New Iboga‑Type Indole Alkaloids from Tabernaemontana divaricata

作     者：Xiang-Mei Li Xian-Jun Jiang Guo-Zhu Wei Li-Hua Ren Li-Xia Wang Xue-Lian Cheng Fei Wang 

作者机构：BioBioPha Co.Ltd.Kunming 650201People’s Republic of China Reference Substance BranchNational Engineering Research Center for Modernization of Traditional Chinese MedicineKunming 650201People’s Republic of China Department of PharmacyThe People’s Hospital of Fengjie CountyChongqing 404600People’s Republic of China 

出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)

年 卷 期：2019年第9卷第6期

页      面：425-429页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 070303[理学-有机化学] 0710[理学-生物学] 0832[工学-食品科学与工程（可授工学、农学学位）] 1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0817[工学-化学工程与技术] 0703[理学-化学] 0901[农学-作物学] 0902[农学-园艺学] 

基　　金：This work was financially supported by the“Large-scale Compound Library”project of National Development and Reform Commission of China 

主　　题：Tabernaemontana divaricata Iboga-type indole alkaloid Single crystal X-ray diffraction 

摘      要：Two hitherto unknown iboga-type indole alkaloids,namely(3R)-7,19-di-epi-3-methoxytabernoxidine(1)and(3R,19R)-19-hydroxy-3-(2-oxopropyl)voacangine(2),together with eight known alkaloids(3-10),were isolated from the twigs and leaves of Tabernaemontana *** structures were established on the basis of spectroscopic data interpretation,single crystal X-ray diffraction analysis and circular dichroism spectrum.