A nanosystem of copper(II)-disulfiram for cancer treatment with high efficacy and few side effects

作     者：Liping ZHAO Xiaoxia WANG Mingxia JIANG Xinghan WU Mogen ZHANG Xiuwen GUAN Jinlong MA Weifen ZHANG Liping ZHAO;Xiaoxia WANG;Mingxia JIANG;Xinghan WU;Mogen ZHANG;Xiuwen GUAN;Jinlong MA;Weifen ZHANG

作者机构：College of PharmacyWeifang Medical UniversityWeifang 261053China Department of PathologyWeifang Medical UniversityWeifang 261053China School of Clinical MedicineWeifang Medical UniversityWeifang 261053China Collaborative Innovation Center for Target Drug Delivery SystemWeifang Medical UniversityWeifang 261053China Shandong Engineering Research Center for Smart Materials and Regenerative MedicineWeifang Medical UniversityWeifang 261053China 

出 版 物：《Frontiers of Materials Science》 (材料学前沿（英文版）)

年 卷 期：2021年第15卷第4期

页      面：553-566页

核心收录：

学科分类：1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 0702[理学-物理学] 10[医学] 

基　　金：the National Natural Science Foundation of China(Grant Nos.81774125 and 81973671) the Natural Science Foundation of Shandong Province(Grant No.ZR2019BB071) the Major Innovation and Technology Engineering Project of Shandong Province(Grant No.2019JZZY011106) the Science and Technology Innovation Fund for College Students of Weifang Medical University,and the Weifang Medical University-Sponsored Visiting Schola Research 

主　　题：disulfiram copper(II)diethyldithiocarbamate complex zeolitic imidazolate framework targeted therapy 

摘      要：Developing chemotherapy drugs with high efficacy and few side effects has been a bottleneck problem that requires an efficient *** active cancer treatment ingredient disulfiram(DSF),inspired by the copper(II)diethyldithiocarbamate complex(CuET),can be used in a one-pot synthesis method to construct a CuET delivery nanosystem(CuET-ZIFCu@HA).Due to the high biocompatibility,targeting of CD44 overexpressed cancer cells,and acid response of zeolitic imidazolate framework(ZIF)materials of hyaluronic acid(HA),we realized that CuET-ZIFCu@HA could become an effective and highly selective cancer *** in vivo and in vitro experiments have demonstrated that CuET-ZIFCu@HA has robust anti-tumor properties without evident side *** research provided a promising strategy for DSF nanosystems that involves simple preparation and high efficacy,both of which are key to reusing DSF in cancer treatment.