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New Taxane Diterpenoids from Taxus yunnanensis

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Natural Products and Bioprospecting 2014年第1期4卷 47-51页

作者： Ping Hai Shi-Zhen Wen Yan Li Yuan Gao xian-jun jiang Fei Wang BioBioPha Co. Ltd.Kunming 650201China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China

Three hitherto unknown taxane diterpenoids,namely baccatin Ⅷ(1),baccatin Ⅸ(2),and baccatin Ⅹ(3),along with 10 known analogues were isolated from an ethanolic extract of the twigs and leaves of Taxus *** new structures were characterized based on extensive spectroscopic *** 1 and 2 were tested for their in vitro cytotoxicity against five human tumor cell lines,and 1 exhibited inhibitory effects on HL-60 and MCF-7,with IC_(50) values of 3.44 and 9.67 μM,respectively.

关键词： Taxus yunnanensis Taxane Baccatin Cytotoxicity

Aristolane‑type Sesquiterpenoids from Nardostachys chinensis and Revised Structure of Aristolanhydride

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Natural Products and Bioprospecting 2019年第2期9卷 149-155页

作者： Li-Xia Wang xian-jun jiang xiang-Mei Li Mei-Fen Mao Guo-Zhu Wei Fei Wang BioBioPha Co. Ltd.Kunming 650201People’s Republic of China Reference Substances Sub-center National Engineering Research Center for Modernization of Traditional Chinese MedicineKunming 650201People’s Republic of China

Four hitherto unknown aristolane-type sesquiterpenes,including one novel 8,9-secoaristolane,namely secoaristolenedioic acid(1),two aristolone derivatives,namely 1α,2β-dihydroxyaristolone(2),9-epidebilon(3),and one rare aristolane-chalcone hybrid,namely 3′-hydroxynardoaristolone A(4)were isolated from the ethanol extract of the roots and rhizomes of Nardostachys *** structures were elucidated on the basis of extensive spectroscopic *** addition,the structure of aristolanhydride,recently isolated from the same species,was corrected by reanalysis of the published NMR data.

关键词： Nardostachys chinensis Aristolane Secoaristolane Aristolane-chalcone hybrid Structural revision

Pterocarpadiols A–D, Rare 6a,11b-Dihydroxypterocarpans from Derris robusta

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Natural Products and Bioprospecting 2015年第6期5卷 287-291页

作者： xiang-Mei Li Mei-Fen Mao Fu-Cai Ren xian-jun jiang Ping Hai Fei Wang BioBioPha Co. Ltd.Kunming 650201People’s Republic of China

Four hitherto unknown 6a,11b-dihydroxypterocarpans,namely pterocarpadiols A–D(1–4),were isolated from the ethanol extract of the twigs and leaves of Derris *** structures were elucidated on the basis of extensive spectroscopic *** A–D are a kind of very rare 6a,11b-dihydroxypterocarpans,and their presence as markers may be helpful in chemotaxonomical classification.

关键词： Derris robusta 6a,11b-Dihydroxypterocarpan Pterocarpadiol

Prenylated Coumarins from Heracleum stenopterum,Peucedanum praeruptorum,Clausena lansium,and Murraya paniculata

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Natural Products and Bioprospecting 2016年第5期6卷 233-237页

作者： xiang-Mei Li xian-jun jiang Ku Yang Li-Xia Wang Shi-Zhen Wen Fei Wang BioBioPha Co. Ltd.Kunming 650201People’s Republic of China

Four hitherto unknown prenylated coumarins,namely 600-O-b-D-apiofuranosylapterin(1),40-O-isobutyroylpeguangxienin(2),6-(3-methyl-2-oxobutyroyl)-7-methoxycoumarin(3),and 6-hydroxycoumurrayin(4),were isolated from the ethanol extract of Heracleum stenopterum,Peucedanum praeruptorum,Clausena lansium,and Murraya paniculata,*** chemical structures were established on the basis of extensive spectroscopic ***pound 2 exhibited in vitro cytotoxic activity against five human cancer cell lines(HL-60,A-549,SMMC-7721,MCF-7,and SW-480)with IC50 values ranging from 15.9 to 23.2μM.

关键词： Heracleum stenopterum Peucedanum praeruptorum Clausena lansium Murraya paniculata Prenylated coumarin Cytotoxicity

Polysubstituted Isoflavonoids from Spatholobus suberectus,Flemingia macrophylla,and Cudrania cochinchinensis

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Natural Products and Bioprospecting 2017年第2期7卷 201-206页

作者： Li-Xia Wang Hai-Rong Zheng Fu-Cai Ren Tian-Gc Chen xiang-Mei Li xian-jun jiang Fei Wang BioBioPha Co. Ltd.Kunming 650201People’s Republic of China

Four hitherto unknown polysubstituted isofiavonoids,including three isofiavans:7,4'-dihydroxy-8,2',3'-trimethoxyisofiavan(1),7,2',4'-trihydroxy-8,3'-dimethoxyisofiavan(2),and 7,2',4'-trihydroxy-5-methoxyisofiavan(3),and one prenylated isofiavone cudraisofiavone M(4)were isolated from the ethanol extracts of Spatholobus suberectus(for 1 and 2),Flemingia macrophylla(for 3),and Cudrania cochinchinensis(for 4),*** structures were established on the basis of extensive spectroscopic *** 1 and 4 exhibited weak cytotoxic activity against five human cancer cell lines(HL-60,A-549,SMMC-7721,MCF-7,and SW-480).

关键词： Spatholobus suberect us Flemingia macrophylla Cudrania cochinchinensis Isofiavan Isofiavone Cytotoxicity

New Iboga‑Type Indole Alkaloids from Tabernaemontana divaricata

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Natural Products and Bioprospecting 2019年第6期9卷 425-429页

作者： xiang-Mei Li xian-jun jiang Guo-Zhu Wei Li-Hua Ren Li-Xia Wang Xue-Lian Cheng Fei Wang BioBioPha Co. Ltd.Kunming 650201People’s Republic of China Reference Substance Branch National Engineering Research Center for Modernization of Traditional Chinese MedicineKunming 650201People’s Republic of China Department of Pharmacy The People’s Hospital of Fengjie CountyChongqing 404600People’s Republic of China

Two hitherto unknown iboga-type indole alkaloids,namely(3R)-7,19-di-epi-3-methoxytabernoxidine(1)and(3R,19R)-19-hydroxy-3-(2-oxopropyl)voacangine(2),together with eight known alkaloids(3-10),were isolated from the twigs and leaves of Tabernaemontana *** structures were established on the basis of spectroscopic data interpretation,single crystal X-ray diffraction analysis and circular dichroism spectrum.

关键词： Tabernaemontana divaricata Iboga-type indole alkaloid Single crystal X-ray diffraction

Multi-model ensemble learning for battery state-of-health estimation:Recent advances and perspectives

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Journal of Energy Chemistry 2025年第1期100卷 739-759页

作者： Chuanping Lin jun Xu Delong jiang Jiayang Hou Ying Liang Zhongyue Zou Xuesong Mei State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Shaanxi Key Laboratory of Intelligent Robots School of Mechanical Engineering Xi'an Jiaotong University Department of Electrical Engineering and Automation Luoyang Institute of Science and Technology School of Mechanical Engineering Hangzhou Dianzi University

The burgeoning market for lithium-ion batteries has stimulated a growing need for more reliable battery performance monitoring. Accurate state-of-health(SOH) estimation is critical for ensuring battery operational performance. Despite numerous data-driven methods reported in existing research for battery SOH estimation, these methods often exhibit inconsistent performance across different application scenarios. To address this issue and overcome the performance limitations of individual data-driven models,integrating multiple models for SOH estimation has received considerable attention. Ensemble learning(EL) typically leverages the strengths of multiple base models to achieve more robust and accurate outputs. However, the lack of a clear review of current research hinders the further development of ensemble methods in SOH estimation. Therefore, this paper comprehensively reviews multi-model ensemble learning methods for battery SOH estimation. First, existing ensemble methods are systematically categorized into 6 classes based on their combination strategies. Different realizations and underlying connections are meticulously analyzed for each category of EL methods, highlighting distinctions, innovations, and typical applications. Subsequently, these ensemble methods are comprehensively compared in terms of base models, combination strategies, and publication trends. Evaluations across 6 dimensions underscore the outstanding performance of stacking-based ensemble methods. Following this, these ensemble methods are further inspected from the perspectives of weighted ensemble and diversity, aiming to inspire potential approaches for enhancing ensemble performance. Moreover, addressing challenges such as base model selection, measuring model robustness and uncertainty, and interpretability of ensemble models in practical applications is emphasized. Finally, future research prospects are outlined, specifically noting that deep learning ensemble is poised to advance ens

关键词： Lithium-ion battery State-of-health estimation Data-driven Machine learning Ensemble learning Ensemble diversity

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渣油中沥青质分子颗粒尺寸及其胶粒模型研究

燃料化学学报 2004年第4期32卷 429-434页

作者：王治卿王宗贤郭爱军姜阿娜张会军石油大学重质油国家重点实验室山东东营257061

分别以苯和硝基苯为溶剂测定了大庆、胜利、孤岛和辽河减压渣油沥青质、胶质和芳香分的分子量;依据球形分子模型计算了这些物质的分子尺寸;构筑了渣油中沥青质胶粒(胶团)模型,并依此计算了渣油中沥青质胶粒尺寸。结果表明,以硝基苯为溶... 详细信息

分别以苯和硝基苯为溶剂测定了大庆、胜利、孤岛和辽河减压渣油沥青质、胶质和芳香分的分子量;依据球形分子模型计算了这些物质的分子尺寸;构筑了渣油中沥青质胶粒(胶团)模型,并依此计算了渣油中沥青质胶粒尺寸。结果表明,以硝基苯为溶剂所测沥青质分子量更能反应沥青质化学结构的实质;就原始沥青质来说,以苯为溶剂测得的沥青质分子直径为3.8nm～5.0nm,以氯代苯为溶剂测得的分子直径为3.2nm～3.7nm,以硝基苯为溶剂测得的分子直径为2.8nm～3.2nm;辽河、胜利与大庆减压渣油中沥青质的胶粒直径为10.0nm～11.0nm,孤岛减压渣油中沥青质的胶粒直径为9.0nm～10.0nm。

关键词：沥青质分子量胶粒尺寸渣油

PVP与放疗联合唑来膦酸治疗多节段胸腰椎转移瘤的疗效分析

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中国伤残医学 2018年第9期26卷 1-3页

作者：张贤俊赵锡江杨小奇范强江南大学附属医院——无锡市第四人民医院江苏无锡214062

目的：回顾性分析经皮椎体成形术与放疗联合唑来膦酸治疗多节段胸腰椎转移瘤的临床疗效。方法：随访自2011年6月～2016年6月我院因椎体转移瘤接受经PVP或放疗并联合唑来膦酸治疗的患者共104例，按照治疗方案，分为PVP组：PVP＋唑来膦酸... 详细信息

目的：回顾性分析经皮椎体成形术与放疗联合唑来膦酸治疗多节段胸腰椎转移瘤的临床疗效。方法：随访自2011年6月～2016年6月我院因椎体转移瘤接受经PVP或放疗并联合唑来膦酸治疗的患者共104例，按照治疗方案，分为PVP组：PVP＋唑来膦酸，共54例；放疗组：放疗＋唑来膦酸，共50例，比较2组患者治疗前后症状改善情况、椎体形态及不良反应发生率。结果：治疗后3天PVP组VAS、EORTC评分较治疗前明显下降（P〈0．05），优于放疗组（P〈0．05）。6个月时2组疗效有显着差异（P〈0．05）。PVP组治疗后各时间点椎体相对高度与术前比较差异无统计学意义（P〉0．05），而放疗组6个月复查时见患椎高度明显丢失（P〈0．05）。2组不良反应症状均较轻，经对症治疗后均消失。结论：PVP与放疗联合唑来膦酸治疗多节段转移瘤，均可有效缓解疼痛，提高生活质量；PVP较放疗起效快，有效维持患椎高度，但需注意骨水泥渗漏压迫神经及穿刺风险；放疗则费用低，更方便，直接杀灭肿瘤细胞，但副反应较常见。

关键词：经皮椎体成形术放射治疗唑来膦酸肿瘤