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A novel dual serotonin transporter and M-channel inhibitor D01 for antidepression and cognitive improvement

Acta Pharmaceutica Sinica B 2024年第3期14卷 1457-1466页

作者： Yaqin Wei Xiangqing xu Qiang Guo Song Zhao Yinli Qiu Dongli Wang Wenwen Yu Yani Liu kewei Wang School of Pharmacy Xuzhou Medical UniversityXuzhou 221004China Institute of Pharmaceutical Research Jiangsu Nhwa Pharmaceutical Co.Ltd.&Jiangsu Key Laboratory of Central Nervous System Drug Research and DevelopmentXuzhou 221116China Department of Pharmacology School of PharmacyQingdao University Medical CollegeQingdao 266073China Institute of Innovative Drug Qingdao UniversityQingdao 266021China Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhou 510515China

Cognitive dysfunction is a core symptom common in psychiatric disorders including depression that is primarily managed by antidepressants lacking efficacy in improving *** this study,we report a novel dual serotonin transporter and voltage-gated potassium Kv7/KCNQ/M-channel inhibitor D01(a 2-methyl-3-aryloxy-3-heteroarylpropylamines derivative)that exhibits both anti-depression effects and improvements in cognition.D01 inhibits serotonin transporters(K_(i)=30.1±6.9 nmol/L)and M channels(IC_(50)=10.1±2.4μmol/L).D01 also reduces the immobility duration in the mouse FST and TST assays in a dose-dependent manner without a stimulatory effect on *** administrations of D01(20 and 40 mg/kg)can significantly shorten the immobility time in a mouse model of chronic restraint stress(CRS)-induced depression-like ***,D01 dose-dependently improves the cognitive deficit induced by CRS in Morris water maze test and increases the exploration time with novel objects in normal or scopolamine-induced cognitive deficits in mice,but not ***,D01 reverses the long-term potentiation(LTP)inhibition induced by *** together,our findings demonstrate that D01,a dual-target serotonin reuptake and M channel inhibitor,is highly effective in the treatment-resistant depression and cognitive deficits,thus holding potential for development as therapy of depression with cognitive deficits.

关键词： SERT 5-HT Kv7/KCNQ/M current D01 Depression Cognition

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Enhancement of hydroxyapatite dissolution through structure modification by Krypton ion irradiation

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Journal of Materials Science & Technology 2020年第3期38卷 148-158页

作者： Hui Zhu Dagang Guo Hang Zang Dorian AHHanaor Sen Yu Franziska Schmidt kewei xu State Key Laboratory for Mechanical Behavior of Materials School of Material Science and EngineeringXi’an Jiaotong UniversityXi’an710049China School of Nuclear Science and Technology Xi’an Jiaotong UniversityXi’an710049China Fachgebiet Keramische Werkstoffe/Chair of Advanced Ceramic Materials Institut für Werkstoffwissenschaften und-TechnologienTechnische Universit?t BerlinHardenbergstra?e 4010623BerlinGermany Shaanxi Key Laboratory of biomedical metal materials Northwest Institute for Non-ferrous Metal ResearchXi’an710016China

Hydroxyapatite(HA)synthesized by a wet chemical route was subjected to heavy ion irradiation,using4 Me V Krypton ion(Kr17+)with ion fluence ranging from 1×1013 to 1×1015 ions/*** incidence X-ray diffraction(GIXRD)results confirmed the phase purity of irradiated HA with a moderate contraction in lattice parameters,and further indicated the irradiation-induced structural disorder,evidenced by broadening of the diffraction ***-resolution transmission electron microscopy(HRTEM)observations indicated that the applied Kr irradiation induced significant damage in the hydroxyapatite ***,cavities were observed with their diameter and density varying with the irradiation fluences,while a radiation-induced crystalline-to-amorphous transition with increasing ion dose was *** and X-ray photoelectron spectroscopy(XPS)analysis further indicated the presence of irradiationinduced *** release from pristine and irradiated materials following immersion in Tris(p H 7.4,37?)buffer showed that dissolution in vitro was enhanced by irradiation,reaching a peak at 0.1 *** examined the effects of irradiation on the early stages of the mouse osteoblast-like cells(MC3 T3-E)response.A cell counting kit-8 assay(CCK-8 test)was carried out to investigate the cytotoxicity of samples,and viable cells can be observed on the irradiated materials.

关键词： High energy heavy ion irradiation Hydroxyapatite HRTEM Crystal defects In vitro dissolution Cell compatibility

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A Method to Prepare Nano-sized Copper Particles and Rods on the Surface of Cu Composite Films

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稀有金属材料与工程 2012年第S1期41卷 113-115页

作者： Sun Haoliang Ming, Wei Zhan Jingmei Song Zhongxiao Fei, Ma xu kewei Henan Univ Sci & Technol Sch Mat Sci & Engn Luoyang 471003 Peoples R China Xi An Jiao Tong Univ State Key Lab Mech Behav Mat Xian 710049 Peoples R China

Nano-sized Copper(Cu)particles and rods were prepared by annealing Cu-Zr,and Cu-Al-Zr composite films on polyimide ***,FESEM and EDS were used to characterize their microstructure and *** show that faceted Cu particles are regular and pure Cu ***,it was interesting to find that Cu nanorods might appear on the surface of annealed Cu-Al-Zr composite thin *** on the experimental results and analysis,it were speculated that these Cu particles are single *** particle average sizes are closely related to the content of Zr as well as annealing temperature and *** work may provide a new approach to prepare metal particles and nanorods on the surface of Cu composite films on polyimide substrates.

关键词： Cu composite films anneal stress relaxation particles nanorods

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Design and construction of ultra-thin MoSe2 nanosheet-based heterojunction for high-speed and low-noise photodetection

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Nano Research 2016年第9期9卷 2641-2651页

作者： Xiangshun Geng Yongqiang Yu Xiaoli Zhou Chunde Wang kewei xu Yan Zhang Chunyan Wu Li Wang Yang Jiang Qing Yang School of Electrical Science and Applied Physics Hefei University of TechnologyHefei 230009China Hefei National Laboratory for Physical Sciences at Microscale Department of ChemistryLaboratory of Nanomaterials for Energy Conversion and Synergetic Innovation Center of Quantum Information & Quantum PhysicsUniversity of Science and Technology of China(USTC)Hefei 230026China School of Materials Science and Engineering Hefei University of TechnologyHefei 230009China

Advances in the photocurrent conversion of two-dimensional (2D) transition metal dichalcogenides have enabled the realization and application of ultrasensitive and broad-spectral photodetectors. The requirements of previous devices constantly drive for complex technological implementation, resulting in limits in scale and complexity. Furthermore, the development of large-area and low-cost photodetectors would be beneficial for applications. Therefore, we demonstrate a novel design of a heterojunction photodetector based on solution-processed ultrathin MoSe2 nanosheets to satisfy the requirements of its application. The photodetector exhibits a high sensitivity to visible–near infrared light, with a linear dynamic range over 124 decibels (dB), a detectivity of ~1.2 × 1012Jones, and noise current approaching 0.1 pA·Hz–1/2at zero bias. Significantly, the device shows an ultra-high response speed up to 30 ns with a 3-dB predicted bandwidth over 32 MHz, which is far better than that of most of the 2D nanostructured and solution-processable photodetectors reported thus far and is comparable to that of commercial Si photodetectors. Combining our results with material-preparation methods, together with the methodology of device fabrication presented herein, can provide a pathway for the large-area integration of low-cost, high-speed photodetectors. [Figure not available: see fulltext.] © 2016, Tsinghua University Press and Springer-Verlag Berlin Heidelberg.

关键词： molybdenum diselenide layer transition metal dichalcogenide (TMD) urtrathin nanosheet heterojunction ultrafast photoresponse

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Characterization of the arrangement feature of copper interconnects by Moir inversion method

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Theoretical & Applied Mechanics Letters 2012年第2期2卷 37-40页

作者： Qinghua Wang Satoshi Kishimoto Huimin Xie kewei xu Jianfeng Wang National Institute for Materials Science TsukubaIbaraki 305-0047Japan AML Department of Engineering MechanicsTsinghua UniversityBeijing 100084China School of Materials Science and Engineering Xi'an Jiaotong UniversityXi'an 710049China

This paper explores the planar arrangement feature of the copper interconnects in a view field of several millimeters by the focused ion-beam （FIB） Moire inversion method quantitatively. The curved FIB Moire patterns indicate that the copper interconnects are a series of curves with continuous variations instead of beelines. The control equation set of the copper interconnects central lines is attained through the Moire inversion method. This work can be extended to inspect the structural defects and provide a reliable support for the interconnects structure fabrication.

关键词： copper interconnects arrangement Moire inversion method focused ion-beam

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超脉冲光纤铥激光碎石术腔内治疗泌尿系结石的有效性和安全性研究

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中华医学杂志 2023年第30期103卷 2302-2306页

作者：刘成邵怡夏磊余虓许可慰中山大学孙逸仙纪念医院泌尿外科广州510120 上海交通大学医学院附属第一人民医院泌尿外科上海200025 上海交通大学医学院附属仁济医院泌尿外科上海200127 华中科技大学同济医学院附属同济医院泌尿外科武汉430030

目的评价超脉冲光纤铥激光碎石术腔内治疗泌尿系结石的有效性和安全性。方法2021年5月至2022年7月间,在4家医疗中心前瞻性纳入符合条件的泌尿系结石患者,采用超脉冲光纤铥激光治疗机经内窥镜直视下碎石,记录患者围手术期情况,主要的有... 详细信息

目的评价超脉冲光纤铥激光碎石术腔内治疗泌尿系结石的有效性和安全性。方法2021年5月至2022年7月间,在4家医疗中心前瞻性纳入符合条件的泌尿系结石患者,采用超脉冲光纤铥激光治疗机经内窥镜直视下碎石,记录患者围手术期情况,主要的有效性指标为术后4周的结石清除率(SFR),主要的安全性指标为术中试验器械的故障发生率,次要的安全性指标为围手术期并发症发生率。结果共76例符合条件的患者完成了超脉冲光纤铥激光碎石术,患者年龄(52.0±11.1)岁,男54例,女22例。肾结石31例,输尿管结石43例,膀胱结石2例。17例患者行经皮肾镜取石术,57例患者行输尿管硬/软镜碎石术,2例患者行经尿道膀胱碎石取石。所有患者的碎石时间为(50.9±31.4)min,术中未出现试验器械故障。6例患者拒绝术后的随访检查。术后不良事件发生率为61.8%(47/76),1例患者术后因腹股沟疝需住院治疗,其余均为Clavien‑dindo分级1~2级。术后4周SFR为94.3%(66/70)。结论超脉冲光纤铥激光治疗机用于泌尿系结石的腔内治疗是有效、安全的。

关键词：结石铥泌尿生殖系统超脉冲光纤铥激光治疗机腔内碎石

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投资者情绪与期货市场功能——基于沪深300股指期货的研究

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系统工程理论与实践 2020年第9期40卷 2252-2268页

作者：熊熊许克维沈德华天津大学管理与经济学部天津300072 中国社会计算研究中心天津300072

本文以2015年股指期货市场实行交易限制措施事件作为自然实验样本,研究了不同市场环境下投资者情绪对沪深300股指期货风险管理功能和价格发现功能的影响及其差异.研究结果表明,在无交易限制的市场环境下,投资者情绪对沪深300股指期货的... 详细信息

本文以2015年股指期货市场实行交易限制措施事件作为自然实验样本,研究了不同市场环境下投资者情绪对沪深300股指期货风险管理功能和价格发现功能的影响及其差异.研究结果表明,在无交易限制的市场环境下,投资者情绪对沪深300股指期货的风险管理能力和短期动态价格发现能力有显著的负面影响;而在有交易限制的市场环境下,投资者情绪对沪深300股指期货市场风险管理能力的影响出现反转,但其对股指期货市场价格发现能力的负面影响却进一步加剧,本文分析这一现象是由于交易限制规则实施后股指期货市场流动性和市场深度极度匮乏、逆向选择效应增强所致.与现有研究相比,本研究可以更有效地从市场微观结构角度揭示投资者情绪对金融市场的影响存在差异的原因.此外,本研究结果在以双重差分模型和以互联网搜索指数作为投资者情绪代理变量的检验中同样稳健.

关键词：股指期货投资者情绪风险管理价格发现

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催化裂化装置采用CSC快分技术的改造

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炼油技术与工程 2005年第5期35卷 11-13页

作者：许可为中国石化扬子石油化工股份有限公司江苏省南京市210048

扬子石油化工股份有限公司炼油厂0.80Mt/a重油催化裂化装置采用CSC快分技术(带有密相环流预汽提器的粗旋快分技术)进行改造,得到了如下效果:①解决了装置存在的安全问题;②提高了装置的处理量;③产品分布得到改善:焦炭产率降低了0.8个... 详细信息

扬子石油化工股份有限公司炼油厂0.80Mt/a重油催化裂化装置采用CSC快分技术(带有密相环流预汽提器的粗旋快分技术)进行改造,得到了如下效果:①解决了装置存在的安全问题;②提高了装置的处理量;③产品分布得到改善:焦炭产率降低了0.8个百分点,轻质油收率提高了1.5个百分点;④待生催化剂汽提效果行到改善,其氢碳质量比下降到6.4%;⑤由于焦炭产率降低和待生催化剂氢碳比的下降,再生器烧焦负荷下降,催化剂再生效果改善,在处理量增加的情况下,再生催化剂碳含量仍保持在0.14%。

关键词： CSC 技术扬子石油化工股份有限公司改造重油催化裂化装置轻质油收率再生催化剂安全问题产品分布再生效果处理量汽提器炼油厂下降质量比氢碳比再生器碳含量分点产率焦炭烧焦

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日本江户兰学中的中国知识及其局限——以《厚生新编》(1811-1845)对《本草纲目》的参考为中心

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自然辩证法通讯 2019年第7期41卷 70-76页

作者：徐克伟北京大学外国语学院北京100871

一般说来,学界将日本学者系统翻译介绍西方近代知识追溯至江户时代的兰学,即借助荷兰语译介欧洲科技文献的学术运动。值得注意的是,兰学并非单纯的西学移入,兰学家于翻译之际确曾积极参考并利用相关的中国知识。其中,尤以作为幕府翻译... 详细信息

一般说来,学界将日本学者系统翻译介绍西方近代知识追溯至江户时代的兰学,即借助荷兰语译介欧洲科技文献的学术运动。值得注意的是,兰学并非单纯的西学移入,兰学家于翻译之际确曾积极参考并利用相关的中国知识。其中,尤以作为幕府翻译事业的日用百科全书《厚生新编》对本草学巨著《本草纲目》的参考最为显著。译者群体普遍具有的汉学素养与医学背景,使其在翻译之初构建起西方百科知识与东方本草学的对应。在利用本草学相关资源吸收消化译文内容的过程中,译者亦逐渐强化了对二者的区别意识,在诸多具体问题上对本草知识予以批判,并通过评判性的比较研究,获取更为实用、准确的新知识。

关键词：《厚生新编》《本草纲目》兰学本草学

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Interface Constraint Effect in Nano-Sandwiched Thin Film

Interface Constraint Effect in Nano-Sandwiched Thin Film

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中国真空学会2014学术年会

作者： Gengrong Chang Fei Ma Dayan Ma kewei xu Institute of Applied Physics Xi'an University State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University

Micro-particles and nano-wires,small outgrowths were found to appear on upper film surface when metal thin film is confined between two SiN layers deposited by magnetron sputtering and is annealed at an appropriate *** stress evolution during this process is monitored by multi-beam optic stress sensor,and is qualitatively interpreted in terms of elastic and plastic deformation,as well as bulk ***,the interface constraint effect among different layers is *** relaxation of nano-sandwiched thin films behaves in different stress *** a comparative study,SiN/Zn/SiN sandwiches were prepared and studied by the same *** results show that the pertinent geometry is strongly dependent on material types and stress states of the ***,an appropriate mode was suggested to interpret this phenomenon.

关键词： Nano-sandwiched thin film interface constraint stress relaxation micro-particles and nano-wires

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