An alternative splicing variant of mineralocorticoid receptor discovered in preeclampsia tissues and its effect on endothelial dysfunction

作     者：Mengxi Guo Chengliang Zhou Gufeng Xu Lin Tang Yechun Ruan Ying Yu Xianhua Lin Dandan Wu Hao Chen Priscilla Yu Luyang Jin Yinyu Wang Yimei Wu Kamran Ullah Tanzil Ur Rahman Xinmei Liu Jianzhong Sheng Hsiao-Chang Chan Hefeng Huang Mengxi Guo;Chengliang Zhou;Gufeng Xu;Lin Tang;Yechun Ruan;Ying Yu;Xianhua Lin;Dandan Wu;Hao Chen;Priscilla Yu;Luyang Jin;Yinyu Wang;Yimei Wu;Kamran Ullah;Tanzil Ur Rahman;Xinmei Liu;Jianzhong Sheng;Hsiao-Chang Chan;Hefeng Huang

作者机构：Women’s HospitalZhejiang University School of MedicineHangzhou 310058China International Peace Maternal and Child Health HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Epithelial Cell Biology Research CenterFaculty of MedicineSchool of Biomedical SciencesThe Chinese University of Hong KongHong KongChina Key Laboratory of Reproductive GeneticsMinistry of Education(Zhejiang University)Hangzhou 310058China Department of Pathology and PathophysiologyZhejiang University School of MedicineHangzhou 310058China Shanghai Key Laboratory of Embryo Original DiseaseShanghai 20030China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2020年第63卷第3期

页      面：388-400页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：This work was supported by the National Key Research and Development Program of China(2017YFC1001303) International Cooperation Project of China and Canada NSFC(81661128010) National Natural Science Foundation of China(31471405,81671456,and 81671412) the National Key Basic Research Program(2013CB967404) 

主　　题：preeclampsia mineralocorticoid receptor alternative splicing variant offspring endothelial dysfunction 

摘      要：The pathophysiology of preeclampsia(PE)remains *** spiral artery remodeling dysfunction and PE offspring cardiovascular future development has been a worldwide *** collected placental and umbilical artery samples from normotensive and PE *** receptor(MR)and its alternative splicing variant(ASV)expression and their biological effects on PE were *** MR ASV was found to be highly expressed in all PE samples and slightly expressed in about half of the normotensive samples(umbilical artery,~57.58%;placenta,~36.84%).The MR ASV expression was positively associated with blood pressure in both *** MR ASV protein changed the aldosterone-induced expression pattern of MR target genes related to ion exchanges and cell signaling *** MR ASV can also impair the proliferation,migration,and tube formation ability of endothelial *** findings indicate that MR ASV in PE placenta plays a pathogenic role in PE pathophysiology,especially in endothelial dysfunction,and the existence of the MR ASV in PE umbilical artery provides a new direction in the study of PE offspring with increased risk of cardiovascular diseases.