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Identification and validation of a major gene for kernel length at the P1 locus in Triticum polonicum

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The Crop Journal 2022年第2期10卷 387-396页

作者： Songyue Chai Qin Yao Rui Liu Wenhui Xiang Xue Xiao Xing Fan Jian Zeng Lina Sha Houyang Kang Haiqin Zhang Dan Long dandan wu Yonghong Zhou Yi Wang Triticeae Research Institute Sichuan Agricultural UniversityWenjiang 611130SichuanChina College of Resources Sichuan Agricultural UniversityWenjiang 611130SichuanChina

Kernel size, one of the traits that determine wheat yield, is controlled by multiple quantitative trait *** wheat(Triticum polonicum) has elongated and plump kernel and is a valuable material for breeding high-yielding wheat cultivars. However, genes or loci determining kernel length(KL) in Polish wheat are unknown. We identified and validated a major KL gene, KL-PW, at the P1 locus in Polish wheat. KL-PW is VRT-A2, which encodes a MIKC-type MADS-box protein(MADS55). An insertion/deletion mutation in intron 1 of VRT-A2;led to an alternatively spliced transcript, VRT-A2;. Quantitative PCR analysis showed that VRT-A2;was more highly expressed in developing seeds than was VRT-A2 ***(BR) sensitivity experiment and the expression of BR-related genes indicated that VRTA2;functions as a positive regulator of BR responses. VRT-A2;significantly increased KL of *** findings not only reveal the molecular basis of KL-PW in controlling KL, but also provide a valuable genetic resource for increasing kernel size in wheat.

关键词： Polish wheat MADS-box gene Alternative splicing Kernel length Breeding

Cellular responses in Bacillus thuringiensis CS33 during bacteriophage BtCS33 infection

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Cellular responses in Bacillus thuringiensis CS33 during bac...

Mg(NO_(3))_(2)·6H_(2O)-Assisted insitu-Fabrication of Tea Residual Biochar for Ultra-Fast and High Adsorption of Rhodamine B

2013年湖北省暨武汉微生物学会会员代表大会暨学术年会

作者： dandan wu Yihui Yuan Pengming Liu Yan wu Meiying Gao Key Laboratory of Agricultural and Environmental Microbiology Wuhan Institute of VirologyChinese Academy of Sciences

Bacillus thuringiensis(Bt) has been widely used for 50 years as a biopesticide for controlling insect ***,bacteriophage infection can cause failures in 50%-80%of the batches during Bt fermentation,resulting in severe ...

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wuhan University Journal of Natural Sciences 2024年第2期29卷 165-176页

作者： HU dandan XUE Yangfan LIU Bo wu Yongjuan LI Zichen School of Chemistry&Chemical Engineering Shaanxi Xueqian Normal UniversityXi'an 710100ShaanxiChina Safe College Xi􀆳an University of Science and TechnologyXi'an 710054ShaanxiChina

In this work,porous biochar(MN-TRB_(750))was fabricated via direct pyrolysis of tea residue(TR)and Mg(NO_(3))_(2)·6H_(2)O(MN).The as-synthesized MN-TRB_(750) reached a specific surface area of 839.54 m^(2)·g^(-1)and an average pore size of 3.75 nm with multi-level pore *** decreased TR's carbonization temperature and promoted the aromatics extent,pore structure for the frizzly flake-like *** B(RhB)was chosen as the adsorbate to explore the removal performance of organic dyes in this *** results indicated that the maximum adsorption capacity of RhB on MN-TRB_(750) at 20℃ is up to 809.0 mg·g^(-1)with isotherms fitted well to Freundlich and Dubinin-Radushkevic *** adsorption kinetics followed pseudo-second-order and Elovich models with an equilibrium adsorption capacity of 757.6 mg·g^(-1)as the initial concentration of RhB is 260 mg·L^(-1).High pore filling,hydrogen bond,π-πinteraction determined the adsorption of RhB onto MN-TRB850 through a multi-active center and exothermic chemical sorption process.

关键词： Mg(NO_(3))_(2)·6H_(2)O porous biochar mechanism rhodamine B adsorption

An alternative splicing variant of mineralocorticoid receptor discovered in preeclampsia tissues and its effect on endothelial dysfunction

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Science China(Life Sciences) 2020年第3期63卷 388-400页

作者： Mengxi Guo Chengliang Zhou Gufeng Xu Lin Tang Yechun Ruan Ying Yu Xianhua Lin dandan wu Hao Chen Priscilla Yu Luyang Jin Yinyu Wang Yimei wu Kamran Ullah Tanzil Ur Rahman Xinmei Liu Jianzhong Sheng Hsiao-Chang Chan Hefeng Huang Women’s Hospital Zhejiang University School of MedicineHangzhou 310058China International Peace Maternal and Child Health Hospital Shanghai Jiao Tong University School of MedicineShanghai 200030China Epithelial Cell Biology Research Center Faculty of MedicineSchool of Biomedical SciencesThe Chinese University of Hong KongHong KongChina Key Laboratory of Reproductive Genetics Ministry of Education(Zhejiang University)Hangzhou 310058China Department of Pathology and Pathophysiology Zhejiang University School of MedicineHangzhou 310058China Shanghai Key Laboratory of Embryo Original Disease Shanghai 20030China

The pathophysiology of preeclampsia(PE)remains *** spiral artery remodeling dysfunction and PE offspring cardiovascular future development has been a worldwide *** collected placental and umbilical artery samples from normotensive and PE *** receptor(MR)and its alternative splicing variant(ASV)expression and their biological effects on PE were *** MR ASV was found to be highly expressed in all PE samples and slightly expressed in about half of the normotensive samples(umbilical artery,~57.58%;placenta,~36.84%).The MR ASV expression was positively associated with blood pressure in both *** MR ASV protein changed the aldosterone-induced expression pattern of MR target genes related to ion exchanges and cell signaling *** MR ASV can also impair the proliferation,migration,and tube formation ability of endothelial *** findings indicate that MR ASV in PE placenta plays a pathogenic role in PE pathophysiology,especially in endothelial dysfunction,and the existence of the MR ASV in PE umbilical artery provides a new direction in the study of PE offspring with increased risk of cardiovascular diseases.

关键词： preeclampsia mineralocorticoid receptor alternative splicing variant offspring endothelial dysfunction

Parboiled rice supplementation alleviates high-fat diet-induced hyperlipidemia by regulating genes and gut microbiota in mice

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Food Science and Human Wellness 2024年第3期13卷 1422-1438页

作者： Xiuxiu wu Tianyi Guo Biao Li Shuai Han Zuomin Hu Yi Luo dandan Qin Yaping Zhou Feijun Luo Qinlu Lin National Research Center of Rice Deep Process and Byproducts Hunan Provincial Key Laboratory of Grain-oil Deep Process and Quality ControlHunan Provincial Key Laboratory of Forestry Edible Resources Safety and ProcessingCentral South University of Forestry and TechnologyChangsha 410004China College of Life Science and Technology Central South University of Forestry and TechnologyChangsha 410004China Department of Clinical Medicine Medical College of XiangyaCentral South UniversityChangsha 410008China

Dietary parboiled rice(PR)has a low risk of disease,but little is known about the contribution of PR to the prevention of *** potential role and underlying mechanisms of PR in hyperlipidemia were evaluated in this *** C57BL/6J mice were fed with a normal diet,high-fat diet(HFD)containing refined rice(HFDRR)or PR(HFDPR).It was found that PR intervention improved lipid accumulation in *** data analysis revealed that 27 genes were up-regulated(mostly involved in lipid breakdown)and 86 genes were down-regulated(mostly involved in inflammatory responses)in the HFDPR group compared to the HFDRR *** 15 differentially expressed genes(DEGs)were validated by quantitative real-time PCR(RT-qPCR),while protein interaction network showed that protein tyrosine phosphatase receptor type C(PTPRC)has a central *** gut microbiota of mice was also altered after different dietary treatments,with higher ratio of Firmicutes and Bacteroidetes,increased abundances of Ruminococcaceae,Lachnospiraceae,Christensenellaceae,Porphyromonadaceae,Rikenellaceae and Prevotellaceae,and decreased abundances of Lactobacillaceae,Peptostreptococcaceae,Erysipelotrichaceae and Actinobacteria in the HFDRR *** addition,it was observed that PPAR signaling pathway may act as a bridge between DEGs and differential gut *** results suggested that PR can prevent hyperlipidemia by modulating liver genes and gut microbiota.

关键词： Parboiled rice Blood lipids Transcriptome Gut microbiota PPAR Signaling pathway

IGF-1通路在美洲大蠊提取物诱导胃癌细胞凋亡中的作用

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沈阳药科大学学报 2021年第4期38卷 395-400页

作者：邬丹丹锦州医科大学附属第一医院消化内科辽宁锦州121000

目的探讨美洲大蠊提取物(Periplaneta americana extract)诱导MGC-803胃癌细胞凋亡的作用和作用机制。方法以胃癌MGC-803细胞为研究对象,MTT法测定细胞增殖抑制率;JC-1染色测定细胞线粒体膜电位情况;DAPI染色观察细胞核形态;流式细胞术... 详细信息

目的探讨美洲大蠊提取物(Periplaneta americana extract)诱导MGC-803胃癌细胞凋亡的作用和作用机制。方法以胃癌MGC-803细胞为研究对象,MTT法测定细胞增殖抑制率;JC-1染色测定细胞线粒体膜电位情况;DAPI染色观察细胞核形态;流式细胞术检测细胞凋亡情况;Western blot测定凋亡相关基因bcl-2、bax和胰岛素样生长因子-1(insulin-like growth factor 1,IGF-1)信号通路相关蛋白的蛋白表达情况。结果与阴性对照组相比,50、100 mg·L-1的美洲大蠊提取物可不同程度地抑制MGC-803细胞的增殖,降低线粒体膜电位,使细胞核固缩,染色质深染,细胞凋亡增加,同时bcl-2表达降低,bax表达增加。机制研究结果显示IGF-1、磷脂酰肌醇-3激酶(phosphatidylinositol 3-kinase, PI3K)和磷酸化蛋白激酶B(protein kinase B,p-Akt)蛋白表达均有不同程度降低。结论美洲大蠊提取物对MGC-803细胞具有诱导凋亡的作用,其机制可能通过抑制IGF-1信号通路的表达实现。

关键词：美洲大蠊提取物胃癌凋亡胰岛素样生长因子-1

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一场慕课革命背后的德性教学反思与重构

课程．教材．教法 2014年第7期34卷 30-35页

作者：毋丹丹中国教育科学研究院北京100088

慕课基于连通主义学习理论,体现的是教学过程中知识与学习的深刻变革。这一深层意义的变革必然引起教学过程中的"学"与"教"呈现出自主性、个体性、存在性和生成性的时代特征。而教学的德性特质则要求从学生的外在身份表现维度和内在道... 详细信息

慕课基于连通主义学习理论,体现的是教学过程中知识与学习的深刻变革。这一深层意义的变革必然引起教学过程中的"学"与"教"呈现出自主性、个体性、存在性和生成性的时代特征。而教学的德性特质则要求从学生的外在身份表现维度和内在道德发展维度对慕课革命进行反思,并从对学生的需求分析、创生性的教学过程和存在式的教育关系三个方面重构德性教学。

关键词：慕课连通主义德性教学

Temporal profiles of the glial roles and neuroimages in APP/PS1 transgenic AD mice

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Temporal profiles of the glial roles and neuroimages in APP/...

Natural variation in the cytochrome c oxidase subunit 5B OsCOX5B regulates seed vigor by altering energy production in rice

中国解剖学会2019年年会

作者： Liu Lifen Liu Yutong wu dandan Huang Liang Yuan Qionglan Tongji University School of Medicine Department of Radiology University of Nebraska Medical Center

＜正＞Although glial alterations are hallmarks of Alzheimer’s disease （AD） patients,their early roles in amyloid-beta （Aβ） deposits are *** this study,we explored the temporal profiles of glial alteration and neurogenesis and neuroimages in APP/PS1 transgenic AD *** found that microglia and astrocytes were initially activated and clustered around Aβplaques at the age of 6 months and increased with ***

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Journal of Integrative Agriculture 2024年第9期23卷 2898-2910页

作者： Chengwei Huang Zhijuan Ji Qianqian Huang Liling Peng Wenwen Li dandan Wang Zepeng wu Jia Zhao Yongqi He Zhoufei Wang Laboratory of Seed Science and Technology/Guangdong Key Laboratory of Plant Molecular Breeding/State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources/South China Agricultural University Guangzhou 510642China National Nanfan Research Institute(Sanya) Chinese Academy of Agricultural SciencesSanya 572025 China National Rice Research Institute Hangzhou 310006China

Seed vigor is a crucial trait for the direct seeding of *** we examined the genetic regulation of seed vigor traits in rice,including germination index(GI)and germination potential(GP),using a genome-wide association study *** major quantitative trait locus,qGI6/qGP6,was identified simultaneously for both GI and *** candidate gene encoding the cytochrome c oxidase subunit 5B(OsCOX5B)was validated for qGI6/*** disruption of OsCOX5B caused the vigor traits to be significantly lower in Oscox5b mutants than in the japonica Nipponbare wild type(WT).Gene co-expression analysis revealed that OsCOX5B influences seed vigor mainly by modulating the tricarboxylic acid cycle *** glucose levels were significantly higher while the pyruvic acid and adenosine triphosphate levels were significantly lower in Oscox5b mutants than in WT during seed *** elite haplotype of OsCOX5B facilitates seed vigor by increasing its expression during seed ***,we propose that OsCOX5B is a potential target for the breeding of rice varieties with enhanced seed vigor for direct seeding.

关键词： cytochrome c oxidase natural variation rice seed vigor