Expression of somatostatin mRNA in various differentiated types of gastric carcinoma

作     者：ZHANG Qin-Xian DOU Ying-Li SHI Xue-Yi DING Yi 

作者机构：Dept. of Histology and Embryology Henan Medical University Zhengzhou 450052 Henan Province China Henan Medical University China 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：1998年第4卷第1期

页      面：53-56页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：stomach neoplasms somatostatin RNA,messenger in situ hybridization immunohistochemistry 

摘      要：IM METHODS By using in situ hybridization and immunohistochemical techniques, the expression of somatostatin mRNA and somatostatin immunoreactivity in the normal gastric mucosa, the poorly, moderately and welldifferentiated gastric carcinomas, and various clinical stages of carcinoma were observed.RESULTS In comparison with the normal gastric mucosa, the significantly increased expression of somatostatin mRNA positive cells was displayed in gastric carcinoma (t=2681, P001). The positive signal cells were distributed in a scattered form or aggregated as a mass or a cord, and the positive cells were more significantly enhanced in poorly differentiated carcinomas than those in well and moderately differentiated carcinomas (t=2962, P001). The somatostatin mRNA hybridization signals in stages Ⅲ and Ⅳ of gastric carcinoma were significantly higher than those in stages Ⅰ and Ⅱ. The results of somatostatin immunoreactivity were consistent with those of in situ hybridization.CONCLUSION The alteration of the expression of somatostatin mRNA was associated with the development of gastric carcinoma and may play an important role in the process of tumor differentiation..