检索结果-南通市图书馆

Journal of Materials Science & Technology 2021年第34期93卷 17-27页

作者： Wenyu Wang Dejun Ding Kunpeng Zhou Man zhang weifen zhang Fang Yan Ni Cheng College of Pharmacy Weifang Medical UniversityWeifang261053China

Nitric oxide(NO)has emerged as a potential wound therapeutic agent due to its pivotal role in the wound healing ***,NO-based therapy for clinical applications is still restricted due to its gaseous state and short *** we exploited a wound dressing by incorporating sodium nitroprusside doped prussian blue nanoparticals and Type I collagen into the chitosan/poly(vinyl alcohol)nanofibers through the electrospinning *** hybrid nanofibrous scaffold possess the excellent abilities of NIR controlled NO release,photothermal therapy,and imitation of extra-cellular matrix-like *** synergistic effects could enhance their anti-bactericidal effects in vitro and furthermore accelerate wound healing in vivo when compared to control *** analysis demonstrated the scaffold could promote fibroblast growth and accelerate ***,no apparent histological toxicology and negligible damage to major organs were observed,which provided sufficient biosafety for in vivo *** data indicate the fabricated hybrid nanofibrous scaffold could be used as an ideal candidate for accelerating wound healing and treating chronic wounds.

关键词： Wound healing Nitric oxide NIR controlled Prussian blue nanoparticals Photothermal therapy Nanofibrous scaffold

A nanosystem of copper(II)-disulfiram for cancer treatment with high efficacy and few side effects

在线全文

学校读者我要写书评

暂无评论

Frontiers of Materials Science 2021年第4期15卷 553-566页

作者： Liping ZHAO Xiaoxia WANG Mingxia JIANG Xinghan WU Mogen zhang Xiuwen GUAN Jinlong MA weifen zhang College of Pharmacy Weifang Medical UniversityWeifang 261053China Department of Pathology Weifang Medical UniversityWeifang 261053China School of Clinical Medicine Weifang Medical UniversityWeifang 261053China Collaborative Innovation Center for Target Drug Delivery System Weifang Medical UniversityWeifang 261053China Shandong Engineering Research Center for Smart Materials and Regenerative Medicine Weifang Medical UniversityWeifang 261053China

Developing chemotherapy drugs with high efficacy and few side effects has been a bottleneck problem that requires an efficient *** active cancer treatment ingredient disulfiram(DSF),inspired by the copper(II)diethyldithiocarbamate complex(CuET),can be used in a one-pot synthesis method to construct a CuET delivery nanosystem(CuET-ZIFCu@HA).Due to the high biocompatibility,targeting of CD44 overexpressed cancer cells,and acid response of zeolitic imidazolate framework(ZIF)materials of hyaluronic acid(HA),we realized that CuET-ZIFCu@HA could become an effective and highly selective cancer *** in vivo and in vitro experiments have demonstrated that CuET-ZIFCu@HA has robust anti-tumor properties without evident side *** research provided a promising strategy for DSF nanosystems that involves simple preparation and high efficacy,both of which are key to reusing DSF in cancer treatment.

关键词： disulfiram copper(II)diethyldithiocarbamate complex zeolitic imidazolate framework targeted therapy

Chitosan and β-cyclodextrin Microspheres as Pulmonary Sustained Delivery Systems

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2008年第4期23卷 541-546页

作者： zhang weifen CHEN Xiguang LI Piwu HE Qiangzhi ZHOU Huiyun CHA Dongsu College of Marine Life Science Ocean University of China Qingdao 266003 China Shandong Academy of Food and Fermentation Industries Jinan 250013 China Graduate School of Biotechnology Korea University Seoul 136-701 Korea Depantment of Pharmacy Weifang Medical University Weifang 261042 China

Chitosan and β-cyclodextrin were used to prepare microspheres with theophylline for pulmonary delivery by spray drying method. The characteristics, mucociliotoxicity, permeation rate and drug release were studied. The drug entrapments of microspheres Ⅰ, Ⅱ and Ⅲ were from 35.70% to 21.09% and 13.33%, while yields and encapsulation efficiencies were higher than 45% and about 90% respectively. The microspheres possessed low tap densities （0.34-0.48 g/cm^3）, appropriate diameters （3.35-3.94 μm） and theoretical aerodynamics diameters （2.20-3.04 μm）. SEM images showed the microspheres were spherical with smooth or wrinkled surface surfaces. FT-IR demonstrated theophylline had formed hydrogen bonds with chitosan and fl-cyclodextrin. The microspheres could effectively reduce the ciliotoxicity and easy to penetrate the memberine. The in vitro release of the microspheres was related to the ratio of drug/polymer and microspheres Ⅱ had a prolong release, providing the release of 72.00% in 12 h. The results suggestes that chitosan/β-cyclodextrin microspheres Ⅱ are a promising carrier as sustained release for pulmonary delivery.

关键词： theophylline chitosan spray-drying microspheres pulmonary delivery

Synergetic burns treatment by self-adaption release system combined with cold atmospheric plasma

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2023年第10期66卷 2808-2823页

作者： WANG XiaoXia LIU ZhiJun ZHAO LiPing YANG HuiJie QIN JiaMin zhang JingQi ZHAO JiaXuan GUAN XiuWen zhang weifen MA JinLong School of Pharmacy Weifang Medical UniversityWeifang 261053China Department of Microbiology School of Basic Medical SciencesWeifang Medical UniversityWeifang 261053China Shandong Engineering Research Center for Smart Materials and Regenerative Medicine Weifang Medical UniversityWeifang 261053China Collaborative Innovation Center for Target Drug Delivery System Weifang Medical UniversityWeifang 261053China

In the tissue remodeling stage of burns,excessive medical therapy can cause scarring by promoting excessive fibroblast proliferation and collagen *** atmospheric plasma(CAP)has emerged in biomedicine for its excellent sterilization and wound-healing function,which is expected to reduce the use of drugs in burns ***,a novel therapy that could rapidly heal burns was developed using a combined self-adaption release system with *** self-adaption release system(Cur-ZIF8@HA)used curcumin(Cur)as the therapeutic drug and ZIF-8 modified with hyaluronic acid(HA)as the *** vitro study results showed that combined treatment methods can inactivate bacteria and enhance fibroblast cells'migration and *** vivo animal wound healing studies have demonstrated that the synergistic treatment of Cur-ZIF8@HA and CAP can help fibroblast proliferation and stimulate angiogenesis,indicating effective wound *** importantly,CAP can reduce collagen synthesis in granulation tissue recombination and further inhibit scar formation by combining with CurZIF8@*** the biomedical field,these findings underscore to a large extent that our research will open up new possibilities for the interaction of nanotechnology with new technologies of physical principles.

关键词： cold atmospheric plasma pH-sensitive release burns treatment nanoparticle

Comparison Study of Chitosan/β-Cyclodextrin and Carboxymethyl Chitosan/β-Cyclodextrin Microspheres

在线全文

学校读者我要写书评

暂无评论

Wuhan University Journal of Natural Sciences 2009年第4期14卷 362-368页

作者： LI Ruobao ZHAO Chunling zhang weifen SHI Lihong TANG Jinbao Department of Basic Medicine Weifang Medical UniversityWeifang 261053Shandong China Shandong Provincial Key Laboratory of Applied Pharmacology Weifang Medical University Weifang 261053 Shandong China

To compare two microspheres of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin loaded theophylline as pulmonary sustained drug delivery carriers, the characteristics and ciliotoxicity were studied. The drug loadings of chitosan/ β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin micro- spheres were 21.09% and 21.42%, and the encapsulation efficiencies were 91.40% and 92.80%. The distributions of 50% （d0.5） of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin microspheres were 4.89 and 5.83 μm, respectively. Both micro- spheres showed spherical shape with smooth or wrinkled surfaces. FT-IR of chitosan/β-cyclodextrin microspheres demonstrated that theophylline had formed hydrogen bonds with chitosan and β-cyclodextrin, while for the carboxymethyl chitosan/β-cyclodextrin microspheres theophylline had interaction with carboxymethyl chitosan. The moisture absorption showed that an equilibrium was reached within 24 h. The two microspheres possessed better adaptability. In vitro release of theophylline from chitosan/ β-cyclodextrin microspheres was slower than that from carboxy- methyl chitosan/β-cyclodcxtrin microspheres at pH 6.8.

关键词： theophylline chitosan carboxymethyl chitosan microspheres in vitro release

在线全文

学校读者我要写书评

暂无评论

一种新的相关机械振源盲分离方法

振动与冲击 2016年第15期35卷 216-221页

作者：于刚周以齐张卫芬山东大学高效洁净机械制造教育部重点实验室解放军72850部队

针对传统盲源分离算法在机械振源不满足统计独立特性时,无法有效分离出振源信号的问题,提出了基于信号稀疏特性的相关机械源盲分离方法。盲源分离算法的关键在于准确地估计出混合矩阵。因此,首先提出了不相关源混合矩阵的估计方法;然后... 详细信息

针对传统盲源分离算法在机械振源不满足统计独立特性时,无法有效分离出振源信号的问题,提出了基于信号稀疏特性的相关机械源盲分离方法。盲源分离算法的关键在于准确地估计出混合矩阵。因此,首先提出了不相关源混合矩阵的估计方法;然后针对相关源,提出了有效剔除相关成分的方法,使得剩余信号可以按照不相关源进行处理。通过理论分析、仿真验证以及实测数据分析,验证了该方法的有效性。

关键词：盲源分离振动源相关源

Effects of theophylline/chitosan/β-cyclodextrin microspheres for oral drug delivery on an asthmatic rat model

在线全文

学校读者我要写书评

暂无评论

TMR Modern Herbal Medicine 2020年第2期3卷 66-76页

作者： Saisai Wang Haijing zhang Xiaoming Cui Liping Zhao Mingxia Jiang Zhilu Xu Dongzhen Mu weifen zhang School of Pharmacy Weifang Medical UniversityWeifangShandong 261053China Intensive Care Unit The First people’s hospital of HefeiHefeiAnhui 230061China Department of Immunology Key lab for Immunology in Shandong ProvinceSchool of clinical MedicineWeifang Medical UniversityWeifangShandong 261053China Institute for Smart Materials and Regenerative Medicine Weifang Medical UniversityWeifangShandong 261053China Shandong Engineering Research Center for Smart Materials and Regenerative Medicine Weifang Medical UniversityWeifangShandong 261053China

Objective:This study aimed to investigate the effects of TH/CTS/β-CD microspheres by oral administration on ovalbumin allergic asthma of a rat ***:Spray drying method was applied for preparing the TH/CTS/β-CD microspheres,which were used in treatment of asthmatic *** a predetermined time,the levels of eosinophil(Eos),protein,lactate dehydrogenase(LDH),aspartate transaminase(AST),glutamic pyruvic transaminase(GPT),and creatinine(Cr)were ascertained by automatic hematology and biochemical *** tissue histology was performed by hematoxylin-eosin ***:No significant differences were found about the contents of Eos in the blood,and the contents of Eos,protein and LDH in the bronchoalveolar lavage fluid between the microsphere-treated and dexamethasone-treated groups,but the levels were lower in both treated groups than in the model *** the microsphere-treated group,the levels of Cr,AST,and GPT in the serum of rats showed no significant differences compared with the normal *** on lung histopathological findings,the microspheres attenuated inflammatory cell infiltration and mucus hypersecretion compared with the model ***:This study demonstrated that TH/CTS/β-CD microspheres exerted an anti-inflammatory effect and could serve as a novel promising drug delivery system for asthma treatment.

关键词： Chitosan Theophylline Asthma Microspheres Pharmacodynamics

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国船舶制造业企业兼并重组研究

学术交流 2013年第1期 102-106页

作者：张为峰苏智哈尔滨工程大学船舶工程学院哈尔滨150001

中国船舶制造企业目前处于快速发展时期,但总体上仍处于初级阶段。尤其是2008年世界金融危机以来,国内船舶企业面临巨大的挑战。一批近年来新兴的民营船舶企业,由于生产规模小,技术力量储备不足,运转资金匮乏,抗风险能力较低,经营战略... 详细信息

中国船舶制造企业目前处于快速发展时期,但总体上仍处于初级阶段。尤其是2008年世界金融危机以来,国内船舶企业面临巨大的挑战。一批近年来新兴的民营船舶企业,由于生产规模小,技术力量储备不足,运转资金匮乏,抗风险能力较低,经营战略风险评估不足,直接导致企业倒闭或破产。为此,船舶企业兼并重组势在必行,在企业重组时要着重考虑兼并重组的动因、时机、对象、风险等因素,制定有效的兼并重组方案和风险评估机制。在兼并重组后,为有效实施企业发展战略和打造核心竞争力,要及时开展整合研究,在文化整合、人力资源、生产经营和资产债务方面有效运作,从而保证船舶企业兼并重组后良好运行和健康发展。

关键词：船舶制造业兼并重组风险

在线全文

学校读者我要写书评

暂无评论

浅议室内装饰工程

山西焦煤科技 2007年第5期31卷 40-41页

作者：张卫芬山西京华建筑装饰工程有限公司

论述了室内装饰工程的基本要素,阐述了室内装饰设计的基本原理和设计方法并且介绍了室内装饰工程的要点(收口)。

关键词：室内装修环境装饰收口

天作之“盒”,“泥”的创意——以主题盒子为载体的创意泥活动开展策略

在线全文

学校读者我要写书评

暂无评论

当代家庭教育 2021年第33期 91-92页

作者：张为芬江苏省苏州市高新区通安实验幼儿园

在学前教育过程中,艺术活动的有效开展对于培养幼儿的多方面能力起到至关重要的作用,其中创意泥活动是幼儿在园参与的一种重要的艺术活动,以具有独特的游戏性、可变性和创造性的特点,深受幼儿喜爱,而如何在幼儿园开展创意泥活动,需要教... 详细信息

在学前教育过程中,艺术活动的有效开展对于培养幼儿的多方面能力起到至关重要的作用,其中创意泥活动是幼儿在园参与的一种重要的艺术活动,以具有独特的游戏性、可变性和创造性的特点,深受幼儿喜爱,而如何在幼儿园开展创意泥活动,需要教师对创意泥活动进行研究与思考。作者针对如何在幼儿园开展创意泥活动进行了实践与研究,以主题盒子为载体开展创意泥活动,希望能促进创意泥活动在幼儿园更好地开展。

关键词：学前教育主题盒子载体创意泥活动