Qing-xian Wu College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing211100China

Game theory can be applied to the air combat decision-making problem of multiple unmanned combat air vehicles(UCAVs).However,it is difficult to have satisfactory decision-making results completely relying on air combat situation information,because there is a lot of time-sensitive information in a complex air combat *** this paper,a constraint strategy game approach is developed to generate intelligent decision-making for multiple UCAVs in complex air combat environment with air combat situation information and time-sensitive ***,a constraint strategy game is employed to model attack-defense decision-making problem in complex air combat ***,an algorithm is proposed for solving the constraint strategy game based on linear programming and linear inequality(CSG-LL).Finally,an example is given to illustrate the effectiveness of the proposed approach.

关键词： Game theory Time-sensitive information Constraint strategy games Polytope strategy games Multiple UCAVs Air combat decision-making

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Expression of somatostatin mRNA in various differentiated types of gastric carcinoma

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World Journal of Gastroenterology 1998年第1期4卷 53-56页

作者： ZHANG Qin-xian DOU ying-Li SHI Xue-yi DING yi Dept. of Histology and Embryology Henan Medical University Zhengzhou 450052 Henan Province China Henan Medical University China

IM METHODS By using in situ hybridization and immunohistochemical techniques, the expression of somatostatin mRNA and somatostatin immunoreactivity in the normal gastric mucosa, the poorly, moderately and welldifferentiated gastric carcinomas, and various clinical stages of carcinoma were observed.RESULTS In comparison with the normal gastric mucosa, the significantly increased expression of somatostatin mRNA positive cells was displayed in gastric carcinoma (t=2681, P<001). The positive signal cells were distributed in a scattered form or aggregated as a mass or a cord, and the positive cells were more significantly enhanced in poorly differentiated carcinomas than those in well and moderately differentiated carcinomas (t=2962, P<001). The somatostatin mRNA hybridization signals in stages Ⅲ and Ⅳ of gastric carcinoma were significantly higher than those in stages Ⅰ and Ⅱ. The results of somatostatin immunoreactivity were consistent with those of in situ hybridization.CONCLUSION The alteration of the expression of somatostatin mRNA was associated with the development of gastric carcinoma and may play an important role in the process of tumor differentiation..

关键词： stomach neoplasms somatostatin RNA,messenger in situ hybridization immunohistochemistry

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High-Performance Biodegradable PBAT/PPC Composite Film Through Reactive Compatibilizer

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Chinese Journal of Polymer Science 2023年第7期41卷 1051-1058页

作者： Feng-xiang Gao yi Cai Shun-Jie Liu xian-Hong Wang University of Science and Technology of China Hefei230026China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry CASChinese Academy of SciencesChangchun130022China

Poly(butylene adipate-co-terephthalate) (PBAT) is currently the largest commercial biodegradable plastics with good toughness and film forming properties, whereas, the inferior barrier and mechanical properties hinder its applications. Biodegradable poly(propylene carbonate) (PPC) with excellent barrier properties and high strength is a natural choice to address above issue. However, it is challenging to improve the compatibility of these two polymers. Herein, we prepared a reactive compatibilizer with double bond side group through terpolymerization of CO_(2)/propylene oxide/glycidyl methacrylate to enhance the properties of PBAT/PPC blends. Upon addition of 1 wt% compatibilizer, the PBAT/PPC blends (75/25, W/W) showed an increased water vapor barrier property changed from 424 g·m^(−2)·d^(−1) to 204 g·m^(−2)·d^(−1) compared to the control sample. Moreover, the tensile strength and elongation at break increased from 24.7 MPa to 30.3 MPa and from 858% to 1142%, respectively. The PBAT/PPC composite also displayed excellent biodegradability under composting conditions, as confirmed by the significantly decreased molecular weight. The present work provides an efficient way to barrier biodegradable film from PBAT of practical utilization.

关键词： Poly(butylene adipate-co-terephthalate) Poly(propylene carbonate) Reactive compatibilizer Barrier property Mechanical property

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New Cassane Diterpenoids from the Seed Kernels of Caesalpinia cucullata, Exhibit Anti-inflammatory Effect in vitro by Inhibiting iNOS Enzymatic Activity

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Chinese Journal of Chemistry 2021年第6期39卷 1625-1634页

作者： Miao Wang yi-Ren yang yan yin Kai-Ru Song Li-Ping Long xian-Zhe Li Bei Zhou Hui-Yuan Gao School of Traditional Chinese Moterio Medico Shenyang Pharmaceutical UniversityShenyangLiaoning 110016China Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of Education Shenyang Pharmoceuticol UniversityShenyangLiaoning 110016China

Inflammation is a complex biological response to *** cassane diterpenoids from Caesalpinia genus exhibit significant anti-inflammation *** new cassane diterpenoids(1-8)along with seven known ones(9-15)were obtained from the seed kernels of Caesalpinia cucullata *** is the first report on chemical investigation of the seed kernels of ***,and the cassane diterpenes were found in this plant for the first *** structures were elucidated based on the extensive spectroscopic analyses,and the absolute configurations were identified by ECD calculation and X-ray *** compounds were evaluated for their anti-inflammation activity by inhibiting NO production in LPS-induced RAW 264.7 *** 1-2 and 9-11 exhibited effective inhibitory activity with inhibition rate more than 50%.The iNOS enzyme activity and molecular docking experiments were performed to explore the preliminary ***,a potential anti-inflammatory mechanism revealed that the bioactive cassane inhibited overproduction of NO by targeting key residues in the iNOS active cavity to reduce iNOS enzymatic activation.

关键词： Caesalpinia cucullata Roxb. Cassane diterpenoids Structure elucidation Biological activity iNOS enzyme activity

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Concise synthesis of 1-epi-castanospermine

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Chinese Chemical Letters 2017年第8期28卷 1688-1692页

作者： Bin Cheng yi-xian Li Yue-Mei Jia Chu-yi Yu Beijing National Laboratory for Molecular Science(BNLMS) CAS Key Laboratory of Molecular Recognition and FunctionCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China National Engineering Research Center for Carbohydrate Synthesis Jiangxi Normal UniversityNanchang 330022China

1-epi-Castanospermine（5） was synthesized from readily available 2,3,4,6-tetra-O-benzyl-1-deoxynojirimycin（11） in 9 steps and 21% overall yield, with selective debenzylation, Barbier reaction and reductive aminatio... 详细信息

关键词： Reductive amination Synthesis Alkaloids Glycosidase inhibitors Polyhydroxylated indolizidines

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Emphasis should be placed on the diagnosis and therapy of tumor induced osteomalacia

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Chinese Medical Journal 2011年第2期124卷 163-165页

作者： WANG xian-ling MU yi-ming Department of Endocrinology General Hospital of Chinese People's Liberation Army Beijing 100853 China

Phosphate plays a critical part in the regulation of cell metabolism,and phosphate homeostasis is closely regulated in normal *** hypophosphatemia can cause abnormal mineralization of bone,increased alkaline phosphatase and,in the longer term,metabolic bone *** is the main metabolic bone disorder caused by chronic hypophosphatemia,which is characterized by inadequate or delayed mineralization of osteoid in mature cortical or spongy bone.

关键词：低磷血症骨和骨组织骨软化症内环境稳定社会控制正式血气分析胰岛素铍人类

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