Synergetic burns treatment by self-adaption release system combined with cold atmospheric plasma

作     者：WANG XiaoXia LIU ZhiJun ZHAO LiPing YANG HuiJie QIN JiaMin ZHANG JingQi ZHAO JiaXuan GUAN XiuWen ZHANG WeiFen MA JinLong 

作者机构：School of PharmacyWeifang Medical UniversityWeifang 261053China Department of MicrobiologySchool of Basic Medical SciencesWeifang Medical UniversityWeifang 261053China Shandong Engineering Research Center for Smart Materials and Regenerative MedicineWeifang Medical UniversityWeifang 261053China Collaborative Innovation Center for Target Drug Delivery SystemWeifang Medical UniversityWeifang 261053China 

出 版 物：《Science China(Technological Sciences)》 (中国科学（技术科学英文版）)

年 卷 期：2023年第66卷第10期

页      面：2808-2823页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：the National Natural Science Foundation of China(Grant No.81973671) the Natural Science Foundation of Shandong Province(Grant Nos.ZR2019BB071,ZR2019MC059,ZR2023QH038,and ZR2023MH037) the Traditional Chinese Medicine Science and Technology Project of Shandong Province(Grant Nos.M-2023084 and Q-2023047) the Science and Technology Innovation Fund for College Students of Weifang Medical University 

主　　题：cold atmospheric plasma pH-sensitive release burns treatment nanoparticle 

摘      要：In the tissue remodeling stage of burns,excessive medical therapy can cause scarring by promoting excessive fibroblast proliferation and collagen *** atmospheric plasma(CAP)has emerged in biomedicine for its excellent sterilization and wound-healing function,which is expected to reduce the use of drugs in burns ***,a novel therapy that could rapidly heal burns was developed using a combined self-adaption release system with *** self-adaption release system(Cur-ZIF8@HA)used curcumin(Cur)as the therapeutic drug and ZIF-8 modified with hyaluronic acid(HA)as the *** vitro study results showed that combined treatment methods can inactivate bacteria and enhance fibroblast cells migration and *** vivo animal wound healing studies have demonstrated that the synergistic treatment of Cur-ZIF8@HA and CAP can help fibroblast proliferation and stimulate angiogenesis,indicating effective wound *** importantly,CAP can reduce collagen synthesis in granulation tissue recombination and further inhibit scar formation by combining with CurZIF8@*** the biomedical field,these findings underscore to a large extent that our research will open up new possibilities for the interaction of nanotechnology with new technologies of physical principles.